{ "uniprot_canonical_ac": "A2VCX1-1", "ptm_annotation": [], "sequence": { "header": "sp|A2VCX1-1|TIPRL_RAT Isoform 1 of TIP41-like protein OS=Rattus norvegicus OX=10116 GN=Tiprl PE=1 SV=1 CANONICAL=A2VCX1-1", "length": 271, "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE" }, "uniprot_id": "TIPRL_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "rats", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17384681", "type": [ "PubMed" ], "id": "17384681" } ], "title": "Identification of a PP2A-interacting protein that functions as a negative regulator of phosphatase activity in the ATM/ATR signaling pathway.", "journal": "Oncogene", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137.1", "id": "NP_001103137.1", "database": "RefSeq" } ], "authors": "McConnell JL, Gomez RJ, McCorvey LR, Law BK, Wadzinski BE", "date": "2007" } ], "uniprot_ac": "A2VCX1", "site_annotation": [ { "end_pos": 70, "annotation": "n_glycosylation_sequon", "start_pos": 68 }, { "end_pos": 199, "annotation": "n_glycosylation_sequon", "start_pos": 197 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1#A2VCX1-1", "isoform_ac": "A2VCX1-1", "locus": { "end_pos": 83479808, "start_pos": 83504403, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000004083", "id": "ENSRNOT00000004083", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000004083", "id": "ENSRNOP00000004083", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2VCX1-1|TIPRL_RAT Isoform 1 of TIP41-like protein OS=Rattus norvegicus OX=10116 GN=Tiprl PE=1 SV=1 CANONICAL=A2VCX1-1", "length": 271, "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSESAPSE" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360869", "resource": "KEGG Pathway", "id": "rno:360869", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1#function", "annotation": "May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as negative regulator of serine/threonine-protein phosphatase 4 probably by inhibiting the formation of the active PPP4C:PPP4R2 complex; the function is proposed to implicate it in DNA damage response by promoting H2AFX phosphorylated on Ser-140 (gamma-H2AFX). May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1#function", "id": "A2VCX1", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O75663-1", "protein_name": "TIP41-like protein", "sequence": { "length": 272, "sequence": "MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7140", "id": "7140", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2VCX1/", "id": "A2VCX1", "database": "OMA" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8BH58-1", "protein_name": "TIP41-like protein", "sequence": { "length": 271, "sequence": "MMIHGFQSSHQDFSFGPWKLTASKTHIMKSADVEKLADELHMPSLPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSKEVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDELHDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRESKIANLMHVPPSLFTEPNEISQYLPIKEAVCEKLVFPERIDPNPVDSQSTPSE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/7140", "id": "7140", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2VCX1/", "id": "A2VCX1", "database": "OMA" } ], "common_name": "mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137.1", "ac": "NP_001103137.1", "name": "TIP41-like protein", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007165", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "name": "signal transduction", "id": "GO:0007165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000077", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "name": "DNA damage checkpoint", "id": "GO:0000077" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032515", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "name": "negative regulation of phosphoprotein phosphatase activity", "id": "GO:0032515" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VCX1", "type": "synonym", "resource": "RefSeq", "name": "Tiprl" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VCX1", "type": "synonym", "resource": "RefSeq", "name": "RGD1310442" }, { "url": "https://www.uniprot.org/uniprot/A2VCX1", "type": "recommended", "resource": "UniProtKB", "name": "Tiprl" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/360869", "id": "360869", "database": "GeneID" }, { "url": "http://www.orthodb.org/?query=1377237at2759", "id": "1377237at2759", "database": "OrthoDB" }, { "url": "https://omabrowser.org/oma/group/TNPDEMQ/", "id": "TNPDEMQ", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007303", "id": "IPR007303", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2VCX1", "id": "PR_A2VCX1", "database": "PRO" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000003048", "id": "ENSRNOG00000003048", "database": "Bgee" }, { "url": "http://pfam.xfam.org/family/PF04176", "id": "PF04176", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1310442", "id": "1310442", "database": "RGD" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:360869", "id": "rno:360869", "database": "KEGG Pathway" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103137.1", "id": "NP_001103137.1", "database": "RefSeq" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR21021:SF16", "id": "PTHR21021:SF16", "database": "PANTHER" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "270", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "265", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "id": "A2VCX1", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "270", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1" } ], "mass": { "monoisotopic_mass": 31225.0, "chemical_mass": 31225.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "name": "Tiprl", "locus": { "end_pos": 83478974, "start_pos": 83504494, "chromosome": "13", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000003048", "id": "ENSRNOG00000003048", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2VCX1", "type": "recommended", "resource": "UniProtKB", "name": "TIP41-like protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VCX1", "type": "synonym", "resource": "RefSeq", "name": "TIP41, TOR signaling pathway regulator-like; CG9578-like; TIP41, TOR signalling pathway regulator-like" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VCX1", "type": "synonym", "resource": "RefSeq", "name": "TIP41-like protein" } ] }