{ "uniprot_canonical_ac": "A2AUC9-1", "ptm_annotation": [ { "annotation": "Ubiquitinated by E3 ubiquitin ligase complex formed by CUL3 and RBX1 and probably targeted for proteasome-independent degradation. Quinone-induced oxidative stress increases its ubiquitination.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/O60662", "id": "O60662", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AUC9-1|KLH41_MOUSE Isoform 1 of Kelch-like protein 41 OS=Mus musculus OX=10090 GN=Klhl41 PE=1 SV=1 CANONICAL=A2AUC9-1", "length": 606, "sequence": "MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEVALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL" }, "uniprot_id": "KLH41_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12692149", "type": [ "PubMed" ], "id": "12692149" } ], "title": "New N-RAP-binding partners alpha-actinin, filamin and Krp1 detected by yeast two-hybrid screening: implications for myofibril assembly.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Lu S, Carroll SL, Herrera AH, Ozanne B, Horowits R", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18178185", "type": [ "PubMed" ], "id": "18178185" } ], "title": "Krp1 (Sarcosin) promotes lateral fusion of myofibril assembly intermediates in cultured mouse cardiomyocytes.", "journal": "Exp. Cell Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Horowits R., Connelly P.S., Daniels M.P., Greenberg C.C.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24960163", "type": [ "PubMed" ], "id": "24960163" } ], "title": "KLHL40 deficiency destabilizes thin filament proteins and promotes nemaline myopathy.", "journal": "The Journal of clinical investigation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Garg A, O'Rourke J, Long C, Doering J, Ravenscroft G, Bezprozvannaya S, Nelson BR, Beetz N, Li L, Chen S, Laing NG, Grange RW, Bassel-Duby R, Olson EN", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21368295", "type": [ "PubMed" ], "id": "21368295" } ], "title": "BTB-Kelch protein Krp1 regulates proliferation and differentiation of myoblasts.", "journal": "Am. J. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Ozanne B.W., Pell J.M., Spence H.J., Cosgrove R.A., Drozd A.C., Paxton C.W., Watson R.A., Wiggins E.L., Woodhouse S.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28826497", "type": [ "PubMed" ], "id": "28826497" } ], "title": "KLHL41 stabilizes skeletal muscle sarcomeres by nonproteolytic ubiquitination.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Ramirez-Martinez A, Cenik BK, Bezprozvannaya S, Chen B, Bassel-Duby R, Liu N, Olson EN", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24268659", "type": [ "PubMed" ], "id": "24268659" } ], "title": "Identification of KLHL41 mutations implicates BTB-Kelch-mediated ubiquitination as an alternate pathway to myofibrillar disruption in nemaline myopathy.", "journal": "Am. J. Hum. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Alkuraya F.S., Beggs A.H., Clarke N.F., Laing N.G., Muntoni F., Nishino I., North K.N., Ravenscroft G., Sewry C.A., Wallgren-Pettersson C., Darras B.T., Gupta V.A., Hashem A., Hayashi Y.K., Matsumoto N., Shaheen R., Yu T.W., Allcock R.J., Thompson E.M., Ogata K., Shiina M., Brownstein C.A., Davis M.R., Hsu C., Yau K.S., Farrar M.A., Manton N.D., Sandaradura S.A., Swanson L.C., Todd E.J.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22562206", "type": [ "PubMed" ], "id": "22562206" } ], "title": "Sarcosin (Krp1) in skeletal muscle differentiation: gene expression profiling and knockdown experiments.", "journal": "Int. J. Dev. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ], "authors": "Beqqali A., Haagsman H.P., Monshouwer-Kloots J., Passier R., Roelen B.A., du Puy L., van Tol H.T.", "date": "2012" } ], "uniprot_ac": "A2AUC9", "site_annotation": [ { "end_pos": 312, "annotation": "n_glycosylation_sequon", "start_pos": 310 }, { "end_pos": 375, "annotation": "n_glycosylation_sequon", "start_pos": 373 }, { "end_pos": 216, "annotation": "n_glycosylation_sequon", "start_pos": 214 }, { "end_pos": 187, "annotation": "n_glycosylation_sequon", "start_pos": 185 }, { "end_pos": 338, "annotation": "n_glycosylation_sequon", "start_pos": 336 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9#A2AUC9-1", "isoform_ac": "A2AUC9-1", "locus": { "end_pos": 69670197, "start_pos": 69683596, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100050", "id": "ENSMUST00000100050", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097627", "id": "ENSMUSP00000097627", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AUC9-1|KLH41_MOUSE Isoform 1 of Kelch-like protein 41 OS=Mus musculus OX=10090 GN=Klhl41 PE=1 SV=1 CANONICAL=A2AUC9-1", "length": 606, "sequence": "MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEVALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKNAEKAGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSLVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVTSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGALYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "resource": "Reactome", "id": "R-MMU-983168", "name": "Antigen processing: Ubiquitination & Proteasome degradation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "resource": "Reactome", "id": "R-MMU-8951664", "name": "Neddylation" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228003", "resource": "KEGG Pathway", "id": "mmu:228003", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "annotation": "Loss of KLHL41 leads to nemaline myopathy. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AUC9#function", "annotation": "Involved in skeletal muscle development and differentiation. Regulates proliferation and differentiation of myoblasts and plays a role in myofibril assembly by promoting lateral fusion of adjacent thin fibrils into mature, wide myofibrils. Required for pseudopod elongation in transformed cells.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9#function", "id": "A2AUC9", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "annotation": "Data show that Sarcosin (Krp1) mRNA is expressed in the myotome part of the mature somites in mouse embryos from embryonic day 9.5 onwards.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "annotation": "Krp1 promotes lateral fusion of adjacent thin fibrils into mature, wide myofibrils and contribute insight into mechanisms of myofibrillogenesis and disassembly", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9ER30-1", "protein_name": "Kelch-like protein 41", "sequence": { "length": 606, "sequence": "MDSQRELAEELRLYQSTLLQDGLKDLLEEKKFIDCTLKAGDKSFPCHRLILSACSPYFREYFLSEIEEEKKKEMALDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALSSRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEVVFEAVMKWVRTDKENRAKNLSEVFDCIRFRLMAEKYFKDHVEKDDIIKSNPEVQKKIKVLKDAFAGKLPEPSKSAEKGGTGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPMENECYLTALAEQIPRNHSSIVTQQNQVYVVGGLYVDEENKDQPLQSYFFQLDNVSSEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWSEVKNLPIKVYGHNVISHNGMIYCLGGKTDDKKCTNRVFIYNPKKGDWKDLAPMKTPRSMFGVAIHKGKIVIAGGVTEDGLSASVEAFDLKTNKWEVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4421", "id": "4421", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AUC9/", "id": "A2AUC9", "database": "OMA" } ], "common_name": "rats", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "O60662-1", "protein_name": "Kelch-like protein 41", "sequence": { "length": 606, "sequence": "MDSQRELAEELRLYQSTLLQDGLKDLLDEKKFIDCTLKAGDKSLPCHRLILSACSPYFREYFLSEIDEAKKKEVVLDNVDPAILDLIIKYLYSASIDLNDGNVQDIFALASRFQIPSVFTVCVSYLQKRLAPGNCLAILRLGLLLDCPRLAISAREFVSDRFVQICKEEDFMQLSPQELISVISNDSLNVEKEEAVFEAVMKWVRTDKENRVKNLSEVFDCIRFRLMTEKYFKDHVEKDDIIKSNPDLQKKIKVLKDAFAGKLPEPSKNAAKTGAGEVNGDVGDEDLLPGYLNDIPRHGMFVKDLILLVNDTAAVAYDPTENECYLTALAEQIPRNHSSIVTQQNQIYVVGGLYVDEENKDQPLQSYFFQLDSIASEWVGLPPLPSARCLFGLGEVDDKIYVVAGKDLQTEASLDSVLCYDPVAAKWNEVKKLPIKVYGHNVISHKGMIYCLGGKTDDKKCTNRVFIFNPKKGDWKDLAPMKIPRSMFGVAVHKGKIVIAGGVTEDGLSASVEAFDLTTNKWDVMTEFPQERSSISLVSLAGSLYAIGGFAMIQLESKEFAPTEVNDIWKYEDDKKEWAGMLKEIRYASGASCLATRLNLFKLSKL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/4421", "id": "4421", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AUC9/", "id": "A2AUC9", "database": "OMA" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "ac": "NP_001074556.1", "name": "kelch-like protein 41", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "18178185", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "22562206", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21368295", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "18178185", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "24268659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031430", "pmid": "22562206", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "M band", "id": "GO:0031430" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033017", "pmid": "24268659", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "sarcoplasmic reticulum membrane", "id": "GO:0033017" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031143", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "pseudopodium", "id": "GO:0031143" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001726", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "ruffle", "id": "GO:0001726" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031463", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "Cul3-RING ubiquitin ligase complex", "id": "GO:0031463" } ], "total": 13, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035914", "pmid": "22562206", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "skeletal muscle cell differentiation", "id": "GO:0035914" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000291", "pmid": "21368295", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "regulation of myoblast proliferation", "id": "GO:2000291" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030239", "pmid": "18178185", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "myofibril assembly", "id": "GO:0030239" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045661", "pmid": "21368295", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "regulation of myoblast differentiation", "id": "GO:0045661" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001014", "pmid": "22562206", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "regulation of skeletal muscle cell differentiation", "id": "GO:2001014" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048741", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "skeletal muscle fiber development", "id": "GO:0048741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016567", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "protein ubiquitination", "id": "GO:0016567" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045214", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "sarcomere organization", "id": "GO:0045214" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031275", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "name": "regulation of lateral pseudopodium assembly", "id": "GO:0031275" } ], "total": 9, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUC9", "type": "synonym", "resource": "RefSeq", "name": "Klhl41" }, { "url": "https://www.uniprot.org/uniprot/A2AUC9", "type": "synonym", "resource": "UniProtKB", "name": "Kbtbd10" }, { "url": "https://www.uniprot.org/uniprot/A2AUC9", "type": "recommended", "resource": "UniProtKB", "name": "Klhl41" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUC9", "type": "synonym", "resource": "RefSeq", "name": "Gm112; Kbtbd10; SARCOSIN" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR006652", "id": "IPR006652", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228003", "id": "mmu:228003", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015915", "id": "IPR015915", "database": "InterPro" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8951664", "id": "R-MMU-8951664", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-983168", "id": "R-MMU-983168", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074556.1", "id": "NP_001074556.1", "database": "RefSeq" }, { "url": "http://pfam.xfam.org/family/PF07707", "id": "PF07707", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228003", "id": "228003", "database": "GeneID" }, { "url": "https://omabrowser.org/oma/group/KMDSQRE/", "id": "KMDSQRE", "database": "OMA" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000075307", "id": "ENSMUSG00000075307", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011705", "id": "IPR011705", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017096", "id": "IPR017096", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AUC9", "id": "PR_A2AUC9", "database": "PRO" }, { "url": "http://pfam.xfam.org/family/PF01344", "id": "PF01344", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR030571", "id": "IPR030571", "database": "InterPro" }, { "url": "http://www.informatics.jax.org/marker/MGI:2683854", "id": "2683854", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=946131at2759", "id": "946131at2759", "database": "OrthoDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011333", "id": "IPR011333", "database": "InterPro" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24412:SF146", "id": "PTHR24412:SF146", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00651", "id": "PF00651", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000210", "id": "IPR000210", "database": "InterPro" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "3", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "id": "A2AUC9", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 68190.0, "chemical_mass": 68190.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "name": "Klhl41", "locus": { "end_pos": 69684230, "start_pos": 69670120, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000075307", "id": "ENSMUSG00000075307", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AUC9", "type": "synonym", "resource": "UniProtKB", "name": "Kelch repeat and BTB domain-containing protein 10" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUC9", "type": "synonym", "resource": "RefSeq", "name": "kelch repeat and BTB (POZ) domain containing 10; kelch repeat and BTB domain-containing protein 10" }, { "url": "https://www.uniprot.org/uniprot/A2AUC9", "type": "recommended", "resource": "UniProtKB", "name": "Kelch-like protein 41" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AUC9", "type": "synonym", "resource": "RefSeq", "name": "kelch-like protein 41" } ] }