{ "uniprot_canonical_ac": "A2AR02-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AR02-1|PPIG_MOUSE Isoform 1 of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" }, "uniprot_id": "PPIG_MOUSE", "enzyme_annotation": [ { "ec": "5.2.1.8", "activity": "Peptidylproline (omega=180) = peptidylproline (omega=0)." }, { "ec": "5.2.1.8", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [], "uniprot_ac": "A2AR02", "site_annotation": [ { "end_pos": 122, "annotation": "n_glycosylation_sequon", "start_pos": 120 }, { "end_pos": 672, "annotation": "n_glycosylation_sequon", "start_pos": 670 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#A2AR02-1", "isoform_ac": "A2AR02-1", "locus": { "end_pos": 69732214, "start_pos": 69750379, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000040915", "id": "ENSMUST00000040915", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000045945", "id": "ENSMUSP00000045945", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AR02-1|PPIG_MOUSE Isoform 1 of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSESSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEAENVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKVEKEKKAKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKPLDPKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRSQESKSSHRKENSEGEKRTYSKSRDHNSSSNNREKKADREQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" } }, { "url": "https://www.uniprot.org/uniprot/A2AR02#A2AR01-1", "isoform_ac": "A2AR01-1", "locus": { "end_pos": 69732214, "start_pos": 69735871, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000144652", "id": "ENSMUST00000144652", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000114570", "id": "ENSMUSP00000114570", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AR01-1|PPIG_MOUSE Computationally mapped isoform of Peptidyl-prolyl cis-trans isomerase G OS=Mus musculus OX=10090 GN=Ppig PE=1 SV=1 CANONICAL=A2AR02-1", "length": 127, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFIT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228005", "resource": "KEGG Pathway", "id": "mmu:228005", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#function", "annotation": "PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02#function", "id": "A2AR02", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q13427-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase G", "sequence": { "length": 754, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELIPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIKQSSQDNELKSSMLKNKEDEKIRSSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDEDKSG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3520", "id": "3520", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AR02/", "id": "A2AR02", "database": "OMA" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "O55035-1", "protein_name": "Peptidyl-prolyl cis-trans isomerase G", "sequence": { "length": 752, "sequence": "MGIKVQRPRCFFDIAINNQPAGRVVFELFSDVCPKTCENFRCLCTGEKGTGKSTQKPLHYKSCLFHRVVKDFMVQGGDFSEGNGRGGESIYGGFFEDESFAVKHNKEFLLSMANRGKDTNGSQFFITTKPTPHLDGHHVVFGQVISGQEVVREIENQKTDAASKPFAEVRILSCGELVPKSKVKKEEKKRHKSSSSSSSSDSDSSSDSQSSSDSSDSESASEEKSRKRKKKHRKNSRKHKKEKKKRKKSKKSPSSESEADNVDAQPQSTVRPEEIPPIPENRFLMRKSPPKADDKERKNRERERERECNPPNSQPASYQRRFLVTRFGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKEKKITDHRHMSESPNRKIEKEKKVKDHKSESKERDIRRNSEKDDKYNKNKVKKRGKSKSRSKSKERSKSKERDSKHSRHEDKRVRSRSKERDHETTKEKEKQLDSKGKDQERSRSKENSKQVESKSNEHDHSKSKEKDRRAQSRSRERDLTKSKHSYNSRTRERSRSRDRSRRVRSRSHDRDRSRSKEYHRYREQEYRRRGRSRSRDRRTPGRSRSKDRRRRRRDSRSSEREESQSRNKEKYRSQDSKSSHRKENSEGEKRMYSKSRDHSSSNNNREKKADIDQSPVSKTKQSSQDNEVKSSTLKNQEDEKTRSPVEKENQKSKGQENDHVHDKNKKCDHESSPGTDEDKSG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/3520", "id": "3520", "database": "MGI" } ], "common_name": "rats", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074555.1", "ac": "NP_001074555.1", "name": "peptidyl-prolyl cis-trans isomerase G", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051082", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "unfolded protein binding", "id": "GO:0051082" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016018", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "cyclosporin A binding", "id": "GO:0016018" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003755", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "peptidyl-prolyl cis-trans isomerase activity", "id": "GO:0003755" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016607", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "nuclear speck", "id": "GO:0016607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016363", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "nuclear matrix", "id": "GO:0016363" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042026", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "protein refolding", "id": "GO:0042026" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000413", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "name": "protein peptidyl-prolyl isomerization", "id": "GO:0000413" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "recommended", "resource": "UniProtKB", "name": "Ppig" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AR02", "type": "synonym", "resource": "RefSeq", "name": "Ppig" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AR02", "type": "synonym", "resource": "RefSeq", "name": "AU019516; AU022200; B230312B02Rik; CYP; SRCyp" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002130", "id": "IPR002130", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/VNKRDAS/", "id": "VNKRDAS", "database": "OMA" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029000", "id": "IPR029000", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AR02*", "id": "A2AR02", "database": "IntAct" }, { "url": "http://www.orthodb.org/?query=1403619at2759", "id": "1403619at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00160", "id": "PF00160", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020892", "id": "IPR020892", "database": "InterPro" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AR02", "id": "PR_A2AR02", "database": "PRO" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:228005", "id": "mmu:228005", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000042133", "id": "ENSMUSG00000042133", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074555.1", "id": "NP_001074555.1", "database": "RefSeq" }, { "url": "http://www.informatics.jax.org/marker/MGI:2445173", "id": "2445173", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/228005", "id": "228005", "database": "GeneID" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "411", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "288", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "694", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "257", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "252", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "356", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "255", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "257", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "254", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "384", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "751", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "395", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "413", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "313", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "255", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "685", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "743", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "254", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "354", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "688", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "742", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "id": "A2AR02", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 88325.0, "chemical_mass": 88325.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "name": "Ppig", "locus": { "end_pos": 69754012, "start_pos": 69722545, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000042133", "id": "ENSMUSG00000042133", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "synonym", "resource": "UniProtKB", "name": "Peptidyl-prolyl isomerase G" }, { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "recommended", "resource": "UniProtKB", "name": "Peptidyl-prolyl cis-trans isomerase G" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AR02", "type": "synonym", "resource": "RefSeq", "name": "peptidylprolyl isomerase G; PPIase G; rotamase G; cyclophilin G" }, { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "synonym", "resource": "UniProtKB", "name": "Cyclophilin G" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AR02", "type": "synonym", "resource": "RefSeq", "name": "peptidyl-prolyl cis-trans isomerase G" }, { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "synonym", "resource": "UniProtKB", "name": "5.2.1.8" }, { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "synonym", "resource": "UniProtKB", "name": "PPIase G" }, { "url": "https://www.uniprot.org/uniprot/A2AR02", "type": "synonym", "resource": "UniProtKB", "name": "Rotamase G" } ] }