{ "uniprot_canonical_ac": "A2APB8-1", "ptm_annotation": [], "sequence": { "header": "sp|A2APB8-1|TPX2_MOUSE Isoform 1 of Targeting protein for Xklp2 OS=Mus musculus OX=10090 GN=Tpx2 PE=1 SV=1 CANONICAL=A2APB8-1", "length": 745, "sequence": "MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ" }, "uniprot_id": "TPX2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28205572", "type": [ "PubMed" ], "id": "28205572" } ], "title": "Ran-dependent TPX2 activation promotes acentrosomal microtubule nucleation in neurons.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ], "authors": "Chen WS, Chen YJ, Huang YA, Hsieh BY, Chiu HC, Kao PY, Chao CY, Hwang E", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27753540", "type": [ "PubMed" ], "id": "27753540" } ], "title": "Bcl2l10, a new Tpx2 binding partner, is a master regulator of Aurora kinase A in mouse oocytes.", "journal": "Cell cycle (Georgetown, Tex.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ], "authors": "Lee SY, Kim EY, Kim KH, Lee KA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19376971", "type": [ "PubMed" ], "id": "19376971" } ], "title": "Role of Filia, a maternal effect gene, in maintaining euploidy during cleavage-stage mouse embryogenesis.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ], "authors": "Zheng P, Dean J", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18663142", "type": [ "PubMed" ], "id": "18663142" } ], "title": "Building a spindle of the correct length in human cells requires the interaction between TPX2 and Aurora A.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "authors": "Hyman A.A., Bird A.W.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "type": [ "PubMed" ], "id": "19144319" } ], "title": "The phagosomal proteome in interferon-gamma-activated macrophages.", "journal": "Immunity", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "authors": "Thibault P., Trost M., Desjardins M., Courcelles M., English L., Lemieux S.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15741177", "type": [ "PubMed" ], "id": "15741177" } ], "title": "Tagging genes with cassette-exchange sites.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ], "authors": "Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23806337", "type": [ "PubMed" ], "id": "23806337" } ], "title": "SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways.", "journal": "Mol. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "authors": "Chen Y., Park J., Zhang Y., Zhao Y., Peng C., Tan M., Xie Z., Zwaans B.M., Lombard D.B., Dai L., Tishkoff D.X., Skinner M.E.", "date": "2013" } ], "uniprot_ac": "A2APB8", "site_annotation": [ { "end_pos": 312, "annotation": "n_glycosylation_sequon", "start_pos": 310 }, { "end_pos": 587, "annotation": "n_glycosylation_sequon", "start_pos": 585 }, { "end_pos": 20, "annotation": "n_glycosylation_sequon", "start_pos": 18 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2APB8#A2APB8-1", "isoform_ac": "A2APB8-1", "locus": { "end_pos": 152867252, "start_pos": 152893688, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000109816", "id": "ENSMUST00000109816", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000105441", "id": "ENSMUSP00000105441", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2APB8-1|TPX2_MOUSE Isoform 1 of Targeting protein for Xklp2 OS=Mus musculus OX=10090 GN=Tpx2 PE=1 SV=1 CANONICAL=A2APB8-1", "length": 745, "sequence": "MSQVPTTYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQRGIGEPFQGKNSLRKAKLQQGFVTPLKAVDNTYHKETEKENLQKQSIPSNDCSSLDAKRAVSGNTPVQPQRRSIRLSAQKDLEQKEKNHVASVEMKAKRCVAPATDCPPQKRMKVSHKKKLEEEEEGSAPATSRKNERETLEKAKGKHTVPGVPPAREKVLKSTEEQEIEKRLRMQQEVVELRRKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKNQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKSVNKIARDPQTPILQTKYRTRAVTCKSTAEQEAEELEKLQQYKFKARELDPRIFESGPILPKRAPVKPPTQPVGFDLEIEKRIHERESKKKTEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPIKDEEEEKPVVIKAQPVPHYGVPYKPHIAEARNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNVTQAEPFSLETDKRGAYKAEMWKHQLEEEQKQQKDAACFKARPNTVIFQEPFVPKKEKKSLAENPSGSLVQEPFQLATERRAKERQELEKKMAEVEAWKLQQLEEVRQQEEEQQKEELARLRKELVHKANPIRKYAAVEVKSSELPLTVPVSPKFSTRFQ" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756", "resource": "Reactome", "id": "R-MMU-6804756", "name": "Regulation of TP53 Activity through Phosphorylation" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72119", "resource": "KEGG Pathway", "id": "mmu:72119", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "resource": "Reactome", "id": "R-MMU-8854518", "name": "AURKA Activation by TPX2" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "annotation": "Bcl2l10, Tpx2, and Aurka co-localized on the meiotic spindles, and Bcl2l10 was present in the same complex with Tpx2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "annotation": "Depleting TPX2 decreases microtubule formation frequency specifically at the tip and the base of the neurite, and these correlate precisely with the regions where active GTP-bound Ran proteins are enriched. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2APB8#function", "annotation": "Spindle assembly factor required for normal assembly of mitotic spindles. Required for normal assembly of microtubules during apoptosis. Required for chromatin and/or kinetochore dependent microtubule nucleation. Mediates AURKA localization to spindle microtubules. Activates AURKA by promoting its autophosphorylation at 'Thr-288' and protects this residue against dephosphorylation. TPX2 is inactivated upon binding to importin-alpha. At the onset of mitosis, GOLGA2 interacts with importin-alpha, liberating TPX2 from importin-alpha, allowing TPX2 to activates AURKA kinase and stimulates local microtubule nucleation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8#function", "id": "A2APB8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZA78-1", "protein_name": "TPX2, microtubule nucleation factor", "sequence": { "length": 744, "sequence": "MAQVPTAYSFDAPTDFINFSSLDAEEDTENIDSWFDEKANLENKFLRQSGIGEPFQGKTSLRKAKLQQGCVTPLKAVDNTYYKETEKENLQKQSIPSNDCPSLNAKRAVTGTTPIQPQRRSVRLSAQKDLEQKEKNHVASVEMKAKRCTAPTTDYPPNKKMKVSHKKKPEEEEEGSAPATSRKDETLERAKGKHTVPAVPPAREKTVKSTEEQELEKSLRMQQEVVEMRKKNEEFKKLALAGPGQPVKKSTSQVTKTVDFHFLTDERIKQHPKSQEEYKEVNFMSELRKHSSTPARGTRGCTIIKPFNLSKGKKRTFDEAASTYVPIAQQVEAFHKRTPNRYHLRNKKDESLLPSKPVNKIVRDPQTPILQTKYRARAVTCKSAAEKEAEELEKLQQYKFKARELDPRIFESGPILPKRPPVKPPTQPVGFDLEIEKRIHERESKKKPEDEQFEFHSRPCPTKILEDVVGVPEKKVIPATVPKSPVFALKNRIRVPVKEDEEEEKPVVIKAQPVPHYGVPYKPPIPETRNVEVCPFSFDTRDKERQLQKEKKIKEMQKGEVPKFKALPVPHFDTINLPEKKVKNATQAEPFSLETDKRGAYKAEIWKHQLEEEQKQQKEAACFKARPNTVIFQEPFVPKKEKKSAAENPSGSLVQEPFQLATEKRAKERQELEKKMAEMEAWKLQQLAEVRQQEEEQQKEELARLRKELVHKANPIRKYSAVEVKSSELPLTVPVSPKFSTRFQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8107", "id": "8107", "database": "MGI" } ], "common_name": "rats", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9ULW0-1", "protein_name": "Targeting protein for Xklp2", "sequence": { "length": 747, "sequence": "MSQVKSSYSYDAPSDFINFSSLDDEGDTQNIDSWFEEKANLENKLLGKNGTGGLFQGKTPLRKANLQQAIVTPLKPVDNTYYKEAEKENLVEQSIPSNACSSLEVEAAISRKTPAQPQRRSLRLSAQKDLEQKEKHHVKMKAKRCATPVIIDEILPSKKMKVSNNKKKPEEEGSAHQDTAEKNASSPEKAKGRHTVPCMPPAKQKFLKSTEEQELEKSMKMQQEVVEMRKKNEEFKKLALAGIGQPVKKSVSQVTKSVDFHFRTDERIKQHPKNQEEYKEVNFTSELRKHPSSPARVTKGCTIVKPFNLSQGKKRTFDETVSTYVPLAQQVEDFHKRTPNRYHLRSKKDDINLLPSKSSVTKICRDPQTPVLQTKHRARAVTCKSTAELEAEELEKLQQYKFKARELDPRILEGGPILPKKPPVKPPTEPIGFDLEIEKRIQERESKKKTEDEHFEFHSRPCPTKILEDVVGVPEKKVLPITVPKSPAFALKNRIRMPTKEDEEEDEPVVIKAQPVPHYGVPFKPQIPEARTVEICPFSFDSRDKERQLQKEKKIKELQKGEVPKFKALPLPHFDTINLPEKKVKNVTQIEPFCLETDRRGALKAQTWKHQLEEELRQQKEAACFKARPNTVISQEPFVPKKEKKSVAEGLSGSLVQEPFQLATEKRAKERQELEKRMAEVEAQKAQQLEEARLQEEEQKKEELARLRRELVHKANPIRKYQGLEIKSSDQPLTVPVSPKFSTRFHC" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/8107", "id": "8107", "database": "MGI" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "ac": "NP_001135447.1", "name": "targeting protein for Xklp2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0061676", "pmid": "26165940", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "importin-alpha family protein binding", "id": "GO:0061676" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019901", "pmid": "18663142", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "protein kinase binding", "id": "GO:0019901" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005819", "pmid": "18663142", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "spindle", "id": "GO:0005819" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043203", "pmid": "19668197", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "axon hillock", "id": "GO:0043203" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000922", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "spindle pole", "id": "GO:0000922" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015630", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "microtubule cytoskeleton", "id": "GO:0015630" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045171", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "intercellular bridge", "id": "GO:0045171" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "microtubule organizing center", "id": "GO:0005815" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072686", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "mitotic spindle", "id": "GO:0072686" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005818", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "aster", "id": "GO:0005818" } ], "total": 12, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090307", "pmid": "26165940", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "mitotic spindle assembly", "id": "GO:0090307" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060236", "pmid": "18663142", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "regulation of mitotic spindle organization", "id": "GO:0060236" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051301", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "cell division", "id": "GO:0051301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006915", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "apoptotic process", "id": "GO:0006915" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032147", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "activation of protein kinase activity", "id": "GO:0032147" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051225", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "name": "spindle assembly", "id": "GO:0051225" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APB8", "type": "synonym", "resource": "RefSeq", "name": "Tpx2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APB8", "type": "synonym", "resource": "RefSeq", "name": "2610005B21Rik; DIL2; p100; REPP86" }, { "url": "https://www.uniprot.org/uniprot/A2APB8", "type": "recommended", "resource": "UniProtKB", "name": "Tpx2" } ], "crossref": [ { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2APB8", "id": "PR_A2APB8", "database": "PRO" }, { "url": "https://omabrowser.org/oma/group/KYQGVEV/", "id": "KYQGVEV", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF12214", "id": "PF12214", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027330", "id": "IPR027330", "database": "InterPro" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6804756", "id": "R-MMU-6804756", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/72119", "id": "72119", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015128", "id": "IPR015128", "database": "InterPro" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14326", "id": "PTHR14326", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF06886", "id": "PF06886", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854518", "id": "R-MMU-8854518", "database": "Reactome" }, { "url": "http://pfam.xfam.org/family/PF09041", "id": "PF09041", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009675", "id": "IPR009675", "database": "InterPro" }, { "url": "http://www.informatics.jax.org/marker/MGI:1919369", "id": "1919369", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027329", "id": "IPR027329", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000027469", "id": "ENSMUSG00000027469", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135447.1", "id": "NP_001135447.1", "database": "RefSeq" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72119", "id": "mmu:72119", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2APB8*", "id": "A2APB8", "database": "IntAct" }, { "url": "http://www.orthodb.org/?query=1390734at2759", "id": "1390734at2759", "database": "OrthoDB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [ { "sequence_org": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18663142", "id": "18663142", "database": "PubMed" } ], "sequence_mut": "", "start_pos": "8", "end_pos": "11", "annotation": "Abolishes interaction with AURKA." } ], 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"Ser", "position": "359", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "294", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "340", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "486", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "312", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "id": "A2APB8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 85894.0, "chemical_mass": 85894.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2APB8", "name": "Tpx2", "locus": { "end_pos": 152895321, "start_pos": 152847964, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000027469", "id": "ENSMUSG00000027469", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APB8", "type": "synonym", "resource": "RefSeq", "name": "TPX2, microtubule-associated protein homolog" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2APB8", "type": "synonym", "resource": "RefSeq", "name": "targeting protein for Xklp2" }, { "url": "https://www.uniprot.org/uniprot/A2APB8", "type": "recommended", "resource": "UniProtKB", "name": "Targeting protein for Xklp2" } ] }