{ "uniprot_canonical_ac": "A2AP18-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AP18-1|PLCH2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1501, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" }, "uniprot_id": "PLCH2_MOUSE", "enzyme_annotation": [ { "ec": "3.1.4.11", "activity": "1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." }, { "ec": "3.1.4.11", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16107206", "type": [ "PubMed" ], "id": "16107206" } ], "title": "Molecular cloning and characterization of PLC-eta2.", "journal": "Biochem. J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Zhou Y., Sondek J., Harden T.K., Wing M.R.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15345747", "type": [ "PubMed" ], "id": "15345747" } ], "title": "Phosphoproteomic analysis of the developing mouse brain.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "authors": "Ballif B.A., Beausoleil S.A., Gygi S.P., Villen J., Schwartz D.", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23237262", "type": [ "PubMed" ], "id": "23237262" } ], "title": "Phospholipase C-eta2 is required for retinoic acid-stimulated neurite growth.", "journal": "Journal of neurochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Popovics P, Gray A, Arastoo M, Finelli DK, Tan AJ, Stewart AJ", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20060933", "type": [ "PubMed" ], "id": "20060933" } ], "title": "Phospholipase C-eta2 is highly expressed in the habenula and retina.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Kanemaru K, Nakahara M, Nakamura Y, Hashiguchi Y, Kouchi Z, Yamaguchi H, Oshima N, Kiyonari H, Fukami K", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19906978", "type": [ "PubMed" ], "id": "19906978" } ], "title": "Brn3a and Nurr1 mediate a gene regulatory pathway for habenula development.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Quina LA, Wang S, Ng L, Turner EE", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17114649", "type": [ "PubMed" ], "id": "17114649" } ], "title": "Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "authors": "Gehrig P., Gerrits B., Mansuy I.M., Longo D., Schlapbach R., Livingstone-Zatchej M., Munton R.P., Panse C., Potthast F., Rutishauser D., Tweedie-Cullen R., Waidelich M., Weinandy F.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15899900", "type": [ "PubMed" ], "id": "15899900" } ], "title": "A novel phospholipase C, PLC(eta)2, is a neuron-specific isozyme.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Nakamura Y., Morita M., Fukami K., Nakahara M., Kudo Y., Irino Y., Shimozawa M.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15583837", "type": [ "PubMed" ], "id": "15583837" } ], "title": "Identification of a novel class of mammalian phosphoinositol-specific phospholipase C enzymes.", "journal": "International journal of molecular medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ], "authors": "Stewart AJ, Mukherjee J, Roberts SJ, Lester D, Farquharson C", "date": "2005" } ], "uniprot_ac": "A2AP18", "site_annotation": [ { "end_pos": 20, "annotation": "n_glycosylation_sequon", "start_pos": 18 }, { "end_pos": 370, "annotation": "n_glycosylation_sequon", "start_pos": 368 }, { "end_pos": 552, "annotation": "n_glycosylation_sequon", "start_pos": 550 }, { "end_pos": 1239, "annotation": "n_glycosylation_sequon", "start_pos": 1237 }, { "end_pos": 383, "annotation": "n_glycosylation_sequon", "start_pos": 381 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AP18#H3BIW6-1", "isoform_ac": "H3BIW6-1", "locus": { "end_pos": 154985385, "start_pos": 155019242, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000176194", "id": "ENSMUST00000176194", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134750", "id": "ENSMUSP00000134750", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BIW6-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 1137, "sequence": "MEEPGPPGGLSQDQVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-4", "isoform_ac": "A2AP18-4", "locus": { "end_pos": 154983665, "start_pos": 155042996, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000135665", "id": "ENSMUST00000135665", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118292", "id": "ENSMUSP00000118292", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-4|PLCH2_MOUSE Isoform 4 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1396, "sequence": "MDAGAAPQKHMERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-5", "isoform_ac": "A2AP18-5", "locus": { "end_pos": 154998165, "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000145662", "id": "ENSMUST00000145662", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119864", "id": "ENSMUSP00000119864", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-5|PLCH2_MOUSE Isoform 5 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 599, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDVSGSPGSACREPGVGPQHPRPILSTKGIYLPQRERGQGVRDKDRRWRVREKGKGTREGARGICPGGRGDKGLPLDREETDRQTWPIGKWWFTNVKK" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-2", "isoform_ac": "A2AP18-2", "locus": {}, "sequence": { "header": "sp|A2AP18-2|PLCH2_MOUSE Isoform 2 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1238, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLRREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-3", "isoform_ac": "A2AP18-3", "locus": {}, "sequence": { "header": "sp|A2AP18-3|PLCH2_MOUSE Isoform 3 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1252, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A2AP18-1", "isoform_ac": "A2AP18-1", "locus": { "end_pos": 154983665, "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105631", "id": "ENSMUST00000105631", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101256", "id": "ENSMUSP00000101256", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AP18-1|PLCH2_MOUSE Isoform 1 of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1501, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F7C3A0-1", "isoform_ac": "F7C3A0-1", "locus": { "end_pos": 154985385, "start_pos": 155010984, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000139976", "id": "ENSMUST00000139976", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122704", "id": "ENSMUSP00000122704", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7C3A0-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=2 CANONICAL=A2AP18-1", "length": 1238, "sequence": "MGGLAWGPSRAAGSSWVNASGTWEQPLRGFSGLQGGRRRGRGEKGIPEEPLCQLTPQLGLSLRVPFGLGDYGLDMPGPQPSAASQTTGAVACLAEVLLWVGGSVVVSPRWQLSLVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNCCFSIYHGSHRESLDLVSPSSEEARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGDCGYVLKPQCMCQGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTVRD" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#H3BK11-1", "isoform_ac": "H3BK11-1", "locus": { "end_pos": 154983663, "start_pos": 155007007, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000175982", "id": "ENSMUST00000175982", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000135209", "id": "ENSMUSP00000135209", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BK11-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 1250, "sequence": "XARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSISEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDASDLQRFLEVEQKMNGVTLESCQNIIEQFEPCLENKSKGMLGIDGFTNYTRSPAGDIFNPEHNRVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVVQQKKMAQYLTDILGDKLDLSSVSSEDATMLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEMEDDCKLLNGDASTNRKRVENIAKKKLDSLIKESKIRDCEDPNDFSVSTLSPSGKLGRKAEAKKGQSKVEEDVEAGEDSGVSRQNSRLFMSSFSKRKKKGSKIKKVASVEEGDETLDSPGSQSRGTARQKKTMKLSRALSDLVKYTKSVGTHDVEIEVVSSWQVSSFSETKAHQILQQKPTQYLRFNQHQLSRIYPSSYRVDSSNYNPQPFWNAGCQMGVFNPNSEDPLPGQLKKQLALRIISGQQLPKPRDSVLGDRGEIIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRDTRLFPLQRPISPLCSLEPIAEEPALGPGLPLQAAAPTGPSQEGSQCPVGLGAKVTSSQQTSLGAFGTLQLRIGGGRENEEPPLRPHNGGISSGPREGTSGRQTDSKSRSRVPGHLPVVRRAKSEGQVLSELSPTPAVYSDATGTDRLWQRLEPGSHRDSVSSSSSMSSNDTVIDLSLPSLGLCRSRESIPGVSLGRLTSRPCLASAARPDLPPVTKSKSNPNLRVAGGLPTAPDELQPRPLAPRLTGHHPRPPWHHLTLVGLRDCPVSAKSKSLGDLTADDFAPSFQGSTSSLSCGLGSLGVAHQVLEPGIRRDALTEQLRWLTGFQQAGDITSPTSLGPAGDGSVGGPSFLRRSSSRSQSRVRAIASRARQAQERQQRLRGQDSRGPPEEERGTPEGACSVGHEGCVDVPMPAKGAPEQVCGAADGQLLLRL" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F6UKG4-1", "isoform_ac": "F6UKG4-1", "locus": { "end_pos": 155007073, "start_pos": 155054578, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000131173", "id": "ENSMUST00000131173", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118629", "id": "ENSMUSP00000118629", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6UKG4-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 111, "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSFDPNC" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A0A087WSR3-1", "isoform_ac": "A0A087WSR3-1", "locus": { "end_pos": 154986165, "start_pos": 155054578, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000186598", "id": "ENSMUST00000186598", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000141152", "id": "ENSMUSP00000141152", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WSR3-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 493, "sequence": "MDSSIGPASLPEDPGPDLGSRWLFLSANVLPVVERCMSAMQEGTQMVKLRGSSKGLVRFYYLDEHRSCLRWRPSRKNEKAKISIDSIQEVSEGRQSEIFQRYPDSSIDPFVEVEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRGKAPGGEATEERTLAQVRSPNAPEGPGPAGMAATCMKCVVGSCAGMDVEGLQREQQPSPGPAGSHMAISHQPRARVDSLGGPCCSPSPRATPGRSKEAPKGPRARRQGPGGGSVSSDSSSPDSPGSPKVAPCQPEGAHRQQGALQGEMNALFVQKLEEIRSHSPMFSTGKACRSAASHALYTWHA" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#A6PWW4-1", "isoform_ac": "A6PWW4-1", "locus": { "end_pos": 155009079, "start_pos": 155019025, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000126098", "id": "ENSMUST00000126098", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000115440", "id": "ENSMUSP00000115440", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A6PWW4-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=8 CANONICAL=A2AP18-1", "length": 57, "sequence": "MPTLQEGSEVLFCRVRCSCPAATVPDFKSNPGDVWRRVERCMSAMQEGTQMVKLRGS" } }, { "url": "https://www.uniprot.org/uniprot/A2AP18#F7C512-1", "isoform_ac": "F7C512-1", "locus": { "end_pos": 154985383, "start_pos": 154989791, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124517", "id": "ENSMUST00000124517", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122139", "id": "ENSMUSP00000122139", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F7C512-1|PLCH2_MOUSE Computationally mapped isoform of 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 OS=Mus musculus OX=10090 GN=Plch2 PE=1 SV=1 CANONICAL=A2AP18-1", "length": 199, "sequence": "XEVIGLPVDCSKEQTRVVDDNGFNPMWEETLVFTVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSIMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQTLGLKGLFLRGTKPGSLDSHAAGQPLPRPSVSQRLLRRTASAPTKSQKPSRKGFPELALGTQDAGSEGAADDVAPSSPNPALEAPTQERSGSSSPRVRD" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "resource": "KEGG Pathway", "id": "mmu:269615", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "resource": "Reactome", "id": "R-MMU-1855204", "name": "Synthesis of IP3 and IP4 in the cytosol" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AP18#function", "annotation": "The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. This phospholipase activity is very sensitive to calcium. May be important for formation and maintenance of the neuronal network in the postnatal brain.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18#function", "id": "A2AP18", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "The molecular cloning and sequencing of phospholipase C eta2 are reported.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "PLCeta2 exhibited a dynamic expression pattern during postnatal retinal development, strongly suggesting that this isozyme might be involved in the development and maturation of the retina.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "PLC(eta)2 is a neuron-specific isozyme that may be important for the formation and/or maintenance of the neuronal network in the postnatal brain", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "The role of PLCeta2 in neuritogenesis was assessed during retinoic acid (RA)-induced Neuro2A cell differentiation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "annotation": "Molecular cloning of PLC-eta1 and PLC-eta2.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "O75038-1", "protein_name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2", "sequence": { "length": 1416, "sequence": "MSGPWPSPDSRTKGTVAWLAEVLLWVGGSVVLSSEWQLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQMLKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKLLNGDASTNRKRVENTAKRKLDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSFSRRKKKGSKLKKAASVEEGDEGQDSPGGQSRGATRQKKTMKLSRALSDLVKYTKSVATHDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLKKQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFVHVAVSDISGKVKQALGLKGLFLRGPKPGSLDSHAAGRPPARPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVADDVVPPGPGPAPEAPAQEGPGSGSPRDTRPLSTQRPLPPLCSLETIAEEPAPGPGPPPPAAVPTSSSQGRPPYPTGPGANVASPLEDTEEPRDSRPRPCNGEGAGGAYERAPGSQTDGRSQPRTLGHLPVIRRVKSEGQVPTEPLGGWRPLAAPFPAPAVYSDATGSDPLWQRLEPCGHRDSVSSSSSMSSSDTVIDLSLPSLGLGRSRENLAGAHMGRLPPRPHSASAARPDLPPVTKSKSNPNLRATGQRPPIPDELQPRSLAPRMAGLPFRPPWGCLSLVGVQDCPVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRRDTLTEQLRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQRLQGLGRQGPPEEERGTPEGACSVGHEGSVDAPAPSKGALGPASAAAENLVLLRL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/85172", "id": "85172", "database": "MGI" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "ac": "NP_001106831.1", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004435", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol phospholipase C activity", "id": "GO:0004435" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004629", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phospholipase C activity", "id": "GO:0004629" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032959", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "inositol trisphosphate biosynthetic process", "id": "GO:0032959" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051209", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "release of sequestered calcium ion into cytosol", "id": "GO:0051209" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048015", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol-mediated signaling", "id": "GO:0048015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046488", "pmid": "15899900", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "phosphatidylinositol metabolic process", "id": "GO:0046488" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016042", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "name": "lipid catabolic process", "id": "GO:0016042" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AP18", "type": "synonym", "resource": "RefSeq", "name": "Plch2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "Plcl4" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "recommended", "resource": "UniProtKB", "name": "Plch2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AP18", "type": "synonym", "resource": "RefSeq", "name": "A930027K05Rik; Plc-eta2; PLCeta2; Plcl4" } ], "crossref": [ { "url": "http://pfam.xfam.org/family/PF09279", "id": "PF09279", "database": "Pfam" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000029055", "id": "ENSMUSG00000029055", "database": "Bgee" }, { "url": "http://pfam.xfam.org/family/PF16457", "id": "PF16457", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336:SF166", "id": "PTHR10336:SF166", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018247", "id": "IPR018247", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000008", "id": "IPR000008", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000909", "id": "IPR000909", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00388", "id": "PF00388", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001711", "id": "IPR001711", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106831.1", "id": "NP_001106831.1", "database": "RefSeq" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AP18*", "id": "A2AP18", "database": "IntAct" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269615", "id": "269615", "database": "GeneID" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269615", "id": "mmu:269615", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2443078", "id": "2443078", "database": "MGI" }, { "url": "http://pfam.xfam.org/family/PF00168", "id": "PF00168", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001192", "id": "IPR001192", "database": "InterPro" }, { "url": "http://www.orthodb.org/?query=368239at2759", "id": "368239at2759", "database": "OrthoDB" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AP18", "id": "PR_A2AP18", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028393", "id": "IPR028393", "database": "InterPro" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1855204", "id": "R-MMU-1855204", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035892", "id": "IPR035892", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015359", "id": "IPR015359", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", "id": "IPR001849", "database": "InterPro" }, { "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=3.1.4.11&UniProtAcc=A2AP18", "id": "3.1.4.11", "database": "BRENDA" }, { "url": "http://pfam.xfam.org/family/PF00387", "id": "PF00387", "database": "Pfam" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10336", "id": "PTHR10336", "database": "PANTHER" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011992", "id": "IPR011992", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002048", "id": "IPR002048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017946", "id": "IPR017946", "database": "InterPro" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [ { "sequence_org": "H", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15899900", "id": "15899900", "database": "PubMed" } ], "sequence_mut": "A", "start_pos": "415", "end_pos": "415", "annotation": "Inhibition of activity." } ], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "565", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "561", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "676", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15345747", "id": "15345747", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "676", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "565", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "686", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "561", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "id": "A2AP18", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "686", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15345747", "id": "15345747", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" } ], "mass": { "monoisotopic_mass": 164297.0, "chemical_mass": 164297.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AP18", "name": "Plch2", "locus": { "end_pos": 154983115, "start_pos": 155056784, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000029055", "id": "ENSMUSG00000029055", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AP18", "type": "synonym", "resource": "RefSeq", "name": "phospholipase C-like protein 4; phosphoinositide phospholipase C-eta-2; phosphoinositide phospholipase C-like 4; 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "Phospholipase C-eta-2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AP18", "type": "synonym", "resource": "RefSeq", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2 isoform b" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "3.1.4.11" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "PLC-L4" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "recommended", "resource": "UniProtKB", "name": "1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "Phospholipase C-like protein 4" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "PLC-eta2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "Phosphoinositide phospholipase C-eta-2" }, { "url": "https://www.uniprot.org/uniprot/A2AP18", "type": "synonym", "resource": "UniProtKB", "name": "Phosphoinositide phospholipase C-like 4" } ] }