{ "uniprot_canonical_ac": "A2ALU4-1", "ptm_annotation": [], "sequence": { "header": "sp|A2ALU4-1|SHRM2_MOUSE Isoform 1 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1", "length": 1481, "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK" }, "uniprot_id": "SHRM2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16615870", "type": [ "PubMed" ], "id": "16615870" } ], "title": "A new standard nomenclature for proteins related to Apx and Shroom.", "journal": "BMC Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "authors": "Ballabio A., Kalscheuer V., Staub O., Schiaffino M.V., Smith P., Wallingford J.B., Hagens O., Hildebrand J.D., Kraehenbuhl J.-P.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16987870", "type": [ "PubMed" ], "id": "16987870" } ], "title": "Shroom2 (APXL) regulates melanosome biogenesis and localization in the retinal pigment epithelium.", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "authors": "Lee C., Wallingford J.B., Ellis A., Hildebrand J.D., Fairbank P.D., Gross J.M.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9503026", "type": [ "PubMed" ], "id": "9503026" } ], "title": "An integrated genetic and man-mouse comparative map of the DXHXS674-Pdha1 region of the mouse X chromosome.", "journal": "Genomics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ], "authors": "Blair HJ, Uwechue IC, Barsh GS, Rowe PS, Boyd Y", "date": "1998" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17666436", "type": [ "PubMed" ], "id": "17666436" } ], "title": "Shroom2, a myosin-VIIa- and actin-binding protein, directly interacts with ZO-1 at tight junctions.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ], "authors": "Etournay R, Zwaenepoel I, Perfettini I, Legrain P, Petit C, El-Amraoui A", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21248203", "type": [ "PubMed" ], "id": "21248203" } ], "title": "Shroom2 regulates contractility to control endothelial morphogenesis.", "journal": "Molecular biology of the cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ], "authors": "Farber MJ, Rizaldy R, Hildebrand JD", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16684770", "type": [ "PubMed" ], "id": "16684770" } ], "title": "Differential actin-dependent localization modulates the evolutionarily conserved activity of Shroom family proteins.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ], "authors": "Bernaciak T.M., Dietz M.L., Hildebrand J.D., Kielec J.M., Vendetti F.", "date": "2006" } ], "uniprot_ac": "A2ALU4", "site_annotation": [ { "end_pos": 1075, "annotation": "n_glycosylation_sequon", "start_pos": 1073 }, { "end_pos": 138, "annotation": "n_glycosylation_sequon", "start_pos": 136 }, { "end_pos": 201, "annotation": "n_glycosylation_sequon", "start_pos": 199 }, { "end_pos": 283, "annotation": "n_glycosylation_sequon", "start_pos": 281 }, { "end_pos": 1076, "annotation": "n_glycosylation_sequon", "start_pos": 1074 }, { "end_pos": 1265, "annotation": "n_glycosylation_sequon", "start_pos": 1263 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4#A2ALU4-2", "isoform_ac": "A2ALU4-2", "locus": {}, "sequence": { "header": "sp|A2ALU4-2|SHRM2_MOUSE Isoform 2 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1", "length": 446, "sequence": "METSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK" } }, { "url": "https://www.uniprot.org/uniprot/A2ALU4#A7TU71-1", "isoform_ac": "A7TU71-1", "locus": { "end_pos": 152612531, "start_pos": 152769450, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000101141", "id": "ENSMUST00000101141", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000098701", "id": "ENSMUSP00000098701", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A7TU71-1|SHRM2_MOUSE Computationally mapped isoform of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1", "length": 1487, "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSSSVLSSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK" } }, { "url": "https://www.uniprot.org/uniprot/A2ALU4#A2ALU4-1", "isoform_ac": "A2ALU4-1", "locus": { "end_pos": 152612531, "start_pos": 152769450, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000062317", "id": "ENSMUST00000062317", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000057500", "id": "ENSMUSP00000057500", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ALU4-1|SHRM2_MOUSE Isoform 1 of Protein Shroom2 OS=Mus musculus OX=10090 GN=Shroom2 PE=1 SV=1 CANONICAL=A2ALU4-1", "length": 1481, "sequence": "MEGAEPRARPERLAEAEAPATDGVRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVAINDVSLSGFRQEAICLVKGSHKTLKLVVKRKSDPSWRPHSWHATKYFDVHPEPAASLFLNTSGSPSWKSQHQASSSSHDLSGSWEHTSLQRTSDHFSSMGSIDSLDHSSQLYPSGHLSSAKSNSSIDHLGGHSKRDSAYGSFSTCSSTPDHTLPKADASSTENILYKVGLWEASRPGSSRQSQSTGDPQGLQDRPSCFIPRVPGNSSKSPRPEDNVEPKIATHGRSNFGPVWYVPDKKKAPSPPPLGLPLRSDSFSVAARGHEKARGPPFSDLASMQHFITLPHVQPRGDHRMETTDRQWKLTHLSSGKEIGNVGYQSEGHLDCRWLCSDDRAGRPSGPPGRLQFSDVHFLKSYHGSQHQQQCSDESPRAPSSPRELLHITPGGGLQEPPEPSQDDNPTQVRWPGSAHQKLDDRGRSHYFPGSLRQPVQGSAQVVIPRGDYWHSDTTPVDLEYPLLRPVGQRTYLQQHEETPASHEKEGYHQLNAGIEGCCSGIQEPPRASRTVRTGLQCPSNDFKLVDGESGRISRQRTPMLHSLTQDGTWRPGNSKDCGNDKPPLFDAQVGKPTRRSDRFATTLRNEIQMRRAKLQKSKSTVTLAGDSEAEDCAGDWRADVGAVPEGSFPSTYKEHLKEAQTRVLKATSFQRRDLDPTPADQYSGPSEHRTFDHSASSSLSSFPGEPDSAPRFCETGLAKAPSSGVGVPHVLRIGGRKRFTAEQKLKSYSEPEKINEVGLSGDHRPHPTVRTPEDTVGTFADRWKFFEETSKSLLQKAGHRQVHCGLPREKAERPQTGHHECESTEPWFQKRSLATSCGEILSDRKVEKASEKLNPPRRLGTFAEYQASWKEQKKPLEARSSGRYHSADDILDAGLDQQQRPQYIHERSRSSPSTDHYSQEVPVEPNRQAEDSGDHKEAILCTLQAEEGCSAPSAQPQDSQHVNEDTTFPQPETQLSSKCQHLQTSAMETSRSPSPQFAPQKLTDKPPLLIHEDNSARIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAELPPLPSGLERDQIKTLSTSEQCYSRFCVYTRQEVEAPHRARPPEPRPPSTPAPPVRDSCSSPPSLNYGKAKEKTMDDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEYLLEEAQQRRKLLPKVPLPRVTEDKKQDPGMPGVVSLATNSTYYSTSAPKAELLIKMKDLQEPEEYSAGDLDHDLSVKKQELIDSISRKLQVLREARESLLEDIQANNALGDEVEAIVKDVCKPNEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDNPSPGDRQSLLEKQRVLTQQHEDAKELKENLDRRERIVFDILATYLSEENLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLFDSLQPERSK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110380", "resource": "KEGG Pathway", "id": "mmu:110380", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "annotation": "Data suggest that Shroom2 facilitates the formation of a contractile network within endothelial cells, the loss of which leads to an increase in endothelial sprouting, migration, and angiogenesis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ALU4#function", "annotation": "May be involved in endothelial cell morphology changes during cell spreading. In the retinal pigment epithelium, may regulate the biogenesis of melanosomes and promote their association with the apical cell surface by inducing gamma-tubulin redistribution.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4#function", "id": "A2ALU4", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "annotation": "Shroom2 and ZO-1 form a tight-junction-associated scaffolding complex, possibly linked to myosin VIIa, that bridges the junctional membrane to the underlying cytoskeleton, thereby contributing to the stabilization of these junctions.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "id": "NP_001277613.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q13796-1", "protein_name": "Protein Shroom2", "sequence": { "length": 1616, "sequence": "MEGAEPRARPERLAEAETRAADGGRLVEVQLSGGAPWGFTLKGGREHGEPLVITKIEEGSKAAAVDKLLAGDEIVGINDIGLSGFRQEAICLVKGSHKTLKLVVKRRSELGWRPHSWHATKFSDSHPELAASPFTSTSGCPSWSGRHHASSSSHDLSSSWEQTNLQRTLDHFSSLGSVDSLDHPSSRLSVAKSNSSIDHLGSHSKRDSAYGSFSTSSSTPDHTLSKADTSSAENILYTVGLWEAPRQGGRQAQAAGDPQGSEEKLSCFPPRVPGDSGKGPRPEYNAEPKLAAPGRSNFGPVWYVPDKKKAPSSPPPPPPPLRSDSFAATKSHEKAQGPVFSEAAAAQHFTALAQAQPRGDRRPELTDRPWRSAHPGSLGKGSGGPGCPQEAHADGSWPPSKDGASSRLQASLSSSDVRFPQSPHSGRHPPLYSDHSPLCADSLGQEPGAASFQNDSPPQVRGLSSCDQKLGSGWQGPRPCVQGDLQAAQLWAGCWPSDTALGALESLPPPTVGQSPRHHLPQPEGPPDARETGRCYPLDKGAEGCSAGAQEPPRASRAEKASQRLAASITWADGESSRICPQETPLLHSLTQEGKRRPESSPEDSATRPPPFDAHVGKPTRRSDRFATTLRNEIQMHRAKLQKSRSTVALTAAGEAEDGTGRWRAGLGGGTQEGPLAGTYKDHLKEAQARVLRATSFKRRDLDPNPGDLYPESLEHRMGDPDTVPHFWEAGLAQPPSSTSGGPHPPRIGGRRRFTAEQKLKSYSEPEKMNEVGLTRGYSPHQHPRTSEDTVGTFADRWKFFEETSKPVPQRPAQKQALHGIPRDKPERPRTAGRTCEGTEPWSRTTSLGDSLNAHSAAEKAGTSDLPRRLGTFAEYQASWKEQRKPLEARSSGRCHSADDILDVSLDPQERPQHVHGRSRSSPSTDHYKQEASVELRRQAGDPGEPREELPSAVRAEEGQSTPRQADAQCREGSPGSQQHPPSQKAPNPPTFSELSHCRGAPELPREGRGRAGTLPRDYRYSEESTPADLGPRAQSPGSPLHARGQDSWPVSSALLSKRPAPQRPPPPKREPRRYRATDGAPADAPVGVLGRPFPTPSPASLDVYVARLSLSHSPSVFSSAQPQDTPKATVCERGSQHVSGDASRPLPEALLPPKQQHLRLQTATMETSRSPSPQFAPQKLTDKPPLLIQDEDSTRIERVMDNNTTVKMVPIKIVHSESQPEKESRQSLACPAEPPALPHGLEKDQIKTLSTSEQFYSRFCLYTRQGAEPEAPHRAQPAEPQPLGTQVPPEKDRCTSPPGLSYMKAKEKTVEDLKSEELAREIVGKDKSLADILDPSVKIKTTMDLMEGIFPKDEHLLEEAQQRRKLLPKIPSPRSTEERKEEPSVPAAVSLATNSTYYSTSAPKAELLIKMKDLQEQQEHEEDSGSDLDHDLSVKKQELIESISRKLQVLREARESLLEDVQANTVLGAEVEAIVKGVCKPSEFDKFRMFIGDLDKVVNLLLSLSGRLARVENALNNLDDGASPGDRQSLLEKQRVLIQQHEDAKELKENLDRRERIVFDILANYLSEESLADYEHFVKMKSALIIEQRELEDKIHLGEEQLKCLLDSLQPERGK" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/84697", "id": "84697", "database": "MGI" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277613.1", "ac": "NP_001277613.1", "name": "protein Shroom2 isoform 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003779", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "actin binding", "id": "GO:0003779" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019904", "pmid": "17666436", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "protein domain specific binding", "id": "GO:0019904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051015", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "actin filament binding", "id": "GO:0051015" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008013", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "beta-catenin binding", "id": "GO:0008013" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "17666436", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005856", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "cytoskeleton", "id": "GO:0005856" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005911", "pmid": "17666436", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "cell-cell junction", "id": "GO:0005911" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005912", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "adherens junction", "id": "GO:0005912" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005923", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "bicellular tight junction", "id": "GO:0005923" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", "pmid": "17666436", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "cell cortex", "id": "GO:0005938" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "pmid": "17666436", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "apical plasma membrane", "id": "GO:0016324" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005913", "pmid": "16684770", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ALU4", "id": "A2ALU4", "database": "UniProtKB" } ], "name": "cell-cell adherens junction", "id": "GO:0005913" }, { "url": 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