{ "uniprot_canonical_ac": "A2AIL4-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AIL4-1|NDUF6_MOUSE Isoform 1 of NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Mus musculus OX=10090 GN=Ndufaf6 PE=1 SV=1 CANONICAL=A2AIL4-1", "length": 333, "sequence": "MATSMLGSVRGPRPFGLANLFHRQPPRDAWERVRRLPGPSAVRRSVAAASGPGIPGSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWKKAVEDMYCDNPPHQPVAIELWKAVKKHNLTKRWLMRIIDEREKNLDDKAYRSMQELENYAENTQGSLLYLTLEVLGVKDLHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHRSVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNMLLPLSLYIQSWRKRY" }, "uniprot_id": "NDUF6_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18614015", "type": [ "PubMed" ], "id": "18614015" } ], "title": "A mitochondrial protein compendium elucidates complex I disease biology.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "authors": "Calvo S.E., Mootha V.K., Pagliarini D.J., Thorburn D.R., Vidal M., Carr S.A., Hill D.E., Chang B., Boneh A., Ong S.E., Sheth S.A., Chen W.K., Evans J.G., Sugiana C., Vafai S.B., Walford G.A.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31097699", "type": [ "PubMed" ], "id": "31097699" } ], "title": "Yin Yang 1 sustains biosynthetic demands during brain development in a stage-specific manner.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078962.1", "id": "NP_001078962.1", "database": "RefSeq" } ], "authors": "Zurkirchen L, Varum S, Giger S, Klug A, Hausel J, Bossart R, Zemke M, Cantu C, Atak ZK, Zamboni N, Basler K, Sommer L", "date": "2019" } ], "uniprot_ac": "A2AIL4", "site_annotation": [ { "end_pos": 148, "annotation": "n_glycosylation_sequon", "start_pos": 146 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4#A2AIL4-1", "isoform_ac": "A2AIL4-1", "locus": { "end_pos": 11051100, "start_pos": 11076176, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000058183", "id": "ENSMUST00000058183", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000062039", "id": "ENSMUSP00000062039", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AIL4-1|NDUF6_MOUSE Isoform 1 of NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 OS=Mus musculus OX=10090 GN=Ndufaf6 PE=1 SV=1 CANONICAL=A2AIL4-1", "length": 333, "sequence": "MATSMLGSVRGPRPFGLANLFHRQPPRDAWERVRRLPGPSAVRRSVAAASGPGIPGSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWKKAVEDMYCDNPPHQPVAIELWKAVKKHNLTKRWLMRIIDEREKNLDDKAYRSMQELENYAENTQGSLLYLTLEVLGVKDLHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHRSVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNMLLPLSLYIQSWRKRY" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", "resource": "Reactome", "id": "R-MMU-6799198", "name": "Complex I biogenesis" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76947", "resource": "KEGG Pathway", "id": "mmu:76947", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4#function", "annotation": "Involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I) at early stages. May play a role in the biogenesis of MT-ND1 (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4#function", "id": "A2AIL4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q330K2-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "sequence": { "length": 333, "sequence": "MAASAHGSVWGPLRLGIPGLCCRRPPLGLYARMRRLPGPEVSGRSVAAASGPGAWGTDHYCLELLRKRDYEGYLCSLLLPAESRSSVFALRAFNVELAQVKDSVSEKTIGLMRMQFWKKTVEDIYCDNPPHQPVAIELWKAVKRHNLTKRWLMKIVDEREKNLDDKAYRNIKELENYAENTQSSLLYLTLEILGIKDLHADHAASHIGKAQGIVTCLRATPYHGSRRKVFLPMDICMLHGVSQEDFLRRNQDKNVRDVIYDIASQAHLHLKHARSFHKTVPVKAFPAFLQTVSLEDFLKKIQRVDFDIFHPSLQQKNTLLPLYLYIQSWRKTY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/43831", "id": "43831", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AIL4/", "id": "A2AIL4", "database": "OMA" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "D3ZN43-1", "protein_name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6", "sequence": { "length": 333, "sequence": "MATSMLGSVPGPRPFGLAGLFRRRPPRDPWERVRRLPRLSAVRRSVAAASGPGIPDSHLYCLELLRKRDYESYLCSLLFPAECQRSASALRAFNVELAQVKDSVSEKTIGLMRMQFWRKAVEDMFCDNPPHQPVAMELWKAVKRHNLTKRWLLRIIDEREKNLDDKAYRSIRELETYAENTQSSLLYLTLEVLGVKDVHADHAASHIGKAQGIVTCLRATPYHSSRRQVFLPMDVCVQHGVSQEDFLRRNQDKNVRDVVYDIASQAHLHLKHARSFHSRVPAEAFPAFLQTVSLEDYLKKIQRVDFDIFHPSLQQKNTLLPLSLYIQSWRKRY" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/43831", "id": "43831", "database": "MGI" } ], "common_name": "rats", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078962.1", "ac": "NP_001078962.1", "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "pmid": "18614015", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005743", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "mitochondrial inner membrane", "id": "GO:0005743" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032981", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "id": "A2AIL4", "database": "UniProtKB" } ], "name": "mitochondrial respiratory chain complex I assembly", "id": "GO:0032981" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "type": "recommended", "resource": "UniProtKB", "name": "Ndufaf6" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIL4", "type": "synonym", "resource": "RefSeq", "name": "2310030N02Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIL4", "type": "synonym", "resource": "RefSeq", "name": "Ndufaf6" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/76947", "id": "76947", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR008949", "id": "IPR008949", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000050323", "id": "ENSMUSG00000050323", "database": "Bgee" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6799198", "id": "R-MMU-6799198", "database": "Reactome" }, { "url": "https://omabrowser.org/oma/group/KIQQVDF/", "id": "KIQQVDF", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=616989at2759", "id": "616989at2759", "database": "OrthoDB" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76947", "id": "mmu:76947", "database": "KEGG Pathway" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078962.1", "id": "NP_001078962.1", "database": "RefSeq" }, { "url": "http://www.informatics.jax.org/marker/MGI:1924197", "id": "1924197", "database": "MGI" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AIL4", "id": "PR_A2AIL4", "database": "PRO" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 38362.0, "chemical_mass": 38362.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "name": "Ndufaf6", "locus": { "end_pos": 11051045, "start_pos": 11076205, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000050323", "id": "ENSMUSG00000050323", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AIL4", "type": "recommended", "resource": "UniProtKB", "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIL4", "type": "synonym", "resource": "RefSeq", "name": "UPF0551 protein C8orf38 homolog, mitochondrial; NADH dehydrogenase (ubiquinone) complex I, assembly factor 6" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AIL4", "type": "synonym", "resource": "RefSeq", "name": "NADH dehydrogenase (ubiquinone) complex I, assembly factor 6 precursor" } ] }