{
    "uniprot_canonical_ac": "A2ABG4-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2ABG4-1|A2ABG4_MOUSE Isoform 1 of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1", 
        "length": 766, 
        "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR"
    }, 
    "uniprot_id": "A2ABG4_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                    "id": "A2ABG4", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12226475", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12226475"
                }
            ], 
            "title": "A molecular profile of a hematopoietic stem cell niche.", 
            "journal": "Proceedings of the National Academy of Sciences of the United States of America", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031.2", 
                    "id": "NP_766031.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Hackney JA, Charbord P, Brunk BP, Stoeckert CJ, Lemischka IR, Moore KA", 
            "date": "2002"
        }
    ], 
    "uniprot_ac": "A2ABG4", 
    "site_annotation": [
        {
            "end_pos": 251, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 249
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4#Q6PFC0-1", 
            "isoform_ac": "Q6PFC0-1", 
            "locus": {
                "end_pos": 119147571, 
                "start_pos": 119210682, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000207655", 
                        "id": "ENSMUST00000207655", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000147182", 
                        "id": "ENSMUSP00000147182", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|Q6PFC0-1|A2ABG4_MOUSE Computationally mapped isoform of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1", 
                "length": 765, 
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4#A2ABG4-1", 
            "isoform_ac": "A2ABG4-1", 
            "locus": {
                "end_pos": 119147571, 
                "start_pos": 119210682, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000036113", 
                        "id": "ENSMUST00000036113", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000048516", 
                        "id": "ENSMUSP00000048516", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2ABG4-1|A2ABG4_MOUSE Isoform 1 of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1", 
                "length": 766, 
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRRRRTTSLGALYQPSPTEPRPPLIPKDEDILVVVQNTQDTAHISPTDEDGEKLAQGPEVDGALSTSQPVHSDSGILSTVSSQDGTEDGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMTPEEQRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVELPSPKPSREGKKGPKAPREAFGFRR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4#A2AFK9-1", 
            "isoform_ac": "A2AFK9-1", 
            "locus": {
                "end_pos": 119210641, 
                "start_pos": 119210682, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000125856", 
                        "id": "ENSMUST00000125856", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119431", 
                        "id": "ENSMUSP00000119431", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2AFK9-1|A2ABG4_MOUSE Computationally mapped isoform of TBC1 domain family, member 16  OS=Mus musculus OX=10090 GN=Tbc1d16 PE=1 SV=1 CANONICAL=A2ABG4-1", 
                "length": 14, 
                "sequence": "MSLGRLLRRASSKA"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214", 
            "resource": "Reactome", 
            "id": "R-MMU-8854214", 
            "name": "TBC/RABGAPs"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "M0R716-1", 
            "protein_name": "TBC1 domain family, member 16", 
            "sequence": {
                "length": 765, 
                "sequence": "MSLGRLLRRASSKASDLLTLTTGGSGGSLSVLDGEVIYSKNNVCVHAPEGLQGPGEHHPGYLCLYMEKDELLGATLILAWVPNSRIQRQDEEALRYITPEGSPVRKAPRPRRRRTTSLGATYQPSPTEPRPPLIPKDEDILVVVQNTQDSVHISPTDEDGVKLAQGPEVDGPLPTSQPVHSDSGILSTVSSQDGTENGREPRPEAVEEEGSLELSADGVSRDSSFDSDSDAFSSPFCLSPISAALAEGNSSAFLESEGSSPSSSDANLRFPDSNGLLQTPRWDEPQRGCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKIFHFHHGGLDKLSEVFQQWKFCTETHLRDQVTDERTCMQFSIRRPKLPSSEIHPEESLYRRLDVSAWLNHLNDLGQVEEEYKLRQAIFFGGIDVSIRGEVWPFLLHYYSHESTSEEREALRSQKRKEYAAIQQKRLSMPPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAIGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMERQLLYLRELLRLTHQRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEGEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGTGMWDSGYMPAVECAGHHPGSESCPYGGTVETPSPKPPREGKKGPKAPREAFGFRR"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2ABG4/", 
                    "id": "A2ABG4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/10380", 
                    "id": "10380", 
                    "database": "MGI"
                }
            ], 
            "common_name": "rats", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8TBP0-1", 
            "protein_name": "TBC1 domain family member 16", 
            "sequence": {
                "length": 767, 
                "sequence": "MSLGRLLRRASSKASDLLTLTPGGSGSGSPSVLDGEIIYSKNNVCVHPPEGLQGLGEHHPGYLCLYMEKDEMLGATLILAWVPNSRIQRQDEEALRYITPESSPVRKAPRPRGRRTRSSGASHQPSPTELRPTLTPKDEDILVVAQSVPDRMLASPAPEDEEKLAQGLGVDGAQPASQPACSPSGILSTVSPQDVTEEGREPRPEAGEEDGSLELSAEGVSRDSSFDSDSDTFSSPFCLSPISAALAESRGSVFLESDSSPPSSSDAGLRFPDSNGLLQTPRWDEPQRVCALEQICGVFRVDLGHMRSLRLFFSDEACTSGQLVVASRESQYKVFHFHHGGLDKLSDVFQQWKYCTEMQLKDQQVAPDKTCMQFSIRRPKLPSSETHPEESMYKRLGVSAWLNHLNELGQVEEEYKLRKAIFFGGIDVSIRGEVWPFLLRYYSHESTSEEREALRLQKRKEYSEIQQKRLSMTPEEHRAFWRNVQFTVDKDVVRTDRNNQFFRGEDNPNVESMRRILLNYAVYNPAVGYSQGMSDLVAPILAEVLDESDTFWCFVGLMQNTIFVSSPRDEDMEKQLLYLRELLRLTHVRFYQHLVSLGEDGLQMLFCHRWLLLCFKREFPEAEALRIWEACWAHYQTDYFHLFICVAIVAIYGDDVIEQQLATDQMLLHFGNLAMHMNGELVLRKARSLLYQFRLLPRIPCSLHDLCKLCGSGMWDSGSMPAVECTGHHPGSESCPYGGTVEMPSPKSLREGKKGPKTPQDGFGFRR"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2ABG4/", 
                    "id": "A2ABG4", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/10380", 
                    "id": "10380", 
                    "database": "MGI"
                }
            ], 
            "common_name": "man", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031.2", 
        "ac": "NP_766031.2", 
        "name": "TBC1 domain family member 16 isoform 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017137", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Rab GTPase binding", 
                        "id": "GO:0017137"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTPase activator activity", 
                        "id": "GO:0005096"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005769", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "early endosome", 
                        "id": "GO:0005769"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006886", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intracellular protein transport", 
                        "id": "GO:0006886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090630", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "activation of GTPase activity", 
                        "id": "GO:0090630"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001919", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ABG4", 
                                "id": "A2ABG4", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of receptor recycling", 
                        "id": "GO:0001919"
                    }
                ], 
                "total": 3, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABG4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "B930087K01; BC026530; Tcd1d16"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Tbc1d16"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABG4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Tbc1d16"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000039976", 
            "id": "ENSMUSG00000039976", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035969", 
            "id": "IPR035969", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_766031.2", 
            "id": "NP_766031.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8854214", 
            "id": "R-MMU-8854214", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000195", 
            "id": "IPR000195", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1495285at2759", 
            "id": "1495285at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2652878", 
            "id": "2652878", 
            "database": "MGI"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/207592", 
            "id": "207592", 
            "database": "GeneID"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/CHRWVLL/", 
            "id": "CHRWVLL", 
            "database": "OMA"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00566", 
            "id": "PF00566", 
            "database": "Pfam"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 86535.0, 
        "chemical_mass": 86535.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4", 
            "name": "Tbc1d16", 
            "locus": {
                "end_pos": 119143045, 
                "start_pos": 119228499, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000039976", 
                        "id": "ENSMUSG00000039976", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ABG4", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "TBC1 domain family member 16 isoform 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ABG4", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "TBC1 domain family, member 16"
        }
    ]
}