{ "uniprot_canonical_ac": "A1L3C1-1", "ptm_annotation": [], "sequence": { "header": "sp|A1L3C1-1|F71E1_MOUSE Isoform 1 of Protein FAM71E1 OS=Mus musculus OX=10090 GN=Fam71e1 PE=2 SV=2 CANONICAL=A1L3C1-1", "length": 212, "sequence": "MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEFQATEARLDPQVSELWGL" }, "uniprot_id": "F71E1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1L3C1", "id": "A1L3C1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18256213", "type": [ "PubMed" ], "id": "18256213" } ], "title": "Large scale screening for novel rab effectors reveals unexpected broad Rab binding specificity.", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "id": "NP_082445.1", "database": "RefSeq" } ], "authors": "Fukuda M, Kanno E, Ishibashi K, Itoh T", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28930687", "type": [ "PubMed" ], "id": "28930687" } ], "title": "The RAB2B-GARIL5 Complex Promotes Cytosolic DNA-Induced Innate Immune Responses.", "journal": "Cell reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "id": "NP_082445.1", "database": "RefSeq" } ], "authors": "Takahama M, Fukuda M, Ohbayashi N, Kozaki T, Misawa T, Okamoto T, Matsuura Y, Akira S, Saitoh T", "date": "2017" } ], "uniprot_ac": "A1L3C1", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1L3C1#A0A0U1RNX3-1", "isoform_ac": "A0A0U1RNX3-1", "locus": { "end_pos": 44496688, "start_pos": 44497060, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000205422", "id": "ENSMUST00000205422", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000146329", "id": "ENSMUSP00000146329", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0U1RNX3-1|F71E1_MOUSE Computationally mapped isoform of Protein FAM71E1 OS=Mus musculus OX=10090 GN=Fam71e1 PE=2 SV=1 CANONICAL=A1L3C1-1", "length": 63, "sequence": "MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVWSPGPPTR" } }, { "url": "https://www.uniprot.org/uniprot/A1L3C1#A0A0U1RNU0-1", "isoform_ac": "A0A0U1RNU0-1", "locus": { "end_pos": 44496688, "start_pos": 44500672, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000205359", "id": "ENSMUST00000205359", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000145700", "id": "ENSMUSP00000145700", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0U1RNU0-1|F71E1_MOUSE Computationally mapped isoform of Protein FAM71E1 OS=Mus musculus OX=10090 GN=Fam71e1 PE=2 SV=1 CANONICAL=A1L3C1-1", "length": 272, "sequence": "MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEVRAGPRAQGCWARKDGKGPGRPAGAWTPGSEGGGLGPRPLGLRKENQSWISRPKEKGTPPFFHLLRGSKEKATGSAAD" } }, { "url": "https://www.uniprot.org/uniprot/A1L3C1#A1L3C1-2", "isoform_ac": "A1L3C1-2", "locus": {}, "sequence": { "header": "sp|A1L3C1-2|F71E1_MOUSE Isoform 2 of Protein FAM71E1 OS=Mus musculus OX=10090 GN=Fam71e1 PE=2 SV=2 CANONICAL=A1L3C1-1", "length": 146, "sequence": "MGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEFQATEARLDPQVSELWGL" } }, { "url": "https://www.uniprot.org/uniprot/A1L3C1#A1L3C1-1", "isoform_ac": "A1L3C1-1", "locus": { "end_pos": 44496688, "start_pos": 44501021, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000107927", "id": "ENSMUST00000107927", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000103560", "id": "ENSMUSP00000103560", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1L3C1-1|F71E1_MOUSE Isoform 1 of Protein FAM71E1 OS=Mus musculus OX=10090 GN=Fam71e1 PE=2 SV=2 CANONICAL=A1L3C1-1", "length": 212, "sequence": "MKGGRDLKAARGGADRPLAPAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDESRQQLKVKFRTGRAFYLQLRSPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTAPEEEEEEEEEEEEEEVKEGQLQPPEFQATEARLDPQVSELWGL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75538", "resource": "KEGG Pathway", "id": "mmu:75538", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "annotation": "The RAB2B-GARIL5 complex promotes IFN responses against DNA viruses by regulating the cGAS-STING signaling axis.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "id": "NP_082445.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D4A176-1", "protein_name": "Family with sequence similarity 71, member E1", "sequence": { "length": 206, "sequence": "MKGGRDLKPASGRADRPLAQAYAPCRPGRLQRHLLSGEFDQLRDFPIFESNFVQVTRFGEVANKVTMGVAASSPALELPDLLLLAGPDKENGHLQLLGLFPLQFVQLFVHDVSRQQLKVKFRTGRAFYLQLRAPPETRDCEFGRWVRLLYRLRFHSPTCAVPFTHEDTVPEESEDEDEVEEGQLQPPEFHATEARLDPQVSELWGL" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A1L3C1/", "id": "A1L3C1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/19259", "id": "19259", "database": "MGI" } ], "common_name": "rats", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q6IPT2-1", "protein_name": "Protein FAM71E1", "sequence": { "length": 247, "sequence": "MGPPLWPDLQEPPPPGTSSQIRSPLLCDVIKPAPHHDVTVRVVPPPRFLPLLLRPLPSDGDIAMRRDRGPKPALGGAGEVEPGGMAASPTGRPRRLQRYLQSGEFDQFRDFPIFESNFVQFCPDIYPAPTSDLWPQVTRLGEVANEVTMGVAASSPALELPDLLLLAGPAKENGHLQLFGLFPLKFVQLFVHDKSRCQLEVKLNTSRTFYLQLRAPLKTRDREFGQWVRLLYRLRFLSASAVPFTQE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/19259", "id": "19259", "database": "MGI" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "ac": "NP_082445.1", "name": "protein FAM71E1 isoform 1", "summary": "" }, "go_annotation": {}, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A1L3C1", "type": "recommended", "resource": "UniProtKB", "name": "Fam71e1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L3C1", "type": "synonym", "resource": "RefSeq", "name": "0610007G24Rik; 1700021N13Rik; 1700021P22Rik; GARI-L5" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L3C1", "type": "synonym", "resource": "RefSeq", "name": "Fam71e1" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000051113", "id": "ENSMUSG00000051113", "database": "Bgee" }, { "url": "http://www.informatics.jax.org/marker/MGI:1922788", "id": "1922788", "database": "MGI" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR022168", "id": "IPR022168", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/75538", "id": "75538", "database": "GeneID" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:75538", "id": "mmu:75538", "database": "KEGG Pathway" }, { "url": "http://pfam.xfam.org/family/PF12480", "id": "PF12480", "database": "Pfam" }, { "url": "http://www.orthodb.org/?query=1443136at2759", "id": "1443136at2759", "database": "OrthoDB" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L3C1", "id": "PR_A1L3C1", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_082445.1", "id": "NP_082445.1", "database": "RefSeq" }, { "url": "https://omabrowser.org/oma/group/RCQLEVK/", "id": "RCQLEVK", "database": "OMA" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 24172.0, "chemical_mass": 24172.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1L3C1", "name": "Fam71e1", "locus": { "end_pos": 44501486, "start_pos": 44496581, "chromosome": "7", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000051113", "id": "ENSMUSG00000051113", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1L3C1", "type": "recommended", "resource": "UniProtKB", "name": "Protein FAM71E1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L3C1", "type": "synonym", "resource": "RefSeq", "name": "protein FAM71E1 isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1L3C1", "type": "synonym", "resource": "RefSeq", "name": "Golgi-associated Rab2B interactor-like 5; Protein FAM71E1" } ] }