{ "uniprot_canonical_ac": "A0A0G2KAP1-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAP1-1|A0A0G2KAP1_RAT Isoform 1 of Endoplasmic reticulum oxidoreductase 1 beta OS=Rattus norvegicus OX=10116 GN=Ero1b PE=1 SV=1 CANONICAL=A0A0G2KAP1-1", "length": 467, "sequence": "MSPGFLRAVAGQGAAAAVQLLVTLGFLSSLVKTQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGRSNKYSQAANNTKELDDCEQANKLGAINSTLSNESKEAFIDWARYDDSQDHFCELDDERSPAAQYVDLLLNPERYTGYKGSSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDNGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKRRFDTVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNLEDDADTKTLLLSIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRELQNFKALLQHRR" }, "uniprot_id": "A0A0G2KAP1_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "rats", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2KAP1", "site_annotation": [ { "end_pos": 385, "annotation": "n_glycosylation_sequon", "start_pos": 383 }, { "end_pos": 147, "annotation": "n_glycosylation_sequon", "start_pos": 145 }, { "end_pos": 124, "annotation": "n_glycosylation_sequon", "start_pos": 122 }, { "end_pos": 142, "annotation": "n_glycosylation_sequon", "start_pos": 140 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1#D3ZNZ5-1", "isoform_ac": "D3ZNZ5-1", "locus": { "end_pos": 90712123, "start_pos": 90755852, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000003526", "id": "ENSRNOT00000003526", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000003526", "id": "ENSRNOP00000003526", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D3ZNZ5-1|A0A0G2KAP1_RAT Computationally mapped isoform of Endoplasmic reticulum oxidoreductase 1 beta OS=Rattus norvegicus OX=10116 GN=Ero1b PE=1 SV=2 CANONICAL=A0A0G2KAP1-1", "length": 462, "sequence": "MSPGFLRAVAGQGAAAAVQLLVTLGFLSSLVKTQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGRSNKYSQAANNTKELDDCEQANKLGAINSTLSNESKEAFIDWARYDDSQDHFCELDDERSPAAQYVDLLLNPERYTGYKGSSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDNGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKRRFDTVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNLEDDADTKTLLLSIFQDTKSFPMHFDEKSMFAGDKKGAKSLKKDFTKLYGRSFTKLLDTQESKDSFTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRELQNFKALLQHRR" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1#A0A0G2KAP1-1", "isoform_ac": "A0A0G2KAP1-1", "locus": { "end_pos": 90712123, "start_pos": 90755852, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085669", "id": "ENSRNOT00000085669", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075470", "id": "ENSRNOP00000075470", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAP1-1|A0A0G2KAP1_RAT Isoform 1 of Endoplasmic reticulum oxidoreductase 1 beta OS=Rattus norvegicus OX=10116 GN=Ero1b PE=1 SV=1 CANONICAL=A0A0G2KAP1-1", "length": 467, "sequence": "MSPGFLRAVAGQGAAAAVQLLVTLGFLSSLVKTQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGRSNKYSQAANNTKELDDCEQANKLGAINSTLSNESKEAFIDWARYDDSQDHFCELDDERSPAAQYVDLLLNPERYTGYKGSSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDNGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKRRFDTVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNLEDDADTKTLLLSIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRELQNFKALLQHRR" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-264876", "resource": "Reactome", "id": "R-RNO-264876", "name": "Insulin processing" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q8R2E9-1", "protein_name": "ERO1-like protein beta", "sequence": { "length": 467, "sequence": "MSPGFRRAVTGQGAAAAVQLLVTLSFLSSLVKTQVTGVLDDCLCDIDSIDKFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGRSNKYSQAANSTKELDDCEQANKLGAINSTLSNESKEAFIDWARYDDSQDHFCELDDERSPAAQYVDLLLNPERYTGYKGSSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFRRRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNVEDDADTKTLLLSIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQNLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRELQNFKALLQHRR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAP1/", "id": "A0A0G2KAP1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8740", "id": "8740", "database": "MGI" } ], "common_name": "mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q86YB8-1", "protein_name": "ERO1-like protein beta", "sequence": { "length": 467, "sequence": "MSQGVRRAGAGQGVAAAVQLLVTLSFLRSVVEAQVTGVLDDCLCDIDSIDNFNTYKIFPKIKKLQERDYFRYYKVNLKRPCPFWAEDGHCSIKDCHVEPCPESKIPVGIKAGHSNKYLKMANNTKELEDCEQANKLGAINSTLSNQSKEAFIDWARYDDSRDHFCELDDERSPAAQYVDLLLNPERYTGYKGTSAWRVWNSIYEENCFKPRSVYRPLNPLAPSRGEDDGESFYTWLEGLCLEKRVFYKLISGLHASINLHLCANYLLEETWGKPSWGPNIKEFKHRFDPVETKGEGPRRLKNLYFLYLIELRALSKVAPYFERSIVDLYTGNAEEDADTKTLLLNIFQDTKSFPMHFDEKSMFAGDKKGAKSLKEEFRLHFKNISRIMDCVGCDKCRLWGKLQTQGLGTALKILFSEKEIQKLPENSPSKGFQLTRQEIVALLNAFGRLSTSIRDLQNFKVLLQHSR" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAP1/", "id": "A0A0G2KAP1", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/8740", "id": "8740", "database": "MGI" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254437.1", "ac": "XP_006254437.1", "name": "ERO1-like protein beta isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015035", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "protein disulfide oxidoreductase activity", "id": "GO:0015035" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003756", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "protein disulfide isomerase activity", "id": "GO:0003756" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016671", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor", "id": "GO:0016671" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "endoplasmic reticulum membrane", "id": "GO:0005789" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034975", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "protein folding in endoplasmic reticulum", "id": "GO:0034975" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019471", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "4-hydroxyproline metabolic process", "id": "GO:0019471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "extracellular matrix organization", "id": "GO:0030198" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042593", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "glucose homeostasis", "id": "GO:0042593" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0022417", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "protein maturation by protein folding", "id": "GO:0022417" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045454", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "cell redox homeostasis", "id": "GO:0045454" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030070", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "id": "A0A0G2KAP1", "database": "UniProtKB" } ], "name": "insulin processing", "id": "GO:0030070" } ], "total": 7, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "type": "recommended", "resource": "UniProtKB", "name": "Ero1b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAP1", "type": "synonym", "resource": "RefSeq", "name": "Ero1b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAP1", "type": "synonym", "resource": "RefSeq", "name": "Ero1lb; RGD1563548" } ], "crossref": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-264876", "id": "R-RNO-264876", "database": "Reactome" }, { "url": "http://www.orthodb.org/?query=1181226at2759", "id": "1181226at2759", "database": "OrthoDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR007266", "id": "IPR007266", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/364755", "id": "364755", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037192", "id": "IPR037192", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000002609", "id": "ENSRNOG00000002609", "database": "Bgee" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563548", "id": "1563548", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/YRENCFQ/", "id": "YRENCFQ", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF04137", "id": "PF04137", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006254437.1", "id": "XP_006254437.1", "database": "RefSeq" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12613", "id": "PTHR12613", "database": "PANTHER" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 53431.0, "chemical_mass": 53431.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "name": "Ero1b", "locus": { "end_pos": 90710555, "start_pos": 90756048, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000002609", "id": "ENSRNOG00000002609", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAP1", "type": "synonym", "resource": "UniProtKB", "name": "Endoplasmic reticulum oxidoreductase 1 beta" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KAP1", "type": "synonym", "resource": "RefSeq", "name": "ERO1-like protein beta isoform X1" } ] }