{ "uniprot_canonical_ac": "A0A096MJS9-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 595, "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" }, "uniprot_id": "A0A096MJS9_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "rats", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A096MJS9", "site_annotation": [ { "end_pos": 85, "annotation": "n_glycosylation_sequon", "start_pos": 83 }, { "end_pos": 316, "annotation": "n_glycosylation_sequon", "start_pos": 314 }, { "end_pos": 476, "annotation": "n_glycosylation_sequon", "start_pos": 474 }, { "end_pos": 290, "annotation": "n_glycosylation_sequon", "start_pos": 288 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A0G2K4A1-1", "isoform_ac": "A0A0G2K4A1-1", "locus": { "end_pos": 42502450, "start_pos": 42517553, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000081500", "id": "ENSRNOT00000081500", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072962", "id": "ENSRNOP00000072962", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K4A1-1|A0A096MJS9_RAT Computationally mapped isoform of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 587, "sequence": "MATFTPRKRKRHTLKADNDDSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTNKPMSSSVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#A0A096MJS9-1", "isoform_ac": "A0A096MJS9-1", "locus": { "end_pos": 42502450, "start_pos": 42517559, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000076451", "id": "ENSRNOT00000076451", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000068247", "id": "ENSRNOP00000068247", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A096MJS9-1|A0A096MJS9_RAT Isoform 1 of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 595, "sequence": "MMMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9#D4ABF1-1", "isoform_ac": "D4ABF1-1", "locus": { "end_pos": 42502450, "start_pos": 42517556, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000021320", "id": "ENSRNOT00000021320", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000021320", "id": "ENSRNOP00000021320", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4ABF1-1|A0A096MJS9_RAT Computationally mapped isoform of RCG52137, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Esco2 PE=4 SV=1 CANONICAL=A0A096MJS9-1", "length": 594, "sequence": "MMATFTPRKRKRHTLKADNDDSLLTDISSSKLRFAENLYSSPNKKHNCQSSVQKEEKPCSHQRHFSSSPLKTTENNMLSFANHSSLFKPVVSTVSFYNKNKHYLNPLERKLIRECKSICLATKNEDKPFPSVTEKIQRKPVCTKNKKRQKSLTANHQPNYKHVKSISRNLKNSKPSQVTYKPVVDKENSCFPPENPPNSPPRVLSQKIRPRVTLQGGAAFFVRKRNFLKKSPLEDKPLPILLQKNEPEVTEDALEAKQVPKSLLVGEKSNVELLDARSESEEKLGKNSSGAVVSSKECKLGKHNFPSEKSLENKTISSESVYSIFSVSSTNTKRSPSEEQSSVGSTACTNFLKQTNVQKNINFRDTNKGGKDQLVIDAGQKHFGTTMCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKYVGWKRERIVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQVVPMCPNKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSTTKECSRAWRCSDVPEPAICGISRIWVFKLKRRKRIARRLVDTVRNCFMFGCFLSINEIAFSDPTPDGKLFATKYCNTPNFLVYNFHS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "resource": "Reactome", "id": "R-RNO-2468052", "name": "Establishment of Sister Chromatid Cohesion" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "resource": "KEGG Pathway", "id": "rno:691979", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q56NI9-1", "protein_name": "N-acetyltransferase ESCO2", "sequence": { "length": 601, "sequence": "MAALTPRKRKQDSLKCDSLLHFTENLFPSPNKKHCFYQNSDKNEENLHCSQQEHFVLSALKTTEINRLPSANQGSPFKSALSTVSFYNQNKWYLNPLERKLIKESRSTCLKTNDEDKSFPIVTEKMQGKPVCSKKNNKKPQKSLTAKYQPKYRHIKPVSRNSRNSKQNRVIYKPIVEKENNCHSAENNSNAPRVLSQKIKPQVTLQGGAAFFVRKKSSLRKSSLENEPSLGRTQKSKSEVIEDSDVETVSEKKTFATRQVPKCLVLEEKLKIGLLSASSKNKEKLIKDSSDDRVSSKEHKVDKNEAFSSEDSLGENKTISPKSTVYPIFSASSVNSKRSLGEEQFSVGSVNFMKQTNIQKNTNTRDTSKKTKDQLIIDAGQKHFGATVCKSCGMIYTASNPEDEMQHVQHHHRFLEGIKYVGWKKERVVAEFWDGKIVLVLPHDPSFAIKKVEDVQELVDNELGFQQVVPKCPNKIKTFLFISDEKRVVGCLIAEPIKQAFRVLSEPIGPESPSSTECPRAWQCSDVPEPAVCGISRIWVFRLKRRKRIARRLVDTLRNCFMFGCFLSTDEIAFSDPTPDGKLFATKYCNTPNFLVYNFNS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12432", "id": "12432", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "id": "A0A096MJS9", "database": "OMA" } ], "common_name": "man", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q8CIB9-1", "protein_name": "N-acetyltransferase ESCO2", "sequence": { "length": 592, "sequence": "MMATCTPRKRKRYTLNADNDDSLLTDISSSKLRCAENLFPSPNKKHNYQSSVQKEDKSCSHQLHFPSSPLKTTENSRFSFANHSSLFKPAMSTVSFYSKEKYYLNPLERKLIRECRSICLATESGDKPIPSVTENIQRKPVCTKKNKKKQKSLTAKYQPNYKHIKSKSRNLKNSKPNQVTYKPVVDQENSCFPAKNYPNSPPRVLSQKIKPQVTLQGGAAFFVRKRNSLKKLPLEDKPLLLQKNLPEVPEGAPEAKQIPKSLLVDEKSSVKVQNARSKNEEKLRKNPSGAVVSSKECNLDKHDFPSENSLDENKTISPESVYPIFNVSSVNTKRPEEQSSVGSTACTNFLKQTNVPKNINSRDTNKGGKDQLVIDAGQKHFGTTVCKSCGMIYTASNPEDEIQHLQHHHRFLEGIKFVGWKRERVVAEFWDGKIVLVLPRDPSYAIKKVEDVQELVDLELGFQQTVPVCPDKTKTFLFIDEKRVVGCLIAEPIKQAFRVLSEPSASKECSRAWRCSDVPEPAICGISRIWVFRLKRRKRIARRLVDTVRNCFMFGCFLSTNEIAFSDPTPDGKLFATKYCNTPNFLVYNFHN" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12432", "id": "12432", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A096MJS9/", "id": "A0A096MJS9", "database": "OMA" } ], "common_name": "mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543.1", "ac": "XP_003751543.1", "name": "N-acetyltransferase ESCO2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004468", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "lysine N-acetyltransferase activity, acting on acetyl phosphate as donor", "id": "GO:0004468" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "cell junction", "id": "GO:0030054" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "site of double-strand break", "id": "GO:0035861" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010369", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "chromocenter", "id": "GO:0010369" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001741", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "XY body", "id": "GO:0001741" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031618", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "nuclear pericentric heterochromatin", "id": "GO:0031618" } ], "total": 6, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006275", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "regulation of DNA replication", "id": "GO:0006275" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007062", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "sister chromatid cohesion", "id": "GO:0007062" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034421", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "post-translational protein acetylation", "id": "GO:0034421" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006302", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "double-strand break repair", "id": "GO:0006302" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "hematopoietic progenitor cell differentiation", "id": "GO:0002244" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071168", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "id": "A0A096MJS9", "database": "UniProtKB" } ], "name": "protein localization to chromatin", "id": "GO:0071168" } ], "total": 6, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "synonym", "resource": "UniProtKB", "name": "rCG_52137" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "recommended", "resource": "UniProtKB", "name": "Esco2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJS9", "type": "synonym", "resource": "RefSeq", "name": "Esco2" } ], "crossref": [ { "url": "http://pfam.xfam.org/family/PF13878", "id": "PF13878", "database": "Pfam" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:691979", "id": "rno:691979", "database": "KEGG Pathway" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000015921", "id": "ENSRNOG00000015921", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_003751543.1", "id": "XP_003751543.1", "database": "RefSeq" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028009", "id": "IPR028009", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR028005", "id": "IPR028005", "database": "InterPro" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-2468052", "id": "R-RNO-2468052", "database": "Reactome" }, { "url": "http://pfam.xfam.org/family/PF13880", "id": "PF13880", "database": "Pfam" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1593313", "id": "1593313", "database": "RGD" }, { "url": "https://omabrowser.org/oma/group/HDPSYAI/", "id": "HDPSYAI", "database": "OMA" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/691979", "id": "691979", "database": "GeneID" }, { "url": "http://www.orthodb.org/?query=1024179at2759", "id": "1024179at2759", "database": "OrthoDB" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 67698.0, "chemical_mass": 67698.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "name": "Esco2", "locus": { "end_pos": 42500929, "start_pos": 42518855, "chromosome": "15", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000015921", "id": "ENSRNOG00000015921", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "synonym", "resource": "UniProtKB", "name": "RCG52137, isoform CRA_a" }, { "url": "https://www.uniprot.org/uniprot/A0A096MJS9", "type": "synonym", "resource": "UniProtKB", "name": "Establishment of sister chromatid cohesion N-acetyltransferase 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A096MJS9", "type": "synonym", "resource": "RefSeq", "name": "N-acetyltransferase ESCO2" } ] }