{
    "uniprot_canonical_ac": "A6BLY7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A6BLY7-1|K1C28_MOUSE Isoform 1 of Keratin, type I cytoskeletal 28  OS=Mus musculus OX=10090 GN=Krt28 PE=1 SV=1 CANONICAL=A6BLY7-1", 
        "length": 462, 
        "sequence": "MSLRFSGGSRHVGIQSGSLRPPSGGAGFAGSSVAGGSVAGSGFSWALGGTLGSAPGGSHATGALGNVSGVCFIGSEGGLLSGNEKVTMQNLNNRLASYLDNVKALEEANSELERKIKTWHEKYGPGSCRGLDRDYSKYHLTIEDLKSKIISSTAANANIILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSATLQQQISNDLGAATSARTELTELKRSLQTLEIELQSLSATKHSLECSLAETEGNYCSQLAQIQAQISALEEQLHQVRTETEGQKLEHEQLLDIKAHLEKEIETYCRLIDGDENSCSVSKGFESGTSGNSPKDVSKTTLVKTVVEEIDQRGKVLSSRIHSIEEKMSKMSNGKAEQRVPF"
    }, 
    "uniprot_id": "K1C28_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                    "id": "A6BLY7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/14996088", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "14996088"
                }
            ], 
            "title": "Functional analysis of keratin components in the mouse hair follicle inner root sheath.", 
            "journal": "Br. J. Dermatol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                    "id": "A6BLY7", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Wilson N.J., McLean W.H.I., Lane E.B., Wood P., Porter R.M., Gandhi M.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16831889", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16831889"
                }
            ], 
            "title": "New consensus nomenclature for mammalian keratins.", 
            "journal": "The Journal of cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081850.1", 
                    "id": "NP_081850.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Schweizer J, Bowden PE, Coulombe PA, Langbein L, Lane EB, Magin TM, Maltais L, Omary MB, Parry DA, Rogers MA, Wright MW", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17920809", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17920809"
                }
            ], 
            "title": "Mutations in the helix termination motif of mouse type I IRS keratin genes impair the assembly of keratin intermediate filament.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                    "id": "A6BLY7", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081850.1", 
                    "id": "NP_081850.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yokoyama H., Tanaka S., Kato Y., Shiroishi T., Miura I., Tamura M., Wakana S., Yoshiki A., Masuya H., Shinogi A.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27234308", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27234308"
                }
            ], 
            "title": "Deletion of the epidermis derived laminin gamma1 chain leads to defects in the regulation of late hair morphogenesis.", 
            "journal": "Matrix biology : journal of the International Society for Matrix Biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081850.1", 
                    "id": "NP_081850.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Fleger-Weckmann A, Ustun Y, Kloepper J, Paus R, Bloch W, Chen ZL, Wegner J, Sorokin L, Langbein L, Eckes B, Zigrino P, Krieg T, Nischt R", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A6BLY7", 
    "site_annotation": [
        {
            "end_pos": 68, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 66
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7#A6BLY7-1", 
            "isoform_ac": "A6BLY7-1", 
            "locus": {
                "end_pos": 99365046, 
                "strand": "+", 
                "start_pos": 99374839, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000006963", 
                        "id": "ENSMUST00000006963", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000006963", 
                        "id": "ENSMUSP00000006963", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A6BLY7-1|K1C28_MOUSE Isoform 1 of Keratin, type I cytoskeletal 28  OS=Mus musculus OX=10090 GN=Krt28 PE=1 SV=1 CANONICAL=A6BLY7-1", 
                "length": 462, 
                "sequence": "MSLRFSGGSRHVGIQSGSLRPPSGGAGFAGSSVAGGSVAGSGFSWALGGTLGSAPGGSHATGALGNVSGVCFIGSEGGLLSGNEKVTMQNLNNRLASYLDNVKALEEANSELERKIKTWHEKYGPGSCRGLDRDYSKYHLTIEDLKSKIISSTAANANIILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSATLQQQISNDLGAATSARTELTELKRSLQTLEIELQSLSATKHSLECSLAETEGNYCSQLAQIQAQISALEEQLHQVRTETEGQKLEHEQLLDIKAHLEKEIETYCRLIDGDENSCSVSKGFESGTSGNSPKDVSKTTLVKTVVEEIDQRGKVLSSRIHSIEEKMSKMSNGKAEQRVPF"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70843", 
            "resource": "KEGG Pathway", 
            "id": "mmu:70843", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", 
            "resource": "Reactome", 
            "id": "R-MMU-6805567", 
            "name": "Keratinization"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6809371", 
            "resource": "Reactome", 
            "id": "R-MMU-6809371", 
            "name": "Formation of the cornified envelope"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7#function", 
            "annotation": "Essential for the proper assembly of types I and II keratin protein complexes and the formation of keratin intermediate filaments in the inner root sheath (irs).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A6BLY7#function", 
                    "id": "A6BLY7", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q6IFW7-1", 
            "protein_name": "Keratin 28", 
            "sequence": {
                "length": 383, 
                "sequence": "MSLRFSGGSRHAGLQSGSLRPPSGGAGFAGSSAAGGSVAGSGFSWALGGTLCSAPGGSHATGALGNVTCVGFAGSEGGLLSGNEKVTMQNLNNRLASYLDNVKALEEANTELERKIKTWHEKYGPGSCRGLDRDYSNYHLTIEDLKSKVISSTAANANIILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKVLQCAAGGNVNVEMNAAPGVDLTVLLNNMRAEYEALAEQNRRDAEAWFQEKSATLQQQISNDLGAATSARTELTELKRSLQTLEIELQSLSATGFESGTSGNSSKDVSKTTLVKTVVEEIDPRGKVLSSRIHSIEEKMTKISNSKAEQRVPF"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/124711", 
                    "id": "124711", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A6BLY7/", 
                    "id": "A6BLY7", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q7Z3Y7-1", 
            "protein_name": "Keratin, type I cytoskeletal 28", 
            "sequence": {
                "length": 464, 
                "sequence": "MSLQFSNGSRHVCLRSGAGSVRPLNGGAGFAGSSACGGSVAGSEFSCALGGGLGSVPGGSHAGGALGNAACIGFAGSEGGLLSGNEKVTMQNLNDRLASYLDNVRALEEANAELERKIKGWYEKYGPGSCRGLDHDYSRYHLTIEDLKNKIISSTTTNANVILQIDNARLAADDFRLKYENELTLHQNVEADINGLRRVLDELTLCRTDQELQYESLSEEMTYLKKNHEEEMKALQCAAGGNVNVEMNAAPGVDLAVLLNNMRAEYEALAEQNRKDAEAWFNEKSASLQQQISHDSGAATFARSQLTEMRRTLQTLEIQLQSLMATKHSLECSLTETESNYCTQLAQIQAQIGALEEQLHQVRTETEGQKLEYEHLLDVKVHLEKEIETYCRLIDGDGNSCSKSKGFGSGSPGNSSKDLSKTTLVKTVVEELDQRGKVLSSRIHSIEEKTSKMTNGKTEQRVPF"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/124711", 
                    "id": "124711", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A6BLY7/", 
                    "id": "A6BLY7", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081850.1", 
        "ac": "NP_081850.1", 
        "name": "keratin, type I cytoskeletal 28", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005198", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                                "id": "A6BLY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "structural molecule activity", 
                        "id": "GO:0005198"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                                "id": "A6BLY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005882", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A6BLY7", 
                                "id": "A6BLY7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "intermediate filament", 
                        "id": "GO:0005882"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6BLY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "4733401L19Rik; CK-28; K25D; K28; Krt25d"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Krt25d"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6BLY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Krt28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Krt28"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000055937", 
            "id": "ENSMUSG00000055937", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/70843", 
            "id": "70843", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002957", 
            "id": "IPR002957", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039008", 
            "id": "IPR039008", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR042180", 
            "id": "IPR042180", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:70843", 
            "id": "mmu:70843", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1918093", 
            "id": "1918093", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/HQNTEAD/", 
            "id": "HQNTEAD", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=805081at2759", 
            "id": "805081at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23239", 
            "id": "PTHR23239", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00038", 
            "id": "PF00038", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A6BLY7", 
            "id": "PR_A6BLY7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6805567", 
            "id": "R-MMU-6805567", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-6809371", 
            "id": "R-MMU-6809371", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081850.1", 
            "id": "NP_081850.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 50346.0, 
        "chemical_mass": 50346.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "name": "Krt28", 
            "locus": {
                "end_pos": 99364872, 
                "strand": "-", 
                "start_pos": 99374903, 
                "chromosome": "11", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000055937", 
                        "id": "ENSMUSG00000055937", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "CK-28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Cytokeratin-28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "K25D"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "K28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Keratin, type I cytoskeletal 28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Keratin-25D"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Keratin-28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A6BLY7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Type I inner root sheath-specific keratin-K25irs4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6BLY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "keratin 25D; cytokeratin-28; type I inner root sheath-specific keratin-K25irs4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A6BLY7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "keratin, type I cytoskeletal 28"
        }
    ]
}