{ "uniprot_canonical_ac": "A5H2Z9-1", "ptm_annotation": [], "sequence": { "header": "tr|A5H2Z9-1|A5H2Z9_RAT Isoform 1 of Toll-like receptor 7 OS=Rattus norvegicus OX=10116 GN=Tlr7 PE=2 SV=1 CANONICAL=A5H2Z9-1", "length": 1050, "sequence": "MVFPMWTLKRQSFIFLNMILVSRVLGFRWYPKTLPCDVSLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFHRLKHLEELDLRCNCVPILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQDLPSSLQLLSLEANNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTILPPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDNDISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVIILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" }, "uniprot_id": "A5H2Z9_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12781911", "type": [ "PubMed" ], "id": "12781911" } ], "title": "Differential regulation of Toll-like receptor mRNAs in experimental murine central nervous system infections.", "journal": "Neuroscience letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Bottcher T, von Mering M, Ebert S, Meyding-Lamade U, Kuhnt U, Gerber J, Nau R", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14976261", "type": [ "PubMed" ], "id": "14976261" } ], "title": "Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/14976262", "type": [ "PubMed" ], "id": "14976262" } ], "title": "Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8.", "journal": "Science (New York, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15723075", "type": [ "PubMed" ], "id": "15723075" } ], "title": "Sequence-specific potent induction of IFN-alpha by short interfering RNA in plasmacytoid dendritic cells through TLR7.", "journal": "Nature medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Hornung V, Guenthner-Biller M, Bourquin C, Ablasser A, Schlee M, Uematsu S, Noronha A, Manoharan M, Akira S, de Fougerolles A, Endres S, Hartmann G", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16111635", "type": [ "PubMed" ], "id": "16111635" } ], "title": "Suppression of RNA recognition by Toll-like receptors: the impact of nucleoside modification and the evolutionary origin of RNA.", "journal": "Immunity", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Kariko K, Buckstein M, Ni H, Weissman D", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25384124", "type": [ "PubMed" ], "id": "25384124" } ], "title": "Development of non-traumatic osteonecrosis of the femoral head requires toll-like receptor 7 and 9 stimulations and is boosted by repression on nuclear factor kappa B in rats.", "journal": "Laboratory investigation; a journal of technical methods and pathology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Okazaki S, Nagoya S, Matsumoto H, Mizuo K, Sasaki M, Watanabe S, Yamashita T, Inoue H", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26363072", "type": [ "PubMed" ], "id": "26363072" } ], "title": "Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via Toll-like receptor 7 signaling.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Feng Y, Chen H, Cai J, Zou L, Yan D, Xu G, Li D, Chao W", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26434622", "type": [ "PubMed" ], "id": "26434622" } ], "title": "The expression of Toll-like receptor 4, 7 and co-receptors in neurochemical sub-populations of rat trigeminal ganglion sensory neurons.", "journal": "Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Helley MP, Abate W, Jackson SK, Bennett JH, Thompson SW", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28665028", "type": [ "PubMed" ], "id": "28665028" } ], "title": "Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.", "journal": "Aging cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ], "authors": "Lee EK, Chung KW, Kim YR, Ha S, Kim SD, Kim DH, Jung KJ, Lee B, Im E, Yu BP, Chung HY", "date": "2017" } ], "uniprot_ac": "A5H2Z9", "site_annotation": [ { "end_pos": 169, "annotation": "n_glycosylation_sequon", "start_pos": 167 }, { "end_pos": 192, "annotation": "n_glycosylation_sequon", "start_pos": 190 }, { "end_pos": 217, "annotation": "n_glycosylation_sequon", "start_pos": 215 }, { "end_pos": 277, "annotation": "n_glycosylation_sequon", "start_pos": 275 }, { "end_pos": 314, "annotation": "n_glycosylation_sequon", "start_pos": 312 }, { "end_pos": 397, "annotation": "n_glycosylation_sequon", "start_pos": 395 }, { "end_pos": 526, "annotation": "n_glycosylation_sequon", "start_pos": 524 }, { "end_pos": 537, "annotation": "n_glycosylation_sequon", "start_pos": 535 }, { "end_pos": 593, "annotation": "n_glycosylation_sequon", "start_pos": 591 }, { "end_pos": 68, "annotation": "n_glycosylation_sequon", "start_pos": 66 }, { "end_pos": 679, "annotation": "n_glycosylation_sequon", "start_pos": 677 }, { "end_pos": 71, "annotation": "n_glycosylation_sequon", "start_pos": 69 }, { "end_pos": 723, "annotation": "n_glycosylation_sequon", "start_pos": 721 }, { "end_pos": 802, "annotation": "n_glycosylation_sequon", "start_pos": 800 }, { "end_pos": 945, "annotation": "n_glycosylation_sequon", "start_pos": 943 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9#A5H2Z9-1", "isoform_ac": "A5H2Z9-1", "locus": { "end_pos": 28487420, "strand": "-", "start_pos": 28512039, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000005620", "id": "ENSRNOT00000005620", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000005620", "id": "ENSRNOP00000005620", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A5H2Z9-1|A5H2Z9_RAT Isoform 1 of Toll-like receptor 7 OS=Rattus norvegicus OX=10116 GN=Tlr7 PE=2 SV=1 CANONICAL=A5H2Z9-1", "length": 1050, "sequence": "MVFPMWTLKRQSFIFLNMILVSRVLGFRWYPKTLPCDVSLDSTNTHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFHRLKHLEELDLRCNCVPILLGSKANVCTKRLQIRPGSFSGLSDLKSLYLDGNQLLEIPQDLPSSLQLLSLEANNIFSITKENLSELVNIESLYLGQNCYYRNPCNVSYSIEKDAFLVMKNLKVLSLKDNNVTAVPTILPPNLLELYLYNNIIKRIQEHDFNKLSQLQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFDSLTELKVLRLHSNSLQHVPAEWFKNMSNLQELDLSQNYLAREIEEAKFLNSLPNLVQLDLSFNYELQVYHASITLPHSLSSLTKLKNLYIKGYVFKELKDSSLSVLHNLSNLEVLDLGTNFIKIADLNIFQQFENLKFIDLSVNKISPSEESREVGLCPNAQTSVDWHGPQVLEALHYFRYDEYARSCRFKNKEPPTFLPLNADCHTYGKTLDLSRNNIFFIKPSDFKHLSFLKCLNLSGNAIGQTLNGSELQPLRELRYLDFSNNRLDLLYSTAFEELQNLEILDLSSNSHYFQAEGITHMLNFTKKLRHLEKLMMNDNDISTSASRTMESESLRVLEFRGNHLDVLWRDGDNRYLDFFKNLLNLEELDISRNSLNSVPPGVFEGMPPNLTTLSLAKNGLRSFSWGRLQLLKHLKNLDLSHNQLTTVPARLANCSKSLTKLILNHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLNMLLLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCAGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMIVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVVKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSRKTVFVMTQKYAKTESFKMAFYLSHQRLMDEKVDVIILIFLEKPLQKSKFLQLRKRLCSSSVLEWPTNPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:317468", "resource": "KEGG Pathway", "id": "rno:317468", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", "resource": "Reactome", "id": "R-RNO-1679131", "name": "Trafficking and processing of endosomal TLR" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168181", "resource": "Reactome", "id": "R-RNO-168181", "name": "Toll Like Receptor 7/8 (TLR7/8) Cascade" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975110", "resource": "Reactome", "id": "R-RNO-975110", "name": "TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975138", "resource": "Reactome", "id": "R-RNO-975138", "name": "TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975155", "resource": "Reactome", "id": "R-RNO-975155", "name": "MyD88 dependent cascade initiated on endosome" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Cardiac RNA induces inflammatory responses in cardiomyocytes and immune cells via MyD88-TLR7 signaling.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Evaluated (1) the incidence of ONFH in rats after the administration of TLR7 or TLR9 ligands together with methylprednisolone (MPSL) and (2) whether transcription factors contribute to the development of ONFH", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "Small RNAs induce the activation of the pro-inflammatory TLR7 signaling pathway in aged rat kidney.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "annotation": "This is the first quantitative description of toll-like receptors 4 and 7 expression within adult mammalian sensory ganglia in relation to functional neuronal phenotype.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P58681-1", "protein_name": "Toll-like receptor 7", "sequence": { "length": 1050, "sequence": "MVFSMWTRKRQILIFLNMLLVSRVFGFRWFPKTLPCEVKVNIPEAHVIVDCTDKHLTEIPEGIPTNTTNLTLTINHIPSISPDSFRRLNHLEEIDLRCNCVPVLLGSKANVCTKRLQIRPGSFSGLSDLKALYLDGNQLLEIPQDLPSSLHLLSLEANNIFSITKENLTELVNIETLYLGQNCYYRNPCNVSYSIEKDAFLVMRNLKVLSLKDNNVTAVPTTLPPNLLELYLYNNIIKKIQENDFNNLNELQVLDLSGNCPRCYNVPYPCTPCENNSPLQIHDNAFNSLTELKVLRLHSNSLQHVPPTWFKNMRNLQELDLSQNYLAREIEEAKFLHFLPNLVELDFSFNYELQVYHASITLPHSLSSLENLKILRVKGYVFKELKNSSLSVLHKLPRLEVLDLGTNFIKIADLNIFKHFENLKLIDLSVNKISPSEESREVGFCPNAQTSVDRHGPQVLEALHYFRYDEYARSCRFKNKEPPSFLPLNADCHIYGQTLDLSRNNIFFIKPSDFQHLSFLKCLNLSGNTIGQTLNGSELWPLRELRYLDFSNNRLDLLYSTAFEELQSLEVLDLSSNSHYFQAEGITHMLNFTKKLRLLDKLMMNDNDISTSASRTMESDSLRILEFRGNHLDVLWRAGDNRYLDFFKNLFNLEVLDISRNSLNSLPPEVFEGMPPNLKNLSLAKNGLKSFFWDRLQLLKHLEILDLSHNQLTKVPERLANCSKSLTTLILKHNQIRQLTKYFLEDALQLRYLDISSNKIQVIQKTSFPENVLNNLEMLVLHHNRFLCNCDAVWFVWWVNHTDVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSVSISSVLFLMVVMTTSHLFFWDMWYIYYFWKAKIKGYQHLQSMESCYDAFIVYDTKNSAVTEWVLQELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTQKYAKTESFKMAFYLSHQRLLDEKVDVIILIFLEKPLQKSKFLQLRKRLCRSSVLEWPANPQAHPYFWQCLKNALTTDNHVAYSQMFKETV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/75060", "id": "75060", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9NYK1-1", "protein_name": "Toll-like receptor 7", "sequence": { "length": 1049, "sequence": "MVFPMWTLKRQILILFNIILISKLLGARWFPKTLPCDVTLDVPKNHVIVDCTDKHLTEIPGGIPTNTTNLTLTINHIPDISPASFHRLDHLVEIDFRCNCVPIPLGSKNNMCIKRLQIKPRSFSGLTYLKSLYLDGNQLLEIPQGLPPSLQLLSLEANNIFSIRKENLTELANIEILYLGQNCYYRNPCYVSYSIEKDAFLNLTKLKVLSLKDNNVTAVPTVLPSTLTELYLYNNMIAKIQEDDFNNLNQLQILDLSGNCPRCYNAPFPCAPCKNNSPLQIPVNAFDALTELKVLRLHSNSLQHVPPRWFKNINKLQELDLSQNFLAKEIGDAKFLHFLPSLIQLDLSFNFELQVYRASMNLSQAFSSLKSLKILRIRGYVFKELKSFNLSPLHNLQNLEVLDLGTNFIKIANLSMFKQFKRLKVIDLSVNKISPSGDSSEVGFCSNARTSVESYEPQVLEQLHYFRYDKYARSCRFKNKEASFMSVNESCYKYGQTLDLSKNSIFFVKSSDFQHLSFLKCLNLSGNLISQTLNGSEFQPLAELRYLDFSNNRLDLLHSTAFEELHKLEVLDISSNSHYFQSEGITHMLNFTKNLKVLQKLMMNDNDISSSTSRTMESESLRTLEFRGNHLDVLWREGDNRYLQLFKNLLKLEELDISKNSLSFLPSGVFDGMPPNLKNLSLAKNGLKSFSWKKLQCLKNLETLDLSHNQLTTVPERLSNCSRSLKNLILKNNQIRSLTKYFLQDAFQLRYLDLSSNKIQMIQKTSFPENVLNNLKMLLLHHNRFLCTCDAVWFVWWVNHTEVTIPYLATDVTCVGPGAHKGQSVISLDLYTCELDLTNLILFSLSISVSLFLMVMMTASHLYFWDVWYIYHFCKAKIKGYQRLISPDCCYDAFIVYDTKDPAVTEWVLAELVAKLEDPREKHFNLCLEERDWLPGQPVLENLSQSIQLSKKTVFVMTDKYAKTENFKIAFYLSHQRLMDEKVDVIILIFLEKPFQKSKFLQLRKRLCGSSVLEWPTNPQAHPYFWQCLKNALATDNHVAYSQVFKETV" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A5H2Z9/", "id": "A5H2Z9", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/75060", "id": "75060", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "ac": "NP_001091051.1", "name": "toll-like receptor 7", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008144", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "drug binding", "id": "GO:0008144" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003727", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "single-stranded RNA binding", "id": "GO:0003727" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008329", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "signaling pattern recognition receptor activity", "id": "GO:0008329" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004888", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "transmembrane signaling receptor activity", "id": "GO:0004888" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "double-stranded RNA binding", "id": "GO:0003725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035197", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "siRNA binding", "id": "GO:0035197" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "receptor complex", "id": "GO:0043235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005764", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "lysosome", "id": "GO:0005764" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032009", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "early phagosome", "id": "GO:0032009" } ], "total": 7, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045359", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-beta biosynthetic process", "id": "GO:0045359" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001774", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "microglial cell activation", "id": "GO:0001774" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006955", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "immune response", "id": "GO:0006955" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051607", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "defense response to virus", "id": "GO:0051607" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032755", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-6 production", "id": "GO:0032755" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045416", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interleukin-8 biosynthetic process", "id": "GO:0045416" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007249", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "I-kappaB kinase/NF-kappaB signaling", "id": "GO:0007249" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002224", "pmid": "16973131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "toll-like receptor signaling pathway", "id": "GO:0002224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045078", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-gamma biosynthetic process", "id": "GO:0045078" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034154", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "toll-like receptor 7 signaling pathway", "id": "GO:0034154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045356", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of interferon-alpha biosynthetic process", "id": "GO:0045356" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "innate immune response", "id": "GO:0045087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901224", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of NIK/NF-kappaB signaling", "id": "GO:1901224" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032722", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "positive regulation of chemokine production", "id": "GO:0032722" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071260", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "cellular response to mechanical stimulus", "id": "GO:0071260" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001932", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "regulation of protein phosphorylation", "id": "GO:0001932" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007252", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "I-kappaB phosphorylation", "id": "GO:0007252" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002755", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "id": "A5H2Z9", "database": "UniProtKB" } ], "name": "MyD88-dependent toll-like receptor signaling pathway", "id": "GO:0002755" } ], "total": 18, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "RGD1563357" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "Tlr7" }, { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "type": "recommended", "resource": "UniProtKB", "name": "Tlr7" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000004249", "id": "ENSRNOG00000004249", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/chembldb/target/inspect/CHEMBL4105914", "id": "CHEMBL4105914", "database": "ChEMBL" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/317468", "id": "317468", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000157", "id": "IPR000157", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000483", "id": "IPR000483", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001611", "id": "IPR001611", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003591", "id": "IPR003591", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR026880", "id": "IPR026880", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", "id": "IPR032675", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035897", "id": "IPR035897", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041283", "id": "IPR041283", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:317468", "id": "rno:317468", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/TNTEMES/", "id": "TNTEMES", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=303561at2759", "id": "303561at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47410:SF2", "id": "PTHR47410:SF2", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00560", "id": "PF00560", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF01582", "id": "PF01582", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF13855", "id": "PF13855", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF18837", "id": "PF18837", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-1679131", "id": "R-RNO-1679131", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-168181", "id": "R-RNO-168181", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975110", "id": "R-RNO-975110", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975138", "id": "R-RNO-975138", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975155", "id": "R-RNO-975155", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091051.1", "id": "NP_001091051.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1563357", "id": "1563357", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 121300.0, "chemical_mass": 121300.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "name": "Tlr7", "locus": { "end_pos": 28512957, "strand": "+", "start_pos": 28486869, "chromosome": "X", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000004249", "id": "ENSRNOG00000004249", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A5H2Z9", "type": "synonym", "resource": "UniProtKB", "name": "Toll-like receptor 7" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A5H2Z9", "type": "synonym", "resource": "RefSeq", "name": "toll-like receptor 7" } ] }