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"MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS" }, "uniprot_id": "CL18A_HUMAN", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "reported_with_glycan.unicarbkb", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8", "id": "A5D8T8", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16336259", "type": [ "PubMed" ], "id": "16336259" } ], "title": "The C-type lectin-like domain superfamily.", "journal": "The FEBS journal", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ], "authors": "Zelensky AN, Gready JE", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26170455", "type": [ "PubMed" ], "id": "26170455" } ], "title": "Human CLEC18 gene cluster contains C-type lectins with differential glycan-binding specificity.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8", "id": "A5D8T8", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ], "authors": "Chen C.H., Huang Y.L., Chou T.Y., Hsieh S.L., Hsu T.L., Mon H.C., Pai F.S., Tsou Y.T., Wong C.H., Wu C.Y., Yang W.B.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30055605", "type": [ "PubMed" ], "id": "30055605" } ], "title": "The human C-type lectin 18 is a potential biomarker in patients with chronic hepatitis B virus infection.", "journal": "Journal of biomedical science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ], "authors": "Tsai TY, Peng CY, Yang HI, Huang YL, Tao MH, Yuan SS, Lai HC, Hsieh SL", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30459171", "type": [ "PubMed" ], "id": "30459171" } ], "title": "Mapping the O-glycoproteome using site-specific extraction of O-linked glycopeptides (EXoO).", "journal": "Molecular systems biology", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A5D8T8/annotated", "id": "A5D8T8", "database": "UniCarbKB" } ], "authors": "Yang W, Ao M, Hu Y, Li QK, Zhang H", "date": "2018" } ], "uniprot_ac": "A5D8T8", "site_annotation": [ { "end_pos": 146, "annotation": "n_glycosylation_sequon", "start_pos": 144 }, { "end_pos": 245, "annotation": "n_glycosylation_sequon", "start_pos": 243 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8#A5D8T8-1", "isoform_ac": "A5D8T8-1", "locus": { "end_pos": 69951367, "strand": "-", "start_pos": 69963608, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000568461", "id": "ENST00000568461", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454685", "id": "ENSP00000454685", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A5D8T8-1|CL18A_HUMAN Isoform 1 of C-type lectin domain family 18 member A OS=Homo sapiens OX=9606 GN=CLEC18A PE=1 SV=3 CANONICAL=A5D8T8-1", "length": 446, "sequence": "MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS" } }, { "url": "https://www.uniprot.org/uniprot/A5D8T8#A5D8T8-2", "isoform_ac": "A5D8T8-2", "locus": {}, "sequence": { "header": "sp|A5D8T8-2|CL18A_HUMAN Isoform 2 of C-type lectin domain family 18 member A OS=Homo sapiens OX=9606 GN=CLEC18A PE=1 SV=3 CANONICAL=A5D8T8-1", "length": 106, "sequence": "MGAASAGKRGQKGSWQQTPGSEWANLDYPGPGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS" } }, { "url": "https://www.uniprot.org/uniprot/A5D8T8#F8W692-1", "isoform_ac": "F8W692-1", "locus": { "end_pos": 69951367, "strand": "-", "start_pos": 69963608, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000449317", "id": "ENST00000449317", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000413990", "id": "ENSP00000413990", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F8W692-1|CL18A_HUMAN Computationally mapped isoform of C-type lectin domain family 18 member A OS=Homo sapiens OX=9606 GN=CLEC18A PE=1 SV=1 CANONICAL=A5D8T8-1", "length": 455, "sequence": "MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGTPTPSLASGLWRTLQVGWNMQLLPAGLVSFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGLVWLSAAMGFGNCVELQASAAFNWNDQRCKTRNRYICQFAQEHISRWGPGS" } }, { "url": "https://www.uniprot.org/uniprot/A5D8T8#H3BNR9-1", "isoform_ac": "H3BNR9-1", "locus": { "end_pos": 69952115, "strand": "-", "start_pos": 69959547, "chromosome": "16", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000561889", "id": "ENST00000561889", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000454976", "id": "ENSP00000454976", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|H3BNR9-1|CL18A_HUMAN Computationally mapped isoform of C-type lectin domain family 18 member A OS=Homo sapiens OX=9606 GN=CLEC18A PE=1 SV=1 CANONICAL=A5D8T8-1", "length": 66, "sequence": "MRRLLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGC" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:348174", "resource": "KEGG Pathway", "id": "hsa:348174", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8#function", "annotation": "Binds polysaccharides in a Ca(2+)-independent manner with a preferentially binding to fucoidan, beta-glucans and galactans (PubMed:26170455).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8#function", "id": "A5D8T8", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "annotation": "Plasma CLEC18 levels were correlated with the stage of HBV infection and could predict HBeAg loss and seroconversion in the patients with chronic hepatitis B (CHB) undergoing NUC therapy Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "annotation": "The human C-type lectin 18 (clec18) gene cluster, which contains three clec18a, clec18b, and clec18c loci, is located in human chromosome 16q22.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8NCF0-1", "protein_name": "C-type lectin domain family 18 member C", "sequence": { "length": 446, "sequence": "MLHPETSPGRGHLLAVLLALLGTAWAEVWPPQLQEQAPMAGALNRKESFLLLSLHNRLRSWVQPPAADMRRLDWSDSLAQLAQARAALCGIPTPSLASGLWRTLQVGWNMQLLPAGLASFVEVVSLWFAEGQRYSHAAGECARNATCTHYTQLVWATSSQLGCGRHLCSAGQAAIEAFVCAYSPRGNWEVNGKTIVPYKKGAWCSLCTASVSGCFKAWDHAGGLCEVPRNPCRMSCQNHGRLNISTCHCHCPPGYTGRYCQVRCSLQCVHGRFREEECSCVCDIGYGGAQCATKVHFPFHTCDLRIDGDCFMVSSEADTYYRARMKCQRKGGVLAQIKSQKVQDILAFYLGRLETTNEVIDSDFETRNFWIGLTYKTAKDSFRWATGEHQAFTSFAFGQPDNHGFGNCVELQASAAFNWNNQRCKTRNRYICQFAQEHISRWGPGS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/138419", "id": "138419", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "L", "start_pos": 100, "alt_nt": "C", "chr_id": "16", "ref_nt": "T", "chr_pos": "69988319", "disease": [ { "synonyms": [ { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "Thyroid gland neoplasm", "description": "" }, { "id": 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(1.5%).", "end_pos": 24, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "M", "start_pos": 312, "alt_nt": "C", "chr_id": "16", "ref_nt": "T", "chr_pos": "69994805", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" } ], "frequency": "1.5", "sequence_mut": "T", "subjects_tested": "66", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", "end_pos": 312, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "I", "start_pos": 360, "alt_nt": "C", "chr_id": "16", "ref_nt": "T", "chr_pos": "69995583", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" } ], "frequency": "1.5", "sequence_mut": "T", "subjects_tested": "66", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (1.5%).", "end_pos": 360, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "N", "start_pos": 420, "alt_nt": "A", "chr_id": "16", "ref_nt": "C", "chr_pos": "69996927", "disease": [ { "synonyms": [ { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "Thyroid gland neoplasm", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "malignant tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid neoplasm", "description": "" } ], "recommended_name": { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" } ], "frequency": "2.0", "sequence_mut": "K", "subjects_tested": "50", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (2.0%).", "end_pos": 420, "minor_allelic_frequency": "", "subjects_positive": "1" }, { "sequence_org": "R", "start_pos": 57, "alt_nt": "A", "chr_id": "16", "ref_nt": "G", "chr_pos": "69985983", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" } ], "frequency": "3.0", "sequence_mut": "H", "subjects_tested": "66", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: patient freq. (3.0%).", "end_pos": 57, "minor_allelic_frequency": "", "subjects_positive": "2" }, { "sequence_org": "D", "start_pos": 73, "alt_nt": "A", "chr_id": "16", "ref_nt": "G", "chr_pos": "69988237", "disease": [ { "synonyms": [], "recommended_name": { "id": "DOID:1324", "url": "http://disease-ontology.org/term/DOID:1324", "resource": "Disease Ontology", "name": "lung cancer", "description": "A respiratory system cancer that is located_in the lung." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" } ], "frequency": "0.1", "sequence_mut": "N", "subjects_tested": "689", "keywords": [ "biomuta", "somatic", "cancer", "disease" ], "annotation": "Somatic mutation passed 1 out of 6 filters: n-glyco-sequon-gain (DWS->NWS).", "end_pos": 73, "minor_allelic_frequency": "", "subjects_positive": "1" } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "ac": "NP_001129686.1", "name": "C-type lectin domain family 18 member A precursor", "summary": "This is one of three closely related paralogous genes on chromosome 16 encoding secreted proteins containing C-type lectin domains. These domains bind to carbohydrates in the presence of calcium, and may be involved in cell adhesion, immune response and apoptosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2012]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030247", "pmid": "26170455", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8", "id": "A5D8T8", "database": "UniProtKB" } ], "name": "polysaccharide binding", "id": "GO:0030247" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "26170455", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8", "id": "A5D8T8", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "26170455", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A5D8T8", "id": "A5D8T8", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "26170455", "evidence": [ { "url": 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"https://bgee.org/?page=gene&gene_id=ENSG00000157322", "id": "ENSG00000157322", "database": "Bgee" }, { "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A5D8T8", "id": "A5D8T8", "database": "BioMuta" }, { "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=CLEC18A", "id": "CLEC18A", "database": "GeneCards" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/348174", "id": "348174", "database": "GeneID" }, { "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=30388", "id": "30388", "database": "HGNC" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A5D8T8*", "id": "A5D8T8", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", "id": "IPR000742", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001283", "id": "IPR001283", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001304", "id": "IPR001304", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", "id": "IPR013032", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014044", "id": "IPR014044", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016186", "id": "IPR016186", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016187", "id": "IPR016187", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018378", "id": "IPR018378", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035940", "id": "IPR035940", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:348174", "id": "hsa:348174", "database": "KEGG Pathway" }, { "url": "http://www.omim.org/entry/616571", "id": "616571", "database": "MIM" }, { "url": "https://www.nextprot.org/entry/NX_A5D8T8", "id": "NX_A5D8T8", "database": "neXtProt" }, { "url": "http://www.orthodb.org/?query=1528782at2759", "id": "1528782at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10334", "id": "PTHR10334", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00059", "id": "PF00059", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00188", "id": "PF00188", "database": "Pfam" }, { "url": "https://pharos.nih.gov/targets/A5D8T8", "id": "A5D8T8", "database": "PHAROS" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A5D8T8", "id": "PR_A5D8T8", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129686.1", "id": "NP_001129686.1", "database": "RefSeq" } ], "expression_disease": [ { "name": "Prostate cancer [DO disease name]", "trend": "Up", "disease": [ { "synonyms": [ { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "NGP - new growth of prostate", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "hereditary prostate cancer", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "malignant tumor of the prostate", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostate cancer, familial", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostate neoplasm", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostatic cancer", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease Ontology", "name": "prostatic neoplasm", "description": "" }, { "id": "DOID:10283", "url": "http://disease-ontology.org/term/DOID:10283", "resource": "Disease 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tumour of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "neoplasm of thyroid gland", "description": "" }, { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid neoplasm", "description": "" } ], "recommended_name": { "id": "DOID:1781", "url": "http://disease-ontology.org/term/DOID:1781", "resource": "Disease Ontology", "name": "thyroid gland cancer", "description": "An endocrine gland cancer located in the thryoid gland located in the neck below the thyroid cartilage." } } ], "evidence": [ { "url": "https://hive.biochemistry.gwu.edu/bioxpress/transcriptview/A5D8T8", "id": "A5D8T8", "database": "BioXpress" } ], "url": "http://disease-ontology.org/term/DOID:1781", "significant": "No" }, { "name": "Liver cancer [DO disease name]", "trend": "Up", "disease": [ { "synonyms": [ { "id": "DOID:3571", "url": 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