{
    "uniprot_canonical_ac": "A4FUQ5-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4FUQ5-1|FPRS4_MOUSE Isoform 1 of Formyl peptide receptor-related sequence 4  OS=Mus musculus OX=10090 GN=Fpr-rs4 PE=2 SV=2 CANONICAL=A4FUQ5-1", 
        "length": 323, 
        "sequence": "MEVNISMPLNGSEVVFYDSTTSRVLWILSLVVLFITFVLGVLGNGLVIWVAGFQMAHTVTTVSYLNLALSDLSFMATLPLHIISMVMRGKWLFGWFLCKLVHIIANINLFVSIFLITLIAMDRCICVLCPVWSQNHRTVSLARKVVLGAWIFALLLTLPHFLFLTTVRDARGDVYCISKFESWVATSEEQLKVSVIAATASGIINFIIGFSMPMSFIAICYGLMAAKICRRGFVNSSRPLRVLTAVAVSFFVCWFPFQLIMLLGNIFNNETLSIIHMLVNPANTLASFNSCLNPILYVFLGQEFRDRLIYSLYASLERALRED"
    }, 
    "uniprot_id": "FPRS4_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "predicted.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17084101", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17084101"
                }
            ], 
            "title": "Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses.", 
            "journal": "Cytokine & growth factor reviews", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032067.2", 
                    "id": "NP_032067.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Migeotte I, Communi D, Parmentier M", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19387439", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19387439"
                }
            ], 
            "title": "Formyl peptide receptor-like proteins are a novel family of vomeronasal chemosensors.", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Riviere S., Spehr M., Rodriguez I., Challet L., Fluegge D.", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19497865", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19497865"
                }
            ], 
            "title": "Formyl peptide receptors are candidate chemosensory receptors in the vomeronasal organ.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032067.2", 
                    "id": "NP_032067.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wilson K.L., Liberles D.A., Buck L.B., Siltberg-Liberles J., Liberles S.D., Contos J.J., Horowitz L.F., Kuang D.", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19498085", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19498085"
                }
            ], 
            "title": "International Union of Basic and Clinical Pharmacology. LXXIII. Nomenclature for the formyl peptide receptor (FPR) family.", 
            "journal": "Pharmacological reviews", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032067.2", 
                    "id": "NP_032067.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ye RD, Boulay F, Wang JM, Dahlgren C, Gerard C, Parmentier M, Serhan CN, Murphy PM", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9722950", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9722950"
                }
            ], 
            "title": "Differential expansion of the N-formylpeptide receptor gene cluster in human and mouse.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Chen H., Kozak C.A., Murphy P.M., Gao J.-L., Filie J.D.", 
            "date": "1998"
        }
    ], 
    "uniprot_ac": "A4FUQ5", 
    "site_annotation": [
        {
            "end_pos": 12, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 10
        }, 
        {
            "end_pos": 237, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 235
        }, 
        {
            "end_pos": 271, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 269
        }, 
        {
            "end_pos": 6, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 4
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5#A4FUQ5-1", 
            "isoform_ac": "A4FUQ5-1", 
            "locus": {
                "end_pos": 18021733, 
                "strand": "-", 
                "start_pos": 18022701, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000095651", 
                        "id": "ENSMUST00000095651", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000093311", 
                        "id": "ENSMUSP00000093311", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A4FUQ5-1|FPRS4_MOUSE Isoform 1 of Formyl peptide receptor-related sequence 4  OS=Mus musculus OX=10090 GN=Fpr-rs4 PE=2 SV=2 CANONICAL=A4FUQ5-1", 
                "length": 323, 
                "sequence": "MEVNISMPLNGSEVVFYDSTTSRVLWILSLVVLFITFVLGVLGNGLVIWVAGFQMAHTVTTVSYLNLALSDLSFMATLPLHIISMVMRGKWLFGWFLCKLVHIIANINLFVSIFLITLIAMDRCICVLCPVWSQNHRTVSLARKVVLGAWIFALLLTLPHFLFLTTVRDARGDVYCISKFESWVATSEEQLKVSVIAATASGIINFIIGFSMPMSFIAICYGLMAAKICRRGFVNSSRPLRVLTAVAVSFFVCWFPFQLIMLLGNIFNNETLSIIHMLVNPANTLASFNSCLNPILYVFLGQEFRDRLIYSLYASLERALRED"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14291", 
            "resource": "KEGG Pathway", 
            "id": "mmu:14291", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594", 
            "resource": "Reactome", 
            "id": "R-MMU-418594", 
            "name": "G alpha (i) signalling events"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-444473", 
            "resource": "Reactome", 
            "id": "R-MMU-444473", 
            "name": "Formyl peptide receptors bind formyl peptides and many other ligands"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5#function", 
            "annotation": "May have an olfactory function associated with the identification of pathogens or of pathogenic states.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5#function", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A942-1", 
            "protein_name": "Formyl peptide receptor,-related sequence 4", 
            "sequence": {
                "length": 323, 
                "sequence": "MEANISMPRNGSEVGFYDSTTSTVLWILSLVVLCITFVLGVLGNGLVIWVSEFRMAHTVTTVCYLNLALSDFSFMATLPLQIISMVMRGKWLFGWFLCKLVHIIANINLFVSIFLITLIAMDRCTCVLHPVWSQNHRTVSLARKVVVGAWIFALLLTLPHFLFLTTVKDARGEVHCISKFESWVATPEEQLKVSITATTASGIINFIIGFSMPMSFIAICYGLMAVKICRRGFVKSSRPLRVLTAVAVSFFVCWFPFQLIMLLGNILNKETLSIIHILVNPANTLASFNSCLNPILYVFLGQEFRDRLMHSLSASLERALRED"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/130629", 
                    "id": "130629", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A4FUQ5/", 
                    "id": "A4FUQ5", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [
        {
            "sequence_org": "N", 
            "alt_nt": "G", 
            "chr_id": "17", 
            "ref_nt": "A", 
            "chr_pos": "18022538", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs231294950", 
                    "id": "rs231294950", 
                    "database": "dbSNP"
                }, 
                {
                    "url": "https://www.ensembl.org/id/rs231294950", 
                    "id": "rs231294950", 
                    "database": "ENSEMBL"
                }
            ], 
            "sequence_mut": "S", 
            "start_pos": 269, 
            "keywords": [
                "ebi", 
                "germline"
            ], 
            "end_pos": 269, 
            "minor_allelic_frequency": "", 
            "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NET->SET)."
        }
    ], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032067.2", 
        "ac": "NP_032067.2", 
        "name": "formyl peptide receptor-related sequence 4", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004930", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "G protein-coupled receptor activity", 
                        "id": "GO:0004930"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004982", 
                        "pmid": "22859307", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "N-formyl peptide receptor activity", 
                        "id": "GO:0004982"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002430", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "complement receptor mediated signaling pathway", 
                        "id": "GO:0002430"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "inflammatory response", 
                        "id": "GO:0006954"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007204", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cytosolic calcium ion concentration", 
                        "id": "GO:0007204"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007200", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
                                "id": "A4FUQ5", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phospholipase C-activating G protein-coupled receptor signaling pathway", 
                        "id": "GO:0007200"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4FUQ5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Fpr-rs4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Fpr-rs4"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048062", 
            "id": "ENSMUSG00000048062", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/14291", 
            "id": "14291", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000276", 
            "id": "IPR000276", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000826", 
            "id": "IPR000826", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017452", 
            "id": "IPR017452", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14291", 
            "id": "mmu:14291", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1278317", 
            "id": "1278317", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/ISKFESW/", 
            "id": "ISKFESW", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=910274at2759", 
            "id": "910274at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR24225", 
            "id": "PTHR24225", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00001", 
            "id": "PF00001", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4FUQ5", 
            "id": "PR_A4FUQ5", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-418594", 
            "id": "R-MMU-418594", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-444473", 
            "id": "R-MMU-444473", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_032067.2", 
            "id": "NP_032067.2", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5#ptm_processing", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "position": 10, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5#ptm_processing", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "position": 269, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }, 
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4FUQ5#ptm_processing", 
                    "id": "A4FUQ5", 
                    "database": "UniProtKB"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "position": 4, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 36294.0, 
        "chemical_mass": 36294.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
            "name": "Fpr-rs4", 
            "locus": {
                "end_pos": 18022704, 
                "strand": "+", 
                "start_pos": 18021733, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048062", 
                        "id": "ENSMUSG00000048062", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Formyl peptide receptor-related sequence 4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4FUQ5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "N-formylpeptide receptor-like 4"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4FUQ5", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "N-formylpeptide receptor-like 4"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A4FUQ5", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "formyl peptide receptor-related sequence 4"
        }
    ]
}