{
    "uniprot_canonical_ac": "A4D2B8-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A4D2B8-1|PM2P1_HUMAN Isoform 1 of Putative postmeiotic segregation increased 2-like protein 1  OS=Homo sapiens OX=9606 GN=PMS2P1 PE=5 SV=1 CANONICAL=A4D2B8-1", 
        "length": 440, 
        "sequence": "MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGEPVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLLAFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRGACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKEFQRNIKKKRACFPFAFCRDCQFPEASPAMLPVQPAELTPRSTPPHPCSLEDNVITVFSSVKNGPGSSR"
    }, 
    "uniprot_id": "PM2P1_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                    "id": "A4D2B8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/10101297", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "10101297"
                }
            ], 
            "title": "The human PMS2L proteins do not interact with hMLH1, a major DNA mismatch repair protein.", 
            "journal": "J. Biochem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                    "id": "A4D2B8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Horii A., Fukushige S., Kondo E.", 
            "date": "1999"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/7980603", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "7980603"
                }
            ], 
            "title": "Cloning, characterization and chromosomal assignment of the human genes homologous to yeast PMS1, a member of mismatch repair genes.", 
            "journal": "Biochem. Biophys. Res. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                    "id": "A4D2B8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Nakamura Y., Shimada M., Horii A., Sasaki S., Han H.J.", 
            "date": "1994"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8586419", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "8586419"
                }
            ], 
            "title": "Genomic organization of the human PMS2 gene family.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                    "id": "A4D2B8", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Kinzler K.W., Papadopoulos N., Vogelstein B., Carter K.C., Nicolaides N.C., Shell B.K.", 
            "date": "1995"
        }
    ], 
    "uniprot_ac": "A4D2B8", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8#A4D2B8-1", 
            "isoform_ac": "A4D2B8-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A4D2B8-1|PM2P1_HUMAN Isoform 1 of Putative postmeiotic segregation increased 2-like protein 1  OS=Homo sapiens OX=9606 GN=PMS2P1 PE=5 SV=1 CANONICAL=A4D2B8-1", 
                "length": 440, 
                "sequence": "MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGEPVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLLAFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRGACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKEFQRNIKKKRACFPFAFCRDCQFPEASPAMLPVQPAELTPRSTPPHPCSLEDNVITVFSSVKNGPGSSR"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8#A4D2B8-2", 
            "isoform_ac": "A4D2B8-2", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A4D2B8-2|PM2P1_HUMAN Isoform 2 of Putative postmeiotic segregation increased 2-like protein 1  OS=Homo sapiens OX=9606 GN=PMS2P1 PE=5 SV=1 CANONICAL=A4D2B8-1", 
                "length": 412, 
                "sequence": "MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGEPVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLLAFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRGACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKEFQRNIKKPPIYSLKHVRGGPELLCKWTHCPEATMLQGSPS"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8#A4D2B8-3", 
            "isoform_ac": "A4D2B8-3", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A4D2B8-3|PM2P1_HUMAN Isoform 3 of Putative postmeiotic segregation increased 2-like protein 1  OS=Homo sapiens OX=9606 GN=PMS2P1 PE=5 SV=1 CANONICAL=A4D2B8-1", 
                "length": 381, 
                "sequence": "MVTMCGGHRPENFLHQVLTEFGEELAGEGKSEVGGGAPRSYLQVASAECWAAAPAVHVGEPVHAGGLHTERGADPVIGLYLVHRGGACQTPTVGNRQTPTLGIHARPRRRATTSLLTLLLAFGKNAVRCALIGPGSLTSRTRPLTEPLGEKERREVFFPPRPERVEHNVESSRWEPRRRGACGSRGGNFPSPRGGSGVASLERAESSSTEPAKAIKPIDRKSVHQICSGPVVPSLSTAVKELVENSLDAGATNIDLKLKDYGVDLIEVSGNGCGVEEENFEGLTLKHHTSKIQEFADLPQVETFGFRGEALSSLCALSDVTISTCHVSAKVGTRLVFDHYGKIIQKTPYPHPRGMTVSVKQLFSTLPVHHKEFQRNIKKDS"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016887", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ATPase activity", 
                        "id": "GO:0016887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016301", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "kinase activity", 
                        "id": "GO:0016301"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032300", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mismatch repair complex", 
                        "id": "GO:0032300"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032389", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "MutLalpha complex", 
                        "id": "GO:0032389"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006298", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mismatch repair", 
                        "id": "GO:0006298"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016446", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A4D2B8", 
                                "id": "A4D2B8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "somatic hypermutation of immunoglobulin genes", 
                        "id": "GO:0016446"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS2L13"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS2L1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS2L6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS2L8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "PMS2P1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMSR2"
        }
    ], 
    "crossref": [
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A4D2B8", 
            "id": "A4D2B8", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=PMS2P1", 
            "id": "PMS2P1", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=9123", 
            "id": "9123", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR014762", 
            "id": "IPR014762", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036890", 
            "id": "IPR036890", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR038973", 
            "id": "IPR038973", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.omim.org/entry/605038", 
            "id": "605038", 
            "database": "MIM"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A4D2B8", 
            "id": "NX_A4D2B8", 
            "database": "neXtProt"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10073", 
            "id": "PTHR10073", 
            "database": "PANTHER"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A4D2B8", 
            "id": "A4D2B8", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A4D2B8", 
            "id": "PR_A4D2B8", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 47508.0, 
        "chemical_mass": 47508.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "name": "PMS2P1", 
            "locus": {
                "end_pos": 100320992, 
                "strand": "-", 
                "start_pos": 100341908, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000078319", 
                        "id": "ENSG00000078319", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PMS2-related protein 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Postmeiotic segregation increased 2-like protein 13"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Postmeiotic segregation increased 2-like protein 6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Postmeiotic segregation increased 2-like protein 8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Postmeiotic segregation increased protein 3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Postmeiotic segregation increased protein 8"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Putative postmeiotic segregation increased 2 pseudogene 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Putative postmeiotic segregation increased 2-like protein 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A4D2B8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "hPMS3"
        }
    ]
}