{ "uniprot_canonical_ac": "A3KN98-1", "ptm_annotation": [], "sequence": { "header": "tr|A3KN98-1|A3KN98_RAT Isoform 1 of Bco2 protein OS=Rattus norvegicus OX=10116 GN=Bco2 PE=1 SV=1 CANONICAL=A3KN98-1", "length": 532, "sequence": "MLGPQQSLPCIAPLLTTVEETLSTVSARVRGHIPEWLNGYLLRVGPGKFEFGKDRYNHWFDGMALLHQFKMEKGTVTYKSKFLQSDTYKANSAGDRIVISEFGTLALPDPCKSIFERFMSRFEPPTMTDNTSVNFVQYKGDYYMSTETNFMNKVDIETLERTEKVDWSKFVAVNGATAHPHYDPDGTAYNMGNTYGPRGSCYNIIRVPPKKKEPGETIHGAQVVCSIASSEKMKPSYYHSFGMTKNYIVFVEQPLKMKLWKIITSKIRGKSFADGISWEPQYNTRFHVVDKHTGQPLPGVYYSKPFLTYHQINAFEDQGCIVIDLCCEDDGRSLDIYQLQNLRKAGEELDQVYKAKAKSFPRRFVLPLDISVGAPEGENLRPLPYSSASVVKQGDREIWCSPENLHQEDLEEEGGIEFPQINYGRFSGKKYSFFYGCGFRHLVGDSLIKVDVVNKTLRVWREEGCYPSEPVFVPVPGADEEDSGAILSVVITPNQGESNFLLVLDAKNFTELGRAEVPVRMPYGFHGTFVPI" }, "uniprot_id": "A3KN98_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11278918", "type": [ "PubMed" ], "id": "11278918" } ], "title": "Identification and characterization of a mammalian enzyme catalyzing the asymmetric oxidative cleavage of provitamin A.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "id": "NP_001121184.1", "database": "RefSeq" } ], "authors": "Kiefer C, Hessel S, Lampert JM, Vogt K, Lederer MO, Breithaupt DE, von Lintig J", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21106934", "type": [ "PubMed" ], "id": "21106934" } ], "title": "A mitochondrial enzyme degrades carotenoids and protects against oxidative stress.", "journal": "FASEB journal : official publication of the Federation of American Societies for Experimental Biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "id": "NP_001121184.1", "database": "RefSeq" } ], "authors": "Amengual J, Lobo GP, Golczak M, Li HN, Klimova T, Hoppel CL, Wyss A, Palczewski K, von Lintig J", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25575786", "type": [ "PubMed" ], "id": "25575786" } ], "title": "Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine.", "journal": "Archives of biochemistry and biophysics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "id": "NP_001121184.1", "database": "RefSeq" } ], "authors": "Raghuvanshi S, Reed V, Blaner WS, Harrison EH", "date": "2015" } ], "uniprot_ac": "A3KN98", "site_annotation": [ { "end_pos": 132, "annotation": "n_glycosylation_sequon", "start_pos": 130 }, { "end_pos": 456, "annotation": "n_glycosylation_sequon", "start_pos": 454 }, { "end_pos": 510, "annotation": "n_glycosylation_sequon", "start_pos": 508 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A3KN98#A3KN98-1", "isoform_ac": "A3KN98-1", "locus": { "end_pos": 54966394, "strand": "+", "start_pos": 54986136, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000059192", "id": "ENSRNOT00000059192", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000055965", "id": "ENSRNOP00000055965", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A3KN98-1|A3KN98_RAT Isoform 1 of Bco2 protein OS=Rattus norvegicus OX=10116 GN=Bco2 PE=1 SV=1 CANONICAL=A3KN98-1", "length": 532, "sequence": "MLGPQQSLPCIAPLLTTVEETLSTVSARVRGHIPEWLNGYLLRVGPGKFEFGKDRYNHWFDGMALLHQFKMEKGTVTYKSKFLQSDTYKANSAGDRIVISEFGTLALPDPCKSIFERFMSRFEPPTMTDNTSVNFVQYKGDYYMSTETNFMNKVDIETLERTEKVDWSKFVAVNGATAHPHYDPDGTAYNMGNTYGPRGSCYNIIRVPPKKKEPGETIHGAQVVCSIASSEKMKPSYYHSFGMTKNYIVFVEQPLKMKLWKIITSKIRGKSFADGISWEPQYNTRFHVVDKHTGQPLPGVYYSKPFLTYHQINAFEDQGCIVIDLCCEDDGRSLDIYQLQNLRKAGEELDQVYKAKAKSFPRRFVLPLDISVGAPEGENLRPLPYSSASVVKQGDREIWCSPENLHQEDLEEEGGIEFPQINYGRFSGKKYSFFYGCGFRHLVGDSLIKVDVVNKTLRVWREEGCYPSEPVFVPVPGADEEDSGAILSVVITPNQGESNFLLVLDAKNFTELGRAEVPVRMPYGFHGTFVPI" } }, { "url": "https://www.uniprot.org/uniprot/A3KN98#F1LMB4-1", "isoform_ac": "F1LMB4-1", "locus": { "end_pos": 54968028, "strand": "+", "start_pos": 54998824, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000059191", "id": "ENSRNOT00000059191", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000055964", "id": "ENSRNOP00000055964", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1LMB4-1|A3KN98_RAT Computationally mapped isoform of Bco2 protein OS=Rattus norvegicus OX=10116 GN=Bco2 PE=1 SV=1 CANONICAL=A3KN98-1", "length": 481, "sequence": "LECGKGPFYFLKTPSWKKKAGNKRKSGSRLIGSARLSRGSRAACWEPRPRRLRKEREALTCCDSEEAGRGGIFDCEWGKRQSLPCIAPLLTTVEETLSTVSARVRGHIPEWLNGYLLRVGPGKFEFGKDRYNHWFDGMALLHQFKMEKGTVTYKSKFLQSDTYKANSAGDRIVISEFGTLALPDPCKSIFERFMSRFEPPTMTDNTSVNFVQYKGDYYMSTETNFMNKVDIETLERTEKPLPGVYYSKPFLTYHQINAFEDQGCIVIDLCCEDDGRSLDIYQLQNLRKAGEELDQVYKAKAKSFPRRFVLPLDISVGAPEGENLRPLPYSSASVVKQGDREIWCSPENLHQEDLEEEGGIEFPQINYGRFSGKKYSFFYGCGFRHLVGDSLIKVDVVNKTLRVWREEGCYPSEPVFVPVPGADEEDSGAILSVVITPNQTSAIVGRMHAPGKGLSQSALPYRRSVLMWLKLMSDDVKGTNL" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315644", "resource": "KEGG Pathway", "id": "rno:315644", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634", "resource": "Reactome", "id": "R-RNO-975634", "name": "Retinoid metabolism and transport" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "annotation": "Cellular localization of beta-carotene 15,15' oxygenase-1 (BCO1) and beta-carotene 9',10' oxygenase-2 (BCO2) in rat liver and intestine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "id": "NP_001121184.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q99NF1-1", "protein_name": "Beta,beta-carotene 9',10'-oxygenase", "sequence": { "length": 532, "sequence": "MLGPKQSLPCIAPLLTTAEETLSAVSARVRGHIPEWLNGYLLRVGPGKFEFGKDRYNHWFDGMALLHQFRMERGTVTYKSKFLQSDTYKANSAGGRIVISEFGTLALPDPCKSIFERFMSRFEPPTMTDNTNVNFVQYKGDYYMSTETNFMNKVDIEMLERTEKVDWSKFIAVNGATAHPHYDPDGTAYNMGNSYGPRGSCYNIIRVPPKKKEPGETIHGAQVLCSIASTEKMKPSYYHSFGMTKNYIIFVEQPVKMKLWKIITSKIRGKPFADGISWEPQYNTRFHVVDKHTGQLLPGMYYSMPFLTYHQINAFEDQGCIVIDLCCQDDGRSLDLYQLQNLRKAGEGLDQVYELKAKSFPRRFVLPLDVSVDAAEGKNLSPLSYSSASAVKQGDGEIWCSPENLHHEDLEEEGGIEFPQINYGRFNGKKYSFFYGCGFRHLVGDSLIKVDVTNKTLRVWREEGFYPSEPVFVPVPGADEEDSGVILSVVITPNQSESNFLLVLDAKSFTELGRAEVPVQMPYGFHGTFVPI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KN98/", "id": "A3KN98", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/12912", "id": "12912", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q9BYV7-1", "protein_name": "Beta,beta-carotene 9',10'-oxygenase", "sequence": { "length": 579, "sequence": "MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNVNYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDLDGTAYNMGNSFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFILVLDAKNFEELGRAEVPVQMPYGFHGTFIPI" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A3KN98/", "id": "A3KN98", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/12912", "id": "12912", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "ac": "NP_001121184.1", "name": "beta,beta-carotene 9',10'-oxygenase", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003834", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "beta-carotene 15,15'-monooxygenase activity", "id": "GO:0003834" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004744", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "retinal isomerase activity", "id": "GO:0004744" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010436", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "carotenoid dioxygenase activity", "id": "GO:0010436" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005739", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "mitochondrion", "id": "GO:0005739" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016121", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "carotene catabolic process", "id": "GO:0016121" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051881", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "regulation of mitochondrial membrane potential", "id": "GO:0051881" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042574", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "retinal metabolic process", "id": "GO:0042574" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000377", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "regulation of reactive oxygen species metabolic process", "id": "GO:2000377" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016122", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "id": "A3KN98", "database": "UniProtKB" } ], "name": "xanthophyll metabolic process", "id": "GO:0016122" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KN98", "type": "synonym", "resource": "RefSeq", "name": "Ab2-079; Bcdo2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KN98", "type": "synonym", "resource": "RefSeq", "name": "Bco2" }, { "url": "https://www.uniprot.org/uniprot/A3KN98", "type": "recommended", "resource": "UniProtKB", "name": "Bco2" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000038746", "id": "ENSRNOG00000038746", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/315644", "id": "315644", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004294", "id": "IPR004294", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:315644", "id": "rno:315644", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/HHIPYGL/", "id": "HHIPYGL", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=895046at2759", "id": "895046at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10543", "id": "PTHR10543", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF03055", "id": "PF03055", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634", "id": "R-RNO-975634", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121184.1", "id": "NP_001121184.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1309022", "id": "1309022", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 60190.0, "chemical_mass": 60190.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "name": "Bco2", "locus": { "end_pos": 54965583, "strand": "-", "start_pos": 54998864, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000038746", "id": "ENSRNOG00000038746", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A3KN98", "type": "synonym", "resource": "UniProtKB", "name": "Bco2 protein" }, { "url": "https://www.uniprot.org/uniprot/A3KN98", "type": "synonym", "resource": "UniProtKB", "name": "Beta-carotene oxygenase 2" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KN98", "type": "synonym", "resource": "RefSeq", "name": "beta,beta-carotene 9',10'-oxygenase" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A3KN98", "type": "synonym", "resource": "RefSeq", "name": "carotenoid 9',10' monoxygenase II; beta-carotene 9', 10'-dioxygenase 2; carotenoid 9',10' monooxygenase II" } ] }