{ "uniprot_canonical_ac": "A2VD12-1", "ptm_annotation": [], "sequence": { "header": "sp|A2VD12-1|PBIP1_RAT Isoform 1 of Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Rattus norvegicus OX=10116 GN=Pbxip1 PE=1 SV=1 CANONICAL=A2VD12-1", "length": 722, "sequence": "MASCPDSDNSWVLAGSETLPVETLGPESRVDPESEEAPQALQDSSKADGKESAGTLNGEEMLFQTESSQGEGAALPEESEAKGALGGDDGHGTKRPGDTAVQEDLQETPMVTSLGPDTQDLERNIHPQNLPSSPRAVWKEHGCSSSDDDTDVDVEGLRRRRGREPSPPQPTAAVDGEDQAKGEGIGELGISLNMCFLGALVLLGLGILLFSGALLEPETEPVEEAELQVFPETELVQTVGNRQDEVEQLQASVPPDSVPSLQSMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGSPQGGKATTEQGHKGQEPDTSLLEQHKQLEAEAKALRQELQKQWQLLGSVHRNLQRGLQDAGQGAPAHAGLAELGHMLAQTLQGLESQGINTGRSSNDSEAWHQKKPRFQHPREWSGREKWRGGQRDQKAEHWKLKKEESGQDRKKSWRDEGREFTGHWKENRPRAEESGSRKDSKRQDPKVHPRKSGNSHSGERQKHSWGKDNSPDSVSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLARLPWAGQLTKELPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFIFSHFFGDKALKRRSKKKEKQPWNHRAVGPREEHSRHPHHYHQG" }, "uniprot_id": "PBIP1_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "reported_with_glycan.unicarbkb" ], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12477932", "type": [ "PubMed" ], "id": "12477932" } ], "title": "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094446.1", "id": "NP_001094446.1", "database": "RefSeq" } ], "authors": "Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD, Altschul SF, Zeeberg B, Buetow KH, Schaefer CF, Bhat NK, Hopkins RF, Jordan H, Moore T, Max SI, Wang J, Hsieh F, Diatchenko L, Marusina K, Farmer AA, Rubin GM, Hong L, Stapleton M, Soares MB, Bonaldo MF, Casavant TL, Scheetz TE, Brownstein MJ, Usdin TB, Toshiyuki S, Carninci P, Prange C, Raha SS, Loquellano NA, Peters GJ, Abramson RD, Mullahy SJ, Bosak SA, McEwan PJ, McKernan KJ, Malek JA, Gunaratne PH, Richards S, Worley KC, Hale S, Garcia AM, Gay LJ, Hulyk SW, Villalon DK, Muzny DM, Sodergren EJ, Lu X, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard GG, Blakesley RW, Touchman JW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Krzywinski MI, Skalska U, Smailus DE, Schnerch A, Schein JE, Jones SJ, Marra MA", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "type": [ "PubMed" ], "id": "24090084" } ], "title": "Site-specific glycan-peptide analysis for determination of N-glycoproteome heterogeneity.", "journal": "Journal of proteome research", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" } ], "authors": "Parker BL, Thaysen-Andersen M, Solis N, Scott NE, Larsen MR, Graham ME, Packer NH, Cordwell SJ", "date": "2013" } ], "uniprot_ac": "A2VD12", "site_annotation": [ { "end_pos": 453, "annotation": "n_glycosylation_sequon", "start_pos": 451 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#A2VD12-1", "isoform_ac": "A2VD12-1", "locus": { "end_pos": 188766570, "strand": "-", "start_pos": 188775664, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000028057", "id": "ENSRNOT00000028057", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000028058", "id": "ENSRNOP00000028058", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2VD12-1|PBIP1_RAT Isoform 1 of Pre-B-cell leukemia transcription factor-interacting protein 1 OS=Rattus norvegicus OX=10116 GN=Pbxip1 PE=1 SV=1 CANONICAL=A2VD12-1", "length": 722, "sequence": "MASCPDSDNSWVLAGSETLPVETLGPESRVDPESEEAPQALQDSSKADGKESAGTLNGEEMLFQTESSQGEGAALPEESEAKGALGGDDGHGTKRPGDTAVQEDLQETPMVTSLGPDTQDLERNIHPQNLPSSPRAVWKEHGCSSSDDDTDVDVEGLRRRRGREPSPPQPTAAVDGEDQAKGEGIGELGISLNMCFLGALVLLGLGILLFSGALLEPETEPVEEAELQVFPETELVQTVGNRQDEVEQLQASVPPDSVPSLQSMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGSPQGGKATTEQGHKGQEPDTSLLEQHKQLEAEAKALRQELQKQWQLLGSVHRNLQRGLQDAGQGAPAHAGLAELGHMLAQTLQGLESQGINTGRSSNDSEAWHQKKPRFQHPREWSGREKWRGGQRDQKAEHWKLKKEESGQDRKKSWRDEGREFTGHWKENRPRAEESGSRKDSKRQDPKVHPRKSGNSHSGERQKHSWGKDNSPDSVSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLARLPWAGQLTKELPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFIFSHFFGDKALKRRSKKKEKQPWNHRAVGPREEHSRHPHHYHQG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310644", "resource": "KEGG Pathway", "id": "rno:310644", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#function", "annotation": "Regulator of pre-B-cell leukemia transcription factors (BPXs) function. Inhibits the binding of PBX1-HOX complex to DNA and blocks the transcriptional activity of E2A-PBX1. Tethers estrogen receptor-alpha (ESR1) to microtubules and allows them to influence estrogen receptors-alpha signaling (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12#function", "id": "A2VD12", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3TVI8-1", "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "sequence": { "length": 727, "sequence": "MASCPDSDNSWVLAGSENLPVETLGPEPRMDPESEGASQALRDSSKADGKELAGTLDGEEKLFQTESSQRETAVLTESAAKGTLGADGHGTEAPGDTVVQEDSQETPVATSLGPDTQDLESEIHPQNLPSSPRAVWKEHRCSSSDDDTDVDVEGLRRRRGREPSSSQPVVPVDVEDQAKGEGIGGELGISLNMCFLGALVLLGLGILLFSGTLLEPETGPMEEAELQVFPETGPETELVETLGNRQDEIEHLQASSVPPDSVPSLQSMGFLLDKLAKENQDIRLLQAQLQAQKEELQSLLHQPKGLEEENARLREALQQGKTSHQALESELQQLRARLQGLEANCVRGVDGVCLNWGGDPQDGKATKEQGHKGQEPDPSLLEQHKQLEAEAKALRQELQRQWQLLGSVHWDLQRGLRDAGRGAPAHPGLAELGHMLAQTLQDLENQGINTGRSPNDSEAWHQKKPHTQSPREWGGKEKWRGGQRDQKAEHWKPRKEESGQERQRSWRDEGREHTGRWREDRLRADESGSRKDSKRQDPKVHPRKDGNSHSVERQKHSWGKDNSPDALSSWEELLRRKYRPPQGCSGVADCARQEGLALFGVELAPVRQQELASVLREYLSRLPWAGQLTKQLPLSPAYFGEDGIFRHDRLRFRDFVDALEDSLEEVALKQTGDDDEVDDFEDFVFGHFFGDKALKKRSRKKEKHSWNPRVVGPREEHSRHPHHYHQG" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2VD12/", "id": "A2VD12", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/10740", "id": "10740", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q96AQ6-1", "protein_name": "Pre-B-cell leukemia transcription factor-interacting protein 1", "sequence": { "length": 731, "sequence": "MASCPDSDNSWVLAGSESLPVETLGPASRMDPESERALQAPHSPSKTDGKELAGTMDGEGTLFQTESPQSGSILTEETEVKGTLEGDVCGVEPPGPGDTVVQGDLQETTVVTGLGPDTQDLEGQSPPQSLPSTPKAAWIREEGRCSSSDDDTDVDMEGLRRRRGREAGPPQPMVPLAVENQAGGEGAGGELGISLNMCLLGALVLLGLGVLLFSGGLSESETGPMEEVERQVLPDPEVLEAVGDRQDGLREQLQAPVPPDSVPSLQNMGLLLDKLAKENQDIRLLQAQLQAQKEELQSLMHQPKGLEEENAQLRGALQQGEAFQRALESELQQLRARLQGLEADCVRGPDGVCLSGGRGPQGDKAIREQGPREQEPELSFLKQKEQLEAEAQALRQELERQRRLLGSVQQDLERSLQDASRGDPAHAGLAELGHRLAQKLQGLENWGQDPGVSANASKAWHQKSHFQNSREWSGKEKWWDGQRDRKAEHWKHKKEESGRERKKNWGGQEDREPAGRWKEGRPRVEESGSKKEGKRQGPKEPPRKSGSFHSSGEKQKQPRWREGTKDSHDPLPSWAELLRPKYRAPQGCSGVDECARQEGLTFFGTELAPVRQQELASLLRTYLARLPWAGQLTKELPLSPAFFGEDGIFRHDRLRFRDFVDALEDSLEEVAVQQTGDDDEVDDFEDFIFSHFFGDKALKKRSGKKDKHSQSPRAAGPREGHSHSHHHHHRG" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2VD12/", "id": "A2VD12", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/10740", "id": "10740", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094446.1", "ac": "NP_001094446.1", "name": "pre-B-cell leukemia transcription factor-interacting protein 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003714", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "transcription corepressor activity", "id": "GO:0003714" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005874", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "microtubule", "id": "GO:0005874" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001106", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "regulation of Rho guanyl-nucleotide exchange factor activity", "id": "GO:2001106" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030154", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "cell differentiation", "id": "GO:0030154" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "name": "negative regulation of transcription, DNA-templated", "id": "GO:0045892" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "type": "synonym", "resource": "UniProtKB", "name": "Hpip" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD12", "type": "synonym", "resource": "RefSeq", "name": "Pbxip1" }, { "url": "https://www.uniprot.org/uniprot/A2VD12", "type": "recommended", "resource": "UniProtKB", "name": "Pbxip1" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000020673", "id": "ENSRNOG00000020673", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/310644", "id": "310644", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR033589", "id": "IPR033589", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:310644", "id": "rno:310644", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/LMQQPKG/", "id": "LMQQPKG", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=640123at2759", "id": "640123at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR28638:SF1", "id": "PTHR28638:SF1", "database": "PANTHER" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2VD12", "id": "PR_A2VD12", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094446.1", "id": "NP_001094446.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305180", "id": "1305180", "database": "RGD" }, { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "reported_with_glycan", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "subtype": "", "relation": "attached", "position": 451, "glytoucan_ac": "G09775CH", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "subtype": "", "relation": "attached", "position": 451, "glytoucan_ac": "G31852PQ", "type": "N-linked" }, { "residue": "Asn", "site_category": "reported_with_glycan", "evidence": [ { "url": "http://unicarbkb.org/proteinsummary/A2VD12/annotated", "id": "A2VD12", "database": "UniCarbKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24090084", "id": "24090084", "database": "PubMed" } ], "subtype": "", "relation": "attached", "position": 451, "glytoucan_ac": "G37135JQ", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "133", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1" }, { "residue": "Ser", "position": "133", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "144", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "145", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "146", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Thr", "position": "150", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "166", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "559", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "id": "22673903", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q703I1-1", "kinase_gene_name": "Oser1" }, { "residue": "Ser", "position": "559", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "id": "A2VD12", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 80276.0, "chemical_mass": 80276.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "name": "Pbxip1", "locus": { "end_pos": 188776439, "strand": "+", "start_pos": 188766535, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000020673", "id": "ENSRNOG00000020673", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2VD12", "type": "synonym", "resource": "UniProtKB", "name": "Hematopoietic PBX-interacting protein" }, { "url": "https://www.uniprot.org/uniprot/A2VD12", "type": "recommended", "resource": "UniProtKB", "name": "Pre-B-cell leukemia transcription factor-interacting protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD12", "type": "synonym", "resource": "RefSeq", "name": "hematopoietic PBX-interacting protein; pre-B-cell leukemia homeobox interacting protein 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2VD12", "type": "synonym", "resource": "RefSeq", "name": "pre-B-cell leukemia transcription factor-interacting protein 1" } ] }