{ "uniprot_canonical_ac": "A2RSY6-1", "ptm_annotation": [], "sequence": { "header": "sp|A2RSY6-1|TRM1L_MOUSE Isoform 1 of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 728, "sequence": "MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW" }, "uniprot_id": "TRM1L_MOUSE", "enzyme_annotation": [ { "ec": "2.1.1.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17198746", "type": [ "PubMed" ], "id": "17198746" } ], "title": "The mouse Trm1-like gene is expressed in neural tissues and plays a role in motor coordination and exploratory behaviour.", "journal": "Gene", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081152.2", "id": "NP_081152.2", "database": "RefSeq" } ], "authors": "Klopstock T., Wurst W., Becker L., de Angelis M.H., Arnold H.-H., Fuchs H., Gailus-Durner V., Hoelter S.M., Vauti F., Beine R., Goller T.", "date": "2007" } ], "uniprot_ac": "A2RSY6", "site_annotation": [ { "end_pos": 240, "annotation": "n_glycosylation_sequon", "start_pos": 238 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6#A0A087WQ23-1", "isoform_ac": "A0A087WQ23-1", "locus": { "end_pos": 151439524, "strand": "-", "start_pos": 151448308, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000189655", "id": "ENSMUST00000189655", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000140009", "id": "ENSMUSP00000140009", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A087WQ23-1|TRM1L_MOUSE Computationally mapped isoform of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 158, "sequence": "MCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATDSSSSLFLPRNNGITVGKAPWKCSQSYN" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY6#A0A0R4J0U8-1", "isoform_ac": "A0A0R4J0U8-1", "locus": { "end_pos": 151428877, "strand": "-", "start_pos": 151457931, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000065625", "id": "ENSMUST00000065625", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000068309", "id": "ENSMUSP00000068309", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0R4J0U8-1|TRM1L_MOUSE Computationally mapped isoform of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 728, "sequence": "MENMAEEELLPQEKEEAQVRVPTRAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY6#A2RSY6-1", "isoform_ac": "A2RSY6-1", "locus": {}, "sequence": { "header": "sp|A2RSY6-1|TRM1L_MOUSE Isoform 1 of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 728, "sequence": "MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDAPLMQFKSILLKYSTPTYTGAQSEGQMPPAAEDTVTDRVEMSVSDKAEASGCRRW" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY6#A2RSY6-2", "isoform_ac": "A2RSY6-2", "locus": {}, "sequence": { "header": "sp|A2RSY6-2|TRM1L_MOUSE Isoform 2 of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 671, "sequence": "MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDALEDDGTLGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSTHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINLAKKQKTDASTAHPPFYYNIHRHSIKGMNMPNFLSLLQVKKIFVLSFASRLSSKPNSL" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY6#A2RSY6-3", "isoform_ac": "A2RSY6-3", "locus": {}, "sequence": { "header": "sp|A2RSY6-3|TRM1L_MOUSE Isoform 3 of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 285, "sequence": "MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGYRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYIAASTAKSSNEILKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAKERKPLECLDAFGATGK" } }, { "url": "https://www.uniprot.org/uniprot/A2RSY6#A2RSY6-4", "isoform_ac": "A2RSY6-4", "locus": {}, "sequence": { "header": "sp|A2RSY6-4|TRM1L_MOUSE Isoform 4 of TRMT1-like protein OS=Mus musculus OX=10090 GN=Trmt1l PE=1 SV=1 CANONICAL=A2RSY6-1", "length": 151, "sequence": "MENMAEEELLPQEKEEAQVRVPTPAPDSAPVPAPAADTALDSAPTPDSDPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNPGTENSQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEG" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:98685", "resource": "KEGG Pathway", "id": "mmu:98685", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6#function", "annotation": "May play a role in motor coordination and exploratory behavior.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6#function", "id": "A2RSY6", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081152.2", "annotation": "Trm1-like deficient mice are viable and show no anatomical defects; behavioural tests, however, revealed significantly altered motor coordination and aberrant exploratory behaviour thus, Trm1 plays a role in modulating postnatal neuronal functions.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081152.2", "id": "NP_081152.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q496Z9-1", "protein_name": "TRMT1-like protein", "sequence": { "length": 723, "sequence": "MENMAEEELLPQEKEEAQVRVPTPDSAPVPAPAADTALDSAPTPDSAPAPALAPAPAPALSPSLASVPEEAESKRHISIQRRLADLEKLAFGTEGDVDSASSLNSDNLENIQTCPLCPKEKFRAYSSHKLRRHLQNLHWKISVEFEGSRMCICHLACRPVKPTIVGEQISSKLGAHYHCIICSATITRRTDMLGHVKRHVNKGETKSRYISASTAKSSNEVLKETDTDIQVFPNYSIPQKTDSYFNPKMKLNRQIIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQKNCHLNKLKVVVDSEEKEEGDGLEDCSTAGDIQVTRMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNVRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGVEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYKQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESIHHGLDDIQPLIKTLIFESECTPQSQCSVHAPSNTNKQEENGVFVKTTDDTTIDIYSAQGKRKSNEMAINVAKKQKTDASTAHPPFYYNIHRHSIKGMNMPKLKKFLCCLSQAGFRVSRTHFDPMGIRTDASLTQFKSILLKYSTPTYTGGQSEGQVPAPEDTVTDPVELSVNDKAEVSGCRRW" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12801", "id": "12801", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q7Z2T5-1", "protein_name": "TRMT1-like protein", "sequence": { "length": 733, "sequence": "MENMAEEELLPLEKEEVEVAQVQVPTPARDSAGVPAPAPDSALDSAPTPASAPAPAPALAQAPALSPSLASAPEEAKSKRHISIQRQLADLENLAFVTDGNFDSASSLNSDNLDAGNRQACPLCPKEKFRACNSHKLRRHLQNLHWKVSVEFEGYRMCICHLPCRPVKPNIIGEQITSKMGAHYHCIICSATITRRTDMLGHVRRHMNKGETKSSYIAASTAKPPKEILKEADTDVQVCPNYSIPQKTDSYFNPKMKLNRQLIFCTLAALAEERKPLECLDAFGATGIMGLQWAKHLGNAVKVTINDLNENSVTLIQENCHLNKLKVVVDSKEKEKSDDILEEGEKNLGNIKVTKMDANVLMHLRSFDFIHLDPFGTSVNYLDSAFRNIRNLGIVSVTSTDISSLYAKAQHVARRHYGCNIVRTEYYKELAARIVVAAVARAAARCNKGIEVLFAVALEHFVLVVVRVLRGPTSADETAKKIQYLIHCQWCEERIFQKDGNMVEENPYRQLPCNCHGSMPGKTAIELGPLWSSSLFNTGFLKRMLFESLHHGLDDIQTLIKTLIFESECTPQSQFSIHASSNVNKQEENGVFIKTTDDTTTDNYIAQGKRKSNEMITNLGKKQKTDVSTEHPPFYYNIHRHSIKGMNMPKLKKFLCYLSQAGFRVSRTHFDPMGVRTDAPLMQFKSILLKYSTPTYTGGQSESHVQSASEDTVTERVEMSVNDKAEASGCRRW" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12801", "id": "12801", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081152.2", "ac": "NP_081152.2", "name": "TRMT1-like protein isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004809", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "tRNA (guanine-N2-)-methyltransferase activity", "id": "GO:0004809" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000049", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "tRNA binding", "id": "GO:0000049" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002940", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "tRNA N2-guanine methylation", "id": "GO:0002940" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008344", "pmid": "17198746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "adult locomotory behavior", "id": "GO:0008344" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030534", "pmid": "17198746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "name": "adult behavior", "id": "GO:0030534" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY6", "type": "synonym", "resource": "RefSeq", "name": "1190005F20Rik; AW226554; C1orf25; Trm1-like; Trm1l" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY6", "type": "synonym", "resource": "RefSeq", "name": "Trmt1l" }, { "url": "https://www.uniprot.org/uniprot/A2RSY6", "type": "recommended", "resource": "UniProtKB", "name": "Trmt1l" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/gene/98685", "id": "98685", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002905", "id": "IPR002905", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029063", "id": "IPR029063", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042296", "id": "IPR042296", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:98685", "id": "mmu:98685", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:1916185", "id": "1916185", "database": "MGI" }, { "url": "http://www.orthodb.org/?query=1414511at2759", "id": "1414511at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10631", "id": "PTHR10631", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02005", "id": "PF02005", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2RSY6", "id": "PR_A2RSY6", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_081152.2", "id": "NP_081152.2", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Thr", "position": "23", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "607", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "63", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "id": "A2RSY6", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" } ], "mass": { "monoisotopic_mass": 80861.0, "chemical_mass": 80861.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "name": "Trmt1l", "locus": { "end_pos": 151458161, "strand": "+", "start_pos": 151428542, "chromosome": "1", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000053286", "id": "ENSMUSG00000053286", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2RSY6", "type": "synonym", "resource": "UniProtKB", "name": "2.1.1.-" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY6", "type": "synonym", "resource": "RefSeq", "name": "TRMT1-like protein isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2RSY6", "type": "synonym", "resource": "RefSeq", "name": "TRMT1-like protein" }, { "url": "https://www.uniprot.org/uniprot/A2RSY6", "type": "recommended", "resource": "UniProtKB", "name": "TRMT1-like protein" } ] }