{ "uniprot_canonical_ac": "A2ARV4-1", "ptm_annotation": [ { "annotation": "A fraction undergoes proteolytic cleavage of the extracellular domain at the cell membrane to generate a cytoplasmic tail fragment. This is internalized into the early endosome from where it trafficks in an LDLRAP1/ARH-dependent manner to the endocytic recycling compartment (ERC). In the ERC, it is further cleaved by gamma-secretase to release a fragment which translocates to the nucleus and mediates transcriptional repression.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P98158", "id": "P98158", "database": "PubMed" } ] }, { "annotation": "N-glycosylation is required for ligand binding. Contains core-fucosylated N-glycans in kidney proximal convoluted tubules (PCTs) and hybrid-type N-glycans in proximal straight tubules (PSTs). Interacts with ligands in a glycoform-dependent manner. Retinol-binding protein and the vitamin D carrier GC/DBP are endocytosed primarily by PCTs, albumin is endocytosed equally by PCTs and PSTs, and the aminoglycoside kanamycin is endocytosed primarily by PSTs.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27773703", "id": "27773703", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2ARV4-1|LRP2_MOUSE Isoform 1 of Low-density lipoprotein receptor-related protein 2 OS=Mus musculus OX=10090 GN=Lrp2 PE=1 SV=1 CANONICAL=A2ARV4-1", "length": 4660, "sequence": "MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSFSAASIIFSNGRDLLVGDLHGRNFRILAESKNRGIVMGVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKANKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCEFGFELDADEHHCVAVKNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTIFYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQIISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTHPFGLTVFKDNVFLTDWRLGAIIRVRKSDGGDMTVVRRGISSIMHVKAYDADLQTGTNYCSQTTHPNGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGCVLNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQWQCPGYSICVNLSALCDGVFDCPNGTDESPLCNQDSCLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTCEDVNECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTASENLLLVVASRDKIIMDNITAHTHNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSAFQNGTDKRVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQANKWHGRNQSVVMYSVPQPLGIIAIHPSRQPSSPNPCASATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNCVRGDQPFLISVRENVIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTAFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILVHHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPNGSNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHIVVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASKQPGNTDPPTVIRDSINLLRDVTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPKCGCAFGTLEDDGKNCATSREDFLIYSLNNSLRSLHFDPQDHNLPFQAISVEGMAIALDYDRRNNRIFFTQKLNPIRGQISYVNLYSGASSPTILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERSTLTGSNREVVISTAFHSFGLTVYGQYIYWTDFYTKKIYRANKYDGSDLIAMTTRLPTQPSGISTVVKTQQQQCSNPCDQFNGGCSHICAPGPNGAECQCPHEGSWYLANDNKYCVVDTGARCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGCLFRSCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPITCQPDFAKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCVSPHRCIPSYWFCDGEADCVDSSDEPDTCGHSLNSCSANQFHCDNGRCISSSWVCDGDNDCGDMSDEDQRHHCELQNCSSTEFTCINSRPPNRRCIPQHWVCDGDADCADALDELQNCTMRACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGCSYPPCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINECQDSSISHCDHNCTDTITSFYCSCLPGYKLMSDKRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKSCRQNSNIEPYLVFSNRYYIRNLTIDGTSYSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTNQETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQRKMLAQHCVDANNTFCFENPRGIVLHPQRGYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGTLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVLHPYRQPIMSNPCATNNGGCSHLCLIKAGGRGFTCECPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDESDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIHECMTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESCVPRECTESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNVPCESPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGCNLGENRTCAEKICEQNCTQLSNGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNISSEKFSEYLEEEEHIQAIDYDWDPEGIGLSVVYYTVLSQGSQFGAIKRAYLPDFESGSNNPVREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDYLNGDRIYWSDSKEDVIESIKYDGTDRRLIINDAMKPFSLDIFEDQLYWVAKEKGEVWRQNKFGKGNKEKLLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVECDAASELPITMPSPCRCMHGGSCYFDENDLPKCKCSSGYSGEYCEIGLSRGIPPGTTMALLLTFAMVIIVGALVLVGFFHYRKTGSLLPSLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEQFVMEVGKQPVIFENPMYAAKDSTSKVGLAVQGPSVSSQVTVPENVENQNYGRSIDPSEIVPEPKPASPGADETQGTKWNIFKRKPKQTTNFENPIYAEMDTEQKEAVAVAPPPSPSLPAKASKRSSTPGYTATEDTFKDTANLVKEDSDV" }, "uniprot_id": "LRP2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly", "reported.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10052453", "type": [ "PubMed" ], "id": "10052453" } ], "title": "An endocytic pathway essential for renal uptake and activation of the steroid 25-(OH) vitamin D3.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Nykjaer A., Willnow T.E., Vorum H., Christensen E.I., Jacobsen C., Walther D., Herz J., Dragun D., Melsen F.", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10766831", "type": [ "PubMed" ], "id": "10766831" } ], "title": "Megalin acts in concert with cubilin to mediate endocytosis of high density lipoproteins.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Argraves W.S., Knaak C., Barth J.L., Hammad S.M.", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10772929", "type": [ "PubMed" ], "id": "10772929" } ], "title": "LDL receptor-related protein as a component of the midkine receptor.", "journal": "Biochem. Biophys. Res. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Muramatsu H., Sakaguchi N., Muramatsu T., Sakuma S., Ikematsu S., Zou K.", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11247302", "type": [ "PubMed" ], "id": "11247302" } ], "title": "Disabled-2 colocalizes with the LDLR in clathrin-coated pits and interacts with AP-2.", "journal": "Traffic", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Cooper J.A., Morris S.M.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11964399", "type": [ "PubMed" ], "id": "11964399" } ], "title": "Megalin functions as an endocytic sonic hedgehog receptor.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Argraves W.S., Chintalapudi M.R., Knaak C., Barth J.L., McCarthy R.A.", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12724130", "type": [ "PubMed" ], "id": "12724130" } ], "title": "Renal uptake of myoglobin is mediated by the endocytic receptors megalin and cubilin.", "journal": "Am. J. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Willnow T.E., Christensen E.I., Moestrup S.K., Jacobsen C., Gburek J., Verroust P.J., Birn H., Goj B.", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15467006", "type": [ "PubMed" ], "id": "15467006" } ], "title": "Megalin binds and internalizes angiotensin II.", "journal": "Am. J. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Allen P.L., Hammond T.G., Klassen R.B., Gonzalez-Villalobos R., Navar L.G.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15623804", "type": [ "PubMed" ], "id": "15623804" } ], "title": "LRP2/megalin is required for patterning of the ventral telencephalon.", "journal": "Development", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Andersen O.M., Spoelgen R., Willnow T.E., Hammes A., Zechner D., Anzenberger U., Jerchow B.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16099815", "type": [ "PubMed" ], "id": "16099815" } ], "title": "Megalin is a receptor for apolipoprotein M, and kidney-specific megalin-deficiency confers urinary excretion of apolipoprotein M.", "journal": "Mol. Endocrinol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Moestrup S.K., Dahlbaeck B., Faber K., Nielsen L.B., Hvidberg V.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16143106", "type": [ "PubMed" ], "id": "16143106" } ], "title": "Role of endocytosis in cellular uptake of sex steroids.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Nykjaer A., Spoelgen R., Willnow T.E., Schulz H., Hubner N., Andreassen T.K., Hammes A., Luppa P.B., Metzger J., Raila J., Schweigert F.J.", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16380466", "type": [ "PubMed" ], "id": "16380466" } ], "title": "Megalin binds and internalizes angiotensin-(1-7).", "journal": "Am. J. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Johanson K., Kobori H., Allen P.L., Hammond T.G., Klassen R.B., Baker C.B., Gonzalez-Villalobos R., Navar L.G.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17462596", "type": [ "PubMed" ], "id": "17462596" } ], "title": "Megalin-mediated endocytosis of cystatin C in proximal tubule cells.", "journal": "Biochem. Biophys. Res. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Kobayashi A., Suzuki Y., Takeda T., Saito A., Yamamoto K., Suzuki A., Gejyo F., Hosaka K., Hosojima M., Iino N., Kaseda R., Kasai A.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17846082", "type": [ "PubMed" ], "id": "17846082" } ], "title": "Estrogen and the inner ear: megalin knockout mice suffer progressive hearing loss.", "journal": "FASEB J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Gross M., Kalbacher H., Erdmann B., Knipper M., Zimmermann U., Mueller M., Ruettiger L., Koenig O.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18174160", "type": [ "PubMed" ], "id": "18174160" } ], "title": "Megalin mediates selenoprotein P uptake by kidney proximal tubule epithelial cells.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Olson G.E., Winfrey V.P., Burk R.F., Hill K.E.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19349973", "type": [ "PubMed" ], "id": "19349973" } ], "title": "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.", "journal": "Nat. Biotechnol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Aebersold R., Bausch-Fluck D., Bibel M., Henderson C., O'Brien R., Schiess R., Watts J.D., Wollscheid B.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20460439", "type": [ "PubMed" ], "id": "20460439" } ], "title": "LRP2 in ependymal cells regulates BMP signaling in the adult neurogenic niche.", "journal": "J. Cell Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Willnow T.E., Christensen E.I., Yoshikawa K., Goetz M., Peterson A.S., Bachmann S., Hammes A., Beckervordersandforth-Bonk R., Christ A., Emich H., Gajera C.R., Kempermann G., Lioubinski O.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20637285", "type": [ "PubMed" ], "id": "20637285" } ], "title": "Megalin interacts with APP and the intracellular adapter protein FE65 in neurons.", "journal": "Mol. Cell. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Vargas T., Garzon M., Antequera D., Carro E., Spuch C., Alvira-Botero X., Bermejo-Pareja F., Perez-Gonzalez R.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22340494", "type": [ "PubMed" ], "id": "22340494" } ], "title": "LRP2 is an auxiliary SHH receptor required to condition the forebrain ventral midline for inductive signals.", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Willnow T.E., Bachmann S., Hammes A., Christ A., Christa A., Kur E., Lioubinski O.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22354480", "type": [ "PubMed" ], "id": "22354480" } ], "title": "Megalin mediates the influence of sonic hedgehog on oligodendrocyte precursor cell migration and proliferation during development.", "journal": "Glia", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Kozyraki R., de Castro F., Cases O., Clemente D., Merchan P., Ortega M.C.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22841573", "type": [ "PubMed" ], "id": "22841573" } ], "title": "Peripheral cannabinoid-1 receptor inverse agonism reduces obesity by reversing leptin resistance.", "journal": "Cell Metab.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Cheng K., Liu J., Cinar R., Godlewski G., Jourdan T., Kunos G., Mukhopadhyay B., Szanda G., Tam J., Chedester L., Chorvat R.J., Deschamps J.R., Innis R.B., Liow J.S., McElroy J.F., Rice K.C., Wesley D.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23825075", "type": [ "PubMed" ], "id": "23825075" } ], "title": "Renal uptake of the antiapoptotic protein survivin is mediated by megalin at the apical membrane of the proximal tubule.", "journal": "Am. J. Physiol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Christensen E.I., Schloetzer-Schrehardt U., Amann K., Eckardt K.U., Hackenbeck T., Knaup K.X., Wiesener M.S., Voll R.E., Goppelt-Struebe M., Buettner-Herold M., Fuernrohr B.G., Jobst-Schwan T., Kroening S., Lechler P., Nielsen R.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24639464", "type": [ "PubMed" ], "id": "24639464" } ], "title": "LRP2 mediates folate uptake in the developing neural tube.", "journal": "J. Cell Sci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Willnow T.E., Hammes A., Mecklenburg N., Cabrera R.M., Kur E.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24825475", "type": [ "PubMed" ], "id": "24825475" } ], "title": "Clusterin/ApoJ enhances central leptin signaling through Lrp2-mediated endocytosis.", "journal": "EMBO Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Huang H., Kim H.K., Lee B., Kim M.S., Shin M.S., Kim Y.B., Youn B.S., Gil S.Y., Kang G.M., Byun K., Namkoong C.", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26439398", "type": [ "PubMed" ], "id": "26439398" } ], "title": "LRP2 acts as SHH clearance receptor to protect the retinal margin from mitogenic stimuli.", "journal": "Dev. Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Willnow T.E., Bachmann S., Hammes A., Christ A., Christa A., Eule J.C., Klippert J., Wallace V.A.", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26822476", "type": [ "PubMed" ], "id": "26822476" } ], "title": "Common arterial trunk and ventricular non-compaction in Lrp2 knockout mice indicate a crucial role of LRP2 in cardiac development.", "journal": "Dis. Model. Mech.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Hofstra R.M., Kerstjens-Frederikse W.S., Hierck B.P., Baardman M.E., Berger R.M., DeRuiter M.C., Gittenberger-de Groot A.C., Jongbloed M.R., Jurdzinski A., Ploesch T., Wisse L.J., Zwier M.V.", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27773703", "type": [ "PubMed" ], "id": "27773703" } ], "title": "N-glycoform-dependent interactions of megalin with its ligands.", "journal": "Biochim. Biophys. Acta", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Gu J., Fukuda T., Suzuki A., Hirano M., Totani K.", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28659595", "type": [ "PubMed" ], "id": "28659595" } ], "title": "Cellular uptake of proMMP-2:TIMP-2 complexes by the endocytic receptor megalin/LRP-2.", "journal": "Sci. Rep.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "authors": "Janssens V., Christensen E.I., Moestrup S.K., Nielsen R., Courtoy P.J., Henriet P., Lemoine P., Marbaix E., Emonard H., Grieco G., Johanns M.", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29916093", "type": [ "PubMed" ], "id": "29916093" } ], "title": "Megalin mediates plasma membrane to mitochondria cross-talk and regulates mitochondrial metabolism.", "journal": "Cellular and molecular life sciences : CMLS", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Li Q, Lei F, Tang Y, Pan JS, Tong Q, Sun Y, Sheikh-Hamad D", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30025861", "type": [ "PubMed" ], "id": "30025861" } ], "title": "Expression Profiles of Metallothionein I/II and Megalin in Cuprizone Model of De- and Remyelination.", "journal": "Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Jakovac H, Grubic Kezele T, Radosevic-Stasic B", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30401801", "type": [ "PubMed" ], "id": "30401801" } ], "title": "Circulating FABP4 is eliminated by the kidney via glomerular filtration followed by megalin-mediated reabsorption.", "journal": "Scientific reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Shrestha S, Sunaga H, Hanaoka H, Yamaguchi A, Kuwahara S, Umbarawan Y, Nakajima K, Machida T, Murakami M, Saito A, Tsushima Y, Kurabayashi M, Iso T", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30940800", "type": [ "PubMed" ], "id": "30940800" } ], "title": "WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis.", "journal": "Nature communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Kaiser K, Gyllborg D, Prochazka J, Salasova A, Kompanikova P, Molina FL, Laguna-Goya R, Radaszkiewicz T, Harnos J, Prochazkova M, Potesil D, Barker RA, Casado AG, Zdrahal Z, Sedlacek R, Arenas E, Villaescusa JC, Bryja V", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7656578", "type": [ "PubMed" ], "id": "7656578" } ], "title": "In situ hybridization mapping of a 500-kDa calcium-sensing protein gene (LRP2) to human chromosome region 2q31-->q32.1 and porcine chromosome region 15q22-->q24.", "journal": "Cytogenetics and cell genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Chowdhary BP, Lundgren S, Johansson M, Hjalm G, Akerstrom G, Gustavsson I, Rask L", "date": "1995" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7720568", "type": [ "PubMed" ], "id": "7720568" } ], "title": "Gp330 is specifically expressed in outer cells during epithelial differentiation in the preimplantation mouse embryo.", "journal": "Development (Cambridge, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Gueth-Hallonet C, Santa-Maria A, Verroust P, Maro B", "date": "1994" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8631881", "type": [ "PubMed" ], "id": "8631881" } ], "title": "A novel family of Cys-Cys, His-Cys zinc finger transcription factors expressed in developing nervous system and pituitary gland.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Jiang Y, Yu VC, Buchholz F, O'Connell S, Rhodes SJ, Candeloro C, Xia YR, Lusis AJ, Rosenfeld MG", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8710893", "type": [ "PubMed" ], "id": "8710893" } ], "title": "Defective forebrain development in mice lacking gp330/megalin.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ], "authors": "Willnow TE, Hilpert J, Armstrong SA, Rohlmann A, Hammer RE, Burns DK, Herz J", "date": "1996" } ], "uniprot_ac": "A2ARV4", "site_annotation": [ { "end_pos": 1065, "annotation": "n_glycosylation_sequon", "start_pos": 1063 }, { "end_pos": 1189, "annotation": "n_glycosylation_sequon", "start_pos": 1187 }, { "end_pos": 1330, "annotation": "n_glycosylation_sequon", "start_pos": 1328 }, { "end_pos": 1343, "annotation": "n_glycosylation_sequon", "start_pos": 1341 }, { "end_pos": 1386, "annotation": "n_glycosylation_sequon", "start_pos": 1384 }, { "end_pos": 1453, "annotation": "n_glycosylation_sequon", "start_pos": 1451 }, { "end_pos": 1499, "annotation": "n_glycosylation_sequon", "start_pos": 1497 }, { "end_pos": 1553, "annotation": "n_glycosylation_sequon", "start_pos": 1551 }, { "end_pos": 161, "annotation": "n_glycosylation_sequon", "start_pos": 159 }, { "end_pos": 1678, "annotation": "n_glycosylation_sequon", "start_pos": 1676 }, { "end_pos": 1735, "annotation": "n_glycosylation_sequon", "start_pos": 1733 }, { "end_pos": 180, "annotation": "n_glycosylation_sequon", "start_pos": 178 }, { "end_pos": 1813, "annotation": "n_glycosylation_sequon", "start_pos": 1811 }, { "end_pos": 2133, "annotation": "n_glycosylation_sequon", "start_pos": 2131 }, { "end_pos": 2136, "annotation": "n_glycosylation_sequon", "start_pos": 2134 }, { "end_pos": 2180, "annotation": "n_glycosylation_sequon", "start_pos": 2178 }, { "end_pos": 2227, "annotation": "n_glycosylation_sequon", "start_pos": 2225 }, { "end_pos": 2398, "annotation": "n_glycosylation_sequon", "start_pos": 2396 }, { "end_pos": 2490, "annotation": "n_glycosylation_sequon", "start_pos": 2488 }, { "end_pos": 2550, "annotation": "n_glycosylation_sequon", "start_pos": 2548 }, { "end_pos": 2784, "annotation": "n_glycosylation_sequon", "start_pos": 2782 }, { "end_pos": 2812, "annotation": "n_glycosylation_sequon", "start_pos": 2810 }, { "end_pos": 2951, "annotation": "n_glycosylation_sequon", "start_pos": 2949 }, { "end_pos": 2991, "annotation": "n_glycosylation_sequon", "start_pos": 2989 }, { "end_pos": 301, "annotation": "n_glycosylation_sequon", "start_pos": 299 }, { "end_pos": 3129, "annotation": "n_glycosylation_sequon", "start_pos": 3127 }, { "end_pos": 3215, "annotation": "n_glycosylation_sequon", "start_pos": 3213 }, { "end_pos": 3261, "annotation": "n_glycosylation_sequon", "start_pos": 3259 }, { "end_pos": 3319, "annotation": "n_glycosylation_sequon", "start_pos": 3317 }, { "end_pos": 3359, "annotation": "n_glycosylation_sequon", "start_pos": 3357 }, { "end_pos": 342, "annotation": "n_glycosylation_sequon", "start_pos": 340 }, { "end_pos": 3450, "annotation": "n_glycosylation_sequon", "start_pos": 3448 }, { "end_pos": 3568, "annotation": "n_glycosylation_sequon", "start_pos": 3566 }, { "end_pos": 3684, "annotation": "n_glycosylation_sequon", "start_pos": 3682 }, { "end_pos": 3842, "annotation": "n_glycosylation_sequon", "start_pos": 3840 }, { "end_pos": 389, "annotation": "n_glycosylation_sequon", "start_pos": 387 }, { "end_pos": 3971, "annotation": "n_glycosylation_sequon", "start_pos": 3969 }, { "end_pos": 3982, "annotation": "n_glycosylation_sequon", "start_pos": 3980 }, { "end_pos": 4072, "annotation": "n_glycosylation_sequon", "start_pos": 4070 }, { "end_pos": 4331, "annotation": "n_glycosylation_sequon", "start_pos": 4329 }, { "end_pos": 464, "annotation": "n_glycosylation_sequon", "start_pos": 462 }, { "end_pos": 659, "annotation": "n_glycosylation_sequon", "start_pos": 657 }, { "end_pos": 867, "annotation": "n_glycosylation_sequon", "start_pos": 865 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4#A2ARV4-1", "isoform_ac": "A2ARV4-1", "locus": { "end_pos": 69425648, "strand": "+", "start_pos": 69585893, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000080953", "id": "ENSMUST00000080953", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000079752", "id": "ENSMUSP00000079752", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ARV4-1|LRP2_MOUSE Isoform 1 of Low-density lipoprotein receptor-related protein 2 OS=Mus musculus OX=10090 GN=Lrp2 PE=1 SV=1 CANONICAL=A2ARV4-1", "length": 4660, "sequence": "MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSFSAASIIFSNGRDLLVGDLHGRNFRILAESKNRGIVMGVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKANKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCEFGFELDADEHHCVAVKNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTIFYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQIISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTHPFGLTVFKDNVFLTDWRLGAIIRVRKSDGGDMTVVRRGISSIMHVKAYDADLQTGTNYCSQTTHPNGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGCVLNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQWQCPGYSICVNLSALCDGVFDCPNGTDESPLCNQDSCLHFNGGCTHRCIQGPFGATCVCPIGYQLANDTKTCEDVNECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTASENLLLVVASRDKIIMDNITAHTHNIYSLVQDVSFVVALDFDSVTGRVFWSDLLEGKTWSAFQNGTDKRVVHDSGLSLTEMIAVDWIGRNIYWTDYTLETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGQNRRQVIASDLVLHHPHALTLFEDSVFWTDRGTHQVMQANKWHGRNQSVVMYSVPQPLGIIAIHPSRQPSSPNPCASATCSHLCLLSAQEPRHYSCACPSGWNLSDDSVNCVRGDQPFLISVRENVIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTAFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLRGDTRYGKTLITNDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNMEHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILVHHLAHPWGLVVHGSFLYYSDEQYEVIERVDKSSGSNKVVFRDNIPYLRGLRVYHHRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFIVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPNGSNFTNIVTYGIGANGIRGVAVDWVAGNLYFTNAFVYETLIEVIRINTTYRRVLLKVSVDMPRHIVVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAVDHDTGYIYWVDDSLDIIARIHRDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLRKVFQASKQPGNTDPPTVIRDSINLLRDVTIFDEHVQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPKCGCAFGTLEDDGKNCATSREDFLIYSLNNSLRSLHFDPQDHNLPFQAISVEGMAIALDYDRRNNRIFFTQKLNPIRGQISYVNLYSGASSPTILLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLTLDLETDLLYWADASLQKIERSTLTGSNREVVISTAFHSFGLTVYGQYIYWTDFYTKKIYRANKYDGSDLIAMTTRLPTQPSGISTVVKTQQQQCSNPCDQFNGGCSHICAPGPNGAECQCPHEGSWYLANDNKYCVVDTGARCNQFQFTCLNGRCISQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCANGRCVPYHYRCDFYNDCGDNSDEAGCLFRSCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPITCQPDFAKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCVSPHRCIPSYWFCDGEADCVDSSDEPDTCGHSLNSCSANQFHCDNGRCISSSWVCDGDNDCGDMSDEDQRHHCELQNCSSTEFTCINSRPPNRRCIPQHWVCDGDADCADALDELQNCTMRACSTGEFSCANGRCIRQSFRCDRRNDCGDYSDERGCSYPPCRDDQFTCQNGQCITKLYVCDEDNDCGDGSDEQEHLCHTPEPTCPPHQFRCDNGHCIEMGTVCNHVDDCSDNSDEKGCGINECQDSSISHCDHNCTDTITSFYCSCLPGYKLMSDKRTCVDIDECKETPQLCSQKCENVIGSYICKCAPGYIREPDGKSCRQNSNIEPYLVFSNRYYIRNLTIDGTSYSLILQGLGNVVALDFDRVEERLYWIDAEKQIIERMFLNKTNQETIISHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRQRKMLAQHCVDANNTFCFENPRGIVLHPQRGYVYWADWGDHAYIARIGMDGTNKTVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGTLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVLHPYRQPIMSNPCATNNGGCSHLCLIKAGGRGFTCECPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDESDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCEANEWQCANKRCIPEYWQCDSVDDCLDNSDEDPSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIHECMTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCGNHHCIPLRWKCDGIDDCGDNSDEESCVPRECTESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNVPCESPQRFRCDNSRCIYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCVSQHYVCDNVDDCGDLSDETGCNLGENRTCAEKICEQNCTQLSNGGFICSCRPGFKPSTLDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNISSEKFSEYLEEEEHIQAIDYDWDPEGIGLSVVYYTVLSQGSQFGAIKRAYLPDFESGSNNPVREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHRSVLASANLGWPNGLSIDYLNGDRIYWSDSKEDVIESIKYDGTDRRLIINDAMKPFSLDIFEDQLYWVAKEKGEVWRQNKFGKGNKEKLLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVECDAASELPITMPSPCRCMHGGSCYFDENDLPKCKCSSGYSGEYCEIGLSRGIPPGTTMALLLTFAMVIIVGALVLVGFFHYRKTGSLLPSLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEQFVMEVGKQPVIFENPMYAAKDSTSKVGLAVQGPSVSSQVTVPENVENQNYGRSIDPSEIVPEPKPASPGADETQGTKWNIFKRKPKQTTNFENPIYAEMDTEQKEAVAVAPPPSPSLPAKASKRSSTPGYTATEDTFKDTANLVKEDSDV" } }, { "url": "https://www.uniprot.org/uniprot/A2ARV4#A2ARV5-1", "isoform_ac": "A2ARV5-1", "locus": { "end_pos": 69506338, "strand": "+", "start_pos": 69585893, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000100051", "id": "ENSMUST00000100051", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000097628", "id": "ENSMUSP00000097628", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2ARV5-1|LRP2_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 2 OS=Mus musculus OX=10090 GN=Lrp2 PE=1 SV=1 CANONICAL=A2ARV4-1", "length": 1363, "sequence": "MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSFSAASIIFSNGRDLLVGDLHGRNFRILAESKNRGIVMGVDFHYQKHRVFWTDPMQAKVFSTDINGLNTQEILNVSIDAPENLAVDWINNKLYLVETRVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKLGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKANKFTDTNPQVYHQSSLTPFGVTVYHALRQPNATNPCGNNNGGCAQICVLSHRTDNGGLGYRCKCEFGFELDADEHHCVAVKNFLLFSSQTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTIFYSDLSKNIIYQQKIDGTGKEVITANRLQNVECLSFDWISRNLYWTDGGSKSVTVMKLADKSRRQIISNLNNPRSIVVHPAAGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSTSRLYWVDAFFDKIEHSNLDGLDRKRLGHVDQMTHPFGLTVFKDNVFLTDWRLGAIIRVRKSDGGDMTVVRRGISSIMHVKAYDADLQTGTNYCSQTTHPNGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSSSFPCNNGKCVPSIFRCDGVDDCHDNSDEHQCGALNNTCSSSAFTCVHGGQCIPGQWRCDKQNDCLDGSDEQNCPTRSPSSTCPPTSFTCDNHMCIPKEWVCDTDNDCSDGSDEKNCQASGTCHPTQFRCPDHRCISPLYVCDGDKDCVDGSDEAGCVLNCTSSQFKCADGSSCINSRYRCDGVYDCKDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIQGSDEHNGCVPKTCSPSHFLCDNGNCIYNSWVCDGDNDCRDMSDEKDCPTQPFHCPSSQWQCPGYSICVNLSALCDGVFDCPNGTDESPLCSKFPDHSLLDTNLF" } }, { "url": "https://www.uniprot.org/uniprot/A2ARV4#Q3V346-1", "isoform_ac": "Q3V346-1", "locus": { "end_pos": 69527180, "strand": "+", "start_pos": 69585893, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000092551", "id": "ENSMUST00000092551", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000090212", "id": "ENSMUSP00000090212", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q3V346-1|LRP2_MOUSE Computationally mapped isoform of Low-density lipoprotein receptor-related protein 2 OS=Mus musculus OX=10090 GN=Lrp2 PE=1 SV=1 CANONICAL=A2ARV4-1", "length": 426, "sequence": "MERGAAAAAWMLLLAIAACLAPVSGQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCGSGFFLCPAEGTCIPSSWVCDQDKDCSDGADEQQNCPGTTCSSQQLTCSNGQCVPIEYRCDHVSDCPDGSDERNCYYPTCDQLTCANGACYNTSQKCDHKVDCRDSSDEANCTTLCSQKEFQCGSGECILRAYVCDHDNDCEDNSDEHNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQRHHTCYPREWACPGSGRCISMDKVCDGVPDCPEGEDENNATSGRYCGTGLCSILNCEYQCHQTPYGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCESRQGRHQCLCEEGYILERGQHCKSNDSLLGIEPKATSLRFSPETGFFFVWPWLSWNSLGFPGWR" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:14725", "resource": "KEGG Pathway", "id": "mmu:14725", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8856825", "resource": "Reactome", "id": "R-MMU-8856825", "name": "Cargo recognition for clathrin-mediated endocytosis" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8856828", "resource": "Reactome", "id": "R-MMU-8856828", "name": "Clathrin-mediated endocytosis" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975634", "resource": "Reactome", "id": "R-MMU-975634", "name": "Retinoid metabolism and transport" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "annotation": "Cuprizone-induced demyelination is followed by high upregulation of MT-I/II and megalin immunoreactivity in astrocytes and epithelial and endothelial cells located in cerebral and cerebellar white and gray matter, as well as in choroid plexus and in numerous constituents of the neurogenic niches in subgranular zone (SGZ) of DG and in SVZ of lateral ventricles.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "annotation": "Megalin is critical for mitochondrial biology; mitochondrial intracrine signaling is a continuum of the retrograde early endosome-to-Golgi-Rab32 pathway and defects in this pathway may underlie disease processes in many systems.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "id": "NP_001074557.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ARV4#function", "annotation": "Multiligand endocytic receptor. Acts together with CUBN to mediate endocytosis of high-density lipoproteins (PubMed:10766831). Mediates receptor-mediated uptake of polybasic drugs such as aprotinin, aminoglycosides and polymyxin B (By similarity). In the kidney, mediates the tubular uptake and clearance of leptin (PubMed:22841573). Also mediates transport of leptin across the blood-brain barrier through endocytosis at the choroid plexus epithelium (By similarity). Endocytosis of leptin in neuronal cells is required for hypothalamic leptin signaling and leptin-mediated regulation of feeding and body weight (PubMed:24825475). Mediates endocytosis and subsequent lysosomal degradation of CST3 in kidney proximal tubule cells (PubMed:17462596). Mediates renal uptake of 25-hydroxyvitamin D3 in complex with the vitamin D3 transporter GC/DBP (PubMed:10052453). Mediates renal uptake of metallothionein-bound heavy metals (By similarity). Together with CUBN, mediates renal reabsorption of myoglobin (By similarity). Mediates renal uptake and subsequent lysosomal degradation of APOM (By similarity). Plays a role in kidney selenium homeostasis by mediating renal endocytosis of selenoprotein SEPP1 (PubMed:18174160). Mediates renal uptake of the antiapoptotic protein BIRC5/survivin which may be important for functional integrity of the kidney (PubMed:23825075). Mediates renal uptake of matrix metalloproteinase MMP2 in complex with metalloproteinase inhibitor TIMP1 (PubMed:28659595). Mediates endocytosis of Sonic hedgehog protein N-product (ShhN), the active product of SHH (By similarity). Also mediates ShhN transcytosis (By similarity). In the embryonic neuroepithelium, mediates endocytic uptake and degradation of BMP4, is required for correct SHH localization in the ventral neural tube and plays a role in patterning of the ventral telencephalon (PubMed:15623804). Required at the onset of neurulation to sequester SHH on the apical surface of neuroepithelial cells of the rostral diencephalon ventral midline and to control PTCH1-dependent uptake and intracellular trafficking of SHH (PubMed:22340494). During neurulation, required in neuroepithelial cells for uptake of folate bound to the folate receptor FOLR1 which is necessary for neural tube closure (PubMed:24639464). In the adult brain, negatively regulates BMP signaling in the subependymal zone which enables neurogenesis to proceed (PubMed:20460439). In astrocytes, mediates endocytosis of ALB which is required for the synthesis of the neurotrophic factor oleic acid (By similarity). Involved in neurite branching (PubMed:20637285). During optic nerve development, required for SHH-mediated migration and proliferation of oligodendrocyte precursor cells (PubMed:22354480). Mediates endocytic uptake and clearance of SHH in the retinal margin which protects retinal progenitor cells from mitogenic stimuli and keeps them quiescent (PubMed:26439398). Plays a role in reproductive organ development by mediating uptake in reproductive tissues of androgen and estrogen bound to the sex hormone binding protein SHBG (PubMed:16143106). Mediates endocytosis of angiotensin-2 (By similarity). Also mediates endocytosis of angiotensin 1-7 (By similarity). Binds to the complex composed of beta-amyloid protein 40 and CLU/APOJ and mediates its endocytosis and lysosomal degradation (By similarity). Required for embryonic heart development (PubMed:26822476). Required for normal hearing, possibly through interaction with estrogen in the inner ear (PubMed:17846082).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4#function", "id": "A2ARV4", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P98158-1", "protein_name": "Low-density lipoprotein receptor-related protein 2", "sequence": { "length": 4660, "sequence": "MERGAAAAAWMLLLAIAACLEPVSSQECGSGNFRCDNGYCIPASWRCDGTRDCLDDTDEIGCPPRSCESGLFLCPAEGTCIPSSWVCDEDKDCSDGADEQQNCAGTTCSAQQMTCSNGQCIPSEYRCDHVSDCPDGSDERNCHYPTCDQLTCANGACYNTSQRCDQKVDCRDSSDEANCTTLCSQKEFECGSGECILRAYVCDHDNDCEDNSDERNCNYDTCGGHQFTCSNGQCINQNWVCDGDDDCQDSGDEDGCESNQSHHRCYPREWACPGSGRCISIDKVCDGVPDCPEGDDENNVTSGRTCGMGVCSVLNCEYQCHQTPFGGECFCPPGHIINSNDSRTCIDFDDCQIWGICDQKCENRQGRHQCLCEEGYILERGQHCKSSDSFSAASVIFSNGRDLLVGDLHGRNFRILAESKNRGMVMGVDFHYQKHRVFWTDPMQEKVFSTDINGLNTQEILNVSVDTPENLAVDWINNKLYLVETKVNRIDVVNLEGNQRVTLITENLGHPRGIALDPTVGYLFFSDWGSLSGQPKVERAFMDGSNRKDLVTTKVGWPAGITLDLVSKRVYWVDSRYDYIETVTYDGIQRKTVARGGSLVPHPFGISLFEEHVFFTDWTKMAVMKASKFTETNPQVYHQSSLRPHGVTVYHALRQPNATNPCGSNNGGCAQVCVLSHRTDNGGLGYRCKCEFGFELDDDEHRCVAVKNFLLFSSKTAVRGIPFTLSTQEDVMVPVTGSPSFFVGIDFDAQHSTVFYSDLSKDIIYKQKIDGTGKEVITANRLESVECLTFDWISRNLYWTDGGLKSVTVLRLADKSRRQIISNLNNPRSIVVHPTAGYMFLSDWFRPAKIMRAWSDGSHLMPIVNTSLGWPNGLAIDWSASRLYWVDAFFDKIEHSTLDGLDRKRLGHVDQMTHPFGLTVFKDNVFITDWRLGAIIRVRKSDGGDMTVIRRGISSVMHVKAYDADLQTGSNYCSQTTHANGDCSHFCFPVPNFQRVCGCPYGMKLQRDQMTCEGDPAREPPTQQCGSLSFPCNNGKCVPSFFRCDGVDDCHDNSDEHQCGVFNNTCSPSAFACVRGGQCIPGQWHCDRQNDCLDGSDEQNCPTHATSSTCPSTSFTCDNHVCIPKDWVCDTDNDCSDGSDEKNCQASGTCQPTQFRCPDHRCISPLYVCDGDKDCADGSDEAGCVLNCTSAQFKCADGSSCINSRYRCDGVYDCRDNSDEAGCPTRPPGMCHPDEFQCQGDGTCIPNTWECDGHPDCIHGSDEHTGCVPKTCSPTHFLCDNGNCIYKAWICDGDNDCRDMSDEKDCPTQPFHCPSTQWQCPGYSTCINLSALCDGVFDCPNGTDESPLCNQDSCSHFNGGCTHQCMQGPFGATCLCPLGYQLANDTKTCEDINECDIPGFCSQHCVNMRGSFRCACDPEYTLESDGRTCKVTGSENPLLVVASRDKIIVDNITAHTHNLYSLVQDVSFVVALDFDSVTGRVFWSDLLQGKTWSVFQNGTDKRVVHDSGLSVTEMIAVDWIGRNLYWTDYALETIEVSKIDGSHRTVLISKNVTKPRGLALDPRMGDNVMFWSDWGHHPRIERASMDGTMRTVIVQEKIYWPCGLSIDYPNRLIYFMDAYLDYIEFCDYDGHNRRQVIASDLVLHHPHALTLFEDFVYWTDRGTRQVMQANKWHGGNQSVVMYSVHQPLGITAIHPSRQPPSRNPCASASCSHLCLLSAQAPRHYSCACPSGWNLSDDSVNCVRGDQPFLMSVRDNIIFGISLDPEVKSNDAMVPISGIQHGYDVEFDDSEQFIYWVENPGEIHRVKTDGSNRTVFAPLSLLGSSLGLALDWVSRNIYYTTPASRSIEVLTLKGDTRYGKTLIANDGTPLGVGFPVGIAVDPARGKLYWSDHGTDSGVPAKIASANMDGTSLKILFTGNLQHLEVVTLDIQEQKLYWAVTSRGVIERGNVDGTERMILVHHLAHPWGLVVYGSFLYYSDEQYEVIERVDKSSGNNKVVLRDNVPYLRGLRVYHRRNAADSSNGCSNNPNACQQICLPVPGGMFSCACASGFKLSPDGRSCSPYNSFMVVSMLPAVRGFSLELSDHSEAMVPVAGQGRNVLHADVDVANGFIYWCDFSSSVRSSNGIRRIKPDGSNFTNVVTYGIGANGIRGVALDWAAGNLYFTNAFVYETLIEVLRINTTYRRVLLKVSVDMPRHIIVDPKHRYLFWADYGQKPKIERSFLDCTNRTVLVSEGIVTPRGLAMDHDTGYIYWVDDSLDLIARIHLDGGESQVVRYGSRYPTPYGITVFGESIIWVDRNLKKVFQASKQPGNTDPPVVIRDKINLLRDVTIFDEHAQPLSPAELNNNPCLQSNGGCSHFCFALPELPTPRCGCAFGTLGNDGKSCATSQEDFLIYSLNNSLRSLHFDPRDHSLPFQVISVAGTAIALDYDRRNNRIFFTQKLNSLRGQISYVSLYSGSSSPTVLLSNIGVTDGIAFDWINRRIYYSDFSNQTINSMAEDGSNRAVIARVSKPRAIVLDPCRGYMYWTDWGTNAKIERATLGGNFRVPIVNTSLVWPNGLALDLETDLLYWADASLQKIERSTLTGTNREVVVSTAFHSFGLTVYGQYIYWTDLYTRKIYRANKYDGSDLVAMTTRLPTQPSGISTVVKTQRQQCSNPCDQFNGGCSHICAPGPNGAECQCPHEGNWYLANDNKYCVVDTGTRCNQLQFTCLNGHCINQDWKCDNDNDCGDGSDELPTVCAFHTCRSTAFTCGNGRCVPYHYRCDYYNDCGDNSDEAGCLFRNCNSTTEFTCSNGRCIPLSYVCNGINNCHDNDTSDEKNCPPHTCPPDFTKCQTTNICVPRAFLCDGDNDCGDGSDENPIYCASHTCRSNEFQCLSPQRCIPSYWFCDGEADCADGSDEPDTCGHSVNTCRASQFQCDNGRCISGNWVCDGDNDCGDMSDEDQRHHCELQNCSSTQFTCVNSRPPNRRCIPQYWVCDGDADCSDALDELQNCTMRTCSAGEFSCANGRCVRQSFRCDRRNDCGDYSDERGCSYPPCHANQFTCQNGRCIPRFFVCDEDNDCGDGSDEQEHLCHTPEPTCPLHQFRCDNGHCIEMGRVCNHVDDCSDNSDEKGCGINECLDSSISRCDHNCTDTITSFYCSCLPGYKLMSDKRSCVDIDECKESPQLCSQKCENVVGSYICKCAPGYIREPDGKSCRQNSNIEPYLIFSNRYYIRNLTTDGSSYSLILQGLGNVVALDFDRVEKRLYWIDAEKQIIERMFLNKTNRETIINHRLRRAESLAVDWVSRKLYWLDAILDCLFVSDLEGRHRKMIAQHCVDANNTFCFEHPRGIVLHPQRGHVYWADWGVHAYIGRIGMDGTNKSVIISTKIEWPNAITIDYTNDLLYWADAHLGYIEFSDLEGHHRHTVYDGSLPHPFALTIFEDTVFWTDWNTRTVEKGNKYDGSGRVVLVNTTHKPFDIHVYHPYRQPIMSNPCGTNNGGCSHLCLIKAGGRGFTCACPDDFQTVQLRDRTLCMPMCSSTQFLCGNNEKCIPIWWKCDGQKDCSDGSDEPDLCPHRFCRLGQFQCRDGNCTSPQALCNARQDCADGSDEDRVLCEHHRCESNEWQCANKRCIPQSWQCDSVNDCLDNSDEDTSHCASRTCRPGQFKCNNGRCIPQSWKCDVDNDCGDYSDEPIDECTTAAYNCDNHTEFSCKTNYRCIPQWAVCNGFDDCRDNSDEQGCESVPCHPSGDFRCANHHCIPLRWKCDGTDDCGDNSDEENCVPRECSESEFRCADQQCIPSRWVCDQENDCGDNSDERDCEMKTCHPEHFQCTSGHCVPKALACDGRADCLDASDESACPTRFPNGTYCPAAMFECKNHVCIQSFWICDGENDCVDGSDEEIHLCFNIPCESPQRFRCDNSRCVYGHQLCNGVDDCGDGSDEKEEHCRKPTHKPCTDTEYKCSNGNCISQHYVCDNVNDCGDLSDETGCNLGDNRTCAENICEQNCTQLSSGGFICSCRPGFKPSTSDKNSCQDINECEEFGICPQSCRNSKGSYECFCVDGFKSMSTHYGERCAADGSPPLLLLPENVRIRKYNTSSEKFSEYLEEEEHIQTIDYDWDPEHIGLSVVYYTVLAQGSQFGAIKRAYIPNFESGSNNPIREVDLGLKYLMQPDGLAVDWVGRHIYWSDAKSQRIEVATLDGRYRKWLITTQLDQPAAIAVNPKLGLMFWTDQGKQPKIESAWMNGEHRSVLVSENLGWPNGLSIDYLNDDRVYWSDSKEDVIEAIKYDGTDRRLIINEAMKPFSLDIFEDKLYWVAKEKGEVWRQNKFGKENKEKVLVVNPWLTQVRIFHQLRYNQSVSNPCKQVCSHLCLLRPGGYSCACPQGSDFVTGSTVQCDAASELPVTMPPPCRCMHGGNCYFDENELPKCKCSSGYSGEYCEVGLSRGIPPGTTMAVLLTFVIVIIVGALVLVGLFHYRKTGSLLPTLPKLPSLSSLAKPSENGNGVTFRSGADVNMDIGVSPFGPETIIDRSMAMNEHFVMEVGKQPVIFENPMYAAKDNTSKVALAVQGPSTGAQVTVPENVENQNYGRPIDPSEIVPEPKPASPGADEIQGKKWNIFKRKPKQTTNFENPIYAEMDSEVKDAVAVAPPPSPSLPAKASKRNLTPGYTATEDTFKDTANLVKEDSDV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20952", "id": "20952", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "P98164-1", "protein_name": "Low-density lipoprotein receptor-related protein 2", "sequence": { "length": 4655, "sequence": "MDRGPAAVACTLLLALVACLAPASGQECDSAHFRCGSGHCIPADWRCDGTKDCSDDADEIGCAVVTCQQGYFKCQSEGQCIPNSWVCDQDQDCDDGSDERQDCSQSTCSSHQITCSNGQCIPSEYRCDHVRDCPDGADENDCQYPTCEQLTCDNGACYNTSQKCDWKVDCRDSSDEINCTEICLHNEFSCGNGECIPRAYVCDHDNDCQDGSDEHACNYPTCGGYQFTCPSGRCIYQNWVCDGEDDCKDNGDEDGCESGPHDVHKCSPREWSCPESGRCISIYKVCDGILDCPGREDENNTSTGKYCSMTLCSALNCQYQCHETPYGGACFCPPGYIINHNDSRTCVEFDDCQIWGICDQKCESRPGRHLCHCEEGYILERGQYCKANDSFGEASIIFSNGRDLLIGDIHGRSFRILVESQNRGVAVGVAFHYHLQRVFWTDTVQNKVFSVDINGLNIQEVLNVSVETPENLAVDWVNNKIYLVETKVNRIDMVNLDGSYRVTLITENLGHPRGIAVDPTVGYLFFSDWESLSGEPKLERAFMDGSNRKDLVKTKLGWPAGVTLDMISKRVYWVDSRFDYIETVTYDGIQRKTVVHGGSLIPHPFGVSLFEGQVFFTDWTKMAVLKANKFTETNPQVYYQASLRPYGVTVYHSLRQPYATNPCKDNNGGCEQVCVLSHRTDNDGLGFRCKCTFGFQLDTDERHCIAVQNFLIFSSQVAIRGIPFTLSTQEDVMVPVSGNPSFFVGIDFDAQDSTIFFSDMSKHMIFKQKIDGTGREILAANRVENVESLAFDWISKNLYWTDSHYKSISVMRLADKTRRTVVQYLNNPRSVVVHPFAGYLFFTDWFRPAKIMRAWSDGSHLLPVINTTLGWPNGLAIDWAASRLYWVDAYFDKIEHSTFDGLDRRRLGHIEQMTHPFGLAIFGEHLFFTDWRLGAIIRVRKADGGEMTVIRSGIAYILHLKSYDVNIQTGSNACNQPTHPNGDCSHFCFPVPNFQRVCGCPYGMRLASNHLTCEGDPTNEPPTEQCGLFSFPCKNGRCVPNYYLCDGVDDCHDNSDEQLCGTLNNTCSSSAFTCGHGECIPAHWRCDKRNDCVDGSDEHNCPTHAPASCLDTQYTCDNHQCISKNWVCDTDNDCGDGSDEKNCNSTETCQPSQFNCPNHRCIDLSFVCDGDKDCVDGSDEVGCVLNCTASQFKCASGDKCIGVTNRCDGVFDCSDNSDEAGCPTRPPGMCHSDEFQCQEDGICIPNFWECDGHPDCLYGSDEHNACVPKTCPSSYFHCDNGNCIHRAWLCDRDNDCGDMSDEKDCPTQPFRCPSWQWQCLGHNICVNLSVVCDGIFDCPNGTDESPLCNGNSCSDFNGGCTHECVQEPFGAKCLCPLGFLLANDSKTCEDIDECDILGSCSQHCYNMRGSFRCSCDTGYMLESDGRTCKVTASESLLLLVASQNKIIADSVTSQVHNIYSLVENGSYIVAVDFDSISGRIFWSDATQGKTWSAFQNGTDRRVVFDSSIILTETIAIDWVGRNLYWTDYALETIEVSKIDGSHRTVLISKNLTNPRGLALDPRMNEHLLFWSDWGHHPRIERASMDGSMRTVIVQDKIFWPCGLTIDYPNRLLYFMDSYLDYMDFCDYNGHHRRQVIASDLIIRHPYALTLFEDSVYWTDRATRRVMRANKWHGGNQSVVMYNIQWPLGIVAVHPSKQPNSVNPCAFSRCSHLCLLSSQGPHFYSCVCPSGWSLSPDLLNCLRDDQPFLITVRQHIIFGISLNPEVKSNDAMVPIAGIQNGLDVEFDDAEQYIYWVENPGEIHRVKTDGTNRTVFASISMVGPSMNLALDWISRNLYSTNPRTQSIEVLTLHGDIRYRKTLIANDGTALGVGFPIGITVDPARGKLYWSDQGTDSGVPAKIASANMDGTSVKTLFTGNLEHLECVTLDIEEQKLYWAVTGRGVIERGNVDGTDRMILVHQLSHPWGIAVHDSFLYYTDEQYEVIERVDKATGANKIVLRDNVPNLRGLQVYHRRNAAESSNGCSNNMNACQQICLPVPGGLFSCACATGFKLNPDNRSCSPYNSFIVVSMLSAIRGFSLELSDHSETMVPVAGQGRNALHVDVDVSSGFIYWCDFSSSVASDNAIRRIKPDGSSLMNIVTHGIGENGVRGIAVDWVAGNLYFTNAFVSETLIEVLRINTTYRRVLLKVTVDMPRHIVVDPKNRYLFWADYGQRPKIERSFLDCTNRTVLVSEGIVTPRGLAVDRSDGYVYWVDDSLDIIARIRINGENSEVIRYGSRYPTPYGITVFENSIIWVDRNLKKIFQASKEPENTEPPTVIRDNINWLRDVTIFDKQVQPRSPAEVNNNPCLENNGGCSHLCFALPGLHTPKCDCAFGTLQSDGKNCAISTENFLIFALSNSLRSLHLDPENHSPPFQTINVERTVMSLDYDSVSDRIYFTQNLASGVGQISYATLSSGIHTPTVIASGIGTADGIAFDWITRRIYYSDYLNQMINSMAEDGSNRTVIARVPKPRAIVLDPCQGYLYWADWDTHAKIERATLGGNFRVPIVNSSLVMPSGLTLDYEEDLLYWVDASLQRIERSTLTGVDREVIVNAAVHAFGLTLYGQYIYWTDLYTQRIYRANKYDGSGQIAMTTNLLSQPRGINTVVKNQKQQCNNPCEQFNGGCSHICAPGPNGAECQCPHEGNWYLANNRKHCIVDNGERCGASSFTCSNGRCISEEWKCDNDNDCGDGSDEMESVCALHTCSPTAFTCANGRCVQYSYRCDYYNDCGDGSDEAGCLFRDCNATTEFMCNNRRCIPREFICNGVDNCHDNNTSDEKNCPDRTCQSGYTKCHNSNICIPRVYLCDGDNDCGDNSDENPTYCTTHTCSSSEFQCASGRCIPQHWYCDQETDCFDASDEPASCGHSERTCLADEFKCDGGRCIPSEWICDGDNDCGDMSDEDKRHQCQNQNCSDSEFLCVNDRPPDRRCIPQSWVCDGDVDCTDGYDENQNCTRRTCSENEFTCGYGLCIPKIFRCDRHNDCGDYSDERGCLYQTCQQNQFTCQNGRCISKTFVCDEDNDCGDGSDELMHLCHTPEPTCPPHEFKCDNGRCIEMMKLCNHLDDCLDNSDEKGCGINECHDPSISGCDHNCTDTLTSFYCSCRPGYKLMSDKRTCVDIDECTEMPFVCSQKCENVIGSYICKCAPGYLREPDGKTCRQNSNIEPYLIFSNRYYLRNLTIDGYFYSLILEGLDNVVALDFDRVEKRLYWIDTQRQVIERMFLNKTNKETIINHRLPAAESLAVDWVSRKLYWLDARLDGLFVSDLNGGHRRMLAQHCVDANNTFCFDNPRGLALHPQYGYLYWADWGHRAYIGRVGMDGTNKSVIISTKLEWPNGITIDYTNDLLYWADAHLGYIEYSDLEGHHRHTVYDGALPHPFAITIFEDTIYWTDWNTRTVEKGNKYDGSNRQTLVNTTHRPFDIHVYHPYRQPIVSNPCGTNNGGCSHLCLIKPGGKGFTCECPDDFRTLQLSGSTYCMPMCSSTQFLCANNEKCIPIWWKCDGQKDCSDGSDELALCPQRFCRLGQFQCSDGNCTSPQTLCNAHQNCPDGSDEDRLLCENHHCDSNEWQCANKRCIPESWQCDTFNDCEDNSDEDSSHCASRTCRPGQFRCANGRCIPQAWKCDVDNDCGDHSDEPIEECMSSAHLCDNFTEFSCKTNYRCIPKWAVCNGVDDCRDNSDEQGCEERTCHPVGDFRCKNHHCIPLRWQCDGQNDCGDNSDEENCAPRECTESEFRCVNQQCIPSRWICDHYNDCGDNSDERDCEMRTCHPEYFQCTSGHCVHSELKCDGSADCLDASDEADCPTRFPDGAYCQATMFECKNHVCIPPYWKCDGDDDCGDGSDEELHLCLDVPCNSPNRFRCDNNRCIYSHEVCNGVDDCGDGTDETEEHCRKPTPKPCTEYEYKCGNGHCIPHDNVCDDADDCGDWSDELGCNKGKERTCAENICEQNCTQLNEGGFICSCTAGFETNVFDRTSCLDINECEQFGTCPQHCRNTKGSYECVCADGFTSMSDRPGKRCAAEGSSPLLLLPDNVRIRKYNLSSERFSEYLQDEEYIQAVDYDWDPKDIGLSVVYYTVRGEGSRFGAIKRAYIPNFESGRNNLVQEVDLKLKYVMQPDGIAVDWVGRHIYWSDVKNKRIEVAKLDGRYRKWLISTDLDQPAAIAVNPKLGLMFWTDWGKEPKIESAWMNGEDRNILVFEDLGWPTGLSIDYLNNDRIYWSDFKEDVIETIKYDGTDRRVIAKEAMNPYSLDIFEDQLYWISKEKGEVWKQNKFGQGKKEKTLVVNPWLTQVRIFHQLRYNKSVPNLCKQICSHLCLLRPGGYSCACPQGSSFIEGSTTECDAAIELPINLPPPCRCMHGGNCYFDETDLPKCKCPSGYTGKYCEMAFSKGISPGTTAVAVLLTILLIVVIGALAIAGFFHYRRTGSLLPALPKLPSLSSLVKPSENGNGVTFRSGADLNMDIGVSGFGPETAIDRSMAMSEDFVMEMGKQPIIFENPMYSARDSAVKVVQPIQVTVSENVDNKNYGSPINPSEIVPETNPTSPAADGTQVTKWNLFKRKSKQTTNFENPIYAQMENEQKESVAATPPPSPSLPAKPKPPSRRDPTPTYSATEDTFKDTANLVKEDSEV" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20952", "id": "20952", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074557.1", "ac": "NP_001074557.1", "name": "low-density lipoprotein receptor-related protein 2 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008144", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "drug binding", "id": "GO:0008144" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017124", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "SH3 domain binding", "id": "GO:0017124" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050750", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "low-density lipoprotein particle receptor binding", "id": "GO:0050750" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051087", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "chaperone binding", "id": "GO:0051087" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042562", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "hormone binding", "id": "GO:0042562" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030492", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "hemoglobin binding", "id": "GO:0030492" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030165", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "PDZ domain binding", "id": "GO:0030165" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035258", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "steroid hormone receptor binding", "id": "GO:0035258" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "12815097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "10766831", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "15616221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "15616221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005903", "pmid": "12815097", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "brush border", "id": "GO:0005903" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005905", "pmid": "15616221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "clathrin-coated pit", "id": "GO:0005905" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "15082773", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030424", "pmid": "20637285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "axon", "id": "GO:0030424" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030425", "pmid": "20637285", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "dendrite", "id": "GO:0030425" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043235", "pmid": "23382219", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "receptor complex", "id": "GO:0043235" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "pmid": "15342463", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "apical part of cell", "id": "GO:0045177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "pmid": "15616221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "apical part of cell", "id": "GO:0045177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045177", "pmid": "24586199", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "apical part of cell", "id": "GO:0045177" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "pmid": "20460439", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "external side of plasma membrane", "id": "GO:0009897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", "pmid": "16143106", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "external side of plasma membrane", "id": "GO:0009897" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016324", "pmid": "21938401", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "apical plasma membrane", "id": "GO:0016324" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030139", "pmid": "15616221", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "endocytic vesicle", "id": "GO:0030139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031526", "pmid": "10662735", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "brush border membrane", "id": "GO:0031526" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031904", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "endosome lumen", "id": "GO:0031904" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045121", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "membrane raft", "id": "GO:0045121" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032991", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "protein-containing complex", "id": "GO:0032991" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044295", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "axonal growth cone", "id": "GO:0044295" } ], "total": 26, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006766", "pmid": "10052453", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "vitamin metabolic process", "id": "GO:0006766" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007507", "pmid": "25807483", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "heart development", "id": "GO:0007507" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008283", "pmid": "15623804", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ARV4", "id": "A2ARV4", "database": "UniProtKB" } ], "name": "cell population 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