{ "uniprot_canonical_ac": "A2AJN7-1", "ptm_annotation": [ { "annotation": "Glycosylated.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19349973", "id": "19349973", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16944957", "id": "16944957", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29415997", "id": "29415997", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P20594", "id": "P20594", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q8TCT7", "id": "Q8TCT7", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23493376", "id": "23493376", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16174766", "id": "16174766", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9BXS0", "id": "Q9BXS0", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q96PE1", "id": "Q96PE1", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9P2K2", "id": "Q9P2K2", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q99972", "id": "Q99972", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P16473", "id": "P16473", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16940290", "id": "16940290", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/O60241", "id": "O60241", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16828986", "id": "16828986", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P30203", "id": "P30203", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17215451", "id": "17215451", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9Y2G1", "id": "Q9Y2G1", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19474308", "id": "19474308", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9HBW9", "id": "Q9HBW9", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P43004", "id": "P43004", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P21439", "id": "P21439", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10894171", "id": "10894171", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15322118", "id": "15322118", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20965152", "id": "20965152", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P21707", "id": "P21707", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q5T601", "id": "Q5T601", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12023293", "id": "12023293", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18096503", "id": "18096503", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9Y5Z0", "id": "Q9Y5Z0", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9822685", "id": "9822685", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q13740", "id": "Q13740", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P20138", "id": "P20138", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q6UWU4", "id": "Q6UWU4", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16895902", "id": "16895902", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12019299", "id": "12019299", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q07092", "id": "Q07092", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15601667", "id": "15601667", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19656770", "id": "19656770", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q16206", "id": "Q16206", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15123619", "id": "15123619", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16145673", "id": "16145673", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9806833", "id": "9806833", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27129275", "id": "27129275", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15254193", "id": "15254193", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24407422", "id": "24407422", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15659399", "id": "15659399", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P28494", "id": "P28494", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18650334", "id": "18650334", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9115635", "id": "9115635", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9BZG2", "id": "Q9BZG2", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9685319", "id": "9685319", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17109118", "id": "17109118", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8982867", "id": "8982867", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/O08603", "id": "O08603", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7488116", "id": "7488116", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q8NBW4", "id": "Q8NBW4", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/P49768", "id": "P49768", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23105095", "id": "23105095", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q64232", "id": "Q64232", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17287360", "id": "17287360", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9HCN3", "id": "Q9HCN3", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1537333", "id": "1537333", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10706709", "id": "10706709", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12765696", "id": "12765696", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17129178", "id": "17129178", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12574114", "id": "12574114", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18795891", "id": "18795891", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9NQA5", "id": "Q9NQA5", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11133656", "id": "11133656", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11723121", "id": "11723121", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2AJN7-1|S4A11_MOUSE Isoform 1 of Sodium bicarbonate transporter-like protein 11 OS=Mus musculus OX=10090 GN=Slc4a11 PE=2 SV=1 CANONICAL=A2AJN7-1", "length": 862, "sequence": "MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP" }, "uniprot_id": "S4A11_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19586905", "type": [ "PubMed" ], "id": "19586905" } ], "title": "Slc4a11 gene disruption in mice: cellular targets of sensorineuronal abnormalities.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Lopez IA, Rosenblatt MI, Kim C, Galbraith GC, Jones SM, Kao L, Newman D, Liu W, Yeh S, Pushkin A, Abuladze N, Kurtz I", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20185830", "type": [ "PubMed" ], "id": "20185830" } ], "title": "SLC4A11 prevents osmotic imbalance leading to corneal endothelial dystrophy, deafness, and polyuria.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Braun T., Boettger T., Maier H., Kostin S., Frohlich H., Groger N., Olbrich A.", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23813972", "type": [ "PubMed" ], "id": "23813972" } ], "title": "Transmembrane water-flux through SLC4A11: a route defective in genetic corneal diseases.", "journal": "Human molecular genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Vilas GL, Loganathan SK, Liu J, Riau AK, Young JD, Mehta JS, Vithana EN, Casey JR", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23942972", "type": [ "PubMed" ], "id": "23942972" } ], "title": "Mice with a targeted disruption of Slc4a11 model the progressive corneal changes of congenital hereditary endothelial dystrophy.", "journal": "Investigative ophthalmology & visual science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Han SB, Ang HP, Poh R, Chaurasia SS, Peh G, Liu J, Tan DT, Vithana EN, Mehta JS", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25123669", "type": [ "PubMed" ], "id": "25123669" } ], "title": "Bicarbonate transport inhibitor SITS modulates pH homeostasis triggering apoptosis of Dalton's lymphoma: implication of novel molecular mechanisms.", "journal": "Molecular and cellular biochemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Kant S, Kumar A, Singh SM", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28934248", "type": [ "PubMed" ], "id": "28934248" } ], "title": "Vps35-deficiency impairs SLC4A11 trafficking and promotes corneal dystrophy.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "authors": "Liu W, Tang FL, Lin S, Zhao K, Mei L, Ye J, Xiong WC", "date": "2017" } ], "uniprot_ac": "A2AJN7", "site_annotation": [ { "end_pos": 118, "annotation": "n_glycosylation_sequon", "start_pos": 116 }, { "end_pos": 449, "annotation": "n_glycosylation_sequon", "start_pos": 447 }, { "end_pos": 48, "annotation": "n_glycosylation_sequon", "start_pos": 46 }, { "end_pos": 513, "annotation": "n_glycosylation_sequon", "start_pos": 511 }, { "end_pos": 521, "annotation": "n_glycosylation_sequon", "start_pos": 519 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7#A2AJN7-1", "isoform_ac": "A2AJN7-1", "locus": { "end_pos": 130684437, "strand": "+", "start_pos": 130696086, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099362", "id": "ENSMUST00000099362", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000096963", "id": "ENSMUSP00000096963", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AJN7-1|S4A11_MOUSE Isoform 1 of Sodium bicarbonate transporter-like protein 11 OS=Mus musculus OX=10090 GN=Slc4a11 PE=2 SV=1 CANONICAL=A2AJN7-1", "length": 862, "sequence": "MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESKVHLLSDTIQGVTATVRGVQYEQSWLCIICTMKTLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPQPPKCKDFFPFGKGIWMDIMRRFPVYPMDFTDGIIGKSKSVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFGKYYYGHHYHTKRTSSLVSLLGIGRSPNSSLHTALNASLLASPVEMATTSSPGSTHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLIGSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAIGSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVDVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP" } }, { "url": "https://www.uniprot.org/uniprot/A2AJN7#A2AJN8-1", "isoform_ac": "A2AJN8-1", "locus": { "end_pos": 130691550, "strand": "+", "start_pos": 130696086, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000127397", "id": "ENSMUST00000127397", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117976", "id": "ENSMUSP00000117976", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AJN8-1|S4A11_MOUSE Computationally mapped isoform of Sodium bicarbonate transporter-like protein 11 OS=Mus musculus OX=10090 GN=Slc4a11 PE=2 SV=1 CANONICAL=A2AJN7-1", "length": 164, "sequence": "MSQNEHCQDSGEYFSAGTQGYFKNNMEDNLEVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDLEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFALDPNHAEPDCDLDLLMAKLFTDAGAPMESK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269356", "resource": "KEGG Pathway", "id": "mmu:269356", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "Data shows that the function of SLCA11 is to facilitate the movement of water across the basolateral corneal epithelium.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "Loss of SLC4A11 leads to morphological changes in the fibrocytes and deafness.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "Results demonstrate the importance of NaBC1 in the audio-vestibular system and provide support for the hypothesis that SLC4A11 should be considered a potential candidate gene in patients with isolated sensorineural vestibular hearing abnormalities.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "Results provide evidence for a critical role of Vps35 in mouse corneal dystrophy; suggest that SLC4A11 appears to be a Vps35/retromer cargo, and Vps35-regulation of SLC4A11 trafficking may underlie Vps35/retromer regulation of corneal dystrophy. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "Successful knockout of the Slc4a11 gene was confirmed by immunohistochemistry and RT-PCR. Slit-lamp photography and AS-OCT showed progressive corneal edema. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "annotation": "The declined tumor cell survival following inhibition of BCT could be the consequence of interplay of several inter-connected regulatory molecular events.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2AJN7#function", "annotation": "Transporter which plays an important role in sodium-mediated fluid transport in different organs. Prevents severe morphological changes of the cornea caused by increased sodium chloride concentrations in the stroma. In the inner ear, is involved in transport of potassium through the fibrocyte layer to the stria vascularis and is essential for the generation of the endocochlear potential but not for regulation of potassium concentrations in the endolymph. In the kidney, is essential for urinary concentration, mediates a sodium flux into the thin descending limb of Henle loop to allow countercurrent multiplication by osmotic equilibration. Involved in borate homeostasis. In the absence of borate, it functions as a Na(+) and OH(-)(H(+)) channel. In the presence of borate functions as an electrogenic Na(+) coupled borate cotransporter.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7#function", "id": "A2AJN7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "D3ZVP9-1", "protein_name": "Solute carrier family 4 member 11", "sequence": { "length": 862, "sequence": "MSQNEHCQDSGEYFSAATLGYFKNDTDDNPDVREDSLGDEVFDTVNSSIVSGESIRFFVNVNLEVQPSKSDIEAATGGCVLLHTSRKYLKLKNFEEEVRAHRDLDGFLAQASIILNETATSLDDVLRTMLNRFAQDPNHAEPDCDLDLLMAKLFTDAGGPMESKVHLLSDTIQGVTATVRGLQYEQSWLCIVCTMKSLQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDITFRQKLLKTRTEEEFKEALVHQRQLLTMMMPRAAGHSMSSLHTHRHPRPPKCKDFFPFGKGIWVDIMRRFPVYPLDFTDGIIGKGKTVGKYVTTTLFLYFACLLPTIAFGSLNDENTNGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLAIYTQVIRVICDDYNLDFNAFYAWTGLWNSFFLALYAFLNLSLLMNLFKRSTEEIIALFISITFVLDAVKGMVKIFWKYYYGHHYHTKRTSSLASLLGISRSPNTSLHTALNTSFLASPIEMTTASSPISTHSNQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVRETLSDCALPIAVLSFSLISSYGFQEIEMSKFRYNPSESLFEVAQIHSLSFKAISSAMGLGFLLSLLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYETIVNVKETRLTALGASVLVGLSLLLLPFPLQWIPKPVLYGLFLYIALTSLDGNQLFSRVALLLKEQTSYPPTHYIRRVPQRKIHYFTGLQILQLLLLCAFGMSSLPYMKMVFPLIMIAMIPIRYNLLPRIIEAKYLDVMDAEHRP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12931", "id": "12931", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2AJN7/", "id": "A2AJN7", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q8NBS3-1", "protein_name": "Sodium bicarbonate transporter-like protein 11", "sequence": { "length": 891, "sequence": "MSQVGGRGDRCTQEVQGLVHGAGDLSASLAENSPTMSQNGYFEDSSYYKCDTDDTFEAREEILGDEAFDTANSSIVSGESIRFFVNVNLEMQATNTENEATSGGCVLLHTSRKYLKLKNFKEEIRAHRDLDGFLAQASIVLNETATSLDNVLRTMLRRFARDPDNNEPNCNLDLLMAMLFTDAGAPMRGKVHLLSDTIQGVTATVTGVRYQQSWLCIICTMKALQKRHVCISRLVRPQNWGENSCEVRFVILVLAPPKMKSTKTAMEVARTFATMFSDIAFRQKLLETRTEEEFKEALVHQRQLLTMVSHGPVAPRTKERSTVSLPAHRHPEPPKCKDFVPFGKGIREDIARRFPLYPLDFTDGIIGKNKAVGKYITTTLFLYFACLLPTIAFGSLNDENTDGAIDVQKTIAGQSIGGLLYALFSGQPLVILLTTAPLALYIQVIRVICDDYDLDFNSFYAWTGLWNSFFLALYAFFNLSLVMSLFKRSTEEIIALFISITFVLDAVKGTVKIFWKYYYGHYLDDYHTKRTSSLVSLSGLGASLNASLHTALNASFLASPTELPSATHSGQATAVLSLLIMLGTLWLGYTLYQFKKSPYLHPCVREILSDCALPIAVLAFSLISSHGFREIEMSKFRYNPSESPFAMAQIQSLSLRAVSGAMGLGFLLSMLFFIEQNLVAALVNAPENRLVKGTAYHWDLLLLAIINTGLSLFGLPWIHAAYPHSPLHVRALALVEERVENGHIYDTIVNVKETRLTSLGASVLVGLSLLLLPVPLQWIPKPVLYGLFLYIALTSLDGNQLVQRVALLLKEQTAYPPTHYIRRVPQRKIHYFTGLQVLQLLLLCAFGMSSLPYMKMIFPLIMIAMIPIRYILLPRIIEAKYLDVMDAEHRP" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/12931", "id": "12931", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "ac": "NP_001074631.1", "name": "sodium bicarbonate transporter-like protein 11", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046983", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "protein dimerization activity", "id": "GO:0046983" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015293", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "symporter activity", "id": "GO:0015293" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005272", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "sodium channel activity", "id": "GO:0005272" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005452", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "inorganic anion exchanger activity", "id": "GO:0005452" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015106", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "bicarbonate transmembrane transporter activity", "id": "GO:0015106" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015252", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "proton channel activity", "id": "GO:0015252" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015301", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "anion:anion antiporter activity", "id": "GO:0015301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046715", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "active borate transmembrane transporter activity", "id": "GO:0046715" } ], "total": 8, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "integral component of membrane", "id": "GO:0016021" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051453", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "regulation of intracellular pH", "id": "GO:0051453" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050801", "pmid": "20185830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "ion homeostasis", "id": "GO:0050801" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042044", "pmid": "20185830", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "fluid transport", "id": "GO:0042044" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006814", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "sodium ion transport", "id": "GO:0006814" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015701", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "bicarbonate transport", "id": "GO:0015701" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030003", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "cellular cation homeostasis", "id": "GO:0030003" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046713", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "borate transport", "id": "GO:0046713" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902600", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "id": "A2AJN7", "database": "UniProtKB" } ], "name": "proton transmembrane transport", "id": "GO:1902600" } ], "total": 8, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJN7", "type": "synonym", "resource": "RefSeq", "name": "AI503023; BTR1; NaBC1" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "synonym", "resource": "UniProtKB", "name": "BTR1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJN7", "type": "synonym", "resource": "RefSeq", "name": "Slc4a11" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "recommended", "resource": "UniProtKB", "name": "Slc4a11" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074796", "id": "ENSMUSG00000074796", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/269356", "id": "269356", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003020", "id": "IPR003020", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011531", "id": "IPR011531", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016152", "id": "IPR016152", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:269356", "id": "mmu:269356", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2138987", "id": "2138987", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/YDHNVSS/", "id": "YDHNVSS", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=265068at2759", "id": "265068at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11453", "id": "PTHR11453", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00955", "id": "PF00955", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AJN7", "id": "PR_A2AJN7", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074631.1", "id": "NP_001074631.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [ { "residue": "Asn", "site_category": "predicted", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7#ptm_processing", "id": "A2AJN7", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "position": 511, "glytoucan_ac": "", "type": "N-linked" }, { "residue": "Asn", "site_category": "predicted", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7#ptm_processing", "id": "A2AJN7", "database": "UniProtKB" } ], "subtype": "", "relation": "attached", "position": 519, "glytoucan_ac": "", "type": "N-linked" } ], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 96751.0, "chemical_mass": 96751.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "name": "Slc4a11", "locus": { "end_pos": 130684113, "strand": "-", "start_pos": 130697519, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000074796", "id": "ENSMUSG00000074796", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "synonym", "resource": "UniProtKB", "name": "Bicarbonate transporter-related protein 1" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "synonym", "resource": "UniProtKB", "name": "NaBC1" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "recommended", "resource": "UniProtKB", "name": "Sodium bicarbonate transporter-like protein 11" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "synonym", "resource": "UniProtKB", "name": "Sodium borate cotransporter 1" }, { "url": "https://www.uniprot.org/uniprot/A2AJN7", "type": "synonym", "resource": "UniProtKB", "name": "Solute carrier family 4 member 11" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJN7", "type": "synonym", "resource": "RefSeq", "name": "bicarbonate transporter-related protein 1; sodium borate cotransporter 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AJN7", "type": "synonym", "resource": "RefSeq", "name": "sodium bicarbonate transporter-like protein 11" } ] }