{
    "uniprot_canonical_ac": "A2ADU9-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2ADU9-1|AWAT1_MOUSE Isoform 1 of Acyl-CoA wax alcohol acyltransferase 1  OS=Mus musculus OX=10090 GN=Awat1 PE=2 SV=1 CANONICAL=A2ADU9-1", 
        "length": 328, 
        "sequence": "MSCSMKTEHLQSLSLLQWPLSYVAMFWIVQPLLICLLFTPLWPLPTVYFVWLLLDWKTPDKGGRRSDWVRNWNVWNHIRDYFPITILKTKDLSPSENYIMGVHPHGLLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPIIRDYIMAKGLCSVSQASIDYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLLLKKRKGFVRTALQHGAHLVPTFTFGETEVYDQVLFHEDSRMFKFQSLFRRIFGFYCCVFYGQGFHQDCKGLLPYHKPIITVVGEALPLPQVKNPSPEIVDKYHALYMDALYKLFEQHKVQYGCSNTQKLIFL"
    }, 
    "uniprot_id": "AWAT1_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.3.1.75", 
            "activity": ""
        }, 
        {
            "ec": "2.3.1.75", 
            "activity": "Acyl-CoA + a long-chain alcohol = CoA + a long-chain ester."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                    "id": "A2ADU9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23730681", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "23730681"
                }
            ], 
            "title": "Detailed characterization of the substrate specificity of mouse wax synthase.", 
            "journal": "Acta biochimica Polonica", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074605.1", 
                    "id": "NP_001074605.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Miklaszewska M, Kawinski A, Banas A", 
            "date": "2013"
        }
    ], 
    "uniprot_ac": "A2ADU9", 
    "site_annotation": [
        {
            "end_pos": 193, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 191
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9#A2ADU9-1", 
            "isoform_ac": "A2ADU9-1", 
            "locus": {
                "end_pos": 100572337, 
                "strand": "-", 
                "start_pos": 100577885, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000096361", 
                        "id": "ENSMUST00000096361", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000094088", 
                        "id": "ENSMUSP00000094088", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2ADU9-1|AWAT1_MOUSE Isoform 1 of Acyl-CoA wax alcohol acyltransferase 1  OS=Mus musculus OX=10090 GN=Awat1 PE=2 SV=1 CANONICAL=A2ADU9-1", 
                "length": 328, 
                "sequence": "MSCSMKTEHLQSLSLLQWPLSYVAMFWIVQPLLICLLFTPLWPLPTVYFVWLLLDWKTPDKGGRRSDWVRNWNVWNHIRDYFPITILKTKDLSPSENYIMGVHPHGLLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPIIRDYIMAKGLCSVSQASIDYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLLLKKRKGFVRTALQHGAHLVPTFTFGETEVYDQVLFHEDSRMFKFQSLFRRIFGFYCCVFYGQGFHQDCKGLLPYHKPIITVVGEALPLPQVKNPSPEIVDKYHALYMDALYKLFEQHKVQYGCSNTQKLIFL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:245533", 
            "resource": "KEGG Pathway", 
            "id": "mmu:245533", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142753", 
            "resource": "Reactome", 
            "id": "R-MMU-2142753", 
            "name": "Arachidonic acid metabolism"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9640463", 
            "resource": "Reactome", 
            "id": "R-MMU-9640463", 
            "name": "Wax biosynthesis"
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9#function", 
            "annotation": "Acyltransferase that catalyzes the formation of ester bonds between fatty alcohols and fatty acyl-CoAs to form wax monoesters (By similarity). Shows a strong preference for decyl alcohol (C10), with less activity towards C16 and C18 alcohols (By similarity). Shows a strong preference for saturated acyl-CoAs (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2ADU9#function", 
                    "id": "A2ADU9", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074605.1", 
            "annotation": "The highest activity was observed for 14:0-CoA, 12:0-CoA, and 16:0-CoA in combination with medium chain alcohols (up to 5.2, 3.4, and 3.3 nmol wax esters/min/mg microsomal protein, respectively", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074605.1", 
                    "id": "NP_001074605.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D3ZVA9-1", 
            "protein_name": "Acyl-CoA wax alcohol acyltransferase 1", 
            "sequence": {
                "length": 328, 
                "sequence": "MSCSMKLEYLQSLSLLQWPLSYLAIFWIVQPLFFSLFFTPLWLLPSLYVVWFILDWKTPNQGGRRSAWVRNWNIWTHIRDYFPITILKTKDLSPSQNYIMGVHPHGLLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPLIRDYIMAKGVCSVSQASIDYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLILKKRKGFVRTALRHGAHLVPTFTFGETEVYDQVVFHEESRMFKFQSFFRRIFGFYFCVFYGQGFHQECKGLLPYHRPIVTVVGEPLPLPQVKNPSPEIVDKYHALYMDALYKLFEQHKVQYGCSDTQKLMFL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/66233", 
                    "id": "66233", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2ADU9/", 
                    "id": "A2ADU9", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q58HT5-1", 
            "protein_name": "Acyl-CoA wax alcohol acyltransferase 1", 
            "sequence": {
                "length": 328, 
                "sequence": "MAHSKQPSHFQSLMLLQWPLSYLAIFWILQPLFVYLLFTSLWPLPVLYFAWLFLDWKTPERGGRRSAWVRNWCVWTHIRDYFPITILKTKDLSPEHNYLMGVHPHGLLTFGAFCNFCTEATGFSKTFPGITPHLATLSWFFKIPFVREYLMAKGVCSVSQPAINYLLSHGTGNLVGIVVGGVGEALQSVPNTTTLILQKRKGFVRTALQHGAHLVPTFTFGETEVYDQVLFHKDSRMYKFQSCFRRIFGFYCCVFYGQSFCQGSTGLLPYSRPIVTVVGEPLPLPQIEKPSQEMVDKYHALYMDALHKLFDQHKTHYGCSETQKLFFL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/66233", 
                    "id": "66233", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2ADU9/", 
                    "id": "A2ADU9", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074605.1", 
        "ac": "NP_001074605.1", 
        "name": "acyl-CoA wax alcohol acyltransferase 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047196", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                                "id": "A2ADU9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "long-chain-alcohol O-fatty-acyltransferase activity", 
                        "id": "GO:0047196"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0102966", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                                "id": "A2ADU9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "arachidoyl-CoA:1-dodecanol O-acyltransferase activity", 
                        "id": "GO:0102966"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                                "id": "A2ADU9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005789", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                                "id": "A2ADU9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum membrane", 
                        "id": "GO:0005789"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006629", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2ADU9", 
                                "id": "A2ADU9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "lipid metabolic process", 
                        "id": "GO:0006629"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADU9", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Awat1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Awat1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADU9", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Dgat2l3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Dgat2l3"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000015665", 
            "id": "ENSMUSG00000015665", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.brenda-enzymes.org/enzyme.php?ecno=2.3.1.75&UniProtAcc=A2ADU9", 
            "id": "2.3.1.75", 
            "database": "BRENDA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/245533", 
            "id": "245533", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007130", 
            "id": "IPR007130", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:245533", 
            "id": "mmu:245533", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3588200", 
            "id": "3588200", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/FYCCVFY/", 
            "id": "FYCCVFY", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1347007at2759", 
            "id": "1347007at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF03982", 
            "id": "PF03982", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2ADU9", 
            "id": "PR_A2ADU9", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2142753", 
            "id": "R-MMU-2142753", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-9640463", 
            "id": "R-MMU-9640463", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074605.1", 
            "id": "NP_001074605.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 37573.0, 
        "chemical_mass": 37573.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "name": "Awat1", 
            "locus": {
                "end_pos": 100578205, 
                "strand": "+", 
                "start_pos": 100572251, 
                "chromosome": "X", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000015665", 
                        "id": "ENSMUSG00000015665", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.3.1.75"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Acyl-CoA wax alcohol acyltransferase 1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Diacylglycerol O-acyltransferase 2-like protein 3"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2ADU9", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Long-chain-alcohol O-fatty-acyltransferase 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADU9", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "acyl-CoA wax alcohol acyltransferase 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2ADU9", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "wax synthase 1; long-chain-alcohol O-fatty-acyltransferase 1; diacylglycerol O-acyltransferase 2-like protein 3"
        }
    ]
}