{
    "uniprot_canonical_ac": "A2A9K7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2A9K7-1|A2A9K7_MOUSE Isoform 1 of Connector enhancer of kinase suppressor of Ras 1  OS=Mus musculus OX=10090 GN=Cnksr1 PE=1 SV=1 CANONICAL=A2A9K7-1", 
        "length": 700, 
        "sequence": "MEPVEAWTPGKVAAWLRGLDDALQDYPFEDWQLPGKYLLQLCPQSLEALTVWPLGHQELILDGVEQLRALGSNLQTENLQSLAQGLLERTQAFQSLVQGSLGNCAETPADVLKAAVELVREAHALLSWLNGYLFSHLNDFSACQEIGVLCGELGQVLQEDCPEAEKERNILRICSHVAGICHNILSCSPEELLEQKAVLESVQVDDPSGLEIHTTSNCLHFVSRVGVQAATSSQILPGDEIVQVNEQVVVGWSHKNMLRELLREPAKVSLVLKKIPVPETPSQTSLDSPHLLSQSLPLNPPSPRVPSEGLLADGTPGPSPAWTDSTSFDAQSPPTPPGPPGVLPEETAEPLESSGHPDKSPILGRKKSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMGPRWRRCWFVLKGHTLYWYRQPQDEKAEGLINLSNYSLESGHDQKKKYVFQLTHDVYKPFIFAAETLSDLSKWVRHLITCISKYQAQGRAPSSAREEDCYSETEAEDPDEEAGSRSASPGPAQAWSDTSPVASPLQSPRTSFNSSPDSSDRALEGMVQGLRQGGVSLLGQPQPLTHEQWRSSFMRRNRDPHLNERAHRIRALQSTLKAKLQELQALEEVLGDPELTSAKFRQWKEQNQELYSEGLRTWGGTWAQTSSSDPNSDSRAHSPQPLPFDPEEPSQLFPLTPENSRQPPDL"
    }, 
    "uniprot_id": "A2A9K7_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A9K7", 
                    "id": "A2A9K7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A2A9K7", 
    "site_annotation": [
        {
            "end_pos": 438, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 436
        }, 
        {
            "end_pos": 441, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 439
        }, 
        {
            "end_pos": 549, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 547
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9K7#A2A9K7-1", 
            "isoform_ac": "A2A9K7-1", 
            "locus": {
                "end_pos": 134228318, 
                "strand": "+", 
                "start_pos": 134238308, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000030645", 
                        "id": "ENSMUST00000030645", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000030645", 
                        "id": "ENSMUSP00000030645", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2A9K7-1|A2A9K7_MOUSE Isoform 1 of Connector enhancer of kinase suppressor of Ras 1  OS=Mus musculus OX=10090 GN=Cnksr1 PE=1 SV=1 CANONICAL=A2A9K7-1", 
                "length": 700, 
                "sequence": "MEPVEAWTPGKVAAWLRGLDDALQDYPFEDWQLPGKYLLQLCPQSLEALTVWPLGHQELILDGVEQLRALGSNLQTENLQSLAQGLLERTQAFQSLVQGSLGNCAETPADVLKAAVELVREAHALLSWLNGYLFSHLNDFSACQEIGVLCGELGQVLQEDCPEAEKERNILRICSHVAGICHNILSCSPEELLEQKAVLESVQVDDPSGLEIHTTSNCLHFVSRVGVQAATSSQILPGDEIVQVNEQVVVGWSHKNMLRELLREPAKVSLVLKKIPVPETPSQTSLDSPHLLSQSLPLNPPSPRVPSEGLLADGTPGPSPAWTDSTSFDAQSPPTPPGPPGVLPEETAEPLESSGHPDKSPILGRKKSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMGPRWRRCWFVLKGHTLYWYRQPQDEKAEGLINLSNYSLESGHDQKKKYVFQLTHDVYKPFIFAAETLSDLSKWVRHLITCISKYQAQGRAPSSAREEDCYSETEAEDPDEEAGSRSASPGPAQAWSDTSPVASPLQSPRTSFNSSPDSSDRALEGMVQGLRQGGVSLLGQPQPLTHEQWRSSFMRRNRDPHLNERAHRIRALQSTLKAKLQELQALEEVLGDPELTSAKFRQWKEQNQELYSEGLRTWGGTWAQTSSSDPNSDSRAHSPQPLPFDPEEPSQLFPLTPENSRQPPDL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:194231", 
            "resource": "KEGG Pathway", 
            "id": "mmu:194231", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5674135", 
            "resource": "Reactome", 
            "id": "R-MMU-5674135", 
            "name": "MAP2K and MAPK activation"
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "G3V8W8-1", 
            "protein_name": "RCG31469", 
            "sequence": {
                "length": 704, 
                "sequence": "MEPVETWTPGKVAAWLRGLDDVLQDYPFEDWELPGKYLLQLCPQNLEALTVWPLGHQELILHGVEQLRALGSKLQTENLKSLAQGLLDRTQAFQSLVQGRLRDCAETPADVLNAAVELVREAHALLSWLNRYLFTHLNDFSACQEIGVLCGELGQVLQEDCLEAEKESNTLRICGRVAGICHNILGCSPEELLEQRAVLELVQLDDPSGLEIHTTSNCLHFVSRVGVQAATGSQILPGDEIIQINEQVVVGWPHKNMLRELLREPARVSLVLKKIPVPETPSKTPPDSPQRLSQSLPLNPPSPRVPREGLFDFNLSTDGNPSPSPAWTDSTSLDAQPTPTPPGPPGTLPEETAEPLEASGHLDKSPTVGRKNSKGIATRLSRRRVSCRELGLPDCDGWLLLRKVPGGFMGARWRRCWFVLKGHTLYWYRQPQDEKAEGLINISNYSLECGHDQKKKYVFQLTHDVYKPFIFAAETLSDLSMWVRHLVTCISKYQTLGRAPSAREEDCYSETEAEDPDEEAGSRSASPGPAQAWNDTSPSASPLQSPRTSFGSSLDSSDRALEGMVQGLRQGGVSLLGQPQPLTHEQWRSSFMRRNRDPHLNEHVHRVRALQSTLKAKLQELQVLEEVLGDPELTGAKFRQWKEQNHELYSEGLRTWGGMWAQTSSPDPNTDSRGQSPQPLPSDPEEPSQLFPSTPENSLQPPDL"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2A9K7/", 
                    "id": "A2A9K7", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q969H4-1", 
            "protein_name": "Connector enhancer of kinase suppressor of ras 1", 
            "sequence": {
                "length": 720, 
                "sequence": "MEPVETWTPGKVATWLRGLDDSLQDYPFEDWQLPGKNLLQLCPQSLEALAVRSLGHQELILGGVEQLQALSSRLQTENLQSLTEGLLGATHDFQSIVQGCLGDCAKTPIDVLCAAVELLHEADALLFWLSRYLFSHLNDFSACQEIRDLLEELSQVLHEDGPAAEKEGTVLRICSHVAGICHNILVCCPKELLEQKAVLEQVQLDSPLGLEIHTTSNCQHFVSQVDTQVPTDSRLQIQPGDEVVQINEQVVVREERDMVGWPRKNMVRELLREPAGLSLVLKKIPIPETPPQTPPQVLDSPHQRSPSLSLAPLSPRAPSEDVFAFDLSSNPSPGPSPAWTDSASLGPEPLPIPPEPPAILPAGVAGTPGLPESPDKSPVGRKKSKGLATRLSRRRVSCRELGRPDCDGWLLLRKAPGGFMGPRWRRRWFVLKGHTLYWYRQPQDEKAEGLINVSNYSLESGHDQKKKYVFQLTHDVYKPFIFAADTLTDLSMWVRHLITCISKYQSPGRAPPPREEDCYSETEAEDPDDEAGSHSASPSPAQAGSPLHGDTSPAATPTQRSPRTSFGSLTDSSEEALEGMVRGLRQGGVSLLGQPQPLTQEQWRSSFMRRNRDPQLNERVHRVRALQSTLKAKLQELQVLEEVLGDPELTGEKFRQWKEQNRELYSEGLGAWGVAQAEGSSHILTSDSTEQSPHSLPSDPEEHSHLCPLTSESSLRPPDL"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2A9K7/", 
                    "id": "A2A9K7", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/4604", 
                    "id": "4604", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074516.1", 
        "ac": "NP_001074516.1", 
        "name": "connector enhancer of kinase suppressor of ras 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030674", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9K7", 
                                "id": "A2A9K7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein binding, bridging", 
                        "id": "GO:0030674"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005938", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9K7", 
                                "id": "A2A9K7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell cortex", 
                        "id": "GO:0005938"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007265", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9K7", 
                                "id": "A2A9K7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Ras protein signal transduction", 
                        "id": "GO:0007265"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007266", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9K7", 
                                "id": "A2A9K7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Rho protein signal transduction", 
                        "id": "GO:0007266"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9K7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "BC037758"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9K7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Cnksr1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A9K7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Cnksr1"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028841", 
            "id": "ENSMUSG00000028841", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/194231", 
            "id": "194231", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001478", 
            "id": "IPR001478", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001660", 
            "id": "IPR001660", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001849", 
            "id": "IPR001849", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", 
            "id": "IPR011993", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013761", 
            "id": "IPR013761", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR017874", 
            "id": "IPR017874", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036034", 
            "id": "IPR036034", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:194231", 
            "id": "mmu:194231", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2670958", 
            "id": "2670958", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/TAIQKHK/", 
            "id": "TAIQKHK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1121556at2759", 
            "id": "1121556at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00169", 
            "id": "PF00169", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF10534", 
            "id": "PF10534", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-5674135", 
            "id": "R-MMU-5674135", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074516.1", 
            "id": "NP_001074516.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 77485.0, 
        "chemical_mass": 77485.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9K7", 
            "name": "Cnksr1", 
            "locus": {
                "end_pos": 134228041, 
                "strand": "-", 
                "start_pos": 134238399, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028841", 
                        "id": "ENSMUSG00000028841", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9K7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Connector enhancer of kinase suppressor of Ras 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9K7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "connector enhancer of kinase suppressor of ras 1"
        }
    ]
}