{
    "uniprot_canonical_ac": "A2A9I7-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2A9I7-1|DMRTB_MOUSE Isoform 1 of Doublesex- and mab-3-related transcription factor B1  OS=Mus musculus OX=10090 GN=Dmrtb1 PE=1 SV=1 CANONICAL=A2A9I7-1", 
        "length": 359, 
        "sequence": "MLRAPKCSRCRNHGYLVPVKGHTGKCRWKQCICDKCYLITERQKIMAAQKVLRTQAAEEQVATVGTQGPQLPPRAPAAAATALSSSICPLPRAVPGGVGPGPTATCFLERPPQAPSPGPSTFQLGPSGRPGPSTFQPGPGAPGGLRDRSSAWLPQLMPQAPRPELCYPDQHLPVRPVPVPGPVRPVPRLPFADYGHPLRFKSDHVVGAGNPEREPFKQCPACVPVSPYQSFPLSEGQDSSSALGVPQQRGFRHVSCSPYHRSGLVSEPARDLQPTYCSPPPPPPPPPPPPLPAPPPQPQQPHFLPPGYLSALHFLPPPPPPPSPPSFSLTYDTDKENTNDQDAEAPTEPSQDSPQEQSN"
    }, 
    "uniprot_id": "DMRTB_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                    "id": "A2A9I7", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/12609607", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "12609607"
                }
            ], 
            "title": "Sexually dimorphic expression of multiple doublesex-related genes in the embryonic mouse gonad.", 
            "journal": "Gene Expr. Patterns", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                    "id": "A2A9I7", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kim S., Bardwell V.J., Kettlewell J.R., Zarkower D., Anderson R.C.", 
            "date": "2003"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17605809", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17605809"
                }
            ], 
            "title": "Vertebrate DM domain proteins bind similar DNA sequences and can heterodimerize on DNA.", 
            "journal": "BMC molecular biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Murphy MW, Zarkower D, Bardwell VJ", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17720152", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17720152"
                }
            ], 
            "title": "The function of Dmrt genes in vertebrate development: it is not just about sex.", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Hong CS, Park BY, Saint-Jeannet JP", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25082981", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25082981"
                }
            ], 
            "title": "Involvement of doublesex and mab-3-related transcription factors in human female germ cell development demonstrated by xenograft and interference RNA strategies.", 
            "journal": "Molecular human reproduction", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Poulain M, Frydman N, Tourpin S, Muczynski V, Souquet B, Benachi A, Habert R, Rouiller-Fabre V, Livera G", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25249458", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25249458"
                }
            ], 
            "title": "The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhang T, Murphy MW, Gearhart MD, Bardwell VJ, Zarkower D", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25804738", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25804738"
                }
            ], 
            "title": "Genome-wide characterisation of Foxa1 binding sites reveals several mechanisms for regulating neuronal differentiation in midbrain dopamine cells.", 
            "journal": "Development (Cambridge, England)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Metzakopian E, Bouhali K, Alvarez-Saavedra M, Whitsett JA, Picketts DJ, Ang SL", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9407065", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9407065"
                }
            ], 
            "title": "The WW domain of neural protein FE65 interacts with proline-rich motifs in Mena, the mammalian homolog of Drosophila enabled.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Ermekova KS, Zambrano N, Linn H, Minopoli G, Gertler F, Russo T, Sudol M", 
            "date": "1997"
        }
    ], 
    "uniprot_ac": "A2A9I7", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7#A2A9I7-1", 
            "isoform_ac": "A2A9I7-1", 
            "locus": {
                "end_pos": 107677008, 
                "strand": "+", 
                "start_pos": 107684162, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000069271", 
                        "id": "ENSMUST00000069271", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000064220", 
                        "id": "ENSMUSP00000064220", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A9I7-1|DMRTB_MOUSE Isoform 1 of Doublesex- and mab-3-related transcription factor B1  OS=Mus musculus OX=10090 GN=Dmrtb1 PE=1 SV=1 CANONICAL=A2A9I7-1", 
                "length": 359, 
                "sequence": "MLRAPKCSRCRNHGYLVPVKGHTGKCRWKQCICDKCYLITERQKIMAAQKVLRTQAAEEQVATVGTQGPQLPPRAPAAAATALSSSICPLPRAVPGGVGPGPTATCFLERPPQAPSPGPSTFQLGPSGRPGPSTFQPGPGAPGGLRDRSSAWLPQLMPQAPRPELCYPDQHLPVRPVPVPGPVRPVPRLPFADYGHPLRFKSDHVVGAGNPEREPFKQCPACVPVSPYQSFPLSEGQDSSSALGVPQQRGFRHVSCSPYHRSGLVSEPARDLQPTYCSPPPPPPPPPPPPLPAPPPQPQQPHFLPPGYLSALHFLPPPPPPPSPPSFSLTYDTDKENTNDQDAEAPTEPSQDSPQEQSN"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7#B1ASP8-1", 
            "isoform_ac": "B1ASP8-1", 
            "locus": {
                "end_pos": 107677008, 
                "strand": "+", 
                "start_pos": 107683580, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000131776", 
                        "id": "ENSMUST00000131776", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000119617", 
                        "id": "ENSMUSP00000119617", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|B1ASP8-1|DMRTB_MOUSE Computationally mapped isoform of Doublesex- and mab-3-related transcription factor B1  OS=Mus musculus OX=10090 GN=Dmrtb1 PE=1 SV=1 CANONICAL=A2A9I7-1", 
                "length": 203, 
                "sequence": "GKPSLVQPTVPPACTRPAASGSKLESQTGAGVGKAPSPGHPLRFKSDHVVGAGNPEREPFKQCPACVPVSPYQSFPLSEGQDSSSALGVPQQRGFRHVSCSPYHRSGLVSEPARDLQPTYCSPPPPPPPPPPPPLPAPPPQPQQPHFLPPGYLSALHFLPPPPPPPSPPSFSLTYDTDKENTNDQDAEAPTEPSQDSPQEQSN"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56296", 
            "resource": "KEGG Pathway", 
            "id": "mmu:56296", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
            "annotation": "The mammalian Doublesex homolog DMRT6 coordinates the transition between mitotic and meiotic developmental programs during spermatogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
                    "id": "NP_063925.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "D4A494-1", 
            "protein_name": "DMRT-like family B with proline-rich C-terminal, 1", 
            "sequence": {
                "length": 348, 
                "sequence": "MLRTPKCSRCRNHGYLVPVKGHAGKCRWKHCICDKCYLITERQKIMAAQKVLKNQATEEQGATVGTQGPQLPPRAPAPAAATATASSSSICPLPRAALGGAGPGPAATCFLERSPQARSPGPSAFQLVPSGRPGPSTFQPGSGGSGGLHDRPPAWLPQLRPQAPRPELCCPDQHLPVRPVPRLPFADYGHPLRFKSDHVVGAGYPEREPFKQCPACIPVPPYQPFPLSEGQDSSSALGVPQQRGFRHVSCGPYHGNSLVSEPARDLQPTYCSPPPPPLPPPPPQPQQPHFLPPGYLSALHFLPPPPPPPSPPSFSLTILYDTDKEKTNEQGADAPSEPSQQSTQEESN"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/13207", 
                    "id": "13207", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2A9I7/", 
                    "id": "A2A9I7", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q96MA1-1", 
            "protein_name": "Doublesex- and mab-3-related transcription factor B1", 
            "sequence": {
                "length": 342, 
                "sequence": "MADKMVRTPKCSRCRNHGFLVPVKGHAGKCRWKQCLCEKCYLISERQKIMAAQKVLKTQAAEEEQEAALCAQGPKQASGAAAAAPAPVPVPAASLRPLSPGTPSGDADPGPEGRAAACFFEQPPRGRNPGPRALQPVLGGRSHVEPSERAAVAMPSLAGPPFGAEAAGSGYPGPLDLRRPMRTVPGPLFTDFVRPLNINPDRALGPEYPGGSSMHPYCPFPLGYLDAPPGVPLQQGFRHVSRSQYQGGGLVSEPGGDFQPSYYLPPPPPPLPPLPPLPPQPQFLPPGYLSALHFLPPPPPPPPPSSFSLTVLFDTDKENTDDQDAEVLSGEPSQPSSQEQSD"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/13207", 
                    "id": "13207", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A2A9I7/", 
                    "id": "A2A9I7", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
        "ac": "NP_063925.1", 
        "name": "doublesex- and mab-3-related transcription factor B1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042803", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                                "id": "A2A9I7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein homodimerization activity", 
                        "id": "GO:0042803"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003677", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                                "id": "A2A9I7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA binding", 
                        "id": "GO:0003677"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                                "id": "A2A9I7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "DNA-binding transcription factor activity", 
                        "id": "GO:0003700"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                                "id": "A2A9I7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metal ion binding", 
                        "id": "GO:0046872"
                    }
                ], 
                "total": 4, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A9I7", 
                                "id": "A2A9I7", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleus", 
                        "id": "GO:0005634"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9I7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Dmrt6; Prp13"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Dmrt6"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9I7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Dmrtb1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Dmrtb1"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028610", 
            "id": "ENSMUSG00000028610", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/56296", 
            "id": "56296", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001275", 
            "id": "IPR001275", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026607", 
            "id": "IPR026607", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036407", 
            "id": "IPR036407", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:56296", 
            "id": "mmu:56296", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1927125", 
            "id": "1927125", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/KQCLCEK/", 
            "id": "KQCLCEK", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1042183at2759", 
            "id": "1042183at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12322", 
            "id": "PTHR12322", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00751", 
            "id": "PF00751", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A9I7", 
            "id": "PR_A2A9I7", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_063925.1", 
            "id": "NP_063925.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 38424.0, 
        "chemical_mass": 38424.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7", 
            "name": "Dmrtb1", 
            "locus": {
                "end_pos": 107676290, 
                "strand": "-", 
                "start_pos": 107684230, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028610", 
                        "id": "ENSMUSG00000028610", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Doublesex- and mab-3-related transcription factor 6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A9I7", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Doublesex- and mab-3-related transcription factor B1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9I7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "doublesex and mab-3 related transcription factor 6; proline-rich protein 13"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A9I7", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "doublesex- and mab-3-related transcription factor B1"
        }
    ]
}