{
    "uniprot_canonical_ac": "A2A8M8-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A2A8M8-1|A2A8M8_MOUSE Isoform 1 of PRAME family member 6  OS=Mus musculus OX=10090 GN=Pramef6 PE=4 SV=1 CANONICAL=A2A8M8-1", 
        "length": 474, 
        "sequence": "MSFKDPPTLQQLARRSLLKDEALTISALPNLPVQLFPPLFKDAFTSRHPNILRQMVAAWPFPTLPVGALMEIPDLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLRDAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPILGEKQTVTIKMNLSLMSRRPSKYLKYLYRWAKERKNGIQVICEKLEFGAIPAYDPLNILKVFDAASIQELAINTRWDIYTLASLAPGVGRMKNLQKLLFKEICIPWDRPWDVEKEALILTEIFSQFSKLHKLQHLYLNDVYFLTERLDQMLRCFESPLETLAITHCTLSESDMRYLSQCPSTHQLKHLDLSGVTFILSHPFLGSLLERLTATLQTLKLKGCMLMDWQISDLLPVLSQCSQLTEVDFVKNFLSMDSLKKLLQHTANLTKLTLEKYPAPNEVYDDSDGVIPDRFVQLCSELMDTLKGVRQPKQVYFVSKMCLYCRNFCIYSFVGNI"
    }, 
    "uniprot_id": "A2A8M8_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                    "id": "A2A8M8", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [], 
    "uniprot_ac": "A2A8M8", 
    "site_annotation": [
        {
            "end_pos": 154, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 152
        }, 
        {
            "end_pos": 407, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 405
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A8M8#A2A8M8-1", 
            "isoform_ac": "A2A8M8-1", 
            "locus": {
                "end_pos": 143895362, 
                "strand": "+", 
                "start_pos": 143897925, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000105767", 
                        "id": "ENSMUST00000105767", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000101393", 
                        "id": "ENSMUSP00000101393", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2A8M8-1|A2A8M8_MOUSE Isoform 1 of PRAME family member 6  OS=Mus musculus OX=10090 GN=Pramef6 PE=4 SV=1 CANONICAL=A2A8M8-1", 
                "length": 474, 
                "sequence": "MSFKDPPTLQQLARRSLLKDEALTISALPNLPVQLFPPLFKDAFTSRHPNILRQMVAAWPFPTLPVGALMEIPDLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLRDAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPILGEKQTVTIKMNLSLMSRRPSKYLKYLYRWAKERKNGIQVICEKLEFGAIPAYDPLNILKVFDAASIQELAINTRWDIYTLASLAPGVGRMKNLQKLLFKEICIPWDRPWDVEKEALILTEIFSQFSKLHKLQHLYLNDVYFLTERLDQMLRCFESPLETLAITHCTLSESDMRYLSQCPSTHQLKHLDLSGVTFILSHPFLGSLLERLTATLQTLKLKGCMLMDWQISDLLPVLSQCSQLTEVDFVKNFLSMDSLKKLLQHTANLTKLTLEKYPAPNEVYDDSDGVIPDRFVQLCSELMDTLKGVRQPKQVYFVSKMCLYCRNFCIYSFVGNI"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A8M8#E9Q2S4-1", 
            "isoform_ac": "E9Q2S4-1", 
            "locus": {
                "end_pos": 143894240, 
                "strand": "+", 
                "start_pos": 143897925, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000081645", 
                        "id": "ENSMUST00000081645", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000080350", 
                        "id": "ENSMUSP00000080350", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|E9Q2S4-1|A2A8M8_MOUSE Computationally mapped isoform of PRAME family member 6  OS=Mus musculus OX=10090 GN=Pramef6 PE=4 SV=1 CANONICAL=A2A8M8-1", 
                "length": 469, 
                "sequence": "MSFKDPPTLQQLARRSLLKDEALTISALPNLPVQLFPPLFKDAFTSRHPNILRQMVAAWPFPTLPVGALMEIPDLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLRDAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPILGEKQTVTIKMNLSLMSRRPSKYLKYLYRWAKERKNGIQVICEKLEFGAIPAYDPLNILKVFDAASIQELAINTRWDIYTLASLAPGVGRMKNLQKLLFKEICIPWDRPWDVEKEALILTEIFSQFSKLHKLQHLYLNDVYFLTERLDQMLRCFESPLETLAITHCTLSESDMRYLSQCPSTHQLKHLDLSGVTFILSHPFLGSLLERLTATLQTLKLKGCMLMDWQISDLLPVLSQCSQLTEVDFVKNFLSMDSLKKLLQHTANLTKLTLEKYPAPNEVYDDSDGVIPDRFVQLCSELMDTLKGVRQPKQVYFVGPSPASSFLIFQTV"
            }
        }
    ], 
    "pathway": [], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A2AGW5-1", 
            "protein_name": "Predicted gene 13083", 
            "sequence": {
                "length": 501, 
                "sequence": "MKYFFPLVISLSSAYLKATMSFKDPPTLQQLARRSLLKDEALTISALPNLPVQLFPPLFKDAFTSRHPNILRQMVAAWPFPTLPVGALMKIPHLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLRDAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPILGENQTVTIKMNLSLMSRRPSKYLKYLYRWAKERKNGIQVICEKLEFGAIPAYDPLNILKVFDAASIQELAINTRWDIYTLASLAPGVGRMKNLQKLLFKQICIPWDRPWDLEKEACCVTEIFSQFSKLHKLQHLYLNDVYFLTERLDQMLRCFKGPLETLAITHCILSESDMMYLSQCPSTHQLKHLDLSGVTFILSHPFLGSLLERLTATLQTLKLKGCMLMDWQISDLLPALSQCSQLTEVNFVNNFLSMDSLKKLLQHTANLTQLTLEKYPAPDEVYDDRDGVIPDRFVRLCSELMYTLKGVRQPKQVYFVSKMFSYCWNFCIYSFVGNIEGEVIARL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/133722", 
                    "id": "133722", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "A2AGW8-1", 
            "protein_name": "Predicted gene 13078", 
            "sequence": {
                "length": 474, 
                "sequence": "MSFKDPPTLQQLARRSLLKDEALTISALPNLPMQLFPPLFKDAFTNKHPNILRQMVVAWPFPTLPVGSLMKIPHLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLRDAHKDFWDGWAGLLHEVCSQDVFGKNQPVGNHPILGGKQTMTIKMNLSLMSRRPSKYLKYLYRWAKERKNGIQVICEKLEFGAIPAYDPLDVLKLCDAASIQELAINTCWDIYTLASLALGVGQMKNLQKLLFKEICISWDRPWDLEKEARIVTEIFSEFSKLHKLQHLYLNDVYFLTERLDQMLRCFESPLETLAITHCTLSESDMSYLSQCPSIHQLKHLDLSGVTLILSHPFLQSLLERLTATLQTLKLKGCKLMDWQISDLLPALSQCSQLTEVDFVENFFSMDSLKKLLQNTANLTQLTLEKYPAPDEVYDDSDGVIPDRFLQLCSELIDTLKVVRQPKQVYFVSKRCLYCRNFCIYSFVGNI"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/133722", 
                    "id": "133722", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q7TPY4-1", 
            "protein_name": "Pramel5 protein", 
            "sequence": {
                "length": 500, 
                "sequence": "MSFKDPPTLQQLARRSLLKDEALTISALLNLPVQLFPPLFKDAFTSRQRKILSLMVAAWPFPVLPVGALGGIDHLETLKAVLDGLDLLMSQKDRPSRWNLQVLDLGNAHQDFWDGWAGLLHEVCSQDVFGKNQPVGNHPIPGGKQTITIKMNLSLKYCRHSKYLNYLHWWAEQRKDGIQVICEKLEFTGPHCPELRFLKFSFVASIQELAIKSIHWDIYNLALIASCLGQMKNLQKLILMNIRRPPDLADLQEAHIVTEIFSEFSKLHKVHYLHVNNVYFLKERLDQMLRCFERPLETLAITHCRLSELDMRYLSQCPSIHQLKYLDMSYTTFKPSSHRFLGSLLERLTATLQTLKLECFHLTDFQIRDLLPGLSQCSQLTEVDIAMNEFSVVSLKKLLKHTANLTQLTLEKYPAPVEVYDDGHSVISDRFVQLCSELMNTLKGVRQAKQVYFVSMPCLRNYEFLIYNLKGLDSSEQLRRRGLSWALINGEQVSRDSLQL"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/133722", 
                    "id": "133722", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017175573.1", 
        "ac": "XP_017175573.1", 
        "name": "PRAME family member 6 isoform X1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                                "id": "A2A8M8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008284", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                                "id": "A2A8M8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of cell population proliferation", 
                        "id": "GO:0008284"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043066", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                                "id": "A2A8M8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of apoptotic process", 
                        "id": "GO:0043066"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045892", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                                "id": "A2A8M8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of transcription, DNA-templated", 
                        "id": "GO:0045892"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045596", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A8M8", 
                                "id": "A2A8M8", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "negative regulation of cell differentiation", 
                        "id": "GO:0045596"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8M8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Gm13099"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8M8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Pramef6"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A8M8", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Pramef6"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000078512", 
            "id": "ENSMUSG00000078512", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/195555", 
            "id": "195555", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR026271", 
            "id": "IPR026271", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR032675", 
            "id": "IPR032675", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:3649940", 
            "id": "3649940", 
            "database": "MGI"
        }, 
        {
            "url": "http://www.orthodb.org/?query=985078at2759", 
            "id": "985078at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/XP_017175573.1", 
            "id": "XP_017175573.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 54471.0, 
        "chemical_mass": 54471.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A8M8", 
            "name": "Pramef6", 
            "locus": {
                "end_pos": 143894237, 
                "strand": "-", 
                "start_pos": 143900380, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000078512", 
                        "id": "ENSMUSG00000078512", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A8M8", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "PRAME family member 6 isoform X1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A8M8", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "PRAME family member 6"
        }
    ]
}