{ "uniprot_canonical_ac": "A2A8L5-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A8L5-1|PTPRF_MOUSE Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "uniprot_id": "PTPRF_MOUSE", "enzyme_annotation": [ { "ec": "3.1.3.48", "activity": "" }, { "ec": "3.1.3.48", "activity": "Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate." } ], "glycation": [], "keywords": [ "glycoprotein", "predicted.uniprotkb_gly", "reported.uniprotkb_gly", "reported_with_glycan.glyconnect" ], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11241288", "type": [ "PubMed" ], "id": "11241288" } ], "title": "Within the hemopoietic system, LAR phosphatase is a T cell lineage-specific adhesion receptor-like protein whose phosphatase activity appears dispensable for T cell development, repertoire selection and function.", "journal": "Eur. J. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Rolink A.G., Kisielow P., Hendriks W.J.A.J., Jankowski A., Terszowski G.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1454056", "type": [ "PubMed" ], "id": "1454056" } ], "title": "Identification and typing of members of the protein-tyrosine phosphatase gene family expressed in mouse brain.", "journal": "Molecular biology reports", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Schepens J, Zeeuwen P, Wieringa B, Hendriks W", "date": "1992" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/1655529", "type": [ "PubMed" ], "id": "1655529" } ], "title": "Cloning, expression and chromosomal localization of a new putative receptor-like protein tyrosine phosphatase.", "journal": "FEBS letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Gebbink MF, van Etten I, Hateboer G, Suijkerbuijk R, Beijersbergen RL, Geurts van Kessel A, Moolenaar WH", "date": "1991" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19349973", "type": [ "PubMed" ], "id": "19349973" } ], "title": "Mass-spectrometric identification and relative quantification of N-linked cell surface glycoproteins.", "journal": "Nat. Biotechnol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Aebersold R., Bausch-Fluck D., Bibel M., Henderson C., O'Brien R., Schiess R., Watts J.D., Wollscheid B.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21402080", "type": [ "PubMed" ], "id": "21402080" } ], "title": "The immunoglobulin-like domains 1 and 2 of the protein tyrosine phosphatase LAR adopt an unusual horseshoe-like conformation.", "journal": "J. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "authors": "Bouyain S., Hammel M., Biersmith B.H., Geisbrecht E.R.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26371508", "type": [ "PubMed" ], "id": "26371508" } ], "title": "The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Bebee TW, Park JW, Sheridan KI, Warzecha CC, Cieply BW, Rohacek AM, Xing Y, Carstens RP", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27074791", "type": [ "PubMed" ], "id": "27074791" } ], "title": "Regulation of Platelet Derived Growth Factor Signaling by Leukocyte Common Antigen-related (LAR) Protein Tyrosine Phosphatase: A Quantitative Phosphoproteomics Study.", "journal": "Molecular & cellular proteomics : MCP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Sarhan AR, Patel TR, Creese AJ, Tomlinson MG, Hellberg C, Heath JK, Hotchin NA, Cunningham DL", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27352860", "type": [ "PubMed" ], "id": "27352860" } ], "title": "LAR protein tyrosine phosphatase regulates focal adhesions through CDK1.", "journal": "Journal of cell science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Sarhan AR, Patel TR, Cowell AR, Tomlinson MG, Hellberg C, Heath JK, Cunningham DL, Hotchin NA", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28637841", "type": [ "PubMed" ], "id": "28637841" } ], "title": "Protein Tyrosine Phosphatase delta Mediates the Sema3A-Induced Cortical Basal Dendritic Arborization through the Activation of Fyn Tyrosine Kinase.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Nakamura F, Okada T, Shishikura M, Uetani N, Taniguchi M, Yagi T, Iwakura Y, Ohshima T, Goshima Y, Strittmatter SM", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2972792", "type": [ "PubMed" ], "id": "2972792" } ], "title": "A new member of the immunoglobulin superfamily that has a cytoplasmic region homologous to the leukocyte common antigen.", "journal": "The Journal of experimental medicine", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Streuli M, Krueger NX, Hall LR, Schlossman SF, Saito H", "date": "1988" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30899004", "type": [ "PubMed" ], "id": "30899004" } ], "title": "Capturing site-specific heterogeneity with large-scale N-glycoproteome analysis.", "journal": "Nature communications", "evidence": [ { "url": "https://glyconnect.expasy.org/browser/proteins/2669", "id": "2669", "database": "GlyConnect" } ], "authors": "Riley NM, Hebert AS, Westphall MS, Coon JJ", "date": "2019" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/7604039", "type": [ "PubMed" ], "id": "7604039" } ], "title": "Capturing genes encoding membrane and secreted proteins important for mouse development.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ], "authors": "Skarnes WC, Moss JE, Hurtley SM, Beddington RS", "date": "1995" } ], "uniprot_ac": "A2A8L5", "site_annotation": [ { "end_pos": 119, "annotation": "n_glycosylation_sequon", "start_pos": 117 }, { "end_pos": 1689, "annotation": "n_glycosylation_sequon", "start_pos": 1687 }, { "end_pos": 1724, "annotation": "n_glycosylation_sequon", "start_pos": 1722 }, { "end_pos": 252, "annotation": "n_glycosylation_sequon", "start_pos": 250 }, { "end_pos": 297, "annotation": "n_glycosylation_sequon", "start_pos": 295 }, { "end_pos": 723, "annotation": "n_glycosylation_sequon", "start_pos": 721 }, { "end_pos": 943, "annotation": "n_glycosylation_sequon", "start_pos": 941 }, { "end_pos": 959, "annotation": "n_glycosylation_sequon", "start_pos": 957 }, { "end_pos": 962, "annotation": "n_glycosylation_sequon", "start_pos": 960 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5#A0A1Y7VNR5-1", "isoform_ac": "A0A1Y7VNR5-1", "locus": { "end_pos": 118236373, "strand": "+", "start_pos": 118277439, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000222620", "id": "ENSMUST00000222620", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000152568", "id": "ENSMUSP00000152568", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A1Y7VNR5-1|PTPRF_MOUSE Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 363, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGGSPIRGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAA" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#A2A8L5-1", "isoform_ac": "A2A8L5-1", "locus": { "end_pos": 118209824, "strand": "+", "start_pos": 118277439, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049074", "id": "ENSMUST00000049074", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000039368", "id": "ENSMUSP00000039368", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A8L5-1|PTPRF_MOUSE Isoform 1 of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKGRTATMLCAAGGNPDPEISWFKDFLPVDPAASNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#F6S1X8-1", "isoform_ac": "F6S1X8-1", "locus": { "end_pos": 118209822, "strand": "+", "start_pos": 118236016, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000124758", "id": "ENSMUST00000124758", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119954", "id": "ENSMUSP00000119954", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6S1X8-1|PTPRF_MOUSE Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1332, "sequence": "XSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSMPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYVFRLAAKNRAGPGEEFEKEITTPEDVPSGFPQNLRVTGLTTSTTELTWDPPVLAERNGHITNYTVVYRDINSQLELQNVTNDTHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#F6Y3V0-1", "isoform_ac": "F6Y3V0-1", "locus": { "end_pos": 118209822, "strand": "+", "start_pos": 118236445, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000150096", "id": "ENSMUST00000150096", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117313", "id": "ENSMUSP00000117313", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6Y3V0-1|PTPRF_MOUSE Computationally mapped isoform of Receptor-type tyrosine-protein phosphatase F OS=Mus musculus OX=10090 GN=Ptprf PE=1 SV=1 CANONICAL=A2A8L5-1", "length": 1291, "sequence": "XSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQANAESDTRIQLSWLLPPQERIVKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEARTAQSMPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWNTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDVLPDTFTLGDKKSYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGSSAPSCPNISSMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPVRGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLANSKAHTSRFVSANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:19268", "resource": "KEGG Pathway", "id": "mmu:19268", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-388844", "resource": "Reactome", "id": "R-MMU-388844", "name": "Receptor-type tyrosine-protein phosphatases" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-8849932", "resource": "Reactome", "id": "R-MMU-8849932", "name": "Synaptic adhesion-like molecules" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "Loss of LAR activity resulted in reduced activity of CDK1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A8L5#function", "annotation": "Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5#function", "id": "A2A8L5", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "Study has identified LAR as a regulator of key signaling pathways, including mTOR and JNK, and has significantly expanded the number of proteins regulated downstream of LAR phosphatase activity.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "annotation": "We show that PTP-3, a LAR homolog in Caenorhabditis elegans, participates in Sema2A-regulated axon guidance. PTPdelta, a member of vertebrate LAR class PTPs, is involved in Sema3A-regulated cortical dendritic growth. In Sema3A signaling, PTPdelta activates Fyn and Src kinases by dephosphorylating their C-terminal Tyr residues.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "id": "NP_035343.2", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "P10586-1", "protein_name": "Receptor-type tyrosine-protein phosphatase F", "sequence": { "length": 1907, "sequence": "MAPEPAPGRTMVPLVPALVMLGLVAGAHGDSKPVFIKVPEDQTGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEEQLPPGFPSIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPATSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGSVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVVRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNSEPVTYYGIQYRAAGTEGPFQEVDGVATTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPPNAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAEVESDTRIQLSWLLPPQERIIMYELVYWAAEDEDQQHKVTFDPTSSYTLEDLKPDTLYRFQLAARSDMGVGVFTPTIEARTAQSTPSAPPQKVMCVSMGSTTVRVSWVPPPADSRNGVITQYSVAYEAVDGEDRGRHVVDGISREHSSWDLVGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVYWKLPVPSKQHGQIRGYQVTYVRLENGEPRGLPIIQDVMLAEAQWRPEESEDYETTISGLTPETTYSVTVAAYTTKGDGARSKPKIVTTTGAVPGRPTMMISTTAMNTALLQWHPPKELPGELLGYRLQYCRADEARPNTIDFGKDDQHFTVTGLHKGTTYIFRLAAKNRAGLGEEFEKEIRTPEDLPSGFPQNLHVTGLTTSTTELAWDPPVLAERNGRIISYTVVFRDINSQQELQNITTDTRFTLTGLKPDTTYDIKVRAWTSKGSGPLSPSIQSRTMPVEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGSSAGGLQHLVSIRTAPDLLPHKPLPASAYIEDGRFDLSMPHVQDPSLVRWFYIVVVPIDRVGGSMLTPRWSTPEELELDELLEAIEQGGEEQRRRRRQAERLKPYVAAQLDVLPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNLEVNKPKNRYANVIAYDHSRVILTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRTATVVMMTRLEEKSRVKCDQYWPARGTETCGLIQVTLLDTVELATYTVRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAATCGHTEVPARNLYAHIQKLGQVPPGESVTAMELEFKLLASSKAHTSRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20623", "id": "20623", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A8L5/", "id": "A2A8L5", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q64604-1", "protein_name": "Receptor-type tyrosine-protein phosphatase F", "sequence": { "length": 1898, "sequence": "MAPEPAPGRRMVPLVPALVMLGLMAGAHGDSKPVFVKVPEDQIGLSGGVASFVCQATGEPKPRITWMKKGKKVSSQRFEVIEFDDGAGSVLRIQPLRVQRDEAIYECTATNSLGEINTSAKLSVLEEDQLPSGFPTIDMGPQLKVVEKARTATMLCAAGGNPDPEISWFKDFLPVDPASSNGRIKQLRSGALQIESSEESDQGKYECVATNSAGTRYSAPANLYVRVRRVAPRFSIPPSSQEVMPGGNVNLTCVAVGAPMPYVKWMMGAEELTKEDEMPVGRNVLELSNVMRSANYTCVAISSLGMIEATAQVTVKALPKPPIDLVVTETTATSVTLTWDSGNTEPVSFYGIQYRAAGTDGPFQEVDGVASTRYSIGGLSPFSEYAFRVLAVNSIGRGPPSEAVRARTGEQAPSSPPRRVQARMLSASTMLVQWEPPEEPNGLVRGYRVYYTPDSRRPLSAWHKHNTDAGLLTTVGSLLPGITYSLRVLAFTAVGDGPPSPTIQVKTQQGVPAQPADFQAKAESDTRIQLSWLLPPQERIIKYELVYWAAEDEGQQHKVTFDPTSSYTLEDLKPDTLYHFQLAARSDLGVGVFTPTVEACTAQSTPSAPPQKVTCVSTGSTTVRVSWVPPPADSRNGIITQYSVAYEAVDGEDRKRHVVDGISREHSSWDLLGLEKWTEYRVWVRAHTDVGPGPESSPVLVRTDEDVPSGPPRKVEVEPLNSTAVHVSWKLPVPNKQHGQIRGYQVTYVRLENGEPRGQPIIQDVMLAEAQETTISGLTPETTYSITVAAYTTKGDGARSKPKVVTTTGAVPGRPTMMVSTTAMHTALLQWHPPKELPGELLGYRLQYRRADEARPNTIDFGKDDQHFTVTGLHKGATYIFRLAAKNRAGPGEEFEKEITTPEDAPSGFPQNLRVTGLTTSTTELAWDPPVLAERNGRITNYTVVYRDINSQHELQNVTGDVHLTLLGLKPDTTYDIKVRAHTSKGAGPLSPSIQSRTMPMEQVFAKNFRVAAAMKTSVLLSWEVPDSYKSAVPFKILYNGQSVEVDGHSMRKLIADLQPNTEYSFVLMNRGTSAGGLQHLVSIRTAPDLLPQKPLPASAFIEDGRFSLSMPQVQDPSLVRWFYIVVVPIDRVGGNLLAPRWSTPEELELDELLEAIEQGEEKQRRRRRQAERLKPYVAAQVDELPETFTLGDKKNYRGFYNRPLSPDLSYQCFVLASLKEPMDQKRYASSPYSDEIVVQVTPAQQQEEPEMLWVTGPVLAVILIILIVIAILLFKRKRTHSPSSKDEQSIGLKDSLLAHSSDPVEMRRLNYQTPGMRDHPPIPITDLADNIERLKANDGLKFSQEYESIDPGQQFTWENSNSEVNKPKNRYANVIAYDHSRVLLTSIDGVPGSDYINANYIDGYRKQNAYIATQGPLPETMGDFWRMVWEQRIATVVMMTRLEEKSRVKCDQYWPARGTETYGLIQVTLVDTVELATYTMRTFALHKSGSSEKRELRQFQFMAWPDHGVPEYPTPILAFLRRVKACNPLDAGPMVVHCSAGVGRTGCFIVIDAMLERMKHEKTVDIYGHVTCMRSQRNYMVQTEDQYVFIHEALLEAAMCGHTEVLARNLYAHIQKLGQVPPGESVTAMELEFKLLAGSKARASRFISANLPCNKFKNRLVNIMPYELTRVCLQPIRGVEGSDYINASFLDGYRQQKAYIATQGPLAESTEDFWRMLWEHNSTIIVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYNMPQYILREFKVTDARDGQSRTIRQFQFTDWPEQGVPKTGEGFIDFIGQVHKTKEQFGQDGPITVHCSAGVGRTGVFITLSIVLERMRYEGVVDMFQTVKTLRTQRPAMVQTEDQYQLCYRAALEYLGSFDHYAT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/20623", "id": "20623", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [ { "sequence_org": "N", "alt_nt": "C", "chr_id": "4", "ref_nt": "T", "chr_pos": "118225931", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/SNP/snp_ref.cgi?type=rs&rs=rs241328477", "id": "rs241328477", "database": "dbSNP" }, { "url": "https://www.ensembl.org/id/rs241328477", "id": "rs241328477", "database": "ENSEMBL" } ], "sequence_mut": "D", "start_pos": 960, "keywords": [ "ebi", "germline" ], "end_pos": 960, "minor_allelic_frequency": "", "annotation": "Germline mutation passed 1 out of 1 filters: n-glyco-sequon-loss (NDT->DDT)." } ], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_035343.2", "ac": "NP_035343.2", "name": "receptor-type tyrosine-protein phosphatase F precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044877", "pmid": "23791195", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "protein-containing complex binding", "id": "GO:0044877" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004721", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "phosphoprotein phosphatase activity", "id": "GO:0004721" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035373", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "chondroitin sulfate proteoglycan binding", "id": "GO:0035373" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042301", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "phosphate ion binding", "id": "GO:0042301" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005158", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "insulin receptor binding", "id": "GO:0005158" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008201", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "heparin binding", "id": "GO:0008201" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050839", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "cell adhesion molecule binding", "id": "GO:0050839" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030971", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "receptor tyrosine kinase binding", "id": "GO:0030971" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005001", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "transmembrane receptor protein tyrosine phosphatase activity", "id": "GO:0005001" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043025", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuronal cell body", "id": "GO:0043025" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043005", "pmid": "11438588", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuron projection", "id": "GO:0043005" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005768", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "endosome", "id": "GO:0005768" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030426", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "growth cone", "id": "GO:0030426" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060076", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "excitatory synapse", "id": "GO:0060076" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0099061", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "integral component of postsynaptic density membrane", "id": "GO:0099061" } ], "total": 10, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048679", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "regulation of axon regeneration", "id": "GO:0048679" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031102", "pmid": "11438588", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "neuron projection regeneration", "id": "GO:0031102" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010975", "pmid": "21976490", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "regulation of neuron projection development", "id": "GO:0010975" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001960", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "negative regulation of cytokine-mediated signaling pathway", "id": "GO:0001960" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046627", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "negative regulation of insulin receptor signaling pathway", "id": "GO:0046627" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035335", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "peptidyl-tyrosine dephosphorylation", "id": "GO:0035335" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007399", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "nervous system development", "id": "GO:0007399" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008285", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "negative regulation of cell population proliferation", "id": "GO:0008285" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016477", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "cell migration", "id": "GO:0016477" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043065", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "positive regulation of apoptotic process", "id": "GO:0043065" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050803", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "regulation of synapse structure or activity", "id": "GO:0050803" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051387", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "negative regulation of neurotrophin TRK receptor signaling pathway", "id": "GO:0051387" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006470", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "protein dephosphorylation", "id": "GO:0006470" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007156", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A8L5", "id": "A2A8L5", "database": "UniProtKB" } ], "name": "homophilic cell adhesion via plasma membrane adhesion molecules", "id": "GO:0007156" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043525", "pmid": "", "evidence": [ { "url": 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