{ "uniprot_canonical_ac": "A2A891-1", "ptm_annotation": [], "sequence": { "header": "sp|A2A891-1|CMTA1_MOUSE Isoform 1 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 1682, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGSSVHHKCNSAKHRIISPKVEPRAGGYGGHSEVQHNDVSEGKHEPSHGRSTSREKRNGKVAKPALLHQNSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSDSLSMLPANVSEELVLSTTLDGGRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNIRHSPPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAASSSLTLTAAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYASSFSQTGHSPHIHQTPSPSFFLQDASKPLPLEQNTHSSLSESGAAFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMAAEGEVTMETSQAAEGNEVLLKSGELQACGSEHYLQPETNGVIRSAGGVPLLPSNVVQGLYPVAQPSLGNSSNMELSLDHFDISFSNQFSDLINDFISVEGGSGTIYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSSAEGGPSTMAYMHVAEVVSAASAQGALGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDYPAPKKHKLNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQPSPETISPSEGVREYSREAAPPTPETAASQASASQPVVKWSAKDLYIGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPLTPSSNASLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" }, "uniprot_id": "CMTA1_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10512203", "type": [ "PubMed" ], "id": "10512203" } ], "title": "Exchangeable gene trap using the Cre/mutated lox system.", "journal": "Cellular and molecular biology (Noisy-le-Grand, France)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Araki K, Imaizumi T, Sekimoto T, Yoshinobu K, Yoshimuta J, Akizuki M, Miura K, Araki M, Yamamura K", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22357600", "type": [ "PubMed" ], "id": "22357600" } ], "title": "The splicing regulator Rbfox2 is required for both cerebellar development and mature motor function.", "journal": "Genes & development", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Gehman LT, Meera P, Stoilov P, Shiue L, O'Brien JE, Meisler MH, Ares M Jr, Otis TS, Black DL", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22715383", "type": [ "PubMed" ], "id": "22715383" } ], "title": "Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage.", "journal": "PloS one", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Muller-Borer B, Esch G, Aldina R, Woon W, Fox R, Bursac N, Hiller S, Maeda N, Shepherd N, Jin JP, Hutson M, Anderson P, Kirby ML, Malouf NN", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/25049392", "type": [ "PubMed" ], "id": "25049392" } ], "title": "Ataxia and Purkinje cell degeneration in mice lacking the CAMTA1 transcription factor.", "journal": "Proceedings of the National Academy of Sciences of the United States of America", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Long C, Grueter CE, Song K, Qin S, Qi X, Kong YM, Shelton JM, Richardson JA, Zhang CL, Bassel-Duby R, Olson EN", "date": "2014" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27194798", "type": [ "PubMed" ], "id": "27194798" } ], "title": "The calmodulin-binding transcription activator CAMTA1 is required for long-term memory formation in mice.", "journal": "Learning & memory (Cold Spring Harbor, N.Y.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "authors": "Bas-Orth C, Tan YW, Oliveira AM, Bengtson CP, Bading H", "date": "2016" } ], "uniprot_ac": "A2A891", "site_annotation": [ { "end_pos": 106, "annotation": "n_glycosylation_sequon", "start_pos": 104 }, { "end_pos": 1473, "annotation": "n_glycosylation_sequon", "start_pos": 1471 }, { "end_pos": 235, "annotation": "n_glycosylation_sequon", "start_pos": 233 }, { "end_pos": 341, "annotation": "n_glycosylation_sequon", "start_pos": 339 }, { "end_pos": 461, "annotation": "n_glycosylation_sequon", "start_pos": 459 }, { "end_pos": 47, "annotation": "n_glycosylation_sequon", "start_pos": 45 }, { "end_pos": 758, "annotation": "n_glycosylation_sequon", "start_pos": 756 }, { "end_pos": 905, "annotation": "n_glycosylation_sequon", "start_pos": 903 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A891#A2A891-1", "isoform_ac": "A2A891-1", "locus": { "end_pos": 151062826, "strand": "+", "start_pos": 151861669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000049790", "id": "ENSMUST00000049790", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000054804", "id": "ENSMUSP00000054804", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A891-1|CMTA1_MOUSE Isoform 1 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 1682, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGSSVHHKCNSAKHRIISPKVEPRAGGYGGHSEVQHNDVSEGKHEPSHGRSTSREKRNGKVAKPALLHQNSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSDSLSMLPANVSEELVLSTTLDGGRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNIRHSPPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAASSSLTLTAAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYASSFSQTGHSPHIHQTPSPSFFLQDASKPLPLEQNTHSSLSESGAAFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMAAEGEVTMETSQAAEGNEVLLKSGELQACGSEHYLQPETNGVIRSAGGVPLLPSNVVQGLYPVAQPSLGNSSNMELSLDHFDISFSNQFSDLINDFISVEGGSGTIYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSSAEGGPSTMAYMHVAEVVSAASAQGALGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDYPAPKKHKLNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQPSPETISPSEGVREYSREAAPPTPETAASQASASQPVVKWSAKDLYIGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPLTPSSNASLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#A2A891-2", "isoform_ac": "A2A891-2", "locus": { "end_pos": 151062826, "strand": "+", "start_pos": 151861669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000097774", "id": "ENSMUST00000097774", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095381", "id": "ENSMUSP00000095381", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A891-2|CMTA1_MOUSE Isoform 2 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 1675, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGSSVHHKCNSAKHRIISPKVEPRAGGYGGHSEVQHNDVSEGKHEPSHGRSTSREKRNGKVAKPALLHQNSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSDSLSMLPANVSEELVLSTTLDGGRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNIRHSPPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAASSSLTLTAAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYASSFSQTGHSPHIHQTPSPSFFLQDASKPLPLEQNTHSSLSESGAAFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMAAEGEVTMETSQAAEGNEVLLKSGELQACGSEHYLQPETNGVIRSAGGVPLLPSNVVQGLYPVAQPSLGNSSNMELSLDHFDISFSNQFSDLINDFISVEGGSGTIYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSSAEGGPSTMAYMHVAEVVSAASAQGALGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDYPAPKKHKLNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQPSPETISPSEGVREYSREAAPPTPETAASQASASQPVVKWSAKDLYIGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPLTPSSNASLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#A2A891-3", "isoform_ac": "A2A891-3", "locus": { "end_pos": 151062826, "strand": "+", "start_pos": 151088967, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105668", "id": "ENSMUST00000105668", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101293", "id": "ENSMUSP00000101293", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A891-3|CMTA1_MOUSE Isoform 3 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 591, "sequence": "MSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPLTPSSNASLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#A2A891-4", "isoform_ac": "A2A891-4", "locus": { "end_pos": 151062795, "strand": "+", "start_pos": 151088967, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105670", "id": "ENSMUST00000105670", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101295", "id": "ENSMUSP00000101295", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A891-4|CMTA1_MOUSE Isoform 4 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 584, "sequence": "MSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPLTPSSNASLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHRVKELKKAKELEDIQQHPLAM" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#A2A891-5", "isoform_ac": "A2A891-5", "locus": {}, "sequence": { "header": "sp|A2A891-5|CMTA1_MOUSE Isoform 5 of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 1661, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGSSVHHKCNSAKHRIISPKVEPRAGGYGGHSEVQHNDVSEGKHEPSHGRSTSREKRNGKVAKPALLHQNSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSDSLSMLPANVSEELVLSTTLDGGRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNIRHSPPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAASSSLTLTAAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYASSFSQTGHSPHIHQTPSPSFFLQDASKPLPLEQNTHSSLSESGAAFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMAAEGEVTMETSQAAEGNEVLLKSGELQACGSEHYLQPETNGVIRSAGGVPLLPSNVVQGLYPVAQPSLGNSSNMELSLDHFDISFSNQFSDLINDFISVEGGSGTIYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSSAEGGPSTMAYMHVAEVVSAASAQGALGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQASRIHCAPSEEPTTDSWMAQWQREAMSPPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDYPAPKKHKLNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQPSPETISPSEGVREYSREAAPPTPETAASQASASQPVVKWSAKDLYIGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEDCPQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSALERTDPATISSTMSWLASYLADADRLPSAAHISLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHRVKELKKAKELEDIQQHPLAM" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#B0QZL6-1", "isoform_ac": "B0QZL6-1", "locus": { "end_pos": 151086124, "strand": "+", "start_pos": 151088967, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000131948", "id": "ENSMUST00000131948", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000118969", "id": "ENSMUSP00000118969", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|B0QZL6-1|CMTA1_MOUSE Computationally mapped isoform of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 75, "sequence": "MSILERLEQMERRMAEMTGSQQHKQASGGGGSGSGSGSGAGGGQAQCASGAGTLGSCFESRVVVVCEKMMSRACW" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#Q3TYE0-1", "isoform_ac": "Q3TYE0-1", "locus": { "end_pos": 151792497, "strand": "+", "start_pos": 151861669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000153938", "id": "ENSMUST00000153938", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000134684", "id": "ENSMUSP00000134684", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q3TYE0-1|CMTA1_MOUSE Computationally mapped isoform of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 80, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNERS" } }, { "url": "https://www.uniprot.org/uniprot/A2A891#Z4YMK8-1", "isoform_ac": "Z4YMK8-1", "locus": { "end_pos": 151062795, "strand": "+", "start_pos": 151079793, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140030", "id": "ENSMUST00000140030", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119067", "id": "ENSMUSP00000119067", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YMK8-1|CMTA1_MOUSE Computationally mapped isoform of Calmodulin-binding transcription activator 1 OS=Mus musculus OX=10090 GN=Camta1 PE=2 SV=1 CANONICAL=A2A891-1", "length": 238, "sequence": "SSALERTDPATISSTMSWLASYLADADRLPSAAHISLSPAGSPVSEVAFEKPSLPSAADWSEFLSASTSEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHRVKELKKAKELEDIQQHPLAM" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100072", "resource": "KEGG Pathway", "id": "mmu:100072", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "annotation": "CAMTA1 plays an essential role in the control of Purkinje cell function and survival.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "annotation": "Cell-cell communications between the stem cells and adjacent cardiomyocytes induce Ca(2+) signals that activate a myocardial gene program in the stem cells via a novel and early Ca(2+)-dependent intermediate, up-regulation of CAMTA1.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "annotation": "Study provides experimental evidence that confirms previous human genetic studies and establishes calmodulin-binding transcription activator, CAMTA1 as a regulator of long-term memory formation. Publication Status: Online-Only", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A891#function", "annotation": "Transcriptional activator.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891#function", "id": "A2A891", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "F1M4M6-1", "protein_name": "Calmodulin-binding transcription activator 1", "sequence": { "length": 1609, "sequence": "QEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVEALYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGSGQQRHHKCNRAKHRIISQKCEPAGGYGGHSEVQHNACVEGKHEPSHSRSTSREKRNGKVKPALLHQNSTEVSSTNQEVPDTTQSSPVSISSGVNSDPDMVDSPVVTGVSSMAVASVMGGLSQSATVFMSEVTNGGRVHHVPTAAPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSDSLSMLPANVSEELVLSTTLDGGRKIPETAMNFDPDCFLNNPKQGQTYGGGGLKAEMVSTNIRHSPPAERSFGFTSVLTKEIKTEDTSFEQQMAKEAAYSSSAAAAAAAAAAAASSSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPLEQNTHGSLSESGAAFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQALAAEGEVTMETSQAAEGSEVLLKSGELQTCGSEHYLQPETNGVIRSAGGVPLLPSNVVQGLYPVAQPSLGTTSNMELSLDHFDISFSNQFSDLINDFISVEGGSGTIYGHQLVSGDSAALSQSEDGARAPFTQAEMCIPCCSPQQGSLQLSSAEGGPSTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASSGGSGSGGSSSGSGSGGGQAQCASGAGTLGSCFESRVVVVCEKMMNRTCWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQTSRIHCAPSEEPSTDSWMAQWPREAVSSPEIPKGVTVIASTNPELRRPRSEPSNYYSTEGHKDYPAPKKHKLNPESFQARQEKLLCTALSLEQPNIRKQSPRSKQSSPETISPSEGVRGYSREASPPTPETAASQASASQPVVKWSSKDPYIGVSTVQVTGNPKGTSVVKDAAPSQVRPREPMSVLMLANREVVNTEMGAYRDRTEHEECSQPMDDIQVNMMTLAEHIIEATPDRIKQETFVPLESASERTDPATISSTMSWLASYLADADRLPSAAHIRSAYTEPMTPSSNASLSPTGSPVSEVAFEKPSLPSAADWSEFLSASASEKVESELAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQLTWIALKYALYKKMTQAAILIQSKFRSYYEQKRFQQSRRAAVLIQNFYRSYKKCGRRRPARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A891/", "id": "A2A891", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9Y6Y1-1", "protein_name": "Calmodulin-binding transcription activator 1", "sequence": { "length": 1673, "sequence": "MWRAEGKWLPKTSRKSVSQSVFCGTSTYCVLNTVPPIEDDHGNSNSSHVKIFLPKKLLECLPKCSSLPKERHRWNTNEEIAAYLITFEKHEEWLTTSPKTRPQNGSMILYNRKKVKYRKDGYCWKKRKDGKTTREDHMKLKVQGVECLYGCYVHSSIIPTFHRRCYWLLQNPDIVLVHYLNVPAIEDCGKPCGPILCSINTDKKEWAKWTKEELIGQLKPMFHGIKWTCSNGNSSSGFSVEQLVQQILDSHQTKPQPRTHNCLCTGSLGAGGSVHHKCNSAKHRIISPKVEPRTGGYGSHSEVQHNDVSEGKHEHSHSKGSSREKRNGKVAKPVLLHQSSTEVSSTNQVEVPDTTQSSPVSISSGLNSDPDMVDSPVVTGVSGMAVASVMGSLSQSATVFMSEVTNEAVYTMSPTAGPNHHLLSPDASQGLVLAVSSDGHKFAFPTTGSSESLSMLPTNVSEELVLSTTLDGGRKIPETTMNFDPDCFLNNPKQGQTYGGGGLKAEMVSSNIRHSPPGERSFSFTTVLTKEIKTEDTSFEQQMAKEAYSSSAAAVAASSLTLTAGSSLLPSGGGLSPSTTLEQMDFSAIDSNKDYTSSFSQTGHSPHIHQTPSPSFFLQDASKPLPVEQNTHSSLSDSGGTFVMPTVKTEASSQTSSCSGHVETRIESTSSLHLMQFQANFQAMTAEGEVTMETSQAAEGSEVLLKSGELQACSSEHYLQPETNGVIRSAGGVPILPGNVVQGLYPVAQPSLGNASNMELSLDHFDISFSNQFSDLINDFISVEGGSSTIYGHQLVSGDSTALSQSEDGARAPFTQAEMCLPCCSPQQGSLQLSSSEGGASTMAYMHVAEVVSAASAQGTLGMLQQSGRVFMVTDYSPEWSYPEGGVKVLITGPWQEASNNYSCLFDQISVPASLIQPGVLRCYCPAHDTGLVTLQVAFNNQIISNSVVFEYKARALPTLPSSQHDWLSLDDNQFRMSILERLEQMERRMAEMTGSQQHKQASGGGSSGGGSGSGNGGSQAQCASGTGALGSCFESRVVVVCEKMMSRACWAKSKHLIHSKTFRGMTLLHLAAAQGYATLIQTLIKWRTKHADSIDLELEVDPLNVDHFSCTPLMWACALGHLEAAVVLYKWDRRAISIPDSLGRLPLGIARSRGHVKLAECLEHLQRDEQAQLGQNPRIHCPASEEPSTESWMAQWHSEAISSPEIPKGVTVIASTNPELRRPRSEPSNYYSSESHKDYPAPKKHKLNPEYFQTRQEKLLPTALSLEEPNIRKQSPSSKQSVPETLSPSEGVRDFSRELSPPTPETAAFQASGSQPVGKWNSKDLYIGVSTVQVTGNPKGTSVGKEAAPSQVRPREPMSVLMMANREVVNTELGSYRDSAENEECGQPMDDIQVNMMTLAEHIIEATPDRIKQENFVPMESSGLERTDPATISSTMSWLASYLADADCLPSAAQIRSAYNEPLTPSSNTSLSPVGSPVSEIAFEKPNLPSAADWSEFLSASTSEKVENEFAQLTLSDHEQRELYEAARLVQTAFRKYKGRPLREQQEVAAAVIQRCYRKYKQYALYKKMTQAAILIQSKFRSYYEQKKFQQSRRAAVLIQKYYRSYKKCGKRRQARRTAVIVQQKLRSSLLTKKQDQAARKIMRFLRRCRHSPLVDHRLYKRSERIEKGQGT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/18942", "id": "18942", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A891/", "id": "A2A891", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "ac": "NP_001075026.1", "name": "calmodulin-binding transcription activator 1 isoform 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "pmid": "25049392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000981", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity, RNA polymerase II-specific", "id": "GO:0000981" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050885", "pmid": "25049392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "neuromuscular process controlling balance", "id": "GO:0050885" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035307", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "positive regulation of protein dephosphorylation", "id": "GO:0035307" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0070886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "id": "A2A891", "database": "UniProtKB" } ], "name": "positive regulation of calcineurin-NFAT signaling cascade", "id": "GO:0070886" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A891", "type": "synonym", "resource": "RefSeq", "name": "1810059M14Rik; 2310058O09Rik; AI316882; AW987475; mKIAA0833" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A891", "type": "synonym", "resource": "RefSeq", "name": "Camta1" }, { "url": "https://www.uniprot.org/uniprot/A2A891", "type": "recommended", "resource": "UniProtKB", "name": "Camta1" }, { "url": "https://www.uniprot.org/uniprot/A2A891", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa0833" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000014592", "id": "ENSMUSG00000014592", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/100072", "id": "100072", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A891*", "id": "A2A891", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000048", "id": "IPR000048", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002110", "id": "IPR002110", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002909", "id": "IPR002909", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR005559", "id": "IPR005559", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", "id": "IPR013783", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR014756", "id": "IPR014756", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020683", "id": "IPR020683", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036770", "id": "IPR036770", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039033", "id": "IPR039033", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:100072", "id": "mmu:100072", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2140230", "id": "2140230", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/GKNEHSH/", "id": "GKNEHSH", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=315169at2759", "id": "315169at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR23335:SF11", "id": "PTHR23335:SF11", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF01833", "id": "PF01833", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF03859", "id": "PF03859", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A891", "id": "PR_A2A891", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001075026.1", "id": "NP_001075026.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 184319.0, "chemical_mass": 184319.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "name": "Camta1", "locus": { "end_pos": 150917322, "strand": "-", "start_pos": 151861876, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000014592", "id": "ENSMUSG00000014592", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2A891", "type": "recommended", "resource": "UniProtKB", "name": "Calmodulin-binding transcription activator 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A891", "type": "synonym", "resource": "RefSeq", "name": "calmodulin-binding transcription activator 1 isoform 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A891", "type": "synonym", "resource": "RefSeq", "name": "camta1" } ] }