{
    "uniprot_canonical_ac": "A2A825-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A2A825-1|CPLN2_MOUSE Isoform 1 of Ciliogenesis and planar polarity effector 2  OS=Mus musculus OX=10090 GN=Cplane2 PE=3 SV=1 CANONICAL=A2A825-1", 
        "length": 258, 
        "sequence": "MARPPMHGSVIVPDWHETVEGKEYLACILRKNRRREFGLLERPVLPPSVVIDTASYKIFVSGKSGVGKTALVAKLAGLEVPIVHHETTGIQTTVVFWPAKLKASDCVVMFRFEFWDCGESALKKFDHMLPACKENADAFLFLFSFTDRASFEDLPGQLTRVAGEAPGLVKIVIGSKFDQYMHTDVPARDLTAFRQAWELPLFRVKSVPGRRLADGRTLDGRAGLADTAHVLNGLAEQLWHQDQVAAGLLPSSPESAPG"
    }, 
    "uniprot_id": "CPLN2_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A825", 
                    "id": "A2A825", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29038301", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "29038301"
                }
            ], 
            "title": "The small GTPase RSG1 controls a final step in primary cilia initiation.", 
            "journal": "The Journal of cell biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643.1", 
                    "id": "NP_001074643.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Agbu SO, Liang Y, Liu A, Anderson KV", 
            "date": "2018"
        }
    ], 
    "uniprot_ac": "A2A825", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A825#A2A825-1", 
            "isoform_ac": "A2A825-1", 
            "locus": {
                "end_pos": 141214361, 
                "strand": "-", 
                "start_pos": 141220083, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000097813", 
                        "id": "ENSMUST00000097813", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000095422", 
                        "id": "ENSMUSP00000095422", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2A825-1|CPLN2_MOUSE Isoform 1 of Ciliogenesis and planar polarity effector 2  OS=Mus musculus OX=10090 GN=Cplane2 PE=3 SV=1 CANONICAL=A2A825-1", 
                "length": 258, 
                "sequence": "MARPPMHGSVIVPDWHETVEGKEYLACILRKNRRREFGLLERPVLPPSVVIDTASYKIFVSGKSGVGKTALVAKLAGLEVPIVHHETTGIQTTVVFWPAKLKASDCVVMFRFEFWDCGESALKKFDHMLPACKENADAFLFLFSFTDRASFEDLPGQLTRVAGEAPGLVKIVIGSKFDQYMHTDVPARDLTAFRQAWELPLFRVKSVPGRRLADGRTLDGRAGLADTAHVLNGLAEQLWHQDQVAAGLLPSSPESAPG"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76166", 
            "resource": "KEGG Pathway", 
            "id": "mmu:76166", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A825#function", 
            "annotation": "Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells (By similarity).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2A825#function", 
                    "id": "A2A825", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643.1", 
            "annotation": "RSG1 localizes to the mother centriole in a process that depends on tau tubulin kinase 2 (TTBK2), the CPLANE complex protein Inturned (INTU), and its own GTPase activity. The data suggest a specific role for RSG1 in the final maturation of the mother centriole and ciliary vesicle that allows extension of the ciliary axoneme.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643.1", 
                    "id": "NP_001074643.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "A0A0G2K9E9-1", 
            "protein_name": "Similar to novel protein (Predicted), isoform CRA_b", 
            "sequence": {
                "length": 258, 
                "sequence": "MARLPMHGSVIVPDWHETVEGKEYLACILRKNRRREFGLLERPVLPPSVVIDTASYKIFVSGKSGVGKTALVAKLAGLEVPVVHHETTGIQTTVVFWPAKLKASGRVVMFRFEFWDCGESALKKFDHILPACKEKADAFLFLFSFTDRASFEDLPGQLSRVAGEAPGVVKIVIGSKFDQYMHTDVPERDLTAFRQAWELPLFRVKSVPGRRLADGRTLDGRAGLADTAHVLNGLAEQLWHQDQVAAGLLPSSPENAPG"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2A825/", 
                    "id": "A2A825", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q9BU20-1", 
            "protein_name": "Ciliogenesis and planar polarity effector 2", 
            "sequence": {
                "length": 258, 
                "sequence": "MARPPVPGSVVVPNWHESAEGKEYLACILRKNRRRVFGLLERPVLLPPVSIDTASYKIFVSGKSGVGKTALVAKLAGLEVPVVHHETTGIQTTVVFWPAKLQASSRVVMFRFEFWDCGESALKKFDHMLLACMENTDAFLFLFSFTDRASFEDLPGQLARIAGEAPGVVRMVIGSKFDQYMHTDVPERDLTAFRQAWELPLLRVKSVPGRRLADGRTLDGRAGLADVAHILNGLAEQLWHQDQVAAGLLPNPPESAPE"
            }, 
            "evidence": [
                {
                    "url": "https://omabrowser.org/oma/group/A2A825/", 
                    "id": "A2A825", 
                    "database": "OMA"
                }, 
                {
                    "url": "http://www.informatics.jax.org/homology/12793", 
                    "id": "12793", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }, 
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643.1", 
        "ac": "NP_001074643.1", 
        "name": "ciliogenesis and planar polarity effector 2", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003924", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTPase activity", 
                        "id": "GO:0003924"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005525", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "GTP binding", 
                        "id": "GO:0005525"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleoplasm", 
                        "id": "GO:0005654"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036064", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ciliary basal body", 
                        "id": "GO:0036064"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein transport", 
                        "id": "GO:0015031"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cilium assembly", 
                        "id": "GO:0060271"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034613", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cellular protein localization", 
                        "id": "GO:0034613"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "exocytosis", 
                        "id": "GO:0006887"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031338", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of vesicle fusion", 
                        "id": "GO:0031338"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017157", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2A825", 
                                "id": "A2A825", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of exocytosis", 
                        "id": "GO:0017157"
                    }
                ], 
                "total": 6, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A825", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "6330545A04Rik; b2b2804Clo; b2b2827Clo; Gm723; Rsg1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A825", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Cplane2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Cplane2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Gm723"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Rsg1"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000073733", 
            "id": "ENSMUSG00000073733", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/76166", 
            "id": "76166", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001806", 
            "id": "IPR001806", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR027417", 
            "id": "IPR027417", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR039677", 
            "id": "IPR039677", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:76166", 
            "id": "mmu:76166", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1923416", 
            "id": "1923416", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/QLWDCGE/", 
            "id": "QLWDCGE", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1324082at2759", 
            "id": "1324082at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR14983", 
            "id": "PTHR14983", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00071", 
            "id": "PF00071", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A825", 
            "id": "PR_A2A825", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074643.1", 
            "id": "NP_001074643.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 28422.0, 
        "chemical_mass": 28422.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "name": "Cplane2", 
            "locus": {}
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ciliogenesis and planar polarity effector 2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2A825", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "REM2- and Rab-like small GTPase 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A825", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "ciliogenesis and planar polarity effector 2"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A2A825", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "miro domain-containing protein C1orf89 homolog; REM2- and Rab-like small GTPase 1; REM2 and RAB-like small GTPase 1"
        }
    ]
}