{ "uniprot_canonical_ac": "A2A7B5-1", "ptm_annotation": [], "sequence": { "header": "tr|A2A7B5-1|A2A7B5_MOUSE Isoform 1 of PR domain-containing 2, with ZNF domain OS=Mus musculus OX=10090 GN=Prdm2 PE=1 SV=1 CANONICAL=A2A7B5-1", "length": 1709, "sequence": "MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRRGKKKSQENKNKGVRTQAAARKASELDSTSANMRGSAEGPKEEDERPLASAPEQPALLPEVVSQDAVPQVAIPLPACESQPGADGKQEVTDCEVNNMKEEEEEEEEELEEEEEEEELGEDGEEEADMPNESSVKEPEIRCEEKPEDLLEEPRSVPTETSEGSPGATPPPHAPRAREEANGEGLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCGKPFGTQINRRRHERRHETGLKRRPSMALQSSEDPDDGKGENVTSKDESSPPQLGQDCLILNSEKTSQEILNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEDGDADDVYIMDISSNISENLNYYIDGKIQTNNSTSDCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQGSVTDDLLKESPSSTNCESKKRRTASPPVLPKIKAETDSDSTAPSCSLSLPLSISTTEVVSFHKEKGVYLSSKLKQLLQTQDKLTPPAGISTAEIPKLGPVCVSAPASMLAVTSSRFKRRTSSPPSSPQHSPALRDFGKQSDGKAAWTDTALTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDEYKISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSEGKEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTESTPEATRSPSPCKSPDTQPDPELATDSSCSAPTAESPPEVVGPSSPPLQAASLSSGQLPPLLIPTEPSSPPPCPPVLTVATPPPPLLPTVPLPNPSCDASPQQCPSPFSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSFSSSSCSSSSPSPPPLSAVSSVVSSGDNLEASLPAITLKQEESESEGLKRKEEAPAAGGQSAVQETFSRNFVCNVCASPFLSIKDLTKHLSVHAEEWPFKCEFCVQLFKGKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDELCTHHEFESGTLRPQNFTDPSKAHVEHMPSLPEEPAEASREEELNDSSEELYTTIKIMASGIKTKEPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKSVDNMPELHKHILACASASDKKRYTPKKNPVPLRQTVQPKNGVLVLDNSGKNAFRRMGQPKRLSFNVELSKMSPNKLKLNALKKKNQLVQKAILQKNRSAKQKADLRDTSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHTSSASSDRNSSSNPRRRTADTEIKMQSMQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAASVKSKKASSSSLRNSSPVRMAKITHVEGKKSKAVAKSHSTQLSSKASRSLHVKVQKSKAVLQSKTALASKKRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKDLSYSLRLASRCASSTAPYITRQCRKVKAAAATQFQGPFFKE" }, "uniprot_id": "A2A7B5_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15282304", "type": [ "PubMed" ], "id": "15282304" } ], "title": "A histone methyltransferase is required for maximal response to female sex hormones.", "journal": "Molecular and cellular biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Carling T, Kim KC, Yang XH, Gu J, Zhang XK, Huang S", "date": "2004" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20417662", "type": [ "PubMed" ], "id": "20417662" } ], "title": "Retinoblastoma protein-interacting zinc finger 1 (RIZ1) participates in RANKL-induced osteoclast formation via regulation of NFATc1 expression.", "journal": "Immunology letters", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20557878", "type": [ "PubMed" ], "id": "20557878" } ], "title": "Retinoblastoma protein-interacting zinc finger 1, a tumor suppressor, augments lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation.", "journal": "Cellular immunology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Noman AS, Koide N, Iftakhar-E-Khuda I, Dagvadorj J, Tumurkhuu G, Naiki Y, Komatsu T, Yoshida T, Yokochi T", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23333759", "type": [ "PubMed" ], "id": "23333759" } ], "title": "Predominant expression of H3K9 methyltransferases in prehypertrophic and hypertrophic chondrocytes during mouse growth plate cartilage development.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Ideno H, Shimada A, Imaizumi K, Kimura H, Abe M, Nakashima K, Nifuji A", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26709097", "type": [ "PubMed" ], "id": "26709097" } ], "title": "Tumor suppressor RIZ1 in obesity and the PI3K/AKT/mTOR pathway.", "journal": "Obesity (Silver Spring, Md.)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "authors": "Xie X, Man X, Zhu Z, Yuan D, Huang S", "date": "2016" } ], "uniprot_ac": "A2A7B5", "site_annotation": [ { "end_pos": 1008, "annotation": "n_glycosylation_sequon", "start_pos": 1006 }, { "end_pos": 1227, "annotation": "n_glycosylation_sequon", "start_pos": 1225 }, { "end_pos": 1256, "annotation": "n_glycosylation_sequon", "start_pos": 1254 }, { "end_pos": 1312, "annotation": "n_glycosylation_sequon", "start_pos": 1310 }, { "end_pos": 1430, "annotation": "n_glycosylation_sequon", "start_pos": 1428 }, { "end_pos": 1501, "annotation": "n_glycosylation_sequon", "start_pos": 1499 }, { "end_pos": 1568, "annotation": "n_glycosylation_sequon", "start_pos": 1566 }, { "end_pos": 299, "annotation": "n_glycosylation_sequon", "start_pos": 297 }, { "end_pos": 435, "annotation": "n_glycosylation_sequon", "start_pos": 433 }, { "end_pos": 465, "annotation": "n_glycosylation_sequon", "start_pos": 463 }, { "end_pos": 558, "annotation": "n_glycosylation_sequon", "start_pos": 556 }, { "end_pos": 574, "annotation": "n_glycosylation_sequon", "start_pos": 572 }, { "end_pos": 575, "annotation": "n_glycosylation_sequon", "start_pos": 573 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5#A2A7B5-1", "isoform_ac": "A2A7B5-1", "locus": { "end_pos": 143111660, "strand": "+", "start_pos": 143194669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105778", "id": "ENSMUST00000105778", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101404", "id": "ENSMUSP00000101404", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A7B5-1|A2A7B5_MOUSE Isoform 1 of PR domain-containing 2, with ZNF domain OS=Mus musculus OX=10090 GN=Prdm2 PE=1 SV=1 CANONICAL=A2A7B5-1", "length": 1709, "sequence": "MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRRGKKKSQENKNKGVRTQAAARKASELDSTSANMRGSAEGPKEEDERPLASAPEQPALLPEVVSQDAVPQVAIPLPACESQPGADGKQEVTDCEVNNMKEEEEEEEEELEEEEEEEELGEDGEEEADMPNESSVKEPEIRCEEKPEDLLEEPRSVPTETSEGSPGATPPPHAPRAREEANGEGLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCGKPFGTQINRRRHERRHETGLKRRPSMALQSSEDPDDGKGENVTSKDESSPPQLGQDCLILNSEKTSQEILNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEDGDADDVYIMDISSNISENLNYYIDGKIQTNNSTSDCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQGSVTDDLLKESPSSTNCESKKRRTASPPVLPKIKAETDSDSTAPSCSLSLPLSISTTEVVSFHKEKGVYLSSKLKQLLQTQDKLTPPAGISTAEIPKLGPVCVSAPASMLAVTSSRFKRRTSSPPSSPQHSPALRDFGKQSDGKAAWTDTALTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDEYKISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSEGKEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTESTPEATRSPSPCKSPDTQPDPELATDSSCSAPTAESPPEVVGPSSPPLQAASLSSGQLPPLLIPTEPSSPPPCPPVLTVATPPPPLLPTVPLPNPSCDASPQQCPSPFSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSFSSSSCSSSSPSPPPLSAVSSVVSSGDNLEASLPAITLKQEESESEGLKRKEEAPAAGGQSAVQETFSRNFVCNVCASPFLSIKDLTKHLSVHAEEWPFKCEFCVQLFKGKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDELCTHHEFESGTLRPQNFTDPSKAHVEHMPSLPEEPAEASREEELNDSSEELYTTIKIMASGIKTKEPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKSVDNMPELHKHILACASASDKKRYTPKKNPVPLRQTVQPKNGVLVLDNSGKNAFRRMGQPKRLSFNVELSKMSPNKLKLNALKKKNQLVQKAILQKNRSAKQKADLRDTSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHTSSASSDRNSSSNPRRRTADTEIKMQSMQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAASVKSKKASSSSLRNSSPVRMAKITHVEGKKSKAVAKSHSTQLSSKASRSLHVKVQKSKAVLQSKTALASKKRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKDLSYSLRLASRCASSTAPYITRQCRKVKAAAATQFQGPFFKE" } }, { "url": "https://www.uniprot.org/uniprot/A2A7B5#A2A7B7-1", "isoform_ac": "A2A7B7-1", "locus": { "end_pos": 143162057, "strand": "+", "start_pos": 143194669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000154280", "id": "ENSMUST00000154280", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117741", "id": "ENSMUSP00000117741", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2A7B7-1|A2A7B5_MOUSE Computationally mapped isoform of PR domain-containing 2, with ZNF domain OS=Mus musculus OX=10090 GN=Prdm2 PE=1 SV=1 CANONICAL=A2A7B5-1", "length": 169, "sequence": "MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRR" } }, { "url": "https://www.uniprot.org/uniprot/A2A7B5#Q8C2W5-1", "isoform_ac": "Q8C2W5-1", "locus": { "end_pos": 143162081, "strand": "+", "start_pos": 143194669, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000134791", "id": "ENSMUST00000134791", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000116458", "id": "ENSMUSP00000116458", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q8C2W5-1|A2A7B5_MOUSE Computationally mapped isoform of PR domain-containing 2, with ZNF domain OS=Mus musculus OX=10090 GN=Prdm2 PE=1 SV=1 CANONICAL=A2A7B5-1", "length": 152, "sequence": "MHQNTESVAVTETLAEVPEHVLRGLPEEVRLLPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110593", "resource": "KEGG Pathway", "id": "mmu:110593", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "annotation": "Data suggest that the histone methyltransferase RIZ1 is required for estrogen response in female reproductive tissues and that estrogen-bound estrogen receptors may turn a transcriptional repressor into a coactivator.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "annotation": "Prevents lipopolysaccharide-induced proinflammatory cytokine production via enhancing nuclear factor-kappaB activation", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "annotation": "RIZ1 is an important regulator of both Akt3 transcription and AKT phosphorylation and suggest a role for RIZ1 in HF-induced obesity and the AKT pathway", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "annotation": "RIZ1 might participate osteoclast formation through the regulation of NFATc1 expression.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q13029-1", "protein_name": "PR domain zinc finger protein 2", "sequence": { "length": 1718, "sequence": "MNQNTTEPVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVKNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRKGKKKSQENKNKGNKIQDIQLKTSEPDFTSANMRDSAEGPKEDEEKPSASALEQPATLQEVASQEVPPELATPAPAWEPQPEPDERLEAAACEVNDLGEEEEEEEEEDEEEEEDDDDDELEDEGEEEASMPNENSVKEPEIRCDEKPEDLLEEPKTTSEETLEDCSEVTPAMQIPRTKEEANGDVFETFMFPCQHCERKFTTKQGLERHMHIHISTVNHAFKCKYCGKAFGTQINRRRHERRHEAGLKRKPSQTLQPSEDLADGKASGENVASKDDSSPPSLGPDCLIMNSEKASQDTINSSVVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLEEPQPPAEQAQATQNVYVPSTEPEEEGEADDVYIMDISSNISENLNYYIDGKIQTNNNTSNCDVIEMESASADLYGINCLLTPVTVEITQNIKTTQVPVTEDLPKEPLGSTNSEAKKRRTASPPALPKIKAETDSDPMVPSCSLSLPLSISTTEAVSFHKEKSVYLSSKLKQLLQTQDKLTPAGISATEIAKLGPVCVSAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPSDGKAAWTDAGLTSKKSKLESHSDSPAWSLSGRDERETVSPPCFDEYKMSKEWTASSAFSSVCNQQPLDLSSGVKQKAEGTGKTPVQWESVLDLSVHKKHCSDSEGKEFKESHSVQPTCSAVKKRKPTTCMLQKVLLNEYNGIDLPVENPADGTRSPSPCKSLEAQPDPDLGPGSGFPAPTVESTPDVCPSSPALQTPSLSSGQLPPLLIPTDPSSPPPCPPVLTVATPPPPLLPTVPLPAPSSSASPHPCPSPLSNATAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSSSSFSSSSSSSSPSPPPLSAISSVVSSGDNLEASLPMISFKQEELENEGLKPREEPQSAAEQDVVVQETFNKNFVCNVCESPFLSIKDLTKHLSIHAEEWPFKCEFCVQLFKDKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDKVCTHHEFESGTLRPQNFTDPSKAHVEHMQSLPEDPLETSKEEEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLNFSVELSKMSSNKLKLNALKKKNQLVQKAILQKNKSAKQKADLKNACESSSHICPYCNREFTYIGSLNKHAAFSCPKKPLSPPKKKVSHSSKKGGHSSPASSDKNSNSNHRRRTADAEIKMQSMQTPLGKTRARSSGPTQVPLPSSSFRSKQNVKFAASVKSKKPSSSSLRNSSPIRMAKITHVEGKKPKAVAKNHSAQLSSKTSRSLHVRVQKSKAVLQSKSTLASKKRTDRFNIKSRERSGGPVTRSLQLAAAADLSENKREDGSAKQELKDFSYSLRLASRCSPPAAPYITRQYRKVKAPAAAQFQGPFFKE" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A2A7B5/", "id": "A2A7B5", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/40822", "id": "40822", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q63755-1", "protein_name": "PR domain zinc finger protein 2", "sequence": { "length": 1706, "sequence": "MHQNTESVAATETLAEVPEHVLRGLPEEVRLFPSAVDKTRIGVWATKPILKGKKFGPFVGDKKKRSQVRNNVYMWEVYYPNLGWMCIDATDPEKGNWLRYVNWACSGEEQNLFPLEINRAIYYKTLKPIAPGEELLVWYNGEDNPEIAAAIEEERASARSKRSSPKSRRGKKKSHENKNKGIRTHPTQLKASELDSTFANMRGSAEGPKEEDERPLASAPEQPAPLPEVGNQDAVPQVAIPLPACEPQPEVDGKQEVTDCEVNDVEEEELEEEEELEEEEEEELGEDGVEEADMPNESSAKEPEIRCEEKPEDLLEEPQSMSNEAREDSPDVTPPPHTPRAREEANGDVLETFMFPCQHCERKFATKQGLERHMHIHISTINHAFKCKYCGKRFGTQINRRRHERRHETGLKRRPSMTLQSSEDPDDGKGENVTSKDESSPPQLGQDCLILNSEKTSQEVLNSSFVEENGEVKELHPCKYCKKVFGTHTNMRRHQRRVHERHLIPKGVRRKGGLLEEPQPPAEQAPPSQNVYVPSTEPEEEGETDDVYIMDISSNISENLNYYIDGKIQTNSSTSNCDVIEMESNSAHLYGIDCLLTPVTVEITQNIKSTQVSVTDDLLKDSPSSTNCESKKRRTASPPVLPKIKTETESDSTAPSCSLSLPLSISTAEVVSFHKEKGVYLSSKLKQLLQTQDKLTLPAGFSAAEIPKLGPVCASAPASMLPVTSSRFKRRTSSPPSSPQHSPALRDFGKPNDGKAAWTDTVLTSKKPKLESRSDSPAWSLSGRDERETGSPPCFDEYKISKEWAASSTFSSVCNQQPLDLSSGVKQKSEGTGKTPVPWESVLDLSVHKKPCDSEGKEFKENHLAQPAAKKKKPTTCMLQKVLLNEYNGVSLPTETTPEVTRSPSPCKSPDTQPDPELGPDSSCSVPTAESPPEVVGPSSPPLQTASLSSGQLPPLLTPTEPSSPPPCPPVLTVATPPPPLLPTVPLSHPSSDASPQQCPSPFSNTTAQSPLPILSPTVSPSPSPIPPVEPLMSAASPGPPTLSSSSSSSSSFPSSSCSSTSPSPPPLSAVSSVVSSGDNLEASLPAVTFKQEESESEGLKPKEEAPPAGGQSVVQETFSKNFICNVCESPFLSIKDLTKHLSVHAEEWPFKCEFCVQLFKVKTDLSEHRFLLHGVGNIFVCSVCKKEFAFLCNLQQHQRDLHPDEVCTHHEFESGTLRPQNFTDPSKANVEHMPSLPEEPLETSREEELNDSSEELYTTIKIMASGIKTKDPDVRLGLNQHYPSFKPPPFQYHHRNPMGIGVTATNFTTHNIPQTFTTAIRCTKCGKGVDNMPELHKHILACASASDKKRYTPKKNPVPLKQTVQPKNGVVVLDNSGKNAFRRMGQPKRLSFNVELGKMSPNKLKLSALKKKNQLVQKAILQKNRAAKQKADLRDTSEASSHICPYCDREFTYIGSLNKHAAFSCPKKPLSPSKRKVSHSSKKGGHASSSSSDRNSSCHPRRRTADTEIKMQSTQAPLGKTRARSTGPAQASLPSSSFRSRQNVKFAASVKSKKASSSSLRNSSPIRMAKITHVEGKKPKAVAKSHSAQLSSKSSRGLHVRVQKSKAVIQSKTALASKRRTDRFIVKSRERSGGPITRSLQLAAAADLSESRREDSSARHELKDFSYSLRLASRCGSSTASYITRQCRKVKAAAATPFQGPFLKE" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/40822", "id": "40822", "database": "MGI" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "ac": "NP_001074824.3", "name": "PR domain zinc finger protein 2 isoform a", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003700", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "DNA-binding transcription factor activity", "id": "GO:0003700" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031490", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "chromatin DNA binding", "id": "GO:0031490" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043565", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "sequence-specific DNA binding", "id": "GO:0043565" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000977", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "RNA polymerase II regulatory region sequence-specific DNA binding", "id": "GO:0000977" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" } ], "total": 6, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "11544182", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "Golgi apparatus", "id": "GO:0005794" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045893", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "positive regulation of transcription, DNA-templated", "id": "GO:0045893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008340", "pmid": "11544182", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "determination of adult lifespan", "id": "GO:0008340" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045944", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "positive regulation of transcription by RNA polymerase II", "id": "GO:0045944" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032355", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "id": "A2A7B5", "database": "UniProtKB" } ], "name": "response to estradiol", "id": "GO:0032355" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7B5", "type": "synonym", "resource": "RefSeq", "name": "4833427P12Rik; E330024L24Rik; Gm1033; Gm19732; KMT8; Riz; Riz1; Znfpr1c1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7B5", "type": "synonym", "resource": "RefSeq", "name": "Prdm2" }, { "url": "https://www.uniprot.org/uniprot/A2A7B5", "type": "recommended", "resource": "UniProtKB", "name": "Prdm2" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000057637", "id": "ENSMUSG00000057637", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/110593", "id": "110593", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001214", "id": "IPR001214", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR009170", "id": "IPR009170", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013087", "id": "IPR013087", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036236", "id": "IPR036236", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:110593", "id": "mmu:110593", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:107628", "id": "107628", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/GSPPCFD/", "id": "GSPPCFD", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=1318335at2759", "id": "1318335at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00096", "id": "PF00096", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF00856", "id": "PF00856", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074824.3", "id": "NP_001074824.3", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 187203.0, "chemical_mass": 187203.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2A7B5", "name": "Prdm2", "locus": { "end_pos": 143107391, "strand": "-", "start_pos": 143212995, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000057637", "id": "ENSMUSG00000057637", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A7B5", "type": "synonym", "resource": "RefSeq", "name": "PR domain zinc finger protein 2 isoform a" }, { "url": "https://www.uniprot.org/uniprot/A2A7B5", "type": "synonym", "resource": "UniProtKB", "name": "PR domain-containing 2, with ZNF domain" } ] }