{ "uniprot_canonical_ac": "A2A5R2-1", "ptm_annotation": [ { "annotation": "In vitro phosphorylated by PKA reducing its GEF activity and dephosphorylated by phosphatase PP1.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/", "id": "", "database": "PubMed" } ] } ], "sequence": { "header": "sp|A2A5R2-1|BIG2_MOUSE Isoform 1 of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Mus musculus OX=10090 GN=Arfgef2 PE=1 SV=1 CANONICAL=A2A5R2-1", "length": 1792, "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAHQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAEIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGLVYKIWIPEEPSQVPAALSSTW" }, "uniprot_id": "BIG2_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12520002", "type": [ "PubMed" ], "id": "12520002" } ], "title": "BayGenomics: a resource of insertional mutations in mouse embryonic stem cells.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Stryke D, Kawamoto M, Huang CC, Johns SJ, King LA, Harper CA, Meng EC, Lee RE, Yee A, L'Italien L, Chuang PT, Young SG, Skarnes WC, Babbitt PC, Ferrin TE", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/15741177", "type": [ "PubMed" ], "id": "15741177" } ], "title": "Tagging genes with cassette-exchange sites.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Cobellis G, Nicolaus G, Iovino M, Romito A, Marra E, Barbarisi M, Sardiello M, Di Giorgio FP, Iovino N, Zollo M, Ballabio A, Cortese R", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "type": [ "PubMed" ], "id": "17242355" } ], "title": "Large-scale phosphorylation analysis of mouse liver.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "authors": "Beausoleil S.A., Gerber S.A., Gygi S.P., Villen J.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18303090", "type": [ "PubMed" ], "id": "18303090" } ], "title": "Fas-associated factor (FAF1) is required for the early cleavage-stages of mouse embryo.", "journal": "Molecular human reproduction", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Adham IM, Khulan J, Held T, Schmidt B, Meyer BI, Meinhardt A, Engel W", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18630941", "type": [ "PubMed" ], "id": "18630941" } ], "title": "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis.", "journal": "J. Proteome Res.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "authors": "Dong J., Han G., Jiang X., Ye M., Zhou H., Zou H., Wu R.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/20857375", "type": [ "PubMed" ], "id": "20857375" } ], "title": "Early embryonic lethality in gene trap mice with disruption of the Arfgef2 gene.", "journal": "The International journal of developmental biology", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Grzmil P, Enkhbaatar Z, Gundsambuu B, Oidovsambuu O, Yalcin S, Wolf S, Engel W, Neesen J", "date": "2010" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22956851", "type": [ "PubMed" ], "id": "22956851" } ], "title": "Brefeldin A-inhibited guanine exchange factor 2 regulates filamin A phosphorylation and neuronal migration.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Zhang J, Neal J, Lian G, Shi B, Ferland RJ, Sheen V", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23386609", "type": [ "PubMed" ], "id": "23386609" } ], "title": "The Sec7 guanine nucleotide exchange factor GBF1 regulates membrane recruitment of BIG1 and BIG2 guanine nucleotide exchange factors to the trans-Golgi network (TGN).", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Lowery J, Szul T, Styers M, Holloway Z, Oorschot V, Klumperman J, Sztul E", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/24089482", "type": [ "PubMed" ], "id": "24089482" } ], "title": "Filamin A regulates neuronal migration through brefeldin A-inhibited guanine exchange factor 2-dependent Arf1 activation.", "journal": "The Journal of neuroscience : the official journal of the Society for Neuroscience", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Zhang J, Neal J, Lian G, Hu J, Lu J, Sheen V", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/30674481", "type": [ "PubMed" ], "id": "30674481" } ], "title": "A crucial role for Arf6 in the response of commissural axons to Slit.", "journal": "Development (Cambridge, England)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "authors": "Kinoshita-Kawada M, Hasegawa H, Hongu T, Yanagi S, Kanaho Y, Masai I, Mishima T, Chen X, Tsuboi Y, Rao Y, Yuasa-Kawada J, Wu JY", "date": "2019" } ], "uniprot_ac": "A2A5R2", "site_annotation": [ { "end_pos": 1203, "annotation": "n_glycosylation_sequon", "start_pos": 1201 }, { "end_pos": 1527, "annotation": "n_glycosylation_sequon", "start_pos": 1525 }, { "end_pos": 180, "annotation": "n_glycosylation_sequon", "start_pos": 178 }, { "end_pos": 814, "annotation": "n_glycosylation_sequon", "start_pos": 812 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2#A2A5R2-1", "isoform_ac": "A2A5R2-1", "locus": { "end_pos": 166805715, "strand": "-", "start_pos": 166894785, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000099078", "id": "ENSMUST00000099078", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000096677", "id": "ENSMUSP00000096677", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2A5R2-1|BIG2_MOUSE Isoform 1 of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Mus musculus OX=10090 GN=Arfgef2 PE=1 SV=1 CANONICAL=A2A5R2-1", "length": 1792, "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSRGTDSGAQEVVKDILEDVVTSAVKEAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYDEIEGKKIAMKETKEHTIATKSTKQSVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFKTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYAHQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDAEIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWDEIQQRLLRVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKISDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGLVYKIWIPEEPSQVPAALSSTW" } }, { "url": "https://www.uniprot.org/uniprot/A2A5R2#F6YCJ0-1", "isoform_ac": "F6YCJ0-1", "locus": { "end_pos": 166827657, "strand": "-", "start_pos": 166848971, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000144847", "id": "ENSMUST00000144847", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000131572", "id": "ENSMUSP00000131572", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6YCJ0-1|BIG2_MOUSE Computationally mapped isoform of Brefeldin A-inhibited guanine nucleotide-exchange protein 2 OS=Mus musculus OX=10090 GN=Arfgef2 PE=1 SV=1 CANONICAL=A2A5R2-1", "length": 283, "sequence": "CLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPMQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKAELPNGDHAQSGLGKVSLENGEAPRERGSPVSGRAEPSREAAEKHGLPEPDRALGALECQECAVPPGVDENSQTNGIADDRQSLSSADNLEPDVQGHQVAARFSHILQKDAFLVFRSLCKLSMKP" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99371", "resource": "KEGG Pathway", "id": "mmu:99371", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "annotation": "An early acting GEF (GBF1) activates ARFs that mediate recruitment of late acting GEFs (BIG1/2) to coordinate coating events within the pre-Golgi/Golgi/TGN continuum.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "annotation": "Big2 inhibition promotes Filamin A phosphorylation, thereby disrupting cell intrinsic neuronal migration.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "annotation": "Coordinated interactions between actin (through FlnA) and vesicle trafficking (through Big2-Arf) direct the assembly and disassembly of membrane protein complexes required for neuronal migration and neuroependymal integrity.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A2A5R2#function", "annotation": "Promotes guanine-nucleotide exchange on ARF1 and ARF3 and to a lower extent on ARF5 and ARF6. Promotes the activation of ARF1/ARF5/ARF6 through replacement of GDP with GTP. Involved in the regulation of Golgi vesicular transport. Required for the integrity of the endosomal compartment. Involved in trafficking from the trans-Golgi network (TGN) to endosomes and is required for membrane association of the AP-1 complex and GGA1. Seems to be involved in recycling of the transferrin receptor from recycling endosomes to the plasma membrane. Probably is involved in the exit of GABA(A) receptors from the endoplasmic reticulum. Involved in constitutive release of tumor necrosis factor receptor 1 via exosome-like vesicles; the function seems to involve PKA and specifically PRKAR2B. Proposed to act as A kinase-anchoring protein (AKAP) and may mediate crosstalk between Arf and PKA pathways (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2#function", "id": "A2A5R2", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "annotation": "Results indicate that murine BIG2 is essential for early embryonic development.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q7TSU1-1", "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "sequence": { "length": 1791, "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAELEKQRLGAAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETVCNCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQATAGSPKFSRLKQSQAQSKPTTPEKTELPNGDHARSSLGKVNSENGEAHRERGSSISGRAEPSGGSDNGAQEVVKDILEDVVTSAVKEAAEKQGLPEPDQAPGVPECQECTVPPAVDENSQTNGIADDRQSLSSADNLEPDAQGHPVAARFSHILQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRSHEMFVTAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQATLGQERLPDQEMGDGKGLDMARRCSVTSVESTVSSGTQTAIPDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGAAVEDIAQFLHQEERLDSTQVGEFLGDSTRFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKEHTMATKSTKQNVASEKQRRLLYNVEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAVRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHSLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMVIRCIAQMVSSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTGHIVSTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFAKHWWQDLFRIVFRIFDNMKLPEQQSEKSEWMTTTCNHALYAICDVFTQFYEALHEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPAVWDETCNCMLDIFRTTIPHVLLTWRPAGMEEEVSDRHLDVDLDRQSLSSIDRNASERGQSQLSNPTDDSWKGAPYANQKLLASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETENQGMYKFMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWGEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASVYYPYLCEMMQFDLIPELRAVLRKFFLRIGLVYKIWVPEEPSQVPAASTAW" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/111880", "id": "111880", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A5R2/", "id": "A2A5R2", "database": "OMA" } ], "common_name": "Rat", "organism": "Rattus norvegicus", "tax_id": 10116 }, { "uniprot_canonical_ac": "Q9Y6D5-1", "protein_name": "Brefeldin A-inhibited guanine nucleotide-exchange protein 2", "sequence": { "length": 1785, "sequence": "MQESQTKSMFVSRALEKILADKEVKRPQHSQLRRACQVALDEIKAEIEKQRLGTAAPPKANFIEADKYFLPFELACQSKSPRVVSTSLDCLQKLIAYGHITGNAPDSGAPGKRLIDRIVETICSCFQGPQTDEGVQLQIIKALLTAVTSPHIEIHEGTILQTVRTCYNIYLASKNLINQTTAKATLTQMLNVIFTRMENQVLQEARELEKPIQSKPQSPVIQAAAVSPKFVRLKHSQAQSKPTTPEKTDLTNGEHARSDSGKVSTENGDAPRERGSSLSGTDDGAQEVVKDILEDVVTSAIKEAAEKHGLTEPERVLGELECQECAIPPGVDENSQTNGIADDRQSLSSADNLESDAQGHQVAARFSHVLQKDAFLVFRSLCKLSMKPLGEGPPDPKSHELRSKVVSLQLLLSVLQNAGPVFRTHEMFINAIKQYLCVALSKNGVSSVPDVFELSLAIFLTLLSNFKMHLKMQIEVFFKEIFLNILETSTSSFEHRWMVIQTLTRICADAQCVVDIYVNYDCDLNAANIFERLVNDLSKIAQGRSGHELGMTPLQELSLRKKGLECLVSILKCMVEWSKDLYVNPNHQTSLGQERLTDQEIGDGKGLDMARRCSVTSMESTVSSGTQTTVQDDPEQFEVIKQQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSARFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEEIEGKKIAMKETKELTIATKSTKQNVASEKQRRLLYNLEMEQMAKTAKALMEAVSHAKAPFTSATHLDHVRPMFKLVWTPLLAAYSIGLQNCDDTEVASLCLEGIRCAIRIACIFGMQLERDAYVQALARFSLLTASSSITEMKQKNIDTIKTLITVAHTDGNYLGNSWHEILKCISQLELAQLIGTGVKTRYLSGSGREREGSLKGHTLAGEEFMGLGLGNLVSGGVDKRQMASFQESVGETSSQSVVVAVDRIFTGSTRLDGNAIVDFVRWLCAVSMDELASPHHPRMFSLQKIVEISYYNMNRIRLQWSRIWHVIGDHFNKVGCNPNEDVAIFAVDSLRQLSMKFLEKGELANFRFQKDFLRPFEHIMKKNRSPTIRDMAIRCIAQMVNSQAANIRSGWKNIFAVFHQAASDHDGNIVELAFQTTCHIVTTIFQHHFPAAIDSFQDAVKCLSEFACNAAFPDTSMEAIRLIRFCGKYVSERPRVLQEYTSDDMNVAPGDRVWVRGWFPILFELSCIINRCKLDVRTRGLTVMFEIMKSYGHTFEKHWWQDLFRIVFRIFDNMKLPEQLSEKSEWMTTTCNHALYAICDVFTQFYEALNEVLLSDVFAQLQWCVKQDNEQLARSGTNCLENLVISNGEKFSPEVWDETCNCMLDIFKTTIPHVLLTWRPVGMEEDSSEKHLDVDLDRQSLSSIDKNPSERGQSQLSNPTDDSWKGRPYANQKLFASLLIKCVVQLELIQTIDNIVFYPATSKKEDAEHMVAAQQDTLDADIHIETEDQGMYKYMSSQHLFKLLDCLQESHSFSKAFNSNYEQRTVLWRAGFKGKSKPNLLKQETSSLACCLRILFRMYVDENRRDSWEEIQQRLLTVCSEALAYFITVNSESHREAWTSLLLLLLTKTLKINDEKFKAHASMYYPYLCEIMQFDLIPELRAVLRKFFLRIGVVYKIWIPEEPSQVPAALSPVW" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/111880", "id": "111880", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A2A5R2/", "id": "A2A5R2", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "ac": "NP_001078964.1", "name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0017022", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "myosin binding", "id": "GO:0017022" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034237", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "protein kinase A regulatory subunit binding", "id": "GO:0034237" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005086", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "ARF guanyl-nucleotide exchange factor activity", "id": "GO:0005086" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050811", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "GABA receptor binding", "id": "GO:0050811" } ], "total": 5, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000139", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "Golgi membrane", "id": "GO:0000139" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "membrane", "id": "GO:0016020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030054", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "cell junction", "id": "GO:0030054" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032279", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "asymmetric synapse", "id": "GO:0032279" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043197", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "dendritic spine", "id": "GO:0043197" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0048471", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "perinuclear region of cytoplasm", "id": "GO:0048471" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055037", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "recycling endosome", "id": "GO:0055037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031410", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "cytoplasmic vesicle", "id": "GO:0031410" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005815", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "microtubule organizing center", "id": "GO:0005815" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032280", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "symmetric synapse", "id": "GO:0032280" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005802", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "trans-Golgi network", "id": "GO:0005802" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005879", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "axonemal microtubule", "id": "GO:0005879" } ], "total": 14, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0015031", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "protein transport", "id": "GO:0015031" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035556", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "intracellular signal transduction", "id": "GO:0035556" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007032", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "endosome organization", "id": "GO:0007032" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032760", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "positive regulation of tumor necrosis factor production", "id": "GO:0032760" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001881", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "receptor recycling", "id": "GO:0001881" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006887", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "exocytosis", "id": "GO:0006887" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006893", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "Golgi to plasma membrane transport", "id": "GO:0006893" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010256", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "endomembrane system organization", "id": "GO:0010256" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032012", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "name": "regulation of ARF protein signal transduction", "id": "GO:0032012" } ], "total": 9, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5R2", "type": "synonym", "resource": "RefSeq", "name": "AI463430; AW493672; BIG2; E230011G24Rik" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2A5R2", "type": "synonym", "resource": "RefSeq", "name": "Arfgef2" }, { "url": "https://www.uniprot.org/uniprot/A2A5R2", "type": "recommended", "resource": "UniProtKB", "name": "Arfgef2" }, { "url": "https://www.uniprot.org/uniprot/A2A5R2", "type": "synonym", "resource": "UniProtKB", "name": "Arfgep2" }, { "url": "https://www.uniprot.org/uniprot/A2A5R2", "type": "synonym", "resource": "UniProtKB", "name": "Big2" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000074582", "id": "ENSMUSG00000074582", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00171", "id": "cd00171", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/99371", "id": "99371", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2A5R2*", "id": "A2A5R2", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000904", "id": "IPR000904", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015403", "id": "IPR015403", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR023394", "id": "IPR023394", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032629", "id": "IPR032629", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR032691", "id": "IPR032691", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035999", "id": "IPR035999", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:99371", "id": "mmu:99371", "database": "KEGG Pathway" }, { "url": "http://www.informatics.jax.org/marker/MGI:2139354", "id": "2139354", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/FRMYSDP/", "id": "FRMYSDP", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=815698at2759", "id": "815698at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF01369", "id": "PF01369", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09324", "id": "PF09324", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF12783", "id": "PF12783", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF16213", "id": "PF16213", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2A5R2", "id": "PR_A2A5R2", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078964.1", "id": "NP_001078964.1", "database": "RefSeq" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Ser", "position": "1518", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1520", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1521", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1532", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1535", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": "21183079", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Ser", "position": "1535", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1541", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "1789", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "214", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2A5R2", "id": "A2A5R2", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "218", "evidence": [ { "url": "http://phospho.elm.eu.org/byAccession/A2A5R2.html", "id": "A2A5R2", "database": "phospho.ELM" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19144319", "id": "19144319", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17242355", "id": "17242355", "database": "PubMed" }, { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21183079", "id": 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"synonym", "resource": "RefSeq", "name": "brefeldin A-inhibited guanine nucleotide-exchange protein 2" } ] }