{ "uniprot_canonical_ac": "A1Z1Q3-2", "ptm_annotation": [], "sequence": { "header": "sp|A1Z1Q3-2|MACD2_HUMAN Isoform 2 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 425, "sequence": "MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK" }, "uniprot_id": "MACD2_HUMAN", "enzyme_annotation": [ { "ec": "3.2.2.-", "activity": "" }, { "ec": "3.5.1.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Human", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "Homo sapiens", "taxid": 9606 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17586838", "type": [ "PubMed" ], "id": "17586838" } ], "title": "The C20orf133 gene is disrupted in a patient with Kabuki syndrome.", "journal": "Journal of medical genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Maas NM, Van de Putte T, Melotte C, Francis A, Schrander-Stumpel CT, Sanlaville D, Genevieve D, Lyonnet S, Dimitrov B, Devriendt K, Fryns JP, Vermeesch JR", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18593871", "type": [ "PubMed" ], "id": "18593871" } ], "title": "Lack of C20orf133 and FLRT3 mutations in 43 patients with Kabuki syndrome in Japan.", "journal": "Journal of medical genetics", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Kuniba H, Tsuda M, Nakashima M, Miura S, Miyake N, Kondoh T, Matsumoto T, Moriuchi H, Ohashi H, Kurosawa K, Tonoki H, Nagai T, Okamoto N, Kato M, Fukushima Y, Naritomi K, Matsumoto N, Kinoshita A, Yoshiura KI, Niikawa N", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18655026", "type": [ "PubMed" ], "id": "18655026" } ], "title": "Proteomic analysis of ubiquitinated proteins in normal hepatocyte cell line Chang liver cells.", "journal": "Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "authors": "Cai Y., Gong Y., Qiang B., Sun X., Wang J., Wang L., Wu J., Yuan J., Lu L., Peng X., Luo Y., Xie Y., Tan F., Xu B.-E.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18987618", "type": [ "PubMed" ], "id": "18987618" } ], "title": "Screening for replication of genome-wide SNP associations in sporadic ALS.", "journal": "European journal of human genetics : EJHG", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Cronin S, Tomik B, Bradley DG, Slowik A, Hardiman O", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21257746", "type": [ "PubMed" ], "id": "21257746" } ], "title": "Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "authors": "von Delft F., Chen D., Gileadi O., Ahel I., Mehrotra P.V., Vollmar M., Slade D., Phillips C., Denu J.M., Crosthwaite S.K., Kraehenbuehl R., Rossi M.N.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23474712", "type": [ "PubMed" ], "id": "23474712" } ], "title": "A family of macrodomain proteins reverses cellular mono-ADP-ribosylation.", "journal": "Nat. Struct. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "authors": "Zacharias M., Rybin V., Ladurner A.G., Golia B., Hassler M., Jankevicius G., Timinszky G.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/23474714", "type": [ "PubMed" ], "id": "23474714" } ], "title": "Macrodomain-containing proteins are new mono-ADP-ribosylhydrolases.", "journal": "Nat. Struct. Mol. Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "authors": "Imhof R., Luescher B., Hassa P.O., Hottiger M.O., Fischer D., Feijs K.L., Forst A.H., Rosenthal F., Bonalli M., Caflisch A., Frugier E., Winkler H.C.", "date": "2013" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27304844", "type": [ "PubMed" ], "id": "27304844" } ], "title": "Association of Polymorphisms in MACRO Domain Containing 2 With Thyroid-Associated Orbitopathy.", "journal": "Investigative ophthalmology & visual science", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Khong JJ, Burdon KP, Lu Y, Leonardos L, Laurie KJ, Walsh JP, Gajdatsy AD, Ebeling PR, McNab AA, Hardy TG, Stawell RJ, Davis GJ, Selva D, Tsirbas A, Montgomery GW, Macgregor S, Craig JE", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/27464500", "type": [ "PubMed" ], "id": "27464500" } ], "title": "Synthesis and Macrodomain Binding of Mono-ADP-Ribosylated Peptides.", "journal": "Angewandte Chemie (International ed. in English)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Kistemaker HA, Nardozza AP, Overkleeft HS, van der Marel GA, Ladurner AG, Filippov DV", "date": "2016" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/28069995", "type": [ "PubMed" ], "id": "28069995" } ], "title": "ATM induces MacroD2 nuclear export upon DNA damage.", "journal": "Nucleic acids research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Golia B, Moeller GK, Jankevicius G, Schmidt A, Hegele A, Preisser J, Tran ML, Imhof A, Timinszky G", "date": "2017" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29880585", "type": [ "PubMed" ], "id": "29880585" } ], "title": "MACROD2 Haploinsufficiency Impairs Catalytic Activity of PARP1 and Promotes Chromosome Instability and Growth of Intestinal Tumors.", "journal": "Cancer discovery", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Sakthianandeswaren A, Parsons MJ, Mouradov D, MacKinnon RN, Catimel B, Liu S, Palmieri M, Love C, Jorissen RN, Li S, Whitehead L, Putoczki TL, Preaudet A, Tsui C, Nowell CJ, Ward RL, Hawkins NJ, Desai J, Gibbs P, Ernst M, Street I, Buchert M, Sieber OM", "date": "2018" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/31055587", "type": [ "PubMed" ], "id": "31055587" } ], "title": "Intragenic Deletion in MACROD2: A Family with Complex Phenotypes Including Microcephaly, Intellectual Disability, Polydactyly, Renal and Pancreatic Malformations.", "journal": "Cytogenetic and genome research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ], "authors": "Lombardo B, Esposito D, Iossa S, Vitale A, Verdesca F, Perrotta C, Di Leo L, Costa V, Pastore L, Franze A", "date": "2019" } ], "uniprot_ac": "A1Z1Q3", "site_annotation": [ { "end_pos": 156, "annotation": "n_glycosylation_sequon", "start_pos": 154 }, { "end_pos": 311, "annotation": "n_glycosylation_sequon", "start_pos": 309 }, { "end_pos": 334, "annotation": "n_glycosylation_sequon", "start_pos": 332 }, { "end_pos": 424, "annotation": "n_glycosylation_sequon", "start_pos": 422 }, { "end_pos": 94, "annotation": "n_glycosylation_sequon", "start_pos": 92 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#A1Z1Q3-1", "isoform_ac": "A1Z1Q3-1", "locus": {}, "sequence": { "header": "sp|A1Z1Q3-1|MACD2_HUMAN Isoform 1 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 448, "sequence": "MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRNGTK" } }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#A1Z1Q3-2", "isoform_ac": "A1Z1Q3-2", "locus": { "end_pos": 13995764, "strand": "-", "start_pos": 16049873, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000217246", "id": "ENST00000217246", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000217246", "id": "ENSP00000217246", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z1Q3-2|MACD2_HUMAN Isoform 2 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 425, "sequence": "MYPSNKKKKVWREEKERLLKMTLEERRKEYLRDYIPLNSILSWKEEMKGKGQNDEENTQETSQVKKSLTEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCDTGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYKSSLKLVKENNIRSVAFPCISTGIYGFPNEPAAVIALNTIKEWLAKNHHEVDRIIFCVFLEVDFKIYKKKMNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK" } }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#A1Z1Q3-4", "isoform_ac": "A1Z1Q3-4", "locus": { "end_pos": 15862805, "strand": "-", "start_pos": 16049873, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000402914", "id": "ENST00000402914", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000385290", "id": "ENSP00000385290", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z1Q3-4|MACD2_HUMAN Isoform 4 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 213, "sequence": "MNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIAGAQDEAKEQRNGTK" } }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#A1Z1Q3-5", "isoform_ac": "A1Z1Q3-5", "locus": {}, "sequence": { "header": "sp|A1Z1Q3-5|MACD2_HUMAN Isoform 5 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 190, "sequence": "MNEFFSVDDNNEEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAKDENITKGGEVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDAGAQDEAKEQRNGTK" } }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#A1Z1Q3-6", "isoform_ac": "A1Z1Q3-6", "locus": { "end_pos": 15986789, "strand": "-", "start_pos": 16049873, "chromosome": "20", "evidence": [ { "url": "https://www.ensembl.org/id/ENST00000407045", "id": "ENST00000407045", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSP00000385516", "id": "ENSP00000385516", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A1Z1Q3-6|MACD2_HUMAN Isoform 6 of ADP-ribose glycohydrolase MACROD2 OS=Homo sapiens OX=9606 GN=MACROD2 PE=1 SV=2 CANONICAL=A1Z1Q3-2", "length": 98, "sequence": "METEELSSNQEDAVIVEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGPDVEMNSQVDKVNDPTESQQEDQLIGAQDEAKEQRNGTK" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+hsa:140733", "resource": "KEGG Pathway", "id": "hsa:140733", "name": "" } ], "function": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "A 250 kb de novo microdeletion at 20p12.1, deleting exon 5 of C20orf133, was seen in a Kabuki syndrome case. The de novo deletion, the expression data & the fact that C20orf133 has a macro domain make it a likely candidate to cause KS in this patient.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "A deletion of chromosome 20p12.1 involving the macrodomain containing 2/mono-ADP ribosylhydrolase 2 gene (MACROD2) was found in several members of the family with complex phenotypes, including microcephaly, intellectual disability, dysmorphic features, and polydactyly. This deletion may affect correct embryonic development. Associated epigenetic modifications at the MACROD2 locus, can influence the phenotype severity.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "ATM induces MacroD2 nuclear export upon DNA damage.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "Authors describe the results of a deletion assay for the exon 5 in C20orf133 and a mutation analysis of C20orf133 and FLRT3 in patients with Kabuki Syndrome. GeneRIF: Observational study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "In patients with Graves' disease, a common genetic variant in MACROD2 may increase susceptibility for thyroid-associated orbitopathy.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator)", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#function", "annotation": "Removes ADP-ribose from asparatate and glutamate residues in proteins bearing a single ADP-ribose moiety (PubMed:23474714, PubMed:23474712). Inactive towards proteins bearing poly-ADP-ribose (PubMed:23474714, PubMed:23474712). Deacetylates O-acetyl-ADP ribose, a signaling molecule generated by the deacetylation of acetylated lysine residues in histones and other proteins (PubMed:21257746).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3#function", "id": "A1Z1Q3", "database": "UniProtKB" } ] }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "annotation": "Study identifies MACROD2 deletion as a cause of chromosome instability (CIN) in human colorectal cancer. MACROD2 loss causes repression of PARP1 activity, impairing DNA repair. MACROD2 haploinsufficiency promotes CIN and intestinal tumor growth. These results reveal MACROD2 as a major caretaker tumor suppressor gene in intestinal neoplasm.", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "id": "NP_001028259.1", "database": "RefSeq" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q3UYG8-1", "protein_name": "ADP-ribose glycohydrolase MACROD2", "sequence": { "length": 475, "sequence": "MYPSNKKKKVWREEKERLLKMTLEERRKEYIRDYVSLSTILSWKEEMKSKGQNDEENTQEAPQMKKSLSEKVSLYRGDITLLEVDAIVNAANASLLGGGGVDGCIHRAAGPCLLAECRNLNGCETGHAKITCGYDLPAKYVIHTVGPIARGHINGSHKEDLANCYQSSLKLVKENNLRSVAFPCISTGIYGFPNEPAAVIALGTIKEWLAKNHQEVDRIIFCVFLEVDFKIYKKKMNEFFPVDDNNEGTDADMKEDSEGPEPKGLSPPHKKSKAKKPESSKDSSEDESGPEEKQTAEEMEGQSQEAGGLRFLLRNLLGLIHRDGVNTTPVPSPASEDKAEVHKDEDSAKDDNTVKDSDMTNHSVCDQELPNGQENDSAKSEGKTEAESPSSSMETEDLSPNQEDAAIVEQPEVIPLIDDQEAQEGGEAQGKDAPAVFAESQGSSEAENTSGPDVDMNSQVDGVNEPTESLQEDLQ" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/85987", "id": "85987", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028259.1", "ac": "NP_001028259.1", "name": "ADP-ribose glycohydrolase MACROD2 isoform 2", "summary": "The protein encoded by this gene is a deacetylase involved in removing ADP-ribose from mono-ADP-ribosylated proteins. The encoded protein has been shown to translocate from the nucleus to the cytoplasm upon DNA damage. [provided by RefSeq, May 2017]." }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019213", "pmid": "21257746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "deacetylase activity", "id": "GO:0019213" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016798", "pmid": "23474712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "hydrolase activity, acting on glycosyl bonds", "id": "GO:0016798" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140293", "pmid": "23474714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "ADP-ribosylglutamate hydrolase activity", "id": "GO:0140293" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "23474712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "nucleolus", "id": "GO:0005730" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005813", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "centrosome", "id": "GO:0005813" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006974", "pmid": "23474712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "cellular response to DNA damage stimulus", "id": "GO:0006974" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051725", "pmid": "23474712", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "protein de-ADP-ribosylation", "id": "GO:0051725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042278", "pmid": "21257746", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "purine nucleoside metabolic process", "id": "GO:0042278" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0140291", "pmid": "23474714", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "peptidyl-glutamate ADP-deribosylation", "id": "GO:0140291" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009617", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "id": "A1Z1Q3", "database": "UniProtKB" } ], "name": "response to bacterium", "id": "GO:0009617" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007420", "pmid": "", 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"https://www.ncbi.nlm.nih.gov/protein/A1Z1Q3", "type": "synonym", "resource": "RefSeq", "name": "MACRO domain-containing protein 2; O-acetyl-ADP-ribose deacetylase MACROD2; [Protein ADP-ribosylglutamate] hydrolase; MACRO domain containing 2; [Protein ADP-ribosylaspartate] hydrolase MACROD2; [Protein ADP-ribosylglutamate] hydrolase MACROD2; ADP-ribose glycohydrolase MACROD2" }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "type": "synonym", "resource": "UniProtKB", "name": "MACRO domain-containing protein 2" }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "type": "synonym", "resource": "UniProtKB", "name": "O-acetyl-ADP-ribose deacetylase MACROD2" }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "type": "synonym", "resource": "UniProtKB", "name": "[Protein ADP-ribosylaspartate] hydrolase MACROD2" }, { "url": "https://www.uniprot.org/uniprot/A1Z1Q3", "type": "synonym", "resource": "UniProtKB", "name": "[Protein ADP-ribosylglutamate] hydrolase MACROD2" } ] }