{
    "uniprot_canonical_ac": "A1L134-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A1L134-1|AUP1_RAT Isoform 1 of Ancient ubiquitous protein 1  OS=Rattus norvegicus OX=10116 GN=Aup1 PE=2 SV=1 CANONICAL=A1L134-1", 
        "length": 410, 
        "sequence": "MEPPPAPGPERLFDSHRLPSDGFLLLALLLYAPVGLCLLVLRLFLGLHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMDRRVELVESLKKFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLHPIRRQLGEENEEFALRVQQLVAKELGQIGTRLTPADKAEHMKRQRHPRLRPQSVQSSFPSPPSPSSDVQLTILAQRVKEVLPHVPLNVIQRDLARTGCVDLTITNLLEGAVAFMPEDVTEGSQSLPTASAPKFPSSGLVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFRERQAQEAE"
    }, 
    "uniprot_id": "AUP1_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L134", 
                    "id": "A1L134", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/18570454", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "18570454"
                }
            ], 
            "title": "Proteomic analysis of exosomes from human neural stem cells by flow field-flow fractionation and nanoflow liquid chromatography-tandem mass spectrometry.", 
            "journal": "Journal of proteome research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073368.1", 
                    "id": "NP_001073368.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Kang D, Oh S, Ahn SM, Lee BH, Moon MH", 
            "date": "2008"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25660456", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25660456"
                }
            ], 
            "title": "Identification of ERAD components essential for dislocation of the null Hong Kong variant of alpha-1-antitrypsin (NHK).", 
            "journal": "Biochemical and biophysical research communications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073368.1", 
                    "id": "NP_001073368.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Zhong Y, Shen H, Wang Y, Yang Y, Yang P, Fang S", 
            "date": "2015"
        }
    ], 
    "uniprot_ac": "A1L134", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L134#A1L134-1", 
            "isoform_ac": "A1L134-1", 
            "locus": {
                "end_pos": 113887159, 
                "strand": "-", 
                "start_pos": 113889952, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000010602", 
                        "id": "ENSRNOT00000010602", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000010602", 
                        "id": "ENSRNOP00000010602", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1L134-1|AUP1_RAT Isoform 1 of Ancient ubiquitous protein 1  OS=Rattus norvegicus OX=10116 GN=Aup1 PE=2 SV=1 CANONICAL=A1L134-1", 
                "length": 410, 
                "sequence": "MEPPPAPGPERLFDSHRLPSDGFLLLALLLYAPVGLCLLVLRLFLGLHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHRVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMDRRVELVESLKKFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLHPIRRQLGEENEEFALRVQQLVAKELGQIGTRLTPADKAEHMKRQRHPRLRPQSVQSSFPSPPSPSSDVQLTILAQRVKEVLPHVPLNVIQRDLARTGCVDLTITNLLEGAVAFMPEDVTEGSQSLPTASAPKFPSSGLVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFRERQAQEAE"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680423", 
            "resource": "KEGG Pathway", 
            "id": "rno:680423", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L134#function", 
            "annotation": "May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L134#function", 
                    "id": "A1L134", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q9Y679-2", 
            "protein_name": "Ancient ubiquitous protein 1", 
            "sequence": {
                "length": 410, 
                "sequence": "MELPSGPGPERLFDSHRLPGDCFLLLVLLLYAPVGFCLLVLRLFLGIHVFLVSCALPDSVLRRFVVRTMCAVLGLVARQEDSGLRDHSVRVLISNHVTPFDHNIVNLLTTCSTPLLNSPPSFVCWSRGFMEMNGRGELVESLKRFCASTRLPPTPLLLFPEEEATNGREGLLRFSSWPFSIQDVVQPLTLQVQRPLVSVTVSDASWVSELLWSLFVPFTVYQVRWLRPVHRQLGEANEEFALRVQQLVAKELGQTGTRLTPADKAEHMKRQRHPRLRPQSAQSSFPPSPGPSPDVQLATLAQRVKEVLPHVPLGVIQRDLAKTGCVDLTITNLLEGAVAFMPEDITKGTQSLPTASASKFPSSGPVTPQPTALTFAKSSWARQESLQERKQALYEYARRRFTERRAQEAD"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/7239", 
                    "id": "7239", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1L134/", 
                    "id": "A1L134", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073368.1", 
        "ac": "NP_001073368.1", 
        "name": "ancient ubiquitous protein 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043130", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin binding", 
                        "id": "GO:0043130"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097027", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-protein transferase activator activity", 
                        "id": "GO:0097027"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane", 
                        "id": "GO:0016020"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030176", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of endoplasmic reticulum membrane", 
                        "id": "GO:0030176"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000839", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Hrd1p ubiquitin ligase ERAD-L complex", 
                        "id": "GO:0000839"
                    }
                ], 
                "total": 3, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030433", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ubiquitin-dependent ERAD pathway", 
                        "id": "GO:0030433"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030970", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1L134", 
                                "id": "A1L134", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "retrograde protein transport, ER to cytosol", 
                        "id": "GO:0030970"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L134", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Aup1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1L134", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Aup1"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007842", 
            "id": "ENSRNOG00000007842", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/680423", 
            "id": "680423", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003892", 
            "id": "IPR003892", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:680423", 
            "id": "rno:680423", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LKFSSWP/", 
            "id": "LKFSSWP", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1319689at2759", 
            "id": "1319689at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02845", 
            "id": "PF02845", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1L134", 
            "id": "PR_A1L134", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073368.1", 
            "id": "NP_001073368.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1591777", 
            "id": "1591777", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "position": "292", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L134", 
                    "id": "A1L134", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }, 
        {
            "residue": "Ser", 
            "position": "363", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L134", 
                    "id": "A1L134", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }, 
        {
            "residue": "Thr", 
            "position": "367", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1L134", 
                    "id": "A1L134", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 46199.0, 
        "chemical_mass": 46199.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L134", 
            "name": "Aup1", 
            "locus": {
                "end_pos": 113890101, 
                "strand": "+", 
                "start_pos": 113887115, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007842", 
                        "id": "ENSRNOG00000007842", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1L134", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ancient ubiquitous protein 1"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1L134", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "ancient ubiquitous protein 1"
        }
    ]
}