{ "uniprot_canonical_ac": "A1IGU3-1", "ptm_annotation": [], "sequence": { "header": "sp|A1IGU3-1|ARH37_RAT Isoform 1 of Rho guanine nucleotide exchange factor 37 OS=Rattus norvegicus OX=10116 GN=Arhgef37 PE=2 SV=1 CANONICAL=A1IGU3-1", "length": 676, "sequence": "MADFETDEASSKSESPEQEGQGSEDKSLLHQRLAIRELIDTEVSYLHTLRLCTSDIRGHLQQLPPGDLDILFSNIDDIIQVSSRFLHGLQETACKEEKQAHLIGNLFLEFQEELEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAVPQAGPSGLSFLLVIPLQRITKYPLLLQKILENTPADASAHPVLQRATSALQDVNSNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLSQLLKQEAGLVPRTEDKEFDDLEERFQWVSLCVTELKSNVAAYMDNLEAFLCFRPHERNLDIPGGAAEQYCSLARDLQLQAFLQFKQRLTGLVWQPLCSLARALVGPQNLIKKRLDKLLDFERVEEKLLDVGSVTYEEEAARHTYQALNSLIVAELPQFNHLVMQWLGQILRTFVVLQRDLADQVLRRAESSMALLPHRHVSEPDFQKLLEDTLGQSSSQLRHFRESFEKVLPPSTSQPLLPGSEHQMQSLLTRYGPGKIYQVTSNINGTGTLDLTLPRGQIVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHPINPSEKEPRRQTGMPEDYWLPTPEPTQPSVPTVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNFLARTPSPTPRGWNLPS" }, "uniprot_id": "ARH37_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "id": "A1IGU3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A1IGU3", "site_annotation": [ { "end_pos": 520, "annotation": "n_glycosylation_sequon", "start_pos": 518 }, { "end_pos": 546, "annotation": "n_glycosylation_sequon", "start_pos": 544 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3#A1IGU3-1", "isoform_ac": "A1IGU3-1", "locus": {}, "sequence": { "header": "sp|A1IGU3-1|ARH37_RAT Isoform 1 of Rho guanine nucleotide exchange factor 37 OS=Rattus norvegicus OX=10116 GN=Arhgef37 PE=2 SV=1 CANONICAL=A1IGU3-1", "length": 676, "sequence": "MADFETDEASSKSESPEQEGQGSEDKSLLHQRLAIRELIDTEVSYLHTLRLCTSDIRGHLQQLPPGDLDILFSNIDDIIQVSSRFLHGLQETACKEEKQAHLIGNLFLEFQEELEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAVPQAGPSGLSFLLVIPLQRITKYPLLLQKILENTPADASAHPVLQRATSALQDVNSNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLSQLLKQEAGLVPRTEDKEFDDLEERFQWVSLCVTELKSNVAAYMDNLEAFLCFRPHERNLDIPGGAAEQYCSLARDLQLQAFLQFKQRLTGLVWQPLCSLARALVGPQNLIKKRLDKLLDFERVEEKLLDVGSVTYEEEAARHTYQALNSLIVAELPQFNHLVMQWLGQILRTFVVLQRDLADQVLRRAESSMALLPHRHVSEPDFQKLLEDTLGQSSSQLRHFRESFEKVLPPSTSQPLLPGSEHQMQSLLTRYGPGKIYQVTSNINGTGTLDLTLPRGQIVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHPINPSEKEPRRQTGMPEDYWLPTPEPTQPSVPTVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNFLARTPSPTPRGWNLPS" } }, { "url": "https://www.uniprot.org/uniprot/A1IGU3#F1LQ74-1", "isoform_ac": "F1LQ74-1", "locus": { "end_pos": 56829346, "strand": "+", "start_pos": 56853774, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000032189", "id": "ENSRNOT00000032189", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000037964", "id": "ENSRNOP00000037964", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1LQ74-1|ARH37_RAT Computationally mapped isoform of Rho guanine nucleotide exchange factor 37 OS=Rattus norvegicus OX=10116 GN=Arhgef37 PE=2 SV=1 CANONICAL=A1IGU3-1", "length": 676, "sequence": "MADFETDEASSKSESPEQEGQGSEDKSLLHQRLAIRELIDTEVSYLHTLRLCTSDIRGHLQQLPPGDLDILFSNIDDIIQVSSRFLHGLQETACKEEKQAHLIGNLFLEFQEELEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAVPQAGPSGLSFLLVIPLQRITKYPLLLQKILENTPADASAHPVLQRATSALQDVNSNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLSQLLKQEAGLVPRTEDKEFDDLEERFQWVSLCVTELKSNVAAYMDNLEAFLCFRPHERNLDIPGGAAEQYCSLARDLQLQAFLQFKQRLTGLVWQPLCSLARALVGPQNLIKKRLDKLLDFERVEEKLLDVGSVTYEEEAARHTYQALNSLIVAELPQFNHLVMQWLGQILRTFVVLQRDLADQVLRRAESSMALLPHRHVSEPDFQKLLEDTLGQSSSQLRHFRESFEKVLPPSTSQPLLPGSEHQMQSLLTRYGPGKIYQVTSNINGTGTLDLTLPRGQIVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHPINPSEKEPRRQTGMPEDYWLPTPEPTQPSVPTVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNFLARTPSPTPWGWNLPS" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307398", "resource": "KEGG Pathway", "id": "rno:307398", "name": "" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", "resource": "Reactome", "id": "R-RNO-193648", "name": "NRAGE signals death through JNK" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "resource": "Reactome", "id": "R-RNO-194840", "name": "Rho GTPase cycle" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", "resource": "Reactome", "id": "R-RNO-416482", "name": "G alpha (12/13) signalling events" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3#function", "annotation": "May act as a guanine nucleotide exchange factor (GEF).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3#function", "id": "A1IGU3", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "A1IGU4-1", "protein_name": "Rho guanine nucleotide exchange factor 37", "sequence": { "length": 676, "sequence": "MADFGADEASSKSESPEQEDQGSEDRSLLHQRLAIRELIDTEVSYLHTLRLCASDIRSHLQQLPPGDLDILFSNIDDIIQVSSRFLRGLQETACREEEQAHLIGNLFLEFQEEFEQVYKVYCANYDQALLLVKAYQKEPELQKEIQGIIEAAMPQAGPSGLSFFLVIPLQRITKYPLLLQKILENTPADASAHPALQRATSALQDVNGNINEYKMRKEVALKYTKVEQLSLRERLARINTHTLSKKTTRLSQMLKQEAGLVSRTEDKEFDDLEERFQWVSLCVKELRNNVVDFMGNLEVFLSFRPHERSLDIPGGPAEQYCSLARDLQLHAFLQFKQRLRSLVWQPLCSLARALAGPQNLIKKRLDKLLDFDRVEEKLLDVGSVTWEEEAARHEYQALNSLLVAELPQFNQLVMQWLGQILCTFVVLQRDLADQVLRRAESTMALLPHHHVSEPDFQKLLEHTLGQSSSQLRLFQESFEKVLPPSTTQPLLPGSEHQMQALLTRYGPEKLYQVSSNINGTGTLDLTLLRGQIVALLQNKDTKGNNSRWLVDTGGHRGYVPAGKLQLYHPIIPSEKELRGQTGTHEDSWLPAPEPTQLSVPTVPTMSQVVAVYPFVARSTHELSLQAGQPVTILEAQDKKGNPEWSLVEANGQRGYVPSNFLARTPSPTPWGWNLPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28467", "id": "28467", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "A1IGU5-1", "protein_name": "Rho guanine nucleotide exchange factor 37", "sequence": { "length": 675, "sequence": "MAKHGADEPSSRSGSPDREGRASEDRSLLHQRLAVRELIDTEVSYLHMLQLCASDIRSRLQQLPQGDLDVLFSNIDDIIKVNSRFLHDLQETASKEEEQVQLVGNIFLEFQEELEQVYKVYCASYDQALLLVDTYRKEPELQRHIQGIVEAVVPQAGSSGLSFLLVIPLQRITRYPLLLQKILENTVPDASAYPVLQRAVSALQDVNTNINEYKMRKEVASKYTKVEQLTLRERLARINTHTLSKKTTRLSQLLKQEAGLIPRTEDKEFDDLEERFQWVSLCVTELKNNVAAYLDNLQAFLYFRPHEYNLDIPEGPAVQYCNLARDLHLEAFLKFKQRLEGLVWQPLCSLAKALLGPQNLIKKRLDKLLDFERVEEKLLEVGSVTYQEEAARHTYQALNSLLVAELPQFNQLVMQWLGQIMCTFVTLQRDLAKQVLQRAEGSMAQLPHHHVPEPAFRKLVEDALGRTSNQLRSFQETFEKVQPPPTTQPLLPGSERQVQALLSRYGPGKLYQVTSNISGTGTLDLTLPRGQIVAILQNKDTKGNSGRWLVDTGGHRGYVPAGKLQLYHVVPSAEELRRQAGLNKDPRCLTPEPSPALVPSIPTMNQVIAAYPFVARSSHEVSLQAGQPVTILEAQDKKGNPEWSLVEVNGQRGYVPSGFLARARSPVLWGWSLPS" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/28467", "id": "28467", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094444.1", "ac": "NP_001094444.1", "name": "rho guanine nucleotide exchange factor 37", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005089", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "id": "A1IGU3", "database": "UniProtKB" } ], "name": "Rho guanyl-nucleotide exchange factor activity", "id": "GO:0005089" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "id": "A1IGU3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "id": "A1IGU3", "database": "UniProtKB" } ], "name": "regulation of Rho protein signal transduction", "id": "GO:0035023" } ], "total": 1, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A1IGU3", "type": "synonym", "resource": "RefSeq", "name": "Arhgef37" }, { "url": "https://www.uniprot.org/uniprot/A1IGU3", "type": "recommended", "resource": "UniProtKB", "name": "Arhgef37" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1IGU3", "type": "synonym", "resource": "RefSeq", "name": "RGD1560471" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "id": "cd00160", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11799", "id": "cd11799", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd11941", "id": "cd11941", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/307398", "id": "307398", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "id": "IPR000219", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001452", "id": "IPR001452", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004148", "id": "IPR004148", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR027267", "id": "IPR027267", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035636", "id": "IPR035636", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035823", "id": "IPR035823", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "id": "IPR035899", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036028", "id": "IPR036028", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:307398", "id": "rno:307398", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=207472at2759", "id": "207472at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00621", "id": "PF00621", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF07653", "id": "PF07653", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF14604", "id": "PF14604", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1IGU3", "id": "PR_A1IGU3", "database": "PRO" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193648", "id": "R-RNO-193648", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-194840", "id": "R-RNO-194840", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-416482", "id": "R-RNO-416482", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094444.1", "id": "NP_001094444.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560471", "id": "1560471", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 76407.0, "chemical_mass": 76407.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "name": "Arhgef37", "locus": { "end_pos": 56817988, "strand": "-", "start_pos": 56870839, "chromosome": "18", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000025502", "id": "ENSRNOG00000025502", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A1IGU3", "type": "synonym", "resource": "UniProtKB", "name": "Protein 2-88" }, { "url": "https://www.uniprot.org/uniprot/A1IGU3", "type": "recommended", "resource": "UniProtKB", "name": "Rho guanine nucleotide exchange factor 37" }, { "url": "https://www.uniprot.org/uniprot/A1IGU3", "type": "synonym", "resource": "UniProtKB", "name": "Scaffold protein tuba 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1IGU3", "type": "synonym", "resource": "RefSeq", "name": "probable guanine nucleotide exchange factor FLJ41603 homolog; protein 2-88; scaffold protein tuba 3; Rho guanine nucleotide exchange factor (GEF) 37" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A1IGU3", "type": "synonym", "resource": "RefSeq", "name": "rho guanine nucleotide exchange factor 37" } ] }