{
    "uniprot_canonical_ac": "A1EC81-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "tr|A1EC81-1|A1EC81_RAT Isoform 1 of Matrix metallopeptidase 28  OS=Rattus norvegicus OX=10116 GN=Mmp28 PE=2 SV=1 CANONICAL=A1EC81-1", 
        "length": 525, 
        "sequence": "MVTGLSLLLRVLPLLLWGCQDAQPTPRGHPELHQEAEAFLEKYGYLSEQGSKVPASTQFSDAIREFQWVSQLPISGVLDRATLRQMTRPRCGVADTDSHETWTERIRALLAGHRAKMRRKKRFAKPGHKWYKQHLSYRLVNWPKSLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDVLAVQNLYGKPLGRSVATQLPGKIFTDFEAWDPHNSQSRRPETRGPKYCHSSFDAITVDGQWRLYVFKGSHFWEVTADGNVSEPHPLQKRWPGLPSSIEAAAVSLEDGDFFFFKGNRCWRFQGTKSVFAQLCRAGGLPRHPDAALFFPPLRRLVLFKGSRYYVLARGGMQVEPYYPRSLRDWAGVPEEVSGALPRPDGSIIFFRDDHYWHLDQAKLRVTSSGRWATELSWMGCWNANSGGALFQRLPVTE"
    }, 
    "uniprot_id": "A1EC81_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC81", 
                    "id": "A1EC81", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17218081", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "17218081"
                }
            ], 
            "title": "Fine-mapping and comprehensive transcript analysis reveals nonsynonymous variants within a novel 1.17 Mb blood pressure QTL region on rat chromosome 10.", 
            "journal": "Genomics", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1EC81", 
                    "id": "A1EC81", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073357.1", 
                    "id": "NP_001073357.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Saad Y., Farms P., Garrett M.R., Joe B., Manickavasagam E., Radecki T., Yerga-Woolwine S.", 
            "date": "2007"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19265166", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19265166"
                }
            ], 
            "title": "Epilysin (MMP-28) restrains early macrophage recruitment in Pseudomonas aeruginosa pneumonia.", 
            "journal": "Journal of immunology (Baltimore, Md. : 1950)", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073357.1", 
                    "id": "NP_001073357.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Manicone AM, Birkland TP, Lin M, Betsuyaku T, van Rooijen N, Lohi J, Keski-Oja J, Wang Y, Skerrett SJ, Parks WC", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27068509", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27068509"
                }
            ], 
            "title": "Extracellular matrix remodelling in response to venous hypertension: proteomics of human varicose veins.", 
            "journal": "Cardiovascular research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073357.1", 
                    "id": "NP_001073357.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Barallobre-Barreiro J, Oklu R, Lynch M, Fava M, Baig F, Yin X, Barwari T, Potier DN, Albadawi H, Jahangiri M, Porter KE, Watkins MT, Misra S, Stoughton J, Mayr M", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A1EC81", 
    "site_annotation": [
        {
            "end_pos": 166, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 164
        }, 
        {
            "end_pos": 357, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 355
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81#A1EC81-1", 
            "isoform_ac": "A1EC81-1", 
            "locus": {
                "end_pos": 70660694, 
                "strand": "+", 
                "start_pos": 70681672, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000013836", 
                        "id": "ENSRNOT00000013836", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000013836", 
                        "id": "ENSRNOP00000013836", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A1EC81-1|A1EC81_RAT Isoform 1 of Matrix metallopeptidase 28  OS=Rattus norvegicus OX=10116 GN=Mmp28 PE=2 SV=1 CANONICAL=A1EC81-1", 
                "length": 525, 
                "sequence": "MVTGLSLLLRVLPLLLWGCQDAQPTPRGHPELHQEAEAFLEKYGYLSEQGSKVPASTQFSDAIREFQWVSQLPISGVLDRATLRQMTRPRCGVADTDSHETWTERIRALLAGHRAKMRRKKRFAKPGHKWYKQHLSYRLVNWPKSLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDVLAVQNLYGKPLGRSVATQLPGKIFTDFEAWDPHNSQSRRPETRGPKYCHSSFDAITVDGQWRLYVFKGSHFWEVTADGNVSEPHPLQKRWPGLPSSIEAAAVSLEDGDFFFFKGNRCWRFQGTKSVFAQLCRAGGLPRHPDAALFFPPLRRLVLFKGSRYYVLARGGMQVEPYYPRSLRDWAGVPEEVSGALPRPDGSIIFFRDDHYWHLDQAKLRVTSSGRWATELSWMGCWNANSGGALFQRLPVTE"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:103694864", 
            "resource": "KEGG Pathway", 
            "id": "rno:103694864", 
            "name": ""
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303384", 
            "resource": "KEGG Pathway", 
            "id": "rno:303384", 
            "name": ""
        }
    ], 
    "function": [], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q8CGV8-1", 
            "protein_name": "Matrix metallopeptidase 28 (epilysin)", 
            "sequence": {
                "length": 520, 
                "sequence": "MVAGVSLLLRALPLLLWGCQDAQPTQHGLPELRQEAEAFLEKYGYLSEQGSKAPASAQFRNAIREFQWISQLPLSGVLDQATLRQMTRPRCGVADTDSHATWTERISTLLAGHRAKMRRKKRFAKPGNKWYKQHLSYRLVNWPERLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLANAFDGPGGALAHAFLPRRGEAHFDGDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKKLGRDALLSWDDVLAVQSLYGKPLGRSVATQLPGKVFTDFEAWDPHNSQSRRPETRGPKYCHSSFDAITVDGQWRLYVFKGSYFWEVTVDGNVSEPRPLQKRWPGLPPGIEAAAVSLEDGDFYFFKGNRCWRFQGTKSVWGFAQLCRAGGLPRHPDAALFFPPLRRLVLFKGSRYYVLAQGGMQVEPYYPRSLRDWAGVPEEVSGALPRPDGSIIFFRDDHYWHLDQAKLRVTSSGRWATELSWMGCWNANSGGALF"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41559", 
                    "id": "41559", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }, 
        {
            "uniprot_canonical_ac": "Q9H239-1", 
            "protein_name": "Matrix metalloproteinase-28", 
            "sequence": {
                "length": 520, 
                "sequence": "MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFSDAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRKKRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPADIRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAHEIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLFTDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFFRDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41559", 
                    "id": "41559", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073357.1", 
        "ac": "NP_001073357.1", 
        "name": "matrix metalloproteinase-28 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004222", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "metalloendopeptidase activity", 
                        "id": "GO:0004222"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008270", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "zinc ion binding", 
                        "id": "GO:0008270"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031012", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular matrix", 
                        "id": "GO:0031012"
                    }
                ], 
                "total": 2, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030198", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular matrix organization", 
                        "id": "GO:0030198"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030574", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1EC81", 
                                "id": "A1EC81", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "collagen catabolic process", 
                        "id": "GO:0030574"
                    }
                ], 
                "total": 2, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "LOC100912318"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "LOC103694864"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC81", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Mmp28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Mmp28"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000047940", 
            "id": "ENSRNOG00000047940", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00094", 
            "id": "cd00094", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd04278", 
            "id": "cd04278", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/103694864", 
            "id": "103694864", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/303384", 
            "id": "303384", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000585", 
            "id": "IPR000585", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001818", 
            "id": "IPR001818", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002477", 
            "id": "IPR002477", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR006026", 
            "id": "IPR006026", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018487", 
            "id": "IPR018487", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR021190", 
            "id": "IPR021190", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR024079", 
            "id": "IPR024079", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR028735", 
            "id": "IPR028735", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR033739", 
            "id": "IPR033739", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036365", 
            "id": "IPR036365", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036375", 
            "id": "IPR036375", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:103694864", 
            "id": "rno:103694864", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:303384", 
            "id": "rno:303384", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/QNLYGKP/", 
            "id": "QNLYGKP", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1075463at2759", 
            "id": "1075463at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR10201:SF16", 
            "id": "PTHR10201:SF16", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00045", 
            "id": "PF00045", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00413", 
            "id": "PF00413", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01471", 
            "id": "PF01471", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073357.1", 
            "id": "NP_001073357.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311573", 
            "id": "1311573", 
            "database": "RGD"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=9149208", 
            "id": "9149208", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 59436.0, 
        "chemical_mass": 59436.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "name": "Mmp28", 
            "locus": {
                "end_pos": 70660691, 
                "strand": "-", 
                "start_pos": 70681672, 
                "chromosome": "10", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000047940", 
                        "id": "ENSRNOG00000047940", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Matrix metallopeptidase 28"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1EC81", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Matrix metalloproteinase 28"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC81", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "matrix metalloproteinase 28 (epilysin); matrix metalloproteinase-28; matrix metallopeptidase 28 (epilysin)"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1EC81", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "matrix metalloproteinase-28 precursor"
        }
    ]
}