{
    "uniprot_canonical_ac": "A1A5P2-1", 
    "ptm_annotation": [
        {
            "annotation": "Citrullinated by PADI4.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                    "id": "A1A5P2", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/P46638", 
                    "id": "P46638", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q8BHX3", 
                    "id": "Q8BHX3", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9CYH6", 
                    "id": "Q9CYH6", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q9DBE9", 
                    "id": "Q9DBE9", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q8VEK3", 
                    "id": "Q8VEK3", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q7TPV4", 
                    "id": "Q7TPV4", 
                    "database": "PubMed"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/Q99JF8", 
                    "id": "Q99JF8", 
                    "database": "PubMed"
                }
            ]
        }
    ], 
    "sequence": {
        "header": "sp|A1A5P2-1|RRS1_RAT Isoform 1 of Ribosome biogenesis regulatory protein homolog  OS=Rattus norvegicus OX=10116 GN=Rrs1 PE=2 SV=1 CANONICAL=A1A5P2-1", 
        "length": 365, 
        "sequence": "MEGQSVEELLAKAKQEEAEKLQRITVHKELELEFDLGNLLASDRNPPTVLRQAGPSPEAELRALARDNTQLLVNQLWQLPTERVEEAVVARLPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYKRARDDTKEWLIEVPGSADPMEDQFAKRIRAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKKKGGRQGPSGRRKGGPPSQGEKRKGVLGGKKHSRPPALGGKKKGVPHHGGKRRK"
    }, 
    "uniprot_id": "RRS1_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Rat", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                    "id": "A1A5P2", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19433866", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19433866"
                }
            ], 
            "title": "Rrs1 is involved in endoplasmic reticulum stress response in Huntington disease.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
                    "id": "NP_001073167.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Carnemolla A, Fossale E, Agostoni E, Michelazzi S, Calligaris R, De Maso L, Del Sal G, MacDonald ME, Persichetti F", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/19465021", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "19465021"
                }
            ], 
            "title": "A nucleolar protein RRS1 contributes to chromosome congression.", 
            "journal": "FEBS letters", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
                    "id": "NP_001073167.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Gambe AE, Matsunaga S, Takata H, Ono-Maniwa R, Baba A, Uchiyama S, Fukui K", 
            "date": "2009"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22658674", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22658674"
                }
            ], 
            "title": "Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.", 
            "journal": "Cell", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
                    "id": "NP_001073167.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24029230", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24029230"
                }
            ], 
            "title": "Haploinsufficiency of SAMD9L, an endosome fusion facilitator, causes myeloid malignancies in mice mimicking human diseases with monosomy 7.", 
            "journal": "Cancer cell", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
                    "id": "NP_001073167.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Nagamachi A, Matsui H, Asou H, Ozaki Y, Aki D, Kanai A, Takubo K, Suda T, Nakamura T, Wolff L, Honda H, Inaba T", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24120868", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24120868"
                }
            ], 
            "title": "The 5S RNP couples p53 homeostasis to ribosome biogenesis and nucleolar stress.", 
            "journal": "Cell reports", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
                    "id": "NP_001073167.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sloan KE, Bohnsack MT, Watkins NJ", 
            "date": "2013"
        }
    ], 
    "uniprot_ac": "A1A5P2", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5P2#A1A5P2-1", 
            "isoform_ac": "A1A5P2-1", 
            "locus": {
                "end_pos": 9431160, 
                "strand": "+", 
                "start_pos": 9432254, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000009482", 
                        "id": "ENSRNOT00000009482", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000009482", 
                        "id": "ENSRNOP00000009482", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A1A5P2-1|RRS1_RAT Isoform 1 of Ribosome biogenesis regulatory protein homolog  OS=Rattus norvegicus OX=10116 GN=Rrs1 PE=2 SV=1 CANONICAL=A1A5P2-1", 
                "length": 365, 
                "sequence": "MEGQSVEELLAKAKQEEAEKLQRITVHKELELEFDLGNLLASDRNPPTVLRQAGPSPEAELRALARDNTQLLVNQLWQLPTERVEEAVVARLPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYKRARDDTKEWLIEVPGSADPMEDQFAKRIRAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKKKGGRQGPSGRRKGGPPSQGEKRKGVLGGKKHSRPPALGGKKKGVPHHGGKRRK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:297784", 
            "resource": "KEGG Pathway", 
            "id": "rno:297784", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5P2#function", 
            "annotation": "Involved in ribosomal large subunit assembly. May regulate the localization of the 5S RNP/5S ribonucleoprotein particle to the nucleolus.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5P2#function", 
                    "id": "A1A5P2", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q15050-1", 
            "protein_name": "Ribosome biogenesis regulatory protein homolog", 
            "sequence": {
                "length": 365, 
                "sequence": "MEGQSVEELLAKAEQDEAEKLQRITVHKELELQFDLGNLLASDRNPPTGLRCAGPTPEAELQALARDNTQLLINQLWQLPTERVEEAIVARLPEPTTRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEVSGQWRRRWGYQRARDDTKEWLIEVPGNADPLEDQFAKRIQAKKERVAKNELNRLRNLARAHKMQLPSAAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKVPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPQLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPGGKRKGGPPSQGGKRKGGLGGKMNSGPPGLGGKRKGGQRPGGKRRK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41014", 
                    "id": "41014", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1A5P2/", 
                    "id": "A1A5P2", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }, 
        {
            "uniprot_canonical_ac": "Q9CYH6-1", 
            "protein_name": "Ribosome biogenesis regulatory protein homolog", 
            "sequence": {
                "length": 365, 
                "sequence": "MEGQRVEELLAKAEQEEAEKLQRITVHKELELEFDLGNLLASDRNPPTVLRQAGPSPEAELRALARDNTQLLINQLWRLPTERVEEAVVARLPEPATRLPREKPLPRPRPLTRWQQFARLKGIRPKKKTNLVWDEASGQWRRRWGYKRARDDTKEWLIEVPGSADPMEDQFAKRTQAKKERVAKNELNRLRNLARAHKMQMPSSAGLHPTGHQSKEELGRAMQVAKVSTASVGRFQERLPKEKAPRGSGKKRKFQPLFGDFAAEKKNQLELLRVMNSKKPRLDVTRATNKQMREEDQEEAAKRRKMSQKGKRKGGRQGPSGKRKGGPPGQGEKRKGGLGSKKHSWPSALAGKKKGVPPQGGKRRK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/41014", 
                    "id": "41014", 
                    "database": "MGI"
                }, 
                {
                    "url": "https://omabrowser.org/oma/group/A1A5P2/", 
                    "id": "A1A5P2", 
                    "database": "OMA"
                }
            ], 
            "common_name": "Mouse", 
            "organism": "Mus musculus", 
            "tax_id": 10090
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }, 
        {
            "name": "homologset.oma", 
            "label": "OMA Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
        "ac": "NP_001073167.1", 
        "name": "ribosome biogenesis regulatory protein homolog", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008097", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "5S rRNA binding", 
                        "id": "GO:0008097"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005730", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "nucleolus", 
                        "id": "GO:0005730"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030687", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "preribosome, large subunit precursor", 
                        "id": "GO:0030687"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000794", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "condensed nuclear chromosome", 
                        "id": "GO:0000794"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001650", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "fibrillar center", 
                        "id": "GO:0001650"
                    }
                ], 
                "total": 5, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000055", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ribosomal large subunit export from nucleus", 
                        "id": "GO:0000055"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042273", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ribosomal large subunit biogenesis", 
                        "id": "GO:0042273"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000447", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)", 
                        "id": "GO:0000447"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902570", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein localization to nucleolus", 
                        "id": "GO:1902570"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1901796", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "regulation of signal transduction by p53 class mediator", 
                        "id": "GO:1901796"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007080", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "mitotic metaphase plate congression", 
                        "id": "GO:0007080"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002244", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "hematopoietic progenitor cell differentiation", 
                        "id": "GO:0002244"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000027", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                                "id": "A1A5P2", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ribosomal large subunit assembly", 
                        "id": "GO:0000027"
                    }
                ], 
                "total": 8, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5P2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Rrs1"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A5P2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Rrs1"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000007240", 
            "id": "ENSRNOG00000007240", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/297784", 
            "id": "297784", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007023", 
            "id": "IPR007023", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:297784", 
            "id": "rno:297784", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/RRWGYKR/", 
            "id": "RRWGYKR", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1264304at2759", 
            "id": "1264304at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR17602", 
            "id": "PTHR17602", 
            "database": "PANTHER"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF04939", 
            "id": "PF04939", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A1A5P2", 
            "id": "PR_A1A5P2", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073167.1", 
            "id": "NP_001073167.1", 
            "database": "RefSeq"
        }, 
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1311403", 
            "id": "1311403", 
            "database": "RGD"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [
        {
            "residue": "Ser", 
            "position": "5", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A1A5P2", 
                    "id": "A1A5P2", 
                    "database": "UniProtKB"
                }
            ], 
            "kinase_uniprot_canonical_ac": "", 
            "kinase_gene_name": ""
        }
    ], 
    "mass": {
        "monoisotopic_mass": 41537.0, 
        "chemical_mass": 41537.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A1A5P2", 
            "name": "Rrs1", 
            "locus": {
                "end_pos": 9430728, 
                "strand": "-", 
                "start_pos": 9432343, 
                "chromosome": "5", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000007240", 
                        "id": "ENSRNOG00000007240", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5P2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "RRS1 ribosome biogenesis regulator homolog"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A1A5P2", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Ribosome biogenesis regulatory protein homolog"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A1A5P2", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "ribosome biogenesis regulatory protein homolog"
        }
    ]
}