{
    "uniprot_canonical_ac": "A0PK84-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0PK84-1|ZDH22_MOUSE Isoform 1 of Palmitoyltransferase ZDHHC22  OS=Mus musculus OX=10090 GN=Zdhhc22 PE=1 SV=1 CANONICAL=A0PK84-1", 
        "length": 263, 
        "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSRVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
    }, 
    "uniprot_id": "ZDH22_MOUSE", 
    "enzyme_annotation": [
        {
            "ec": "2.3.1.225", 
            "activity": ""
        }, 
        {
            "ec": "2.3.1.225", 
            "activity": "Palmitoyl-CoA + [protein]-L-cysteine = [protein]-S-palmitoyl-L-cysteine + CoA."
        }
    ], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "common_name": "Mouse", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/29287726", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "29287726"
                }
            ], 
            "title": "CCN3 secretion is regulated by palmitoylation via ZDHHC22.", 
            "journal": "Biochem. Biophys. Res. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
                    "id": "NP_001074412.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Yang H., Jang S.W., Kim Y., Park Y.J., Shim S., Jeong S.H., Min J.K.", 
            "date": "2018"
        }
    ], 
    "uniprot_ac": "A0PK84", 
    "site_annotation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84#A0PK84-1", 
            "isoform_ac": "A0PK84-1", 
            "locus": {
                "end_pos": 86983384, 
                "strand": "+", 
                "start_pos": 86988676, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000222543", 
                        "id": "ENSMUST00000222543", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000152660", 
                        "id": "ENSMUSP00000152660", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A0PK84-1|ZDH22_MOUSE Isoform 1 of Palmitoyltransferase ZDHHC22  OS=Mus musculus OX=10090 GN=Zdhhc22 PE=1 SV=1 CANONICAL=A0PK84-1", 
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYVLVIQNSPDDLGTCQGTMSQRPQCPPPSTHFCRVCSRVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGMAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:238331", 
            "resource": "KEGG Pathway", 
            "id": "mmu:238331", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84#function", 
            "annotation": "Palmitoyltransferase that mediates palmitoylation of KCNMA1, regulating localization of KCNMA1 to the plasma membrane (By similarity). Might also mediate palmitoylation of CNN3 (PubMed:29287726).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0PK84#function", 
                    "id": "A0PK84", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
            "annotation": "Taken together, our results suggest that palmitoylation by ZDHHC22 at C241 in the CCN3 TSP1 domain may be required for the secretion of CCN3. Aberrant palmitoylation induces intracellular accumulation of CCN3, inhibiting neuronal axon growth.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
                    "id": "NP_001074412.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [
        {
            "uniprot_canonical_ac": "Q2TGI8-1", 
            "protein_name": "Palmitoyltransferase ZDHHC22", 
            "sequence": {
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPTATPLFSPAVLHGALFLFLSANALGNYILVVQNSPDDLGACQGTSSQRPQRPPPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFILFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSDMFVILMLYLWFAVGLACAGFCCHQLLLILRGQTRYQVRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGTESSKQQDK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/45486", 
                    "id": "45486", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Rat", 
            "organism": "Rattus norvegicus", 
            "tax_id": 10116
        }, 
        {
            "uniprot_canonical_ac": "Q8N966-1", 
            "protein_name": "Palmitoyltransferase ZDHHC22", 
            "sequence": {
                "length": 263, 
                "sequence": "MLALRLLNVVAPAYFLCISLVTFVLQLFLFLPSMREDPAAARLFSPALLHGALFLFLSANALGNYVLVIQNSPDDLGACQGASARKTPCPSPSTHFCRVCARVTLRHDHHCFFTGNCIGSRNMRNFVLFCLYTSLACLYSMVAGVAYISAVLSISFAHPLAFLTLLPTSISQFFSGAVLGSEMFVILMLYLWFAIGLACAGFCCHQLLLILRGQTRHQVRKGVAVRARPWRKNLQEVFGKRWLLGLLVPMFNVGSESSKQQDK"
            }, 
            "evidence": [
                {
                    "url": "http://www.informatics.jax.org/homology/45486", 
                    "id": "45486", 
                    "database": "MGI"
                }
            ], 
            "common_name": "Human", 
            "organism": "Homo sapiens", 
            "tax_id": 9606
        }
    ], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "homologset.mgi", 
            "label": "MGI Homologs"
        }
    ], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
        "ac": "NP_001074412.1", 
        "name": "palmitoyltransferase ZDHHC22", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019706", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein-cysteine S-palmitoyltransferase activity", 
                        "id": "GO:0019706"
                    }
                ], 
                "total": 1, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "endoplasmic reticulum", 
                        "id": "GO:0005783"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005794", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "Golgi apparatus", 
                        "id": "GO:0005794"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "plasma membrane", 
                        "id": "GO:0005886"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072659", 
                        "pmid": "22399288", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein localization to plasma membrane", 
                        "id": "GO:0072659"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006612", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein targeting to membrane", 
                        "id": "GO:0006612"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018345", 
                        "pmid": "22399288", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "protein palmitoylation", 
                        "id": "GO:0018345"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0018230", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0PK84", 
                                "id": "A0PK84", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "peptidyl-L-cysteine S-palmitoylation", 
                        "id": "GO:0018230"
                    }
                ], 
                "total": 4, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0PK84", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Gm262"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Gm262"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0PK84", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "Zdhhc22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Zdhhc22"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000048483", 
            "id": "ENSMUSG00000048483", 
            "database": "Bgee"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/238331", 
            "id": "238331", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000731", 
            "id": "IPR000731", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001594", 
            "id": "IPR001594", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:238331", 
            "id": "mmu:238331", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:2685108", 
            "id": "2685108", 
            "database": "MGI"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/LPSMRQD/", 
            "id": "LPSMRQD", 
            "database": "OMA"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1402394at2759", 
            "id": "1402394at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF01529", 
            "id": "PF01529", 
            "database": "Pfam"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0PK84", 
            "id": "PR_A0PK84", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074412.1", 
            "id": "NP_001074412.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 29318.0, 
        "chemical_mass": 29318.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "name": "Zdhhc22", 
            "locus": {
                "end_pos": 86980763, 
                "strand": "-", 
                "start_pos": 86990430, 
                "chromosome": "12", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000048483", 
                        "id": "ENSMUSG00000048483", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "2.3.1.225"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "DHHC-22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "Palmitoyltransferase ZDHHC22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "Zinc finger DHHC domain-containing protein 22"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0PK84", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "palmitoyltransferase ZDHHC22"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/A0PK84", 
            "type": "synonym", 
            "resource": "RefSeq", 
            "name": "putative palmitoyltransferase ZDHHC22; DHHC-22; zinc finger DHHC domain-containing protein 22"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0PK84", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "zDHHC22"
        }
    ]
}