{ "uniprot_canonical_ac": "A0JPP7-1", "ptm_annotation": [], "sequence": { "header": "sp|A0JPP7-1|DDI1_RAT Isoform 1 of Protein DDI1 homolog 1 OS=Rattus norvegicus OX=10116 GN=Ddi1 PE=1 SV=1 CANONICAL=A0JPP7-1", "length": 408, "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPSTQQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQQRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQEDSSDKEVAGSIKHPVKGPGRKKH" }, "uniprot_id": "DDI1_RAT", "enzyme_annotation": [ { "ec": "3.4.23.-", "activity": "" } ], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/29290612", "type": [ "PubMed" ], "id": "29290612" } ], "title": "Removal of RTF2 from Stalled Replisomes Promotes Maintenance of Genome Integrity.", "journal": "Molecular cell", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", "id": "NP_001078944.1", "database": "RefSeq" } ], "authors": "Kottemann MC, Conti BA, Lach FP, Smogorzewska A", "date": "2018" } ], "uniprot_ac": "A0JPP7", "site_annotation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7#A0JPP7-1", "isoform_ac": "A0JPP7-1", "locus": {}, "sequence": { "header": "sp|A0JPP7-1|DDI1_RAT Isoform 1 of Protein DDI1 homolog 1 OS=Rattus norvegicus OX=10116 GN=Ddi1 PE=1 SV=1 CANONICAL=A0JPP7-1", "length": 408, "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGPRPPGRAPNHPRTDFTGSGSAVPGTSSSRHPHPHQHHHHQHQRIPSTQQAHGLASGENMAFAQDLNSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLVEQQRERAMREQEMFRLYSADPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGAVQEDSSDKEVAGSIKHPVKGPGRKKH" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:367012", "resource": "KEGG Pathway", "id": "rno:367012", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7#function", "annotation": "Probable aspartic protease (By similarity). Seems to act as a proteasomal shuttle which links the proteasome and replication fork proteins like RTF2. Required, with DDI2, for cellular survival following replication stress. Together or redudantly with DDI2, removes RTF2 from stalled forks to allow cell cycle progression after replication stress and maintains genome integrity (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7#function", "id": "A0JPP7", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q8WTU0-1", "protein_name": "Protein DDI1 homolog 1", "sequence": { "length": 396, "sequence": "MLITVYCVRRDLSEVTFSLQVSPDFELRNFKVLCEAESRVPVEEIQIIHMERLLIEDHCSLGSYGLKDGDIVVLLQKDNVGPRAPGRAPNQPRVDFSGIAVPGTSSSRPQHPGQQQQRTPAAQRSQGLASGEKVAGLQGLGSPALIRSMLLSNPHDLSLLKERNPPLAEALLSGSLETFSQVLMEQQREKALREQERLRLYTADPLDREAQAKIEEEIRQQNIEENMNIAIEEAPESFGQVTMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWAGVAKGVGTQRIIGRVHLAQIQIEGDFLQCSFSILEDQPMDMLLGLDMLRRHQCSIDLKKNVLVIGTTGTQTYFLPEGELPLCSRMVSGQDESSDKEITHSVMDSGRKEH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/100549", "id": "100549", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q9DAF3-1", "protein_name": "Protein DDI1 homolog 1", "sequence": { "length": 408, "sequence": "MLITVYCVRRDLTEVTFSLQVNPDFELSNFRVLCELESGVPAEEAQIVYMEQLLTDDHCSLGSYGLKDGDMVVLLQKDNVGLRTPGRTPNHPRADFTGSGSAVPGTSSSRHPHQHQHHYHHHQRIPSTQQAHGLASGENMTFAQELDSPALIRSMLLSNPHDLSLLKERNPALAEALLSGNLETFSQVLMEQQRERTLREQEMFRLYSTNPFDQETQARIEEEIRQQNIEENMNIAMEEAPESFGQVAMLYINCKVNGHPLKAFVDSGAQMTIMSQACAERCNIMRLVDRRWGGVAKGVGTQRIMGRVHLAQIQIEGDFLQCSFSILEEQPMDILLGLDMLRRHQCSIDLKKNVLVIGTTGSQTHFLPEGELPLCAKLLSGTVQEESSDREVGGTIKHPVKGPGRKKH" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/100549", "id": "100549", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", "ac": "NP_001078944.1", "name": "protein DDI1 homolog 1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004190", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "aspartic-type endopeptidase activity", "id": "GO:0004190" } ], "total": 1, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031647", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "regulation of protein stability", "id": "GO:0031647" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0010498", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "proteasomal protein catabolic process", "id": "GO:0010498" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0097752", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "regulation of DNA stability", "id": "GO:0097752" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0072711", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "id": "A0JPP7", "database": "UniProtKB" } ], "name": "cellular response to hydroxyurea", "id": "GO:0072711" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP7", "type": "synonym", "resource": "RefSeq", "name": "Ddi1" }, { "url": "https://www.uniprot.org/uniprot/A0JPP7", "type": "recommended", "resource": "UniProtKB", "name": "Ddi1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP7", "type": "synonym", "resource": "RefSeq", "name": "RGD1559430" } ], "crossref": [ { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd05479", "id": "cd05479", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/367012", "id": "367012", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000626", "id": "IPR000626", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR019103", "id": "IPR019103", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR021109", "id": "IPR021109", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029071", "id": "IPR029071", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:367012", "id": "rno:367012", "database": "KEGG Pathway" }, { "url": "http://www.orthodb.org/?query=817208at2759", "id": "817208at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00240", "id": "PF00240", "database": "Pfam" }, { "url": "http://pfam.xfam.org/family/PF09668", "id": "PF09668", "database": "Pfam" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0JPP7", "id": "PR_A0JPP7", "database": "PRO" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078944.1", "id": "NP_001078944.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559430", "id": "1559430", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 45451.0, "chemical_mass": 45451.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "name": "Ddi1", "locus": { "end_pos": 4547725, "strand": "-", "start_pos": 4549573, "chromosome": "8", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000022081", "id": "ENSRNOG00000022081", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0JPP7", "type": "synonym", "resource": "UniProtKB", "name": "3.4.23.-" }, { "url": "https://www.uniprot.org/uniprot/A0JPP7", "type": "recommended", "resource": "UniProtKB", "name": "Protein DDI1 homolog 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0JPP7", "type": "synonym", "resource": "RefSeq", "name": "protein DDI1 homolog 1" } ] }