{
    "uniprot_canonical_ac": "A0A5B9-1", 
    "ptm_annotation": [], 
    "sequence": {
        "header": "sp|A0A5B9-1|TRBC2_HUMAN Isoform 1 of T cell receptor beta constant 2  OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1", 
        "length": 178, 
        "sequence": "DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG"
    }, 
    "uniprot_id": "TRBC2_HUMAN", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "reported.uniprotkb_gly"
    ], 
    "species": [
        {
            "common_name": "Human", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Homo sapiens", 
            "taxid": 9606
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15040585", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "15040585"
                }
            ], 
            "title": "The many important facets of T-cell repertoire diversity.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Messaoudi I., Nikolich-Zugich J., Slifka M.K.", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16505140", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "16505140"
                }
            ], 
            "title": "A structural basis for selection and cross-species reactivity of the semi-invariant NKT cell receptor in CD1d/glycolipid recognition.", 
            "journal": "J. Exp. Med.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Clements C.S., Kjer-Nielsen L., McCluskey J., Godfrey D.I., Pellicci D.G., Beddoe T., Kostenko L., Reid H.H., Besra G.S., Bharadwaj M., Borg N.A., Smyth M.J., Williamson N.A.", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20452950", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20452950"
                }
            ], 
            "title": "Structural biology of the T-cell receptor: insights into receptor assembly, ligand recognition, and initiation of signaling.", 
            "journal": "Cold Spring Harb. Perspect. Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Gagnon E., Wucherpfennig K.W., Call M.E., Call M.J., Huseby E.S.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20483993", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20483993"
                }
            ], 
            "title": "Hard wiring of T cell receptor specificity for the major histocompatibility complex is underpinned by TCR adaptability.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Chen Z., Rossjohn J., Brooks A.G., Burrows S.R., Clements C.S., Gras S., Kjer-Nielsen L., McCluskey J., Purcell A.W., Khanna R., Beddoe T., Kostenko L., Liu Y.C., Miles J.J., Archbold J.K., Brennan R.M., Tynan F.E., Moss D.J.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/20921281", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "20921281"
                }
            ], 
            "title": "The Valpha14 invariant natural killer T cell TCR forces microbial glycolipids and CD1d into a conserved binding mode.", 
            "journal": "J. Exp. Med.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li Y., Wang J., Zajonc D.M., Kronenberg M., Girardi E., Painter G.F., Yu E.D.", 
            "date": "2010"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21297580", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "21297580"
                }
            ], 
            "title": "Structure of a TCR with high affinity for self-antigen reveals basis for escape from negative selection.", 
            "journal": "EMBO J.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li Y., Yin Y., Mariuzza R.A., Martin R., Kerzic M.C.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21552205", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "21552205"
                }
            ], 
            "title": "Galactose-modified iNKT cell agonists stabilized by an induced fit of CD1d prevent tumour metastasis.", 
            "journal": "EMBO J.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li Y., Wang J., Zajonc D.M., Girardi E., Van Beneden K., Franck R.W., Pauwels N., Van Calenbergh S., Yu E.D., Aspeslagh S., Decruy T., Drennan M., Elewaut D., Leybaert L., Trappeniers M., Venken K.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22069376", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22069376"
                }
            ], 
            "title": "Unique interplay between sugar and lipid in determining the antigenic potency of bacterial antigens for NKT cells.", 
            "journal": "PLoS Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li Y., Wang J., Zajonc D.M., Kronenberg M., Kinjo Y., Girardi E., Yu E.D., Illarionov P., Pei B., Tarumoto N.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22195564", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22195564"
                }
            ], 
            "title": "Glycolipids that elicit IFN-gamma-biased responses from natural killer T cells.", 
            "journal": "Chem. Biol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li Y., Wang J., Zajonc D.M., Howell A.R., Kronenberg M., Porcelli S.A., Arora P., Girardi E., Khurana A., Farber E., Birkholz A., Chitale S., So R., Tyznik A.J.", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22431638", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "22431638"
                }
            ], 
            "title": "Crystal structure of a complete ternary complex of T-cell receptor, peptide-MHC, and CD4.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Yin Y., Mariuzza R.A., Wang X.X.", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/23524462", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "23524462"
                }
            ], 
            "title": "T cell receptor signalling networks: branched, diversified and bounded.", 
            "journal": "Nat. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Zamoyska R., Brownlie R.J.", 
            "date": "2013"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24600447", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24600447"
                }
            ], 
            "title": "Immunoglobulin and T Cell Receptor Genes: IMGT((R)) and the Birth and Rise of Immunoinformatics.", 
            "journal": "Front. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lefranc M.P.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/24995984", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "24995984"
                }
            ], 
            "title": "Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity.", 
            "journal": "Cell", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Crawford F., Wang Y., Dai S., Kappler J.W., Marrack P., Falta M.T., Novikov A., Bowerman N.A., Clayton G.M., Fontenot A.P., Kieft J.S., Wimberly B.T.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25015819", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25015819"
                }
            ], 
            "title": "Structure of the superantigen staphylococcal enterotoxin B in complex with TCR and peptide-MHC demonstrates absence of TCR-peptide contacts.", 
            "journal": "J. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lindkvist-Petersson K., Rodstrom K.E., Elbing K.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25298532", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25298532"
                }
            ], 
            "title": "Molecular basis of mycobacterial lipid antigen presentation by CD1c and its recognition by alphabeta T cells.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Roy S., Adams E.J., Moody D.B., Li N.S., Piccirilli J.A., Altman J.D., Ly D.", 
            "date": "2014"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/25493333", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "25493333"
                }
            ], 
            "title": "T cell antigen receptor recognition of antigen-presenting molecules.", 
            "journal": "Annu. Rev. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Gras S., McCluskey J., Godfrey D.I., Miles J.J., Turner S.J.", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26018083", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26018083"
                }
            ], 
            "title": "Lipid and Carbohydrate Modifications of alpha-Galactosylceramide Differently Influence Mouse and Human Type I Natural Killer T Cell Activation.", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Wang J., Tsuji M., Zajonc D.M., Howell A., Kronenberg M., Girardi E., Khurana A., Farber E., Birkholz A., Chitale S., Franck R.W., Nemcovic M., Pauwels N., Van Calenbergh S., Yu E.D.", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26078271", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26078271"
                }
            ], 
            "title": "A Novel Glycolipid Antigen for NKT Cells That Preferentially Induces IFN-gamma Production.", 
            "journal": "J. Immunol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Li M., Wang J., Zhao M., Yuan W., Wen X., Zajonc D.M., Besra G.S., Illarionov P.A., Kronenberg M., Porcelli S.A., Girardi E., Khurana A., Birkholz A.M., Wingender G., Zahner S.", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26147596", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26147596"
                }
            ], 
            "title": "Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.", 
            "journal": "PLoS ONE", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Lindkvist-Petersson K., Regenthal P., Rodstrom K.E.", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26758806", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26758806"
                }
            ], 
            "title": "Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.", 
            "journal": "Sci. Rep.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Jakobsen B.K., Mahon T., Simmons R., Cole D.K., Rizkallah P.J., Bossi G., Sami M., Baston E., Donnellan Z., Dukes J., Hassan N., Hickman E., Le Provost G.S., Raman M.C., Todorov P., Vuidepot A.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26875526", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26875526"
                }
            ], 
            "title": "Atypical natural killer T-cell receptor recognition of CD1d-lipid antigens.", 
            "journal": "Nat. Commun.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Gras S., Godfrey D.I., Pellicci D.G., Uldrich A.P., Gherardin N.A., Howell A.R., Keshipeddy S., Le Nours J., Lim R.T., Praveena T., Richardson S.K., Besra G.S., Ross F.J.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26917722", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "26917722"
                }
            ], 
            "title": "A Molecular Switch Abrogates Glycoprotein 100 (gp100) T-cell Receptor (TCR) Targeting of a Human Melanoma Antigen.", 
            "journal": "J. Biol. Chem.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Bianchi V., Cole D.K., Dolton G., Fuller A., Rizkallah P.J., Sewell A.K., Attaf M., Bulek A., Lloyd A.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27036003", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27036003"
                }
            ], 
            "title": "Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Gras S., Miller A., Clemens E.B., Doherty P.C., Grant E.J., Josephs T.M., Kedzierska K., Nguyen T.H., Price D.A., Thomas P.G., Tong S.Y., Valkenburg S.A., Wang G.C.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27180909", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27180909"
                }
            ], 
            "title": "Two common structural motifs for TCR recognition by staphylococcal enterotoxins.", 
            "journal": "Sci. Rep.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Baker D., Ford A., Bahl C., Lindkvist-Petersson K., Regenthal P., Rodstrom K.E.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27183386", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27183386"
                }
            ], 
            "title": "A 'hotspot' for autoimmune T cells in type 1 diabetes.", 
            "journal": "J. Clin. Invest.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Obst R., Huseby E.S., Stadinski B.D.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27183389", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27183389"
                }
            ], 
            "title": "Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.", 
            "journal": "J. Clin. Invest.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Zhu C., Bulek A.M., Cole D.K., Dolton G., Fuller A., Jothikumar P., Miles J.J., Peakman M., Rittase W., Rizkallah P.J., Schauenberg A.J., Sewell A.K., Skowera A., Szomolay B., Trimby A., Wooldridge L.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27568928", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "27568928"
                }
            ], 
            "title": "Diverse T cell receptor gene usage in HLA-DQ8-associated celiac disease converges into a consensus binding solution.", 
            "journal": "Structure", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Rossjohn J., Koning F., Kooy-Winkelaar Y., Loh K.L., Petersen J., Reid H.H., Tran M., van Bergen J.", 
            "date": "2016"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/3860845", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "3860845"
                }
            ], 
            "title": "Sequence and evolution of the human T-cell antigen receptor beta-chain genes.", 
            "journal": "Proc. Natl. Acad. Sci. U.S.A.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Milstein C., Forster A., Tunnacliffe A., Rabbitts T.H., Kefford R.", 
            "date": "1985"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8650574", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "8650574"
                }
            ], 
            "title": "The complete 685-kilobase DNA sequence of the human beta T cell receptor locus.", 
            "journal": "Science", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Hood L., Koop B.F., Rowen L.", 
            "date": "1996"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/8906788", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "8906788"
                }
            ], 
            "title": "Structure of the complex between human T-cell receptor, viral peptide and HLA-A2.", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Garboczi D.N., Wiley D.C., Ghosh P., Biddison W.E., Fan Q.R., Utz U.", 
            "date": "1996"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/9586631", 
                    "type": [
                        "PubMed"
                    ], 
                    "id": "9586631"
                }
            ], 
            "title": "Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids.", 
            "journal": "Immunity", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Garboczi D.N., Wiley D.C., Ding Y.H., Smith K.J., Biddison W.E., Utz U.", 
            "date": "1998"
        }
    ], 
    "uniprot_ac": "A0A5B9", 
    "site_annotation": [
        {
            "end_pos": 71, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 69
        }
    ], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9#A0A0G2JMB4-1", 
            "isoform_ac": "A0A0G2JMB4-1", 
            "locus": {
                "end_pos": 142862134, 
                "strand": "-", 
                "start_pos": 142863620, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENST00000622053", 
                        "id": "ENST00000622053", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSP00000478873", 
                        "id": "ENSP00000478873", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A0A0G2JMB4-1|TRBC2_HUMAN Computationally mapped isoform of T cell receptor beta constant 2  OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1", 
                "length": 179, 
                "sequence": "XDLKNVFPPEVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9#A0A5B9-1", 
            "isoform_ac": "A0A5B9-1", 
            "locus": {}, 
            "sequence": {
                "header": "sp|A0A5B9-1|TRBC2_HUMAN Isoform 1 of T cell receptor beta constant 2  OS=Homo sapiens OX=9606 GN=TRBC2 PE=1 SV=2 CANONICAL=A0A5B9-1", 
                "length": 178, 
                "sequence": "DLKNVFPPKVAVFEPSEAEISHTQKATLVCLATGFYPDHVELSWWVNGKEVHSGVSTDPQPLKEQPALNDSRYCLSSRLRVSATFWQNPRNHFRCQVQFYGLSENDEWTQDRAKPVTQIVSAEAWGRADCGFTSESYQQGVLSATILYEILLGKATLYAVLVSALVLMAMVKRKDSRG"
            }
        }
    ], 
    "pathway": [], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9#function", 
            "annotation": "Constant region of T cell receptor (TR) beta chain (PubMed:24600447). Alpha-beta T cell receptors are antigen specific receptors which are essential to the immune response and are present on the cell surface of T lymphocytes. Recognize peptide-major histocompatibility (MH) (pMH) complexes that are displayed by antigen presenting cells (APC), a prerequisite for efficient T cell adaptive immunity against pathogens (PubMed:25493333). Binding of alpha-beta TR to pMH complex initiates TR-CD3 clustering on the cell surface and intracellular activation of LCK that phosphorylates the ITAM motifs of CD3G, CD3D, CD3E and CD247 enabling the recruitment of ZAP70. In turn, ZAP70 phosphorylates LAT, which recruits numerous signaling molecules to form the LAT signalosome. The LAT signalosome propagates signal branching to three major signaling pathways, the calcium, the mitogen-activated protein kinase (MAPK) kinase and the nuclear factor NF-kappa-B (NF-kB) pathways, leading to the mobilization of transcription factors that are critical for gene expression and essential for T cell growth and differentiation (PubMed:23524462). The T cell repertoire is generated in the thymus, by V-(D)-J rearrangement. This repertoire is then shaped by intrathymic selection events to generate a peripheral T cell pool of self-MH restricted, non-autoaggressive T cells. Post-thymic interaction of alpha-beta TR with the pMH complexes shapes TR structural and functional avidity (PubMed:15040585).", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9#function", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "snv": [], 
    "cluster_types": [
        {
            "name": "isoformset.uniprotkb", 
            "label": "Isoforms"
        }
    ], 
    "refseq": {}, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0034987", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin receptor binding", 
                        "id": "GO:0034987"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003823", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "antigen binding", 
                        "id": "GO:0003823"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009897", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "external side of plasma membrane", 
                        "id": "GO:0009897"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042571", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "immunoglobulin complex, circulating", 
                        "id": "GO:0042571"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016021", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "integral component of membrane", 
                        "id": "GO:0016021"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042101", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "T cell receptor complex", 
                        "id": "GO:0042101"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006911", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, engulfment", 
                        "id": "GO:0006911"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045087", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "innate immune response", 
                        "id": "GO:0045087"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050853", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "B cell receptor signaling pathway", 
                        "id": "GO:0050853"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042742", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "defense response to bacterium", 
                        "id": "GO:0042742"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006910", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "phagocytosis, recognition", 
                        "id": "GO:0006910"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050871", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "positive regulation of B cell activation", 
                        "id": "GO:0050871"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006958", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A0A5B9", 
                                "id": "A0A5B9", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "complement activation, classical pathway", 
                        "id": "GO:0006958"
                    }
                ], 
                "total": 7, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9", 
            "type": "synonym", 
            "resource": "UniProtKB", 
            "name": "TCRBC2"
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "TRBC2"
        }
    ], 
    "crossref": [
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSG00000211772", 
            "id": "ENSG00000211772", 
            "database": "Bgee"
        }, 
        {
            "url": "https://hive.biochemistry.gwu.edu/biomuta/proteinview/A0A5B9", 
            "id": "A0A5B9", 
            "database": "BioMuta"
        }, 
        {
            "url": "http://www.genecards.org/cgi-bin/carddisp.pl?gene=TRBC2", 
            "id": "TRBC2", 
            "database": "GeneCards"
        }, 
        {
            "url": "https://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=12157", 
            "id": "12157", 
            "database": "HGNC"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003597", 
            "id": "IPR003597", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR007110", 
            "id": "IPR007110", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013783", 
            "id": "IPR013783", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036179", 
            "id": "IPR036179", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.omim.org/entry/615445", 
            "id": "615445", 
            "database": "MIM"
        }, 
        {
            "url": "https://www.nextprot.org/entry/NX_A0A5B9", 
            "id": "NX_A0A5B9", 
            "database": "neXtProt"
        }, 
        {
            "url": "https://www.rcsb.org/structure/1AO7", 
            "id": "1AO7", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/1BD2", 
            "id": "1BD2", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/2EYR", 
            "id": "2EYR", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/2EYS", 
            "id": "2EYS", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/2EYT", 
            "id": "2EYT", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3KXF", 
            "id": "3KXF", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3O6F", 
            "id": "3O6F", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3O8X", 
            "id": "3O8X", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3O9W", 
            "id": "3O9W", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3QUX", 
            "id": "3QUX", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3T0E", 
            "id": "3T0E", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3TA3", 
            "id": "3TA3", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/3TVM", 
            "id": "3TVM", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4C56", 
            "id": "4C56", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4MVB", 
            "id": "4MVB", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4MXQ", 
            "id": "4MXQ", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4N0C", 
            "id": "4N0C", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4N5E", 
            "id": "4N5E", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4NHU", 
            "id": "4NHU", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4ONH", 
            "id": "4ONH", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4P4K", 
            "id": "4P4K", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4UDT", 
            "id": "4UDT", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4UDU", 
            "id": "4UDU", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4WW1", 
            "id": "4WW1", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4WW2", 
            "id": "4WW2", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4WWK", 
            "id": "4WWK", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4Y16", 
            "id": "4Y16", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4Y2D", 
            "id": "4Y2D", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4Y4F", 
            "id": "4Y4F", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4Y4H", 
            "id": "4Y4H", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4Y4K", 
            "id": "4Y4K", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/4ZAK", 
            "id": "4ZAK", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5BRZ", 
            "id": "5BRZ", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5BS0", 
            "id": "5BS0", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C07", 
            "id": "5C07", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C08", 
            "id": "5C08", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C09", 
            "id": "5C09", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C0A", 
            "id": "5C0A", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C0B", 
            "id": "5C0B", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5C0C", 
            "id": "5C0C", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5EU6", 
            "id": "5EU6", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5FK9", 
            "id": "5FK9", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5FKA", 
            "id": "5FKA", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5HHM", 
            "id": "5HHM", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5HHO", 
            "id": "5HHO", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5HYJ", 
            "id": "5HYJ", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5KS9", 
            "id": "5KS9", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5KSA", 
            "id": "5KSA", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/5KSB", 
            "id": "5KSB", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6CPH", 
            "id": "6CPH", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6CQL", 
            "id": "6CQL", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6CQQ", 
            "id": "6CQQ", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6CQR", 
            "id": "6CQR", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MIY", 
            "id": "6MIY", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJ4", 
            "id": "6MJ4", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJ6", 
            "id": "6MJ6", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJA", 
            "id": "6MJA", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJI", 
            "id": "6MJI", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJJ", 
            "id": "6MJJ", 
            "database": "PDB"
        }, 
        {
            "url": "https://www.rcsb.org/structure/6MJQ", 
            "id": "6MJQ", 
            "database": "PDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07654", 
            "id": "PF07654", 
            "database": "Pfam"
        }, 
        {
            "url": "https://pharos.nih.gov/targets/A0A5B9", 
            "id": "A0A5B9", 
            "database": "PHAROS"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A0A5B9", 
            "id": "PR_A0A5B9", 
            "database": "PRO"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "reported", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A0A5B9#ptm_processing", 
                    "id": "A0A5B9", 
                    "database": "UniProtKB"
                }, 
                {
                    "url": "https://prosite.expasy.org/rule/PRU00498", 
                    "id": "PRU00498", 
                    "database": "PROSITE-PRORULE"
                }
            ], 
            "subtype": "", 
            "relation": "attached", 
            "position": 69, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "mutagenesis": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 19968.0, 
        "chemical_mass": 19968.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9", 
            "name": "TRBC2", 
            "locus": {
                "end_pos": 142802748, 
                "strand": "+", 
                "start_pos": 142801041, 
                "chromosome": "7", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSG00000211772", 
                        "id": "ENSG00000211772", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "url": "https://www.uniprot.org/uniprot/A0A5B9", 
            "type": "recommended", 
            "resource": "UniProtKB", 
            "name": "T cell receptor beta constant 2"
        }
    ]
}
