{ "uniprot_canonical_ac": "A0A0G2KB73-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KB73-1|A0A0G2KB73_RAT Isoform 1 of Replication timing regulatory factor 1 OS=Rattus norvegicus OX=10116 GN=Rif1 PE=1 SV=1 CANONICAL=A0A0G2KB73-1", "length": 2416, "sequence": "MTAPGRSPLEPLLETWEDPSVSPGEQTDAYLTLTSRMTGEEGKEVIAEIEKNLPRLYTVLKAHICSQSSELSSAALQALGFCLYNPRITSGLSETNIQELLLTLNGIIKSSDKNVCTRALWVISKQTFPTELVSKMVSSIIDSLEVILSKGEIHSAVVDFEALNVIISHWFLRCRLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSSASPQGSSSRGSTPGLSPLTPGNKGASYGTPRVNLGSNIGGMATIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVAVGKDASDAVVSAIWKELISLVKSVTESGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANMDILNGTPALFLIQLILNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDSVLTVINQNAKQLANKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALTLPINHIFSTPTFPTGTMKTLLKTWSELYRAFARCAAVVATAEENLCCEELSSKIMCSLEDEALSDLLFLDRISHVVVVMVDCIDFSPYNIKYQPKIKSPQRSSDWSRKKKEPLGKLASLFKLIVRIIDSFHTLSLKETYSDTLLAIGNSIISMLSNIFGHISLSSMIREIFTTFTRPLALLYENSKLDEVPKVYTSLNNKLEKLLGEIVACLQFNYLGAYDSELLGQLSPLLCIIFLHKNKQIRKQSAVLWNATFAKATALIYPEELKPILRQAKQKILLLLPGLENVEMSESSGPYSDAKQENSQLNVKSGMRKSSGKRDLLAHTKKKRKVRLSAKLKKRSRSPDLKNGEGSWERKVSDFVFHPSREKENKGVVVSEYWKGLCFFTRCDIPAFNNLMRHQGTLFLLQLVVSMKRESLTLTEKPKEDAKIIKEEQMESAIFIPQDAPENCTIDQHPEKASLPNYGGSVAETNPETLSTGFDARKEMLISSKMSAECSSSSETTVVSSSSVSNATFSGTPQPTSRRQTFITLEKFDGSETRPFSPSPLSNLSSTVTVRNNQDNTTKTDMPQKARKREVTHSKSDSEKLANGGKKSSRRWSKAEQSVNKKFKPSPTSEQEEQSFENNPPDLLSSAECVSENHDHPSEATLEHEDRDPRASVENASLEDLAEGKNVGINKDPKESASPVVAATEQTVNEGSQAAAAAPNPKALRRSSRRRSEAVESSGDSQEKESGQQKRERRKEEERTISKSPCHIKDDKLPKQKLTAEPPIQENLTEKENSLQERTLGEPSANAEIDQNRRKPDLETVSSEGGGGTLDNVDKSSEKPLRGRTRYQTRRASQGLISGVENSESDSSEAKEEVSRKKRSGKWKNKSSDSVDIEEQEEKMVEDEVMKTASQTHDGQAVPDDINAVAQICEKNINNRVILQDSSGSTDSLQVSLTGEDKSKTSKCLDSSLVSLPVPESNLRTRNASKRLYKRDTDSNVGASDMSMSPEKCTQVVECQHKRSRRVRRSKSCDCCGEKSQSQEKSFTGLKNTESSAMKSLETKKTDLQMPETAPETQEANEHVETKSVGKQPVVNFHLGLEEISATGDLIKSEPKLEEDSKNSPPSEPVNMKEKTYGTDASEAVSEIQEPCGEEYNAPEDPCLSDCKDISQKYPLDNKELDISNVGKACKVMDGSSPEGVESIESSVRKDTFGAAVSEKSTQMDVSVDVATEEDNKKDECEAVTTEVNAEGVATEDFNSSMGLSDTTTPVSKDVQAEHPASGELEAGSNESDSGSCEEMNKEMESYKAQMNTEIDNARVKDMDMIASTSKSEEALIGRLDVNTEGFVSDIEMSSGEGTGKCKTETNIELNKLDEIKLGGNQTTVGNETLQEVCFTSEKVEELPQPLIPEVTSELGAESNNVSPVKLELDPSFGSASESPSGVQARCVWSPLASPSTSILKRALKRSQEDEISPINKVRRVSFADPIYQAGLADDIDRRCSVVRSHSSNSSPVIKSVKTSPTSHSKHNTTSAKGFLSPGSQSSKFKSSKKCLITEMAQESMLSPTESVYPALVNCAASVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVFNVKKALRVYHEQQMKSRGLEEIPIFDISEKAVNGVESKTLSTDEERFASDLIDPVTLDTPLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNLQSRWRSTAHENS" }, "uniprot_id": "A0A0G2KB73_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KB73", "site_annotation": [ { "end_pos": 1137, "annotation": "n_glycosylation_sequon", "start_pos": 1135 }, { "end_pos": 1200, "annotation": "n_glycosylation_sequon", "start_pos": 1198 }, { "end_pos": 1237, "annotation": "n_glycosylation_sequon", "start_pos": 1235 }, { "end_pos": 1250, "annotation": "n_glycosylation_sequon", "start_pos": 1248 }, { "end_pos": 1349, "annotation": "n_glycosylation_sequon", "start_pos": 1347 }, { "end_pos": 1461, "annotation": "n_glycosylation_sequon", "start_pos": 1459 }, { "end_pos": 1559, "annotation": "n_glycosylation_sequon", "start_pos": 1557 }, { "end_pos": 1657, "annotation": "n_glycosylation_sequon", "start_pos": 1655 }, { "end_pos": 1929, "annotation": "n_glycosylation_sequon", "start_pos": 1927 }, { "end_pos": 1960, "annotation": "n_glycosylation_sequon", "start_pos": 1958 }, { "end_pos": 2051, "annotation": "n_glycosylation_sequon", "start_pos": 2049 }, { "end_pos": 2057, "annotation": "n_glycosylation_sequon", "start_pos": 2055 }, { "end_pos": 2091, "annotation": "n_glycosylation_sequon", "start_pos": 2089 }, { "end_pos": 2179, "annotation": "n_glycosylation_sequon", "start_pos": 2177 }, { "end_pos": 2198, "annotation": "n_glycosylation_sequon", "start_pos": 2196 }, { "end_pos": 254, "annotation": "n_glycosylation_sequon", "start_pos": 252 }, { "end_pos": 581, "annotation": "n_glycosylation_sequon", "start_pos": 579 }, { "end_pos": 679, "annotation": "n_glycosylation_sequon", "start_pos": 677 }, { "end_pos": 940, "annotation": "n_glycosylation_sequon", "start_pos": 938 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73#A0A0G2KB73-1", "isoform_ac": "A0A0G2KB73-1", "locus": { "end_pos": 37599728, "strand": "-", "start_pos": 37647628, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000090575", "id": "ENSRNOT00000090575", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075681", "id": "ENSRNOP00000075681", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB73-1|A0A0G2KB73_RAT Isoform 1 of Replication timing regulatory factor 1 OS=Rattus norvegicus OX=10116 GN=Rif1 PE=1 SV=1 CANONICAL=A0A0G2KB73-1", "length": 2416, "sequence": "MTAPGRSPLEPLLETWEDPSVSPGEQTDAYLTLTSRMTGEEGKEVIAEIEKNLPRLYTVLKAHICSQSSELSSAALQALGFCLYNPRITSGLSETNIQELLLTLNGIIKSSDKNVCTRALWVISKQTFPTELVSKMVSSIIDSLEVILSKGEIHSAVVDFEALNVIISHWFLRCRLIEQAPVQMGEESVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIALITEHLMTTKLISELQKLFMSKNETYVLKLWPLFVKLLGKTLHRSGSFINSLLQLEELGFRSGTPMIKKIAFIAWKSLIDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPQLPANFEQVCVPLIQSTISVDSSASPQGSSSRGSTPGLSPLTPGNKGASYGTPRVNLGSNIGGMATIPSIQLLGLEMMLHFLLGPEVLSFAKQHKIVLSLEPLEHPLISSPSFFSKYAHTLITAVHDSFVAVGKDASDAVVSAIWKELISLVKSVTESGNRKERSGSEVLTLLLKSLENIVKSEVFPVSKTLVLMEITVKGLPQKVLGSPAYQVANMDILNGTPALFLIQLILNNNLLECGVEDEKFFLNLETLVGCVLSGPTSPLAFSDSVLTVINQNAKQLANKEHLWRMWSMIVSPLTDVIHQTNEVNQGDALEHNFSAIYGALTLPINHIFSTPTFPTGTMKTLLKTWSELYRAFARCAAVVATAEENLCCEELSSKIMCSLEDEALSDLLFLDRISHVVVVMVDCIDFSPYNIKYQPKIKSPQRSSDWSRKKKEPLGKLASLFKLIVRIIDSFHTLSLKETYSDTLLAIGNSIISMLSNIFGHISLSSMIREIFTTFTRPLALLYENSKLDEVPKVYTSLNNKLEKLLGEIVACLQFNYLGAYDSELLGQLSPLLCIIFLHKNKQIRKQSAVLWNATFAKATALIYPEELKPILRQAKQKILLLLPGLENVEMSESSGPYSDAKQENSQLNVKSGMRKSSGKRDLLAHTKKKRKVRLSAKLKKRSRSPDLKNGEGSWERKVSDFVFHPSREKENKGVVVSEYWKGLCFFTRCDIPAFNNLMRHQGTLFLLQLVVSMKRESLTLTEKPKEDAKIIKEEQMESAIFIPQDAPENCTIDQHPEKASLPNYGGSVAETNPETLSTGFDARKEMLISSKMSAECSSSSETTVVSSSSVSNATFSGTPQPTSRRQTFITLEKFDGSETRPFSPSPLSNLSSTVTVRNNQDNTTKTDMPQKARKREVTHSKSDSEKLANGGKKSSRRWSKAEQSVNKKFKPSPTSEQEEQSFENNPPDLLSSAECVSENHDHPSEATLEHEDRDPRASVENASLEDLAEGKNVGINKDPKESASPVVAATEQTVNEGSQAAAAAPNPKALRRSSRRRSEAVESSGDSQEKESGQQKRERRKEEERTISKSPCHIKDDKLPKQKLTAEPPIQENLTEKENSLQERTLGEPSANAEIDQNRRKPDLETVSSEGGGGTLDNVDKSSEKPLRGRTRYQTRRASQGLISGVENSESDSSEAKEEVSRKKRSGKWKNKSSDSVDIEEQEEKMVEDEVMKTASQTHDGQAVPDDINAVAQICEKNINNRVILQDSSGSTDSLQVSLTGEDKSKTSKCLDSSLVSLPVPESNLRTRNASKRLYKRDTDSNVGASDMSMSPEKCTQVVECQHKRSRRVRRSKSCDCCGEKSQSQEKSFTGLKNTESSAMKSLETKKTDLQMPETAPETQEANEHVETKSVGKQPVVNFHLGLEEISATGDLIKSEPKLEEDSKNSPPSEPVNMKEKTYGTDASEAVSEIQEPCGEEYNAPEDPCLSDCKDISQKYPLDNKELDISNVGKACKVMDGSSPEGVESIESSVRKDTFGAAVSEKSTQMDVSVDVATEEDNKKDECEAVTTEVNAEGVATEDFNSSMGLSDTTTPVSKDVQAEHPASGELEAGSNESDSGSCEEMNKEMESYKAQMNTEIDNARVKDMDMIASTSKSEEALIGRLDVNTEGFVSDIEMSSGEGTGKCKTETNIELNKLDEIKLGGNQTTVGNETLQEVCFTSEKVEELPQPLIPEVTSELGAESNNVSPVKLELDPSFGSASESPSGVQARCVWSPLASPSTSILKRALKRSQEDEISPINKVRRVSFADPIYQAGLADDIDRRCSVVRSHSSNSSPVIKSVKTSPTSHSKHNTTSAKGFLSPGSQSSKFKSSKKCLITEMAQESMLSPTESVYPALVNCAASVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASEIKTLPIRSPKVFNVKKALRVYHEQQMKSRGLEEIPIFDISEKAVNGVESKTLSTDEERFASDLIDPVTLDTPLSKNLVAQISALALQLDSEDLYSYSGSQLFEMHEKLGTMANSIIRNLQSRWRSTAHENS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693571", "resource": "Reactome", "id": "R-RNO-5693571", "name": "Nonhomologous End-Joining (NHEJ)" } ], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000790", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "nuclear chromatin", "id": "GO:0000790" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005886", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "plasma membrane", "id": "GO:0005886" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0031965", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "nuclear membrane", "id": "GO:0031965" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051233", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "spindle midzone", "id": "GO:0051233" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016604", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "nuclear body", "id": "GO:0016604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000793", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "condensed chromosome", "id": "GO:0000793" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001939", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "female pronucleus", "id": "GO:0001939" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035861", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "site of double-strand break", "id": "GO:0035861" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001940", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "male pronucleus", "id": "GO:0001940" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000781", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "chromosome, telomeric region", "id": "GO:0000781" } ], "total": 11, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000723", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "telomere maintenance", "id": "GO:0000723" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006348", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "chromatin silencing at telomere", "id": "GO:0006348" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2000042", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "negative regulation of double-strand break repair via homologous recombination", "id": "GO:2000042" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:2001034", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "positive regulation of double-strand break repair via nonhomologous end joining", "id": "GO:2001034" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043247", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "telomere maintenance in response to DNA damage", "id": "GO:0043247" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000122", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "negative regulation of transcription by RNA polymerase II", "id": "GO:0000122" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1990830", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "cellular response to leukemia inhibitory factor", "id": "GO:1990830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0019827", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "stem cell population maintenance", "id": "GO:0019827" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045830", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "positive regulation of isotype switching", "id": "GO:0045830" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051574", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "id": "A0A0G2KB73", "database": "UniProtKB" } ], "name": "positive regulation of histone H3-K9 methylation", "id": "GO:0051574" } ], "total": 10, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "type": "recommended", "resource": "UniProtKB", "name": "Rif1" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000054901", "id": "ENSRNOG00000054901", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016024", "id": "IPR016024", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR022031", "id": "IPR022031", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/NANKRLH/", "id": "NANKRLH", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF12231", "id": "PF12231", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-5693571", "id": "R-RNO-5693571", "database": "Reactome" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1562474", "id": "1562474", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 266247.0, "chemical_mass": 266247.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "name": "Rif1", "locus": { "end_pos": 37647631, "strand": "+", "start_pos": 37599728, "chromosome": "3", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000054901", "id": "ENSRNOG00000054901", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB73", "type": "synonym", "resource": "UniProtKB", "name": "Replication timing regulatory factor 1" } ] }