{ "uniprot_canonical_ac": "A0A0G2KB18-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KB18-1|A0A0G2KB18_RAT Isoform 1 of Protein tyrosine phosphatase domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Ptpdc1 PE=1 SV=1 CANONICAL=A0A0G2KB18-1", "length": 796, "sequence": "MYLALLEILESGSILFKGASIAHTSDGAEKGEKQGAKPDRSLETRMAAGVLPQNENPYSTLVNDSGHAAYMDENSGRPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIEQFLSHGIKTIINLQRPGEHASCGNSLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLMRQRHLLHGYEARLLKYVPKIVHLVCKLLLDVAENRPVVMKSVLEGPELSAEIEKTVSEMVTMQLDQELLRQNSDVPDPFNPTAEVAEFDSQDVILSNEHEFDPLWKRRNIERLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQQQTPTSHCFLPPTPELGLHKDTLVRNTFSFWTESKCGGLEEPKDEGSLLLCRKDSPKEVQRSRTFSVGVSCSHNPGEPAPPNFTRTHKDSERGAHCRCEAPEGWVPGPVPKMGRSPCSPLHCDTSPKAQFSCGQETQDSTYLPEATPHAGLQSELNAEARRILAAKALANLTEFVEEEEVKRRVEMWQKELNSREGAWERICGERDPFILCSLMWSWVEQLKEPVISKEDVDMLVDRHADAAEALFLLEKGQYQTILCVLHCIVSLQTLPVEVEEACLSHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSPRPGLS" }, "uniprot_id": "A0A0G2KB18_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/22673903", "type": [ "PubMed" ], "id": "22673903" } ], "title": "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues.", "journal": "Nat. Commun.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "authors": "Olsen J.V., Lage K., Secher A., Dmytriyev A., Lundby A., Lundby C., Nordsborg N.B.", "date": "2012" } ], "uniprot_ac": "A0A0G2KB18", "site_annotation": [ { "end_pos": 554, "annotation": "n_glycosylation_sequon", "start_pos": 552 }, { "end_pos": 65, "annotation": "n_glycosylation_sequon", "start_pos": 63 }, { "end_pos": 642, "annotation": "n_glycosylation_sequon", "start_pos": 640 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18#A0A0G2KB18-1", "isoform_ac": "A0A0G2KB18-1", "locus": { "end_pos": 16340416, "strand": "-", "start_pos": 16380052, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000089140", "id": "ENSRNOT00000089140", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075617", "id": "ENSRNOP00000075617", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KB18-1|A0A0G2KB18_RAT Isoform 1 of Protein tyrosine phosphatase domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Ptpdc1 PE=1 SV=1 CANONICAL=A0A0G2KB18-1", "length": 796, "sequence": "MYLALLEILESGSILFKGASIAHTSDGAEKGEKQGAKPDRSLETRMAAGVLPQNENPYSTLVNDSGHAAYMDENSGRPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIEQFLSHGIKTIINLQRPGEHASCGNSLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLMRQRHLLHGYEARLLKYVPKIVHLVCKLLLDVAENRPVVMKSVLEGPELSAEIEKTVSEMVTMQLDQELLRQNSDVPDPFNPTAEVAEFDSQDVILSNEHEFDPLWKRRNIERLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQQQTPTSHCFLPPTPELGLHKDTLVRNTFSFWTESKCGGLEEPKDEGSLLLCRKDSPKEVQRSRTFSVGVSCSHNPGEPAPPNFTRTHKDSERGAHCRCEAPEGWVPGPVPKMGRSPCSPLHCDTSPKAQFSCGQETQDSTYLPEATPHAGLQSELNAEARRILAAKALANLTEFVEEEEVKRRVEMWQKELNSREGAWERICGERDPFILCSLMWSWVEQLKEPVISKEDVDMLVDRHADAAEALFLLEKGQYQTILCVLHCIVSLQTLPVEVEEACLSHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSPRPGLS" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18#D4ACD9-1", "isoform_ac": "D4ACD9-1", "locus": { "end_pos": 16354218, "strand": "-", "start_pos": 16380052, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000060550", "id": "ENSRNOT00000060550", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000057289", "id": "ENSRNOP00000057289", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|D4ACD9-1|A0A0G2KB18_RAT Computationally mapped isoform of Protein tyrosine phosphatase domain-containing 1 OS=Rattus norvegicus OX=10116 GN=Ptpdc1 PE=1 SV=1 CANONICAL=A0A0G2KB18-1", "length": 751, "sequence": "MAAGVLPQNENPYSTLVNDSGHAAYMDENSGRPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIEQFLSHGIKTIINLQRPGEHASCGNSLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLMRQRHLLHGYEARLLKYVPKIVHLVCKLLLDVAENRPVVMKSVLEGPELSAEIEKTVSEMVTMQLDQELLRQNSDVPDPFNPTAEVAEFDSQDVILSNEHEFDPLWKRRNIERLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQQQTPTSHCFLPPTPELGLHKDTLVRNTFSFWTESKCGGLEEPKDEGSLLLCRKDSPKEVQRSRTFSVGVSCSHNPGEPAPPNFTRTHKDSERGAHCRCEAPEGWVPGPVPKMGRSPCSPLHCDTSPKAQFSCGQETQDSTYLPEATPHAGLQSELNAEARRILAAKALANLTEFVEEEEVKRRVEMWQKELNSREGAWERICGERDPFILCSLMWSWVEQLKEPVISKEDVDMLVDRHADAAEALFLLEKGQYQTILCVLHCIVSLQTLPVEVEEACLSHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSPRPGLS" } } ], "pathway": [], "function": [], "orthologs": [ { "uniprot_canonical_ac": "A2A3K4-1", "protein_name": "Protein tyrosine phosphatase domain-containing protein 1", "sequence": { "length": 754, "sequence": "MAAGVLPQNEQPYSTLVNNSECVANMKGNLERPTPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYHIIDQFLSHGIKTIINLQRPGEHASCGNPLEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTTILDMVKVMTFALQEGKVAIHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLTPLRNIFSCCDPKAHAVTLPQYLIRQRHLLHGYEARLLKHVPKIIHLVCKLLLDLAENRPVMMKDVSEGPGLSAEIEKTMSEMVTMQLDKELLRHDSDVSNPPNPTAVAADFDNRGMIFSNEQQFDPLWKRRNVECLQPLTHLKRRLSYSDSDLKRAENLLEQGETPQTVPAQILVGHKPRQQKLISHCYIPQSPEPDLHKEALVRSTLSFWSQSKFGGLEGLKDNGSPIFHGRIIPKEAQQSGAFSADVSGSHSPGEPVSPSFANVHKDPNPAHQQVSHCQCKTHGVGSPGSVRQNSRTPRSPLDCGSSPKAQFLVEHETQDSKDLSEAASHSALQSELSAEARRILAAKALANLNESVEKEELKRKVEMWQKELNSRDGAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRRADAAEALFLLEKGQHQTILCVLHCIVNLQTIPVDVEEAFLAHAIKAFTKVNFDSENGPTVYNTLKKIFKHTLEEKRKMTKDGPKPGL" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/17576", "id": "17576", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 }, { "uniprot_canonical_ac": "Q6NZK8-1", "protein_name": "Protein tyrosine phosphatase domain-containing protein 1", "sequence": { "length": 747, "sequence": "MAAGVLPQNEDPYSTLVNSSGHAAHMDENSGRPAPKYTKVGERLRHVIPGHMACSMACGGRACKYENPARWSEQEQAIKGVYSSWVTDNILAMARPSSELLEKYRIIEQFLGQGIKTIINLQRPGEHASCGSALEQESGFTYLPEAFMEAGIYFYNFGWKDYGVASLTAILDMVKVMTFALQEGKVAVHCHAGLGRTGVLIACYLVFATRMTADQAIIFVRAKRPNSIQTRGQLLCVREFTQFLAPLRNIFSCCDPKAHAVTLAQYLIRQRHLLHGYEARLLKYVPKIIHLVCKLLLDLAENRPVVMKSMLEGPVLSAEIEKTVSEMVTLQLDQELLRQNSDVPDPFNPTAEVAEFENQDVILSTEQEFDPLWKRRDIECLQPLTHLKRQLSYSDSDLKRAKAILEQGETPWTVPAQELLDHSLQHQKPTSHCYMPPTPELGFNKEALVQNTFSFWTPSKCGGLEGLKDEGSLLLCRKDIPKEVQRSRTFSVGVSCSHNPGEPVPPNFTSIHKDPEQVTHCRCEAPGGWVPGPVHEMVRSPCSPLNCGSSPKAQFPHGQETQDSTDLSEAVPHAGLQPELSAEARRILAAKALANLNEFVEKEEVKRKVEMWQKELNSREEAWERICGERDPFILCSLMWSWVEQLKEPVITKEDVDMLVDRQADAAEALFLLEKGQYQTILCVLHCIVSLQTLPMEVEEACLLHAIKAFTKVNFDSENGPIVYDTLKKIFKHTLEEKRKMAKDSLS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KB18/", "id": "A0A0G2KB18", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/17576", "id": "17576", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006253763.1", "ac": "XP_006253763.1", "name": "protein tyrosine phosphatase domain-containing protein 1 isoform X2", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004725", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "protein tyrosine phosphatase activity", "id": "GO:0004725" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008138", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "protein tyrosine/serine/threonine phosphatase activity", "id": "GO:0008138" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005654", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "nucleoplasm", "id": "GO:0005654" } ], "total": 2, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0060271", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "cilium assembly", "id": "GO:0060271" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007224", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "id": "A0A0G2KB18", "database": "UniProtKB" } ], "name": "smoothened signaling pathway", "id": "GO:0007224" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB18", "type": "synonym", "resource": "RefSeq", "name": "Ptpdc1" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "type": "recommended", "resource": "UniProtKB", "name": "Ptpdc1" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000026564", "id": "ENSRNOG00000026564", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/291022", "id": "291022", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000340", "id": "IPR000340", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000387", "id": "IPR000387", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR003595", "id": "IPR003595", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR016130", "id": "IPR016130", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR020422", "id": "IPR020422", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029021", "id": "IPR029021", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/HIVLQSE/", "id": "HIVLQSE", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=828691at2759", "id": "828691at2759", "database": "OrthoDB" }, { "url": "http://pfam.xfam.org/family/PF00782", "id": "PF00782", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006253763.1", "id": "XP_006253763.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1307698", "id": "1307698", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 89326.0, "chemical_mass": 89326.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "name": "Ptpdc1", "locus": { "end_pos": 16380573, "strand": "+", "start_pos": 16333415, "chromosome": "17", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000026564", "id": "ENSRNOG00000026564", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KB18", "type": "synonym", "resource": "UniProtKB", "name": "Protein tyrosine phosphatase domain-containing 1" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2KB18", "type": "synonym", "resource": "RefSeq", "name": "protein tyrosine phosphatase domain-containing protein 1 isoform X2" } ] }