{ "uniprot_canonical_ac": "A0A0G2KAI3-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2KAI3-1|A0A0G2KAI3_RAT Isoform 1 of Cytochrome P450, family 2, subfamily w, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2w1 PE=3 SV=1 CANONICAL=A0A0G2KAI3-1", "length": 492, "sequence": "MELLVLCVWGILLLLGLWGLLRGCAQDPSMTRQWPPPRPLPFLGNLHLLGVTHQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQLIQRGGGIFFSSGVHWKVARQFTVRTLQSLGIRQPPMVGKVLQELVCLKGQLDSYGGQPFPLTLLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPVLSKIEEVRTILRTLLEAQRPPLPNGSPARSYVEALLQQGQQDDPEDMFSEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEDQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGCFMKRGAFLPFSTGRRVCVGESLARTELFLLFAGLLQQYHLLPPPGLSPADLDLRPAPAFTMRPPAQTLRVVPRS" }, "uniprot_id": "A0A0G2KAI3_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2KAI3", "site_annotation": [ { "end_pos": 181, "annotation": "n_glycosylation_sequon", "start_pos": 179 }, { "end_pos": 261, "annotation": "n_glycosylation_sequon", "start_pos": 259 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3#A0A0G2KAI3-1", "isoform_ac": "A0A0G2KAI3-1", "locus": { "end_pos": 17383162, "strand": "+", "start_pos": 17387879, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000091003", "id": "ENSRNOT00000091003", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000075407", "id": "ENSRNOP00000075407", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2KAI3-1|A0A0G2KAI3_RAT Isoform 1 of Cytochrome P450, family 2, subfamily w, polypeptide 1 OS=Rattus norvegicus OX=10116 GN=Cyp2w1 PE=3 SV=1 CANONICAL=A0A0G2KAI3-1", "length": 492, "sequence": "MELLVLCVWGILLLLGLWGLLRGCAQDPSMTRQWPPPRPLPFLGNLHLLGVTHQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQLIQRGGGIFFSSGVHWKVARQFTVRTLQSLGIRQPPMVGKVLQELVCLKGQLDSYGGQPFPLTLLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGALLRLHRPVLSKIEEVRTILRTLLEAQRPPLPNGSPARSYVEALLQQGQQDDPEDMFSEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEDQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGCFMKRGAFLPFSTGRRVCVGESLARTELFLLFAGLLQQYHLLPPPGLSPADLDLRPAPAFTMRPPAQTLRVVPRS" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211958", "resource": "Reactome", "id": "R-RNO-211958", "name": "Miscellaneous substrates" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211981", "resource": "Reactome", "id": "R-RNO-211981", "name": "Xenobiotics" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "E9Q816-1", "protein_name": "Cytochrome P450 2W1", "sequence": { "length": 493, "sequence": "MALLLLGVWGILLLLGLWGLLQGCTRSPSLAPRWPPGPRPLPFLGNLHLLGVTQQDRALMELSERYGPMFTIHLGSQKTVVLSGYEVVREALVGTGHELADRPPIPIFQHIQRGGGIFFSSGARWRAGRQFTVRTLQSLGVQQPSMVGKVLQELACLKGQLDSYGGQPLPLALLGWAPCNITFTLLFGQRFDYQDPVFVSLLSLIDQVMVLLGSPGIQLFNTFPRLGAFLRLHRPVLSKIEEVRTILRTLLETRRPPLPTGGPAQSYVEALLQQGQEDDPEDMFGEANVLACTLDMVMAGTETTAATLQWAVFLMVKHPHVQGRVQEELDRVLGPGQLPQPEHQRALPYTSAVLHEVQRYITLLPHVPRCTAADIQLGGYLLPKGTPVIPLLTSVLLDKTQWETPSQFNPNHFLDAKGRFMKRGAFLPFSAGRRVCVGKSLARTELFLLFAGLLQRYRLLPPPGLSPADLDLRPAPAFTMRPPAQTLCVVPRS" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAI3/", "id": "A0A0G2KAI3", "database": "OMA" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q8TAV3-1", "protein_name": "Cytochrome P450 2W1", "sequence": { "length": 490, "sequence": "MALLLLLFLGLLGLWGLLCACAQDPSPAARWPPGPRPLPLVGNLHLLRLSQQDRSLMELSERYGPVFTVHLGRQKTVVLTGFEAVKEALAGPGQELADRPPIAIFQLIQRGGGIFFSSGARWRAARQFTVRALHSLGVGREPVADKILQELKCLSGQLDGYRGRPFPLALLGWAPSNITFALLFGRRFDYRDPVFVSLLGLIDEVMVLLGSPGLQLFNVYPWLGALLQLHRPVLRKIEEVRAILRTLLEARRPHVCPGDPVCSYVDALIQQGQGDDPEGLFAEANAVACTLDMVMAGTETTSATLQWAALLMGRHPDVQGRVQEELDRVLGPGRTPRLEDQQALPYTSAVLHEVQRFITLLPHVPRCTAADTQLGGFLLPKGTPVIPLLTSVLLDETQWQTPGQFNPGHFLDANGHFVKREAFLPFSAGRRVCVGERLARTELFLLFAGLLQRYRLLPPPGVSPASLDTTPARAFTMRPRAQALCAVPRP" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2KAI3/", "id": "A0A0G2KAI3", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0020037", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "heme binding", "id": "GO:0020037" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016712", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen", "id": "GO:0016712" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008395", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "steroid hydroxylase activity", "id": "GO:0008395" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005506", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "iron ion binding", "id": "GO:0005506" } ], "total": 4, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "cytoplasm", "id": "GO:0005737" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043231", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "intracellular membrane-bounded organelle", "id": "GO:0043231" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005788", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "endoplasmic reticulum lumen", "id": "GO:0005788" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" } ], "total": 4, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042738", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "exogenous drug catabolic process", "id": "GO:0042738" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0055114", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "oxidation-reduction process", "id": "GO:0055114" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006805", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "xenobiotic metabolic process", "id": "GO:0006805" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006082", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "organic acid metabolic process", "id": "GO:0006082" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043390", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "id": "A0A0G2KAI3", "database": "UniProtKB" } ], "name": "aflatoxin B1 metabolic process", "id": "GO:0043390" } ], "total": 5, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "type": "recommended", "resource": "UniProtKB", "name": "Cyp2w1" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000051770", "id": "ENSRNOG00000051770", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001128", "id": "IPR001128", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002401", "id": "IPR002401", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017972", "id": "IPR017972", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036396", "id": "IPR036396", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/HLGCQKT/", "id": "HLGCQKT", "database": "OMA" }, { "url": "http://pfam.xfam.org/family/PF00067", "id": "PF00067", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211958", "id": "R-RNO-211958", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-211981", "id": "R-RNO-211981", "database": "Reactome" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1305193", "id": "1305193", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 54670.0, "chemical_mass": 54670.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "name": "Cyp2w1", "locus": { "end_pos": 17383159, "strand": "-", "start_pos": 17387879, "chromosome": "12", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000051770", "id": "ENSRNOG00000051770", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2KAI3", "type": "synonym", "resource": "UniProtKB", "name": "Cytochrome P450, family 2, subfamily w, polypeptide 1" } ] }