{ "uniprot_canonical_ac": "A0A0G2K331-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2K331-1|A0A0G2K331_RAT Isoform 1 of cAMP responsive element binding protein 3, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Creb3 PE=4 SV=1 CANONICAL=A0A0G2K331-1", "length": 387, "sequence": "MDPGGQDLLALDPGDQDLLALDPGDQDLLGFLLEESGDLWAATEQDIETPLDLELSPSENSVQELSDWEVEDLLSSLLSPSSSPDVLNSSSSSILHDHNYSLPQEHVSIDLDPGSFEKEGFRMNPLRVEETAAEQELSTLILTEEEKRLLEKEGLTLPSTLPLTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLESRVLKYTAQNQELQNKVQHLEEQNLSLLDQLRKLQAMVTEIANKTSSGSTCVLVLLLSFCLLLVPAMYSSDVRGSVPAEYVVLHRKLRALPSEDQHQPKLSALQPELPMGSTNQLESSEHTFLAPSNVSCLNHMAQTEQPPHWPLLDLSSEMPFSGSDLLLQANLTESGGWLSTHSPSSIILQGRYSG" }, "uniprot_id": "A0A0G2K331_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2K331", "site_annotation": [ { "end_pos": 225, "annotation": "n_glycosylation_sequon", "start_pos": 223 }, { "end_pos": 244, "annotation": "n_glycosylation_sequon", "start_pos": 242 }, { "end_pos": 328, "annotation": "n_glycosylation_sequon", "start_pos": 326 }, { "end_pos": 365, "annotation": "n_glycosylation_sequon", "start_pos": 363 }, { "end_pos": 90, "annotation": "n_glycosylation_sequon", "start_pos": 88 }, { "end_pos": 101, "annotation": "n_glycosylation_sequon", "start_pos": 99 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331#A0A0G2K331-1", "isoform_ac": "A0A0G2K331-1", "locus": { "end_pos": 59063714, "strand": "-", "start_pos": 59067954, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000085311", "id": "ENSRNOT00000085311", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000072482", "id": "ENSRNOP00000072482", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2K331-1|A0A0G2K331_RAT Isoform 1 of cAMP responsive element binding protein 3, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Creb3 PE=4 SV=1 CANONICAL=A0A0G2K331-1", "length": 387, "sequence": "MDPGGQDLLALDPGDQDLLALDPGDQDLLGFLLEESGDLWAATEQDIETPLDLELSPSENSVQELSDWEVEDLLSSLLSPSSSPDVLNSSSSSILHDHNYSLPQEHVSIDLDPGSFEKEGFRMNPLRVEETAAEQELSTLILTEEEKRLLEKEGLTLPSTLPLTKVEEQVLKRVRRKIRNKRAAQESRKKKKVYVVGLESRVLKYTAQNQELQNKVQHLEEQNLSLLDQLRKLQAMVTEIANKTSSGSTCVLVLLLSFCLLLVPAMYSSDVRGSVPAEYVVLHRKLRALPSEDQHQPKLSALQPELPMGSTNQLESSEHTFLAPSNVSCLNHMAQTEQPPHWPLLDLSSEMPFSGSDLLLQANLTESGGWLSTHSPSSIILQGRYSG" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K331#Q6P6G3-1", "isoform_ac": "Q6P6G3-1", "locus": { "end_pos": 59063714, "strand": "-", "start_pos": 59067548, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000065909", "id": "ENSRNOT00000065909", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000061486", "id": "ENSRNOP00000061486", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Q6P6G3-1|A0A0G2K331_RAT Computationally mapped isoform of cAMP responsive element binding protein 3, isoform CRA_a OS=Rattus norvegicus OX=10116 GN=Creb3 PE=4 SV=1 CANONICAL=A0A0G2K331-1", "length": 154, "sequence": "MDPGGQDLLALDPGDQDLLALDPGDQDLLGFLLEESGDLWAATEQDIETPLDLELSPSENSVQELSDWEVEDLLSSLLSPSSSPDVLNSSSSSILHDHNYSLPQEHVSIDLDPGSFEKEGFRMNPLRVEETAAEQELSTLILTEEEKRLLECAR" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874211", "resource": "Reactome", "id": "R-RNO-8874211", "name": "CREB3 factors activate genes" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "O43889-2", "protein_name": "Cyclic AMP-responsive element-binding protein 3", "sequence": { "length": 371, "sequence": "MELELDAGDQDLLAFLLEESGDLGTAPDEAVRAPLDWALPLSEVPSDWEVDDLLCSLLSPPASLNILSSSNPCLVHHDHTYSLPRETVSMDLESESCRKEGTQMTPQHMEELAEQEIARLVLTDEEKSLLEKEGLILPETLPLTKTEEQILKRVRRKIRNKRSAQESRRKKKVYVGGLESRVLKYTAQNMELQNKVQLLEEQNLSLLDQLRKLQAMVIEISNKTSSSSTCILVLLVSFCLLLVPAMYSSDTRGSLPAEHGVLSRQLRALPSEDPYQLELPALQSEVPKDSTHQWLDGSDCVLQAPGNTSCLLHYMPQAPSAEPPLEWPFPDLFSEPLCRGPILPLQANLTRKGGWLPTGSPSVILQDRYSG" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/31375", "id": "31375", "database": "MGI" }, { "url": "https://omabrowser.org/oma/group/A0A0G2K331/", "id": "A0A0G2K331", "database": "OMA" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" }, { "name": "homologset.oma", "label": "OMA Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238112.1", "ac": "XP_006238112.1", "name": "cyclic AMP-responsive element-binding protein 3 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0001228", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "DNA-binding transcription activator activity, RNA polymerase II-specific", "id": "GO:0001228" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035497", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "cAMP response element binding", "id": "GO:0035497" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005634", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "nucleus", "id": "GO:0005634" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005783", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "endoplasmic reticulum", "id": "GO:0005783" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 3, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0090026", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "positive regulation of monocyte chemotaxis", "id": "GO:0090026" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:1902236", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway", "id": "GO:1902236" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006990", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "id": "A0A0G2K331", "database": "UniProtKB" } ], "name": "positive regulation of transcription from RNA polymerase II promoter involved in unfolded protein response", "id": "GO:0006990" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K331", "type": "synonym", "resource": "RefSeq", "name": "Creb3" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "type": "recommended", "resource": "UniProtKB", "name": "Creb3" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "type": "synonym", "resource": "UniProtKB", "name": "rCG_55070" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000016452", "id": "ENSRNOG00000016452", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/298400", "id": "298400", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004827", "id": "IPR004827", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR029808", "id": "IPR029808", "database": "InterPro" }, { "url": "https://omabrowser.org/oma/group/VIQISNK/", "id": "VIQISNK", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=644485at2759", "id": "644485at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR45996:SF4", "id": "PTHR45996:SF4", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF00170", "id": "PF00170", "database": "Pfam" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-8874211", "id": "R-RNO-8874211", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006238112.1", "id": "XP_006238112.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1308831", "id": "1308831", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 42930.0, "chemical_mass": 42930.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "name": "Creb3", "locus": { "end_pos": 59068188, "strand": "+", "start_pos": 59063531, "chromosome": "5", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000016452", "id": "ENSRNOG00000016452", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "type": "synonym", "resource": "UniProtKB", "name": "cAMP responsive element binding protein 3, isoform CRA_a" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2K331", "type": "synonym", "resource": "UniProtKB", "name": "cAMP-responsive element-binding protein 3" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2K331", "type": "synonym", "resource": "RefSeq", "name": "cyclic AMP-responsive element-binding protein 3 isoform X1" } ] }