{ "uniprot_canonical_ac": "A0A0G2JUI2-1", "ptm_annotation": [], "sequence": { "header": "tr|A0A0G2JUI2-1|A0A0G2JUI2_RAT Isoform 1 of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=1 CANONICAL=A0A0G2JUI2-1", "length": 563, "sequence": "MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT" }, "uniprot_id": "A0A0G2JUI2_RAT", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Rat", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "Rattus norvegicus", "taxid": 10116 } ], "publication": [], "uniprot_ac": "A0A0G2JUI2", "site_annotation": [ { "end_pos": 287, "annotation": "n_glycosylation_sequon", "start_pos": 285 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2#A0A0G2JUI2-1", "isoform_ac": "A0A0G2JUI2-1", "locus": { "end_pos": 81403598, "strand": "-", "start_pos": 81421274, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000083595", "id": "ENSRNOT00000083595", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000069107", "id": "ENSRNOP00000069107", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0G2JUI2-1|A0A0G2JUI2_RAT Isoform 1 of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=1 CANONICAL=A0A0G2JUI2-1", "length": 563, "sequence": "MAEKETILKISRNLKNAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRQRGYTEQMNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT" } }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2#F1M513-1", "isoform_ac": "F1M513-1", "locus": { "end_pos": 81405184, "strand": "-", "start_pos": 81421274, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOT00000046019", "id": "ENSRNOT00000046019", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSRNOP00000042319", "id": "ENSRNOP00000042319", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F1M513-1|A0A0G2JUI2_RAT Computationally mapped isoform of RUN and FYVE domain-containing 4 OS=Rattus norvegicus OX=10116 GN=Rufy4 PE=4 SV=3 CANONICAL=A0A0G2JUI2-1", "length": 479, "sequence": "MNFICSQDKLKTSLGKGRAFIRLCLAHGQLAESMQLCLLNPQLTREWYGPRSPLLCPELQGDILDSLYTLNGVAFNLDLQRPDLDEAWPMFSESHYSSPSRTRERRPRKPKGFPEEVRCSKGQQLQGPEAGGTSCLQDATTEDLPPDLRTPLQQDHLPTFLEEKREDSRSLSCPQSIWETGREGFRLDQEGGPKTRKLLENSTASIQQQKGGAKDVQMQLTGRKDEGKGSLPGTEGRKTTEGIQERATDWNHAQELLAPSLQGREEDAELGYRHGWDQPGALGQSWVLGSKKGPTTGKPQEWTGVTRATVQKDQTEVPLQQEVIKEPGYGLQLTEVQAQCQEQLQAQEGELQALQEQLSRCQEERALLQAMLEQKQQEAERRAAMYEKELEGQRDLVQAMKRRVLELIQEKDHQWQRLQQLSTVTPGHCMGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPACAQQEEIQVT" } } ], "pathway": [ { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301510", "resource": "KEGG Pathway", "id": "rno:301510", "name": "" } ], "function": [], "orthologs": [ { "uniprot_canonical_ac": "Q3TYX8-1", "protein_name": "RUN and FYVE domain-containing protein 4", "sequence": { "length": 563, "sequence": "MANNGTILKISRSLKNAVSAILQGYGDGQEPVTETSAELHRLCGCLELLLQFDQKEQRSFLGARKDYWDFLFTALRRHRGYTEQMSFICSQDKLKTSLGKGRAFIRLCLARGQLAESMQLCLLNPQLTREWYGPRSPLLCAELQEDILDSLYALNGVAFNLDLQRPDLDEAWPMFSESRCSSPSRTGKRRPGKPKGFPEEVRCSRGEQLQEPDTGGTSCLQDATREDRTPDLCKPLQPSHLPTFLEEKREDSRSLSCPQSTWETEREGFQLDQKDGGPKPRKFLENSTASIQQQRSRAKDVKMQLTGRKVEGKGSLSGTEDQRTTEGIQKRAADWDLGQGLMAPGLQGREDAELGYRCEWNQPDVLRQSWVLGTKKSSPTEKPQEWTGVTSGTMQEDGSEVPLQQEVIKDPGYGLQLAKEQAQCQEQLRAQEAELQALQEQLSRCQKERALLQVKLEQKQQEAERRDAMYQTELEGQRDLVQAMKRRVLELIHEKDLQWQRLQQLSTVAPGHCIGCNKVFRRLSRRYPCRLCGGLVCHACSVDYKKRERCCPTCAQQEEIQDT" }, "evidence": [ { "url": "https://omabrowser.org/oma/group/A0A0G2JUI2/", "id": "A0A0G2JUI2", "database": "OMA" }, { "url": "http://www.informatics.jax.org/homology/52359", "id": "52359", "database": "MGI" } ], "common_name": "Mouse", "organism": "Mus musculus", "tax_id": 10090 }, { "uniprot_canonical_ac": "Q6ZNE9-2", "protein_name": "RUN and FYVE domain-containing protein 4", "sequence": { "length": 571, "sequence": "MAEEGAILKVTKDLRAAVSAILQGYGDGQGPVTDTSAELHRLCGCLELLLQFDQKEQKSFLGPRKDYWDFLCTALRRQRGNMEPIHFVRSQDKLKTPLGKGRAFIRFCLARGQLAEALQLCLLNSELTREWYGPRSPLLCPERQEDILDSLYALNGVAFELDLQQPDLDGAWPMFSESRCSSSTQTQGRRPRKNKDAPKKIPAAYGGPENVQIEDSHTSQAICLQDAPSGQQLAGLPRSQQQRHLPFFLEKKGESSRKHRYPQSMWEPEGKELQLDQEERAPWIEIFLGNSTPSTQGQGKGAMGTQKEVIGMEAEVTGVLLVAEGQRTTEGTHKKEAEWSHVQRLLMPSPRGAVEGAVSGSRQGSGGSSILGEPWVLQGHATKEDSTVENPQVQTEVTLVARREEQAEVSLQDEIKSLRLGLRKAEEQAQRQEQLLREQEGELQALREQLSRCQEERAELQAQLEQKQQEAERRDAMYQEELGGQRDLVQAMKRRVLELIQEKDRLWQRLQHLSSMAPECCVACSKIFGRFSRRYPCRLCGGLLCHACSMDYKKRDRCCPPCAQGREAQVT" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/52359", "id": "52359", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.oma", "label": "OMA Homologs" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006226938.1", "ac": "XP_006226938.1", "name": "RUN and FYVE domain-containing protein 4 isoform X1", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032266", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "phosphatidylinositol-3-phosphate binding", "id": "GO:0032266" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0046872", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "metal ion binding", "id": "GO:0046872" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005776", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "autophagosome", "id": "GO:0005776" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0000045", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "autophagosome assembly", "id": "GO:0000045" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016239", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "positive regulation of macroautophagy", "id": "GO:0016239" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0071353", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "id": "A0A0G2JUI2", "database": "UniProtKB" } ], "name": "cellular response to interleukin-4", "id": "GO:0071353" } ], "total": 3, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JUI2", "type": "synonym", "resource": "RefSeq", "name": "Rufy4" }, { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "type": "recommended", "resource": "UniProtKB", "name": "Rufy4" } ], "crossref": [ { "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000032991", "id": "ENSRNOG00000032991", "database": "Bgee" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/301510", "id": "301510", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR004012", "id": "IPR004012", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011011", "id": "IPR011011", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR013083", "id": "IPR013083", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR017455", "id": "IPR017455", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037213", "id": "IPR037213", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR042939", "id": "IPR042939", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:301510", "id": "rno:301510", "database": "KEGG Pathway" }, { "url": "https://omabrowser.org/oma/group/VCHACSA/", "id": "VCHACSA", "database": "OMA" }, { "url": "http://www.orthodb.org/?query=962969at2759", "id": "962969at2759", "database": "OrthoDB" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR47732", "id": "PTHR47732", "database": "PANTHER" }, { "url": "http://pfam.xfam.org/family/PF02759", "id": "PF02759", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/XP_006226938.1", "id": "XP_006226938.1", "database": "RefSeq" }, { "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1560678", "id": "1560678", "database": "RGD" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 63844.0, "chemical_mass": 63844.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "name": "Rufy4", "locus": { "end_pos": 81421990, "strand": "+", "start_pos": 81402124, "chromosome": "9", "evidence": [ { "url": "https://www.ensembl.org/id/ENSRNOG00000032991", "id": "ENSRNOG00000032991", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A0A0G2JUI2", "type": "synonym", "resource": "UniProtKB", "name": "RUN and FYVE domain-containing 4" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A0A0G2JUI2", "type": "synonym", "resource": "RefSeq", "name": "RUN and FYVE domain-containing protein 4 isoform X1" } ] }