{
    "bcoid": "GLY_000420",
    "title": "SARS-CoV2 Protein Enzyme Annotation (UniProtKB)",
    "description": "The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Enzyme Annotation (UniProtKB) dataset contains ...",
    "filename": "sarscov2_protein_enzyme_annotation_uniprotkb.csv",
    "filetype": "csv",
    "categories": {
        "species": "SARS coronavirus (SARS-CoV-2 or 2019-nCoV)",
        "molecule": "Protein",
        "tags": "enzyme annotation",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "P0DTD1-1...",
                "3.1.13.-..."
            ],
            [
                "P0DTD1-1...",
                "2.7.7.48..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "enzyme_ec..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "enzyme_ec"
                },
                {
                    "type": "string",
                    "label": "enzyme_activity"
                }
            ],
            [
                "P0DTD1-1",
                "3.1.13.-",
                ""
            ],
            [
                "P0DTD1-1",
                "2.7.7.48",
                "Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)."
            ],
            [
                "P0DTD1-1",
                "3.1.-.-",
                ""
            ],
            [
                "P0DTD1-1",
                "2.1.1.-",
                ""
            ],
            [
                "P0DTD1-1",
                "3.4.19.12",
                "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)."
            ],
            [
                "P0DTD1-1",
                "3.4.22.-",
                ""
            ],
            [
                "P0DTD1-1",
                "3.6.4.12",
                "ATP + H(2)O = ADP + phosphate."
            ],
            [
                "P0DTD1-1",
                "3.6.4.13",
                "ATP + H(2)O = ADP + phosphate."
            ],
            [
                "P0DTD1-1",
                "3.4.22.69",
                "TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position."
            ],
            [
                "P0DTC1-1",
                "3.4.19.12",
                "Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin (a 76-residue protein attached to proteins as an intracellular targeting signal)."
            ],
            [
                "P0DTC1-1",
                "3.4.22.-",
                ""
            ],
            [
                "P0DTC1-1",
                "3.4.22.69",
                "TSAVLQ-|-SGFRK-NH(2) and SGVTFQ-|-GKFKK the two peptides corresponding to the two self-cleavage sites of the SARS 3C-like proteinase are the two most reactive peptide substrates. The enzyme exhibits a strong preference for substrates containing Gln at P1 position and Leu at P2 position."
            ]
        ]
    },
    "readme": "Name\n   - SARS-CoV2 Protein Enzyme Annotation (UniProtKB)\n\nVersion\n   - 1.7.13\n\nCreated on\n  - 2020-04-02T23:34:46.503960\n\nModified on\n   - 2020-04-10T12:50:33.285258\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The SARS coronavirus (SARS-CoV-2 or 2019-nCov) Protein Enzyme Annotation (UniProtKB) dataset contains sarscov2 [taxid:2697049] enzyme annotations for UniProtKB canonical accessions. The dataset contains ec numbers and enzyme activity that describes the enzymatic reactions. The dataset is derived form 2020-01 UniprotKB release. If you use this dataset please give proper attribution to UniProtKB and GlyGen\n\nDescription Domain\n   Keywords\n   - enzyme annotation\n   - enzyme \n   - UniProtKB\n   - enzyme activity\n   - EC number\n\n   Pipeline Steps\n   - Step-1: The script extracts the enzyme annotation triples from the triplestore for the UniProtKB canonical sequnces asnd extracts as a dataset in a csv format\n\nExecution Domain\n   Scripts   - https://github.com/GW-HIVE/glygen-backend-integration/blob/master/pipeline/integrator/make-protein-dataset.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: uniprot-proteome-sars-cov-2.nt\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/uniprot-proteome-sars-cov-2.nt\n      Name: sarscov2_protein_masterlist.csv\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/sarscov2_protein_masterlist.csv\n   Output Subdomain\n      Name: sarscov2_protein_enzyme_annotation_uniprotkb.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.csv\n      Name: sarscov2_protein_enzyme_annotation_uniprotkb.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"2\"\n      Name: \"enzyme_ec\"\n     Description: \"Enzyme Commision number assigned to an enzyme by Nomenclature Committee of the International Union of Biochemistry and Molecular Biology (IUBMB)\"\n      Unique Values: \"9\"\n      Name: \"enzyme_activity\"\n     Description: \"The catalytic reaction activity of an enzyme in UniProtKB\"\n      Unique Values: \"5\"",
    "downloadurl": "/ln2data/releases/data/v-1.7.13/reviewed/sarscov2_protein_enzyme_annotation_uniprotkb.csv"
}