{ "uniprot_canonical_ac": "A2AWP8-1", "ptm_annotation": [], "sequence": { "header": "sp|A2AWP8-1|ARGAL_MOUSE Isoform 1 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1280, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" }, "uniprot_id": "ARGAL_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "common_name": "Mouse", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16112081", "type": [ "PubMed" ], "id": "16112081" } ], "title": "GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor.", "journal": "Biochemical and biophysical research communications", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" } ], "authors": "Winkler S, Mohl M, Wieland T, Lutz S", "date": "2005" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12711221", "type": [ "PubMed" ], "id": "12711221" } ], "title": "Class II histone deacetylases: versatile regulators.", "journal": "Trends in genetics : TIG", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" } ], "authors": "Verdin E, Dequiedt F, Kasler HG", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12466305", "type": [ "PubMed" ], "id": "12466305" } ], "title": "Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set.", "journal": "Genome research", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" } ], "authors": "VanBuren V, Piao Y, Dudekula DB, Qian Y, Carter MG, Martin PR, Stagg CA, Bassey UC, Aiba K, Hamatani T, Kargul GJ, Luo AG, Kelso J, Hide W, Ko MS", "date": "2002" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/26371508", "type": [ "PubMed" ], "id": "26371508" } ], "title": "The splicing regulators Esrp1 and Esrp2 direct an epithelial splicing program essential for mammalian development.", "journal": "eLife", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" } ], "authors": "Bebee TW, Park JW, Sheridan KI, Warzecha CC, Cieply BW, Rohacek AM, Xing Y, Carstens RP", "date": "2015" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17947660", "type": [ "PubMed" ], "id": "17947660" } ], "title": "Quantitative time-resolved phosphoproteomic analysis of mast cell signaling.", "journal": "J. Immunol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "authors": "Kawakami T., Nguyen V., Salomon A.R., Cao L., Yu K., Kawakami Y., Raphael B.J., Banh C., Ritz A.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12799088", "type": [ "PubMed" ], "id": "12799088" } ], "title": "Dynamic and coordinated expression profile of dbl-family guanine nucleotide exchange factors in the developing mouse brain.", "journal": "Gene expression patterns : GEP", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" } ], "authors": "Yoshizawa M, Sone M, Matsuo N, Nagase T, Ohara O, Nabeshima Y, Hoshino M", "date": "2003" } ], "uniprot_ac": "A2AWP8", "site_annotation": [ { "end_pos": 684, "annotation": "n_glycosylation_sequon", "start_pos": 682 }, { "end_pos": 416, "annotation": "n_glycosylation_sequon", "start_pos": 414 } ], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8#A8Y5U3-1", "isoform_ac": "A8Y5U3-1", "locus": { "end_pos": 140593169, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000154979", "id": "ENSMUST00000154979", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000122667", "id": "ENSMUSP00000122667", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A8Y5U3-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 119, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDR" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#F6S3V7-1", "isoform_ac": "F6S3V7-1", "locus": { "end_pos": 140517728, "strand": "+", "start_pos": 140577094, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000138493", "id": "ENSMUST00000138493", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000119471", "id": "ENSMUSP00000119471", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6S3V7-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 611, "sequence": "XPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPDRSLIKCSPRA" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-2", "isoform_ac": "A2AWP8-2", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000069623", "id": "ENSMUST00000069623", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000066249", "id": "ENSMUSP00000066249", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWP8-2|ARGAL_MOUSE Isoform 2 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1241, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-3", "isoform_ac": "A2AWP8-3", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000097820", "id": "ENSMUST00000097820", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000095431", "id": "ENSMUSP00000095431", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWP8-3|ARGAL_MOUSE Isoform 3 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1236, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-1", "isoform_ac": "A2AWP8-1", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105799", "id": "ENSMUST00000105799", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101425", "id": "ENSMUSP00000101425", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWP8-1|ARGAL_MOUSE Isoform 1 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1280, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-4", "isoform_ac": "A2AWP8-4", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000039204", "id": "ENSMUST00000039204", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000040531", "id": "ENSMUSP00000040531", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWP8-4|ARGAL_MOUSE Isoform 4 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1275, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRETEDLGWSSSEFESYSEDSGEETKPEAEPTKHRGSFQPKLSPDLTRLKERYVRTKRDILALRVGGRDMQELKLKCDCKMTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP8-5", "isoform_ac": "A2AWP8-5", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140581783, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105797", "id": "ENSMUST00000105797", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101423", "id": "ENSMUSP00000101423", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2AWP8-5|ARGAL_MOUSE Isoform 5 of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 988, "sequence": "MLPSSSWGKRKPRSQRLGWVRCDARGNMWARQEGLRQPHPHPHALIRCPSSSSSSVSCSGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP4-1", "isoform_ac": "A2AWP4-1", "locus": { "end_pos": 140575428, "strand": "+", "start_pos": 140581783, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000147426", "id": "ENSMUST00000147426", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000123642", "id": "ENSMUSP00000123642", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AWP4-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=8 CANONICAL=A2AWP8-1", "length": 261, "sequence": "MLPSSSWGKRKPRSQRLGWVRCDARGNMWARQEGLRQPHPHPHALIRCPSSSSSSVSCSGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGH" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#F6ZH54-1", "isoform_ac": "F6ZH54-1", "locus": { "end_pos": 140551816, "strand": "+", "start_pos": 140568381, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000140403", "id": "ENSMUST00000140403", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000117038", "id": "ENSMUSP00000117038", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|F6ZH54-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 205, "sequence": "HAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQMRTLSSGTGERAWDPAQINSRRSRAGWAVDWGAKS" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP6-1", "isoform_ac": "A2AWP6-1", "locus": { "end_pos": 140514993, "strand": "+", "start_pos": 140583932, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105798", "id": "ENSMUST00000105798", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101424", "id": "ENSMUSP00000101424", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AWP6-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 1040, "sequence": "MTQLMKAAKSGTRDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVGVTDIKPPAPELGPMPDGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTNAMSIIKKACLTKPAFLEFLKRRQVCSTDRVTLYGLMVKPVQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPSNHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNLLIQHAGAKKATAAGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCVPAFSSRTLSLQLGGLVHSPVNSPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPVAAPVLCIEYIPDPEEEAEGAEESRAATDPSVTVHPTVCLGLQDGSILLYGSVDTGTQCLATCKSPGPQPVLCLRHSPFYLLAGLQDGTLAAYPRTSGDIPWDLESPPMCITVGPGPIRTLLSLEDAAWASCGPRVTVLDAATLQTQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGSSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVAMSILAPDILRSDQEEAEGPQAEEDKPDGQAHETVPGPDSHTARELTRKKGILLQYRLRSTAHLPGPLLSVREPAPADGSALEHSEEDGSIYEMADDPDVWVRSRPCARDAHRKEICSVAIISGGQGYRHFGGAPGGLSGRAAPCSETDSTLLIWQVPLAL" } }, { "url": "https://www.uniprot.org/uniprot/A2AWP8#A2AWP7-1", "isoform_ac": "A2AWP7-1", "locus": { "end_pos": 140591932, "strand": "+", "start_pos": 140616949, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000143614", "id": "ENSMUST00000143614", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000120437", "id": "ENSMUSP00000120437", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AWP7-1|ARGAL_MOUSE Computationally mapped isoform of Rho guanine nucleotide exchange factor 10-like protein OS=Mus musculus OX=10090 GN=Arhgef10l PE=1 SV=1 CANONICAL=A2AWP8-1", "length": 163, "sequence": "MASSNPPPQPAIGAPLAPSAPGPSPEVEEDSGEAFEFDDSDEEEDTSSGLVVPGLAPERDTEPSLICFDTVPGSDLDPAAAPPQTEAPTVVSNGDAVGAAISGVRRSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERGLVYEDVHRAGAPRE" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-194840", "resource": "Reactome", "id": "R-MMU-194840", "name": "Rho GTPase cycle" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "resource": "Reactome", "id": "R-MMU-193648", "name": "NRAGE signals death through JNK" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "resource": "Reactome", "id": "R-MMU-416482", "name": "G alpha (12/13) signalling events" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72754", "resource": "KEGG Pathway", "id": "mmu:72754", "name": "" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8#function", "annotation": "Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8#function", "id": "A2AWP8", "database": "UniProtKB" } ] } ], "orthologs": [ { "uniprot_canonical_ac": "Q9HCE6-1", "protein_name": "Rho guanine nucleotide exchange factor 10-like protein", "sequence": { "length": 1279, "sequence": "MASSNPPPQPAIGDQLVPGVPGPSSEAEDDPGEAFEFDDSDDEEDTSAALGVPSLAPERDTDPPLIHLDSIPVTDPDPAAAPPGTGVPAWVSNGDAADAAFSGARHSSWKRKSSRRIDRFTFPALEEDVIYDDVPCESPDAHQPGAERNLLYEDAHRAGAPRQAEDLGWSSSEFESYSEDSGEEAKPEVEVEPAKHRVSFQPKLSPDLTRLKERYARTKRDILALRVGGRDMQELKHKYDCKMTQLMKAAKSGTKDGLEKTRMAVMRKVSFLHRKDVLGDSEEEDMGLLEVSVSDIKPPAPELGPMPEGLSPQQVVRRHILGSIVQSEGSYVESLKRILQDYRNPLMEMEPKALSARKCQVVFFRVKEILHCHSMFQIALSSRVAEWDSTEKIGDLFVASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAFLEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTELETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSLNKLLTSGQRQLLLCETLTETVYGDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQVQVVEVGQDGGTYDKDNVLIQHSGAKKASASGQAQNKVYLGPPRLFQELQDLQKDLAVVEQITLLISTLHGTYQNLNMTVAQDWCLALQRLMRVKEEEIHSANKCRLRLLLPGKPDKSGRPISFMVVFITPNPLSKISWVNRLHLAKIGLREENQPGWLCPDEDKKSKAPFWCPILACCIPAFSSRALSLQLGALVHSPVNCPLLGFSAVSTSLPQGYLWVGGGQEGAGGQVEIFSLNRPSPRTVKSFPLAAPVLCMEYIPELEEEAESRDESPTVADPSATVHPTICLGLQDGSILLYSSVDTGTQCLVSCRSPGLQPVLCLRHSPFHLLAGLQDGTLAAYPRTSGGVLWDLESPPVCLTVGPGPVRTLLSLEDAVWASCGPRVTVLEATTLQPQQSFEAHQDEAVSVTHMVKAGSGVWMAFSSGTSIRLFHTETLEHLQEINIATRTTFLLPGQKHLCVTSLLICQGLLWVGTDQGVIVLLPVPRLEGIPKITGKGMVSLNGHCGPVAFLAVATSILAPDILRSDQEEAEGPRAEEDKPDGQAHEPMPDSHVGRELTRKKGILLQYRLRSTAHLPGPLLSMREPAPADGAALEHSEEDGSIYEMADDPDIWVRSRPCARDAHRKEICSVAIISGGQGYRNFGSALGSSGRQAPCGETDSTLLIWQVPLML" }, "evidence": [ { "url": "http://www.informatics.jax.org/homology/10017", "id": "10017", "database": "MGI" } ], "common_name": "Human", "organism": "Homo sapiens", "tax_id": 9606 } ], "interactions": [], "synthesized_glycans": [], "snv": [], "cluster_types": [ { "name": "isoformset.uniprotkb", "label": "Isoforms" }, { "name": "homologset.mgi", "label": "MGI Homologs" } ], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "ac": "NP_001106193.1", "name": "rho guanine nucleotide exchange factor 10-like protein isoform b", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005085", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "guanyl-nucleotide exchange factor activity", "id": "GO:0005085" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005089", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "Rho guanyl-nucleotide exchange factor activity", "id": "GO:0005089" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005096", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "GTPase activator activity", "id": "GO:0005096" } ], "total": 3, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "cytosol", "id": "GO:0005829" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030036", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "actin cytoskeleton organization", "id": "GO:0030036" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0051496", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "positive regulation of stress fiber assembly", "id": "GO:0051496" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035023", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "regulation of Rho protein signal transduction", "id": "GO:0035023" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032933", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "name": "SREBP signaling pathway", "id": "GO:0032933" } ], "total": 4, "name": "Biological Process" } ] }, "gene_names": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "type": "recommended", "resource": "UniProtKB", "name": "Arhgef10l" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AWP8", "type": "synonym", "resource": "RefSeq", "name": "Arhgef10l" }, { "url": "https://www.uniprot.org/uniprot/A2AWP8", "type": "synonym", "resource": "UniProtKB", "name": "Kiaa1626" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AWP8", "type": "synonym", "resource": "RefSeq", "name": "2810441C07Rik" } ], "crossref": [ { "url": "https://www.ebi.ac.uk/interpro/entry/IPR011993", "id": "IPR011993", "database": "InterPro" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/72754", "id": "72754", "database": "GeneID" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR12877", "id": "PTHR12877", "database": "PANTHER" }, { "url": "http://www.orthodb.org/?query=67600at2759", "id": "67600at2759", "database": "OrthoDB" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-193648", "id": "R-MMU-193648", "database": "Reactome" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-194840", "id": "R-MMU-194840", "database": "Reactome" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000219", "id": "IPR000219", "database": "InterPro" }, { "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:72754", "id": "mmu:72754", "database": "KEGG Pathway" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR036322", "id": "IPR036322", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/intact/interactors/id:A2AWP8*", "id": "A2AWP8", "database": "IntAct" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR035899", "id": "IPR035899", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF00621", "id": "PF00621", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001106193.1", "id": "NP_001106193.1", "database": "RefSeq" }, { "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AWP8", "id": "PR_A2AWP8", "database": "PRO" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR015943", "id": "IPR015943", "database": "InterPro" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000040964", "id": "ENSMUSG00000040964", "database": "Bgee" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-416482", "id": "R-MMU-416482", "database": "Reactome" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00160", "id": "cd00160", "database": "CDD" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR039919", "id": "IPR039919", "database": "InterPro" }, { "url": "http://www.informatics.jax.org/marker/MGI:1920004", "id": "1920004", "database": "MGI" } ], "expression_disease": [], "glycosylation": [], "mutagenesis": [], "disease": [], "phosphorylation": [ { "residue": "Tyr", "position": "131", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "40", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Tyr", "position": "152", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Ser", "position": "279", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "id": "A2AWP8", "database": "UniProtKB" } ], "kinase_uniprot_canonical_ac": "", "kinase_gene_name": "" }, { "residue": "Tyr", "position": "152", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17947660", "id": "17947660", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" }, { "residue": "Tyr", "position": "131", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17947660", "id": "17947660", "database": "PubMed" } ], "kinase_uniprot_canonical_ac": "Q3UD01-1", "kinase_gene_name": "Atxn7l3b" } ], "mass": { "monoisotopic_mass": 139987.0, "chemical_mass": 139987.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "name": "Arhgef10l", "locus": { "end_pos": 140514485, "strand": "-", "start_pos": 140666012, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000040964", "id": "ENSMUSG00000040964", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "url": "https://www.uniprot.org/uniprot/A2AWP8", "type": "synonym", "resource": "UniProtKB", "name": "GrinchGEF" }, { "url": "https://www.uniprot.org/uniprot/A2AWP8", "type": "recommended", "resource": "UniProtKB", "name": "Rho guanine nucleotide exchange factor 10-like protein" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AWP8", "type": "synonym", "resource": "RefSeq", "name": "rho guanine nucleotide exchange factor 10-like protein isoform b" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/A2AWP8", "type": "synonym", "resource": "RefSeq", "name": "rho guanine nucleotide exchange factor 10-like protein; GrinchGEF" } ] }