{
    "bcoid": "GLY_000134",
    "title": "Mouse Protein Function (NCBI Refseq)",
    "description": "The Mouse Protein Function (NCBI RefSeq) dataset contains biological function annotaion of mouse [taxid:10090] ...",
    "filename": "mouse_protein_function_refseq.csv",
    "filetype": "csv",
    "categories": {
        "species": "Mus musculus",
        "molecule": "Protein",
        "tags": "Protein Function",
        "file_type": "csv",
        "status": "Reviewed",
        "scope": "internal"
    },
    "minitable": {
        "content": [
            [
                "Q61718-1...",
                "protein_xref..."
            ],
            [
                "Q61718-1...",
                "protein_xref..."
            ]
        ],
        "headers": [
            "uniprotkb_ca...",
            "xref_key..."
        ],
        "colwidth": [
            "40%",
            "20%"
        ]
    },
    "sampledata": {
        "type": "table",
        "data": [
            [
                {
                    "type": "string",
                    "label": "uniprotkb_canonical_ac"
                },
                {
                    "type": "string",
                    "label": "xref_key"
                },
                {
                    "type": "string",
                    "label": "xref_id"
                },
                {
                    "type": "string",
                    "label": "evidence"
                },
                {
                    "type": "string",
                    "label": "annotation"
                }
            ],
            [
                "Q61718-1",
                "protein_xref_refseq",
                "NP_996753.1",
                "21172865",
                "A distinct subset of plasmacytoid dendritic cells (pDC) is responsible for nearly all IFN-alpha production, while in bone marrow and spleen, cells that ultimately differentiate into pDC produce little or no IFN-alpha and instead promote immune tolerance."
            ],
            [
                "Q61718-1",
                "protein_xref_refseq",
                "NP_996753.1",
                "16611902",
                "Results suggest that activation of the Ras/Raf/MEK pathway downregulates IFN-induced antiviral response"
            ],
            [
                "A0A0B4J1F4-1",
                "protein_xref_refseq",
                "NP_001036057.1",
                "19605364",
                "Txnip regulates cellular metabolism independent of its binding to thioredoxin and the arrestin domains are crucial structural elements in metabolic functions of alpha-arrestin proteins"
            ],
            [
                "Q9JMG3-1",
                "protein_xref_refseq",
                "NP_071863.1",
                "24240191",
                "HOPS has distinct, isoform-specific functions in the nucleolus, nucleus, and cytoplasm."
            ],
            [
                "Q9JMG3-1",
                "protein_xref_refseq",
                "NP_071863.1",
                "22890319",
                "HOPS acts as a functional bridge in the interaction between NPM and p19(Arf)"
            ],
            [
                "Q9JMG3-1",
                "protein_xref_refseq",
                "NP_071863.1",
                "20582322",
                "Results implicate Tmub1 in the regulation of locomotor activity and wakefulness and suggest that Tmub1 binds to and functions together with CAMLG Publication Status: Online-Only"
            ],
            [
                "Q9JMG3-1",
                "protein_xref_refseq",
                "NP_071863.1",
                "18665261",
                "Transmission; it contributes to maintain the synaptic surface number of the GluR2-containing AMPARs by facilitating the recycling of GluR2 to the plasma membrane Publication Status: Online-Only"
            ],
            [
                "Q9JMG3-1",
                "protein_xref_refseq",
                "NP_071863.1",
                "18418082",
                "HOPS is involved in centrosome assembly and maintenance."
            ],
            [
                "Q99JS0-1",
                "protein_xref_refseq",
                "NP_001161970.1",
                "18650334",
                "This study identified an evolutionarily conserved novel component of myelin called Mp11. The Mp11 genomic locus contains multiple conserved Egr binding sites, and Mp11 induction is regulated by the expression of Egr2 and expression in peripheral nerve."
            ],
            [
                "Q9DCN2-1",
                "protein_xref_refseq",
                "NP_084063.1",
                "29706024",
                "Results highlight the importance of CYB5R3 and NQO1, two NAD(+) producers, for the promotion of health and extended lifespan"
            ],
            [
                "Q9DCN2-1",
                "protein_xref_refseq",
                "NP_084063.1",
                "20927338",
                "Amino and carboxy terminal fragments of mDia1 form a tetrameric complex composed of two interlocking N+C dimers. Publication Status: Online-Only"
            ],
            [
                "Q9DCN2-1",
                "protein_xref_refseq",
                "NP_084063.1",
                "20566685",
                "Nucleation is achieved by a mechanism involving APC-B dimerization and recruitment of multiple actin monomers. Further, APC-B nucleation activity is synergistic with its in vivo binding partner, the formin mDia1"
            ],
            [
                "P25916-1",
                "protein_xref_refseq",
                "NP_031578.2",
                "30209188",
                "This study shows that Bmi1 regulates IkappaBalpha degradation via association with the SCF complex"
            ],
            [
                "Q60972-1",
                "protein_xref_refseq",
                "NP_033056.2",
                "30026490",
                "ARMC12 promotes neuroblastoma progression through interaction with RBBP4. Publication Status: Online-Only"
            ],
            [
                "Q60972-1",
                "protein_xref_refseq",
                "NP_033056.2",
                "25788661",
                "RBBP4 is a regulator of histone deacetylation during oocyte maturation and deacetylation is required for bipolar spindle assembly through Aurora kinase C"
            ],
            [
                "Q60972-1",
                "protein_xref_refseq",
                "NP_033056.2",
                "26376479",
                "RbAp48 was identified as critical in the proliferation of hypopharyngeal carcinoma in both in vitro and in vivo experiments."
            ],
            [
                "Q9JHF7-1",
                "protein_xref_refseq",
                "NP_062328.3",
                "30161143",
                "Validation of differentially expressed genes (DEGs) by quantitative RT-PCR showed a significant increase in PLA2 group 4c (Pla2g4c)/COX-2 (Ptgs2)/PGD2 synthase 2 (Hpgds) axis. PGD2 level in bronchoalveolar fluids of the OA-challenged mice was significantly increased. A 24-h incubation of BSM tissues with PGD2 caused a hyperresponsiveness to acetylcholine in naive control mice. Publication Status: Online-Only"
            ],
            [
                "Q9JHF7-1",
                "protein_xref_refseq",
                "NP_062328.3",
                "26159556",
                "H-PGDS deficiency accelerates the production of SDF-1alpha and the activity of MMP-9 in the antigen-stimulated intestine. SDF-1alpha receptor blockade or MMP-9 inhibition relieves the exacerbated mast cell hyperplasia and manifestations observed in H-PGDS(-/-). Publication Status: Online-Only"
            ],
            [
                "Q9JHF7-1",
                "protein_xref_refseq",
                "NP_062328.3",
                "16547141",
                "HPGD(2)S-derived cyclopentenone prostaglandins may protect against inflammatory diseases, where T lymphocytes play a pathogenic role, as in rheumatoid arthritis, atopic eczema, and chronic rejection"
            ],
            [
                "Q9DAX9-1",
                "protein_xref_refseq",
                "NP_080101.1",
                "18780968",
                "Amyloid beta precursor protein gene is associated with Alzheimer's disease"
            ],
            [
                "Q08652-1",
                "protein_xref_refseq",
                "NP_033060.3",
                "28970247",
                "Study demonstrates that Piasy may prevent exaggerated transcription of IFNI by Rbp2-mediated demethylation of H3K4me3 of IFNI, avoiding excessive immune responses"
            ],
            [
                "Q08652-1",
                "protein_xref_refseq",
                "NP_033060.3",
                "28874522",
                "Genetic deletion of RBP1 and RBP2 did not impair synapse ultrastructure of ribbon-type synapses formed between rod bipolar cells (RBCs) and amacrine type-2 (AII) cells in the mouse retina but dramatically reduced the density of presynaptic Ca(2+) channels, decreased and desynchronized evoked neurotransmitter release"
            ],
            [
                "Q08652-1",
                "protein_xref_refseq",
                "NP_033060.3",
                "27537484",
                "RBPs perform unexpectedly broad roles at the active zone that together with those of RIMs are essential for all active zone functions."
            ],
            [
                "Q08652-1",
                "protein_xref_refseq",
                "NP_033060.3",
                "25255718",
                "The present study was designed to detect the expression of Histone H3 lysine 4 methylation and its demethylases LSD1, RBP2 and SMCX in 21-, 40- and 60-day-old mouse testes."
            ],
            [
                "Q99M80-1",
                "protein_xref_refseq",
                "NP_001278078.1",
                "24895325",
                "Receptor protein tyrosine phosphatase rho (RPTPrho, gene symbol PTPRT) is a transmembrane protein expressed at high levels in the developing hippocampus, olfactory bulb, cortex, and cerebellum."
            ],
            [
                "Q99M80-1",
                "protein_xref_refseq",
                "NP_001278078.1",
                "24949727",
                "These studies implicate PTPRT-modulated STAT3 signaling in the regulation of high-fat diet-induced obesity Publication Status: Online-Only"
            ],
            [
                "Q99M80-1",
                "protein_xref_refseq",
                "NP_001278078.1",
                "22767509",
                "BCR is a novel substrate of PTPRT ."
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "29595914",
                "Our findings suggest a role for UMOD-dependent inhibition of KIM-1 expression and its apoptotic cell scavenging responses during chronic obstruction-associated tubular injury"
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "29074644",
                "By preventing ERK1/2 phosphorylation following renal injury, STAT3 phosphorylation is decreased, leading to less phosphorylated STAT3 within the nucleus, and subsequently less KIM-1 mRNA increases post injury"
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "28978444",
                "Study used a previously described highly mobile membrane mimetic membrane in combination with a conventional lipid bilayer model to generate a membrane-bound configuration of Tim1 in silico, identified two possible states for a membrane-bound form of Tim1."
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "28951472",
                "Findings provide evidence for the role of Tim-1 in the induction of a cytokine storm phenomenon and the pathogenesis of Ebola virus disease Publication Status: Online-Only"
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "15793576",
                "TIM-1-TIM-4 interaction is involved in regulating T cell proliferation"
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "15793575",
                "TIM-1 is a molecule that costimulates T cell activation"
            ],
            [
                "Q5QNS5-1",
                "protein_xref_refseq",
                "NP_001160103.1",
                "14534576",
                "Protective effects of hepatitis A virus on atopic disease depends on a common TIM-1 allele"
            ],
            [
                "Q8K5B8-1",
                "protein_xref_refseq",
                "NP_034593.1",
                "27977683",
                "We find a subtle impact of deleting the Hotair locus upon the expression of the neighboring Hoxc11 and Hoxc12 genes in cis. Our results do not support any substantial role for Hotair during mammalian development in vivo Publication Status: Online-Only"
            ],
            [
                "Q3UJK4-1",
                "protein_xref_refseq",
                "NP_001139451.1",
                "25061210",
                "These results not only define GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes."
            ],
            [
                "P56481-1",
                "protein_xref_refseq",
                "NP_031653.1",
                "27448962",
                "Our data suggest a progression model for BE to EAC in which CCK2R+ progenitor cells, stimulated by hypergastrinemia, proliferate to give rise to metaplasia and dysplasia."
            ],
            [
                "P56481-1",
                "protein_xref_refseq",
                "NP_031653.1",
                "26751218",
                "CCKBR and D5R synergistically interact in the kidney, which may contribute to the maintenance of normal sodium balance following an increase in sodium intake Publication Status: Online-Only"
            ],
            [
                "P56481-1",
                "protein_xref_refseq",
                "NP_031653.1",
                "25875176",
                "There is functional synergy between cholecystokinin receptors CCKAR and CCKBR in mammalian brain development. Publication Status: Online-Only"
            ],
            [
                "O88845-1",
                "protein_xref_refseq",
                "NP_064305.2",
                "17485678",
                "These studies suggest a role for AKAP10 in heart rhythm control."
            ],
            [
                "O88845-1",
                "protein_xref_refseq",
                "NP_064305.2",
                "14531807",
                "D-AKAP2 may play an important role in the parathyroid hormone (PTH)-mediated regulation of NaPi-IIa by compartmentalization of PKA."
            ],
            [
                "O88845-1",
                "protein_xref_refseq",
                "NP_064305.2",
                "12206784",
                "Deuterium exchange-mass spectrometry (DXMS) and limited proteolysis to probe the folded regions of D-AKAP2, providing for the first time insight into the intra-domain dynamics of a scaffold protein"
            ],
            [
                "Q8BXR6-1",
                "protein_xref_refseq",
                "NP_766423.3",
                "26310831",
                "Pellino-3 is involved in endotoxin tolerance and functions as a negative regulator of Toll-like receptor 2/4 signaling."
            ],
            [
                "Q8BXR6-1",
                "protein_xref_refseq",
                "NP_766423.3",
                "25483963",
                "Autophagy causes PELI3 degradation during TLR4-signaling, thereby impairing the hyperinflammatory phase during sepsis by inhibiting proinflammatory IL1B expression"
            ],
            [
                "Q8BXR6-1",
                "protein_xref_refseq",
                "NP_766423.3",
                "23892723",
                "Our findings identify RIP2 as a substrate for Pellino3 and Pellino3 as an important mediator in the Nod2 pathway and regulator of intestinal inflammation."
            ],
            [
                "Q8BXR6-1",
                "protein_xref_refseq",
                "NP_766423.3",
                "24113711",
                "Pellino3 targets RIP1 and regulates the pro-apoptotic effects of TNF-alpha."
            ],
            [
                "Q8BXR6-1",
                "protein_xref_refseq",
                "NP_766423.3",
                "23042151",
                "Pellino3 targets the IRF7 pathway and facilitates autoregulation of TLR3- and viral-induced expression of type I interferons."
            ],
            [
                "Q8BHN5-1",
                "protein_xref_refseq",
                "NP_700454.1",
                "18782777",
                "ARC may protect cardiomyocytes from hypoxic cell death by regulating its downstream, Drbp1 and pMe(2)GlyDH"
            ],
            [
                "Q8BSN9-1",
                "protein_xref_refseq",
                "NP_001317352.1",
                "20869947",
                "These results introduce FASTKD3 as an essential component of mitochondrial respiration that may modulate energy balance in cells exposed to adverse conditions by functionally coupling mitochondrial protein synthesis to respiration."
            ],
            [
                "Q9DAU7-1",
                "protein_xref_refseq",
                "NP_080599.1",
                "21807117",
                "Causal testing implicates Wfdc2 and Hdac3 as novel genes affecting high density lipoprotein levels"
            ],
            [
                "Q9CQA3-1",
                "protein_xref_refseq",
                "NP_075863.2",
                "30159755",
                "The present study identified a potential role for the tumor microenvironment in influencing phenotypic features of SDHB-mutated Pheochromocytomas and paragangliomas."
            ],
            [
                "Q08890-1",
                "protein_xref_refseq",
                "NP_034628.2",
                "29648648",
                "We also show that mucopolysaccharidosis type II patient fibroblasts harboring different mutations spanning the IDS gene exhibit perturbed FGF signaling-related markers expression. Our work opens a new venue to discover possible druggable novel key targets in mucopolysaccharidosis type II Erratum:[Hum Mol Genet. 2018 Jul 1;27(13):2407. PMID: 29917101]"
            ],
            [
                "Q3UFT3-1",
                "protein_xref_refseq",
                "NP_001028617.2",
                "24003223",
                "Data indicate that a subtype of GAREM, GAREM2, is specifically expressed in the mouse, rat, and human brain."
            ],
            [
                "Q923J1-1",
                "protein_xref_refseq",
                "NP_001157797.1",
                "30305398",
                "Internal Mg(2+)-, polyamine-, and pH-mediated inhibition of TRPM7 channels is not direct but, rather, reflects electrostatic screening and resultant disruption of PI(4,5)P2-channel interactions."
            ],
            [
                "Q923J1-1",
                "protein_xref_refseq",
                "NP_001157797.1",
                "30322909",
                "The identification of TRPM7 and CaV3.2 as key mediators of Ca(2+) influx following fertilization."
            ],
            [
                "Q923J1-1",
                "protein_xref_refseq",
                "NP_001157797.1",
                "30076216",
                "Findings suggest that TRPM7 channel activities play a key role in HG-associated ERS and cytotoxicity through an apoptosis-inducing signaling cascade involving HG, iNOS, TRPM7, ERS proteins, and caspases"
            ],
            [
                "Q923J1-1",
                "protein_xref_refseq",
                "NP_001157797.1",
                "30108148",
                "Results provide a structural framework for understanding the TRPM1/3/6/7 subfamily and extend the knowledge base upon which to study the diversity and evolution of TRP channels."
            ],
            [
                "Q923J1-1",
                "protein_xref_refseq",
                "NP_001157797.1",
                "12508053",
                "The Trpm7 ion channel possesses the unique ability to efficiently conduct many essential trace metal ions such as Zn2+, Fe2+, Cu2+, Mn2+, and Co2+ into cells, along with several toxic metal ions such as Cd2+, Ba2+, and Sr2+ as well."
            ],
            [
                "Q8CIT9-1",
                "protein_xref_refseq",
                "NP_001077372.1",
                "25283635",
                "Findings suggest that SBSN is involved in the angiogenic potential of tumor endothelial cells (TEC) and may be a novel TEC marker."
            ],
            [
                "Q8CIT9-1",
                "protein_xref_refseq",
                "NP_001077372.1",
                "17330888",
                "Sbsn, Dmkn and Krtdap are coordinately expressed during epidermal morphogenesis."
            ],
            [
                "Q8CIT9-1",
                "protein_xref_refseq",
                "NP_001077372.1",
                "12228223",
                "These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation. GeneRIF: These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation"
            ],
            [
                "Q8BFT9-1",
                "protein_xref_refseq",
                "NP_081081.1",
                "19013223",
                "These results indicate that msvop is a central nervous system-specific gene and could be utilized for elucidating gene regulation in neuronal cells."
            ],
            [
                "Q571F8-1",
                "protein_xref_refseq",
                "NP_001028436.2",
                "29274472",
                "Data (including data from studies in knockout/transgenic mice) suggest Ppp2ca supports cortical neuronal growth and cognitive function via regulating p73/Gls2 signal transduction in neurons of hippocampus. Ppp2ca gene knock-out results in embryonic cortical atrophy with learning/memory deficits. (Ppp2ca = protein phosphatase 2a catalytic subunit alpha isoform; p73 = transformation related protein 73; Gls2 = glutaminase-2)"
            ],
            [
                "Q571F8-1",
                "protein_xref_refseq",
                "NP_001028436.2",
                "27466601",
                "Gls2 expression is regulated by the dietary protein/carbohydrate ratio. This effect was not observed in Ppara-null mice."
            ],
            [
                "Q571F8-1",
                "protein_xref_refseq",
                "NP_001028436.2",
                "22679499",
                "Study demonstrated expression of alternative transcripts of the mammalian Gls2 gene. Transcriptional mechanisms giving rise to GLS2 variants and isolation of novel GLS2 transcripts in human, rat and mouse are presented."
            ],
            [
                "Q571F8-1",
                "protein_xref_refseq",
                "NP_001028436.2",
                "20351271",
                "Phosphate-activated glutaminase (GLS2) is a p53-inducible regulator of glutamine metabolism and reactive oxygen species"
            ],
            [
                "Q9DCD6-1",
                "protein_xref_refseq",
                "NP_062723.1",
                "28604719",
                "Cells that lacked GABARAPs and mice that lacked Gate-16 alone were defective in the IFN-gamma-induced clearance of vacuolar pathogens such as Toxoplasma. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases."
            ],
            [
                "Q9DCD6-1",
                "protein_xref_refseq",
                "NP_062723.1",
                "28497576",
                "GABAergic synapse is proposed as a focus of aging. (Review) Review article"
            ],
            [
                "Q9DCD6-1",
                "protein_xref_refseq",
                "NP_062723.1",
                "28320742",
                "Development of LC3/GABARAP sensors containing a LIR and a hydrophobic domain to monitor autophagy."
            ],
            [
                "Q9DCD6-1",
                "protein_xref_refseq",
                "NP_062723.1",
                "27124579",
                "Ablation of GABARAP inhibits tumor initiation and progression through enhancement of both antitumor immunity and cell death signaling. Publication Status: Online-Only"
            ],
            [
                "Q8C9X1-1",
                "protein_xref_refseq",
                "NP_808292.1",
                "18829862",
                "Data suggest that sentan is the first molecular component of the ciliary tip to bridge the cell membrane and peripheral singlet microtubules, making the distal portion of the cilia narrow and stiff to allow for better airway clearance or ovum transport."
            ],
            [
                "P40237-1",
                "protein_xref_refseq",
                "NP_001129527.1",
                "30133344",
                "Data provide evidence that CD82 is an important regulator of HSPC bone marrow maintenance, homing, and engraftment."
            ],
            [
                "P40237-1",
                "protein_xref_refseq",
                "NP_001129527.1",
                "29782939",
                "Loss of CD82 resulted in defects in osteoclast, osteoblast, and adipocyte lineages."
            ],
            [
                "P40237-1",
                "protein_xref_refseq",
                "NP_001129527.1",
                "29760437",
                "CD82-RUNX1-Rab5/22 axis may be a previously unrecognized virulence mechanism of Mycobacterium tuberculosis pathogenesis. Publication Status: Online-Only"
            ],
            [
                "P40237-1",
                "protein_xref_refseq",
                "NP_001129527.1",
                "26996598",
                "The CD82 is a functional surface marker of long-term repopulating hematopoietic stem cells (LT-HSCs) that maintains quiescence through interaction with DARC-expressing macrophages in the bone marrow stem cell niche."
            ],
            [
                "P40237-1",
                "protein_xref_refseq",
                "NP_001129527.1",
                "16372335",
                "An antibody to this protein that can specifically detect murine Kai1/CD82, should be useful in addressing the mechanism of action of Kai1 in metastatic suppression."
            ],
            [
                "Q4VC17-1",
                "protein_xref_refseq",
                "NP_766054.2",
                "29421655",
                "The underlying molecular mechanisms could be attributed in part to the abnormal vascular remodeling, including deficiency of carotid body (glomus) and aberrant carotid basal lamina. These results indicate a novel function of ADAMTS18 in vascular remodeling and associated thrombus formation."
            ],
            [
                "Q4VC17-1",
                "protein_xref_refseq",
                "NP_766054.2",
                "28145888",
                "Adamts18 deficiency enhances tumorigenesis and intestinal inflammation through elevated Wnt/beta-catenin and p38MAPK/ERK1/2 signaling and promotes colon cancer in a mouse model."
            ],
            [
                "Q4VC17-1",
                "protein_xref_refseq",
                "NP_766054.2",
                "22386991",
                "These data demonstrate a thrombin cleavage site and confirm a short form of ADAMTS-18 presents in vivo."
            ],
            [
                "Q4VC17-1",
                "protein_xref_refseq",
                "NP_766054.2",
                "21862674",
                "Adamts18 is expressed in the lens and retina in the developing murine eye."
            ],
            [
                "Q8QZS5-1",
                "protein_xref_refseq",
                "NP_705724.1",
                "30413537",
                "These results indicate that (i) RNF183 is predominantly expressed in the normal renal medulla, (ii) NFAT5 stimulates transcriptional activation of Rnf183 by binding to its cognate binding motif in the Rnf183 promoter, and (iii) RNF183 protects renal medullary cells from hypertonicity-induced apoptosis."
            ],
            [
                "Q8QZS5-1",
                "protein_xref_refseq",
                "NP_705724.1",
                "26818663",
                "RNF183, which is negatively regulated by miR-7, is a novel regulator promoting intestinal inflammation by increasing the ubiquitination and degradation of IkappaBalpha, thereby inducing NF-kappaB activation. The interaction between RNF183-mediated ubiquitination and miRNA may be an important novel epigenetic mechanism in the pathogenesis of inflammatory bowel disease."
            ],
            [
                "P23298-1",
                "protein_xref_refseq",
                "NP_001300906.1",
                "24705298",
                "Genetic deficiency results in defective suppressive activity of T reg cells"
            ],
            [
                "P23298-1",
                "protein_xref_refseq",
                "NP_001300906.1",
                "22155788",
                "Data suggest that PKCeta shares some redundant roles with PKCtheta; in T cell biology and also performs nonredundant functions that are required for T cell homeostasis and activation Publication Status: Online-Only"
            ]
        ]
    },
    "readme": "Name\n   - Mouse Protein Function (NCBI Refseq)\n\nVersion\n   - 1.7.10\n\nCreated on\n  - 2019-03-16T15:38:06.344586\n\nModified on\n   - 2020-04-10T12:44:03.077091\n\nCreated by\n   - Jeet Vora [jeetvora@gwu.edu], Rahi Navelkar [rsn13@gwu.edu], Robel Kahsay [rykahsay@gwu.edu], Xavier Holmes [xavierh@email.gwu.edu]\n\nAuthors\n   - Maria Martin [martin@ebi.ac.uk], Preethi Vasudev [pvasudev@ebi.ac.uk]\n\nChecksum\n   - \n\nUsability Domain\n   - The Mouse Protein Function (NCBI RefSeq) dataset contains biological function annotaion of mouse [taxid:10090] genes from GeneRIF section in the NCBI RefSeq database. The dataset is derived from NCBI RefSeq Release 96, September 9, 2019. If you use this dataset please provide proper attribution to NCBI RefSeq and GlyGen\n\nDescription Domain\n   Keywords\n   - protein function\n   - NCBI RefSeq\n   - geneRIF\n   - PMID\n\n   Pipeline Steps\n   - Step-1: The script extract-from-gp.py extracts protein function information from NCBI RefSeq gpff format files and maps it to the UniProtKb canonical accessions for a final dataset output in a csv format\n\nExecution Domain\n   Scripts   - https://github.com/glygener/glygen-backend-integration/blob/master/pipeline/extractor/extract-from-endpoint.py\n\n\n   Software Prerequisites\n      Name: Python\n      Version: 2.7.5\n      URI: https://www.python.org/download/releases/2.7.5/\n\nI/O Domain\n   Input Subdomain\n      Name: mouse_protein_xref_refseq.csv\n      URI: https://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_xref_refseq.csv\n      Name: efseq_protein_all_10090.gpff\n      URI: https://data.glygen.org/ln2wwwdata/source/refseq_protein_all_10090.gpff\n   Output Subdomain\n      Name: mouse_protein_function_refseq.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_function_refseq.csv\n      Name: mouse_protein_function_refseq.stat.csv\n      URI: http://data.glygen.org/ln2wwwdata/reviewed/mouse_protein_function_refseq.stat.csv\n\nFields\n      Name: \"uniprotkb_canonical_ac\"\n     Description: \"\"\n      Unique Values: \"10860\"\n      Name: \"evidence\"\n     Description: \"NCBI PubMed Id (PMID) or DOI (Digital Object Identifier) as evidence for the entry/annotation\"\n      Unique Values: \"26579\"\n      Name: \"annotation\"\n     Description: \"Function annotation from UniProtKB|RefSeq database\"\n      Unique Values: \"27216\"\n      Name: \"xref_id\"\n     Description: \"ID of the X-ref\"\n      Unique Values: \"10860\"\n      Name: \"xref_key\"\n     Description: \"Source key associated to the  xref_id\"\n      Unique Values: \"1\"",
    "downloadurl": "/ln2data/releases/data/v-1.7.10/reviewed/mouse_protein_function_refseq.csv"
}
