{
    "uniprot_canonical_ac": "A2VD16-1", 
    "sequence": {
        "header": "tr|A2VD16-1|A2VD16_RAT Isoform 1 of Aldo-keto reductase family 1, member C12-like 1  OS=Rattus norvegicus OX=10116 GN=Akr1c12l1 PE=2 SV=1 CANONICAL=A2VD16-1", 
        "length": 323, 
        "sequence": "MSSKHHCVKLNDGHFIPALGFGTSIPNEVPKSKSLEAVHLAIDAGYHHIDTASAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDKYLPVDDKGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYMNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDVAKKNKRSPALIALRYLVQREVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY"
    }, 
    "uniprot_id": "A2VD16_RAT", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2VD16", 
                    "id": "A2VD16", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Rattus norvegicus", 
            "taxid": 10116
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/17475203", 
                    "type": "PUBMED", 
                    "id": "17475203"
                }
            ], 
            "title": "Rat NAD+-dependent 3alpha-hydroxysteroid dehydrogenase (AKR1C17): a member of the aldo-keto reductase family highly expressed in kidney cytosol.", 
            "journal": "Archives of biochemistry and biophysics", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
                    "id": "NP_001129216.1", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sanai M, Endo S, Matsunaga T, Ishikura S, Tajima K, El-Kabbani O, Hara A", 
            "date": "2007"
        }
    ], 
    "uniprot_ac": "A2VD16", 
    "site_annotation": [
        {
            "end_pos": 200, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 198
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16#A2VD16-1", 
            "isoform_ac": "A2VD16-1", 
            "locus": {
                "end_pos": 69588146, 
                "start_pos": 69598949, 
                "chromosome": "17", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOT00000064884", 
                        "id": "ENSRNOT00000064884", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOP00000059125", 
                        "id": "ENSRNOP00000059125", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "tr|A2VD16-1|A2VD16_RAT Isoform 1 of Aldo-keto reductase family 1, member C12-like 1  OS=Rattus norvegicus OX=10116 GN=Akr1c12l1 PE=2 SV=1 CANONICAL=A2VD16-1", 
                "length": 323, 
                "sequence": "MSSKHHCVKLNDGHFIPALGFGTSIPNEVPKSKSLEAVHLAIDAGYHHIDTASAYQIEEEIGQAIQSKIKAGVVKREDMFITTKLWCTCFRPELVKPALEKSLKNLQLDYADLYIMHYPVPMKSGDKYLPVDDKGKWLLDTVDFCDTWEMLEKCKDAGLVKSIGVSNFNHKQLERLLNKPGLKYKPVCNQVECHLYMNQSKLLDYCKSKDIVLVAYGALGTQRYKEWVDQNSPVLLDDPVLCDVAKKNKRSPALIALRYLVQREVVPLAQSFKENEMRENLQVFEFQLSPEDMKTLDGLNKNFRYLSAEFLAGHPEYPFSEEY"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498790", 
            "resource": "KEGG Pathway", 
            "id": "rno:498790", 
            "name": ""
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193807", 
            "resource": "Reactome", 
            "id": "R-RNO-193807", 
            "name": "Synthesis of bile acids and bile salts via 27-hydroxycholesterol"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193368", 
            "resource": "Reactome", 
            "id": "R-RNO-193368", 
            "name": "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634", 
            "resource": "Reactome", 
            "id": "R-RNO-975634", 
            "name": "Retinoid metabolism and transport"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193775", 
            "resource": "Reactome", 
            "id": "R-RNO-193775", 
            "name": "Synthesis of bile acids and bile salts via 24-hydroxycholesterol"
        }
    ], 
    "function": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
            "annotation": "AKR1C17 is a member of the aldo-keto reductase family highly expressed in kidney cytosol.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
                    "id": "NP_001129216.1", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
        "ac": "NP_001129216.1", 
        "name": "aldo-keto reductase family 1, member C12-like 1", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016229", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "steroid dehydrogenase activity", 
                        "id": "GO:0016229"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004032", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alditol:NADP+ 1-oxidoreductase activity", 
                        "id": "GO:0004032"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016491", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "oxidoreductase activity", 
                        "id": "GO:0016491"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008106", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "alcohol dehydrogenase (NADP+) activity", 
                        "id": "GO:0008106"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047023", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "androsterone dehydrogenase activity", 
                        "id": "GO:0047023"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0032052", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "bile acid binding", 
                        "id": "GO:0032052"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0047086", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "ketosteroid monooxygenase activity", 
                        "id": "GO:0047086"
                    }
                ], 
                "total": 7, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005829", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytosol", 
                        "id": "GO:0005829"
                    }
                ], 
                "total": 1, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006693", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "prostaglandin metabolic process", 
                        "id": "GO:0006693"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044597", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "daunorubicin metabolic process", 
                        "id": "GO:0044597"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044598", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "doxorubicin metabolic process", 
                        "id": "GO:0044598"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0008202", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "steroid metabolic process", 
                        "id": "GO:0008202"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042448", 
                        "pmid": "21873635", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2VD16", 
                                "id": "A2VD16", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "progesterone metabolic process", 
                        "id": "GO:0042448"
                    }
                ], 
                "total": 5, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "type": "recommended", 
            "resource": "uniprotkb", 
            "name": "Akr1c12l1"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "Akr1c12l1"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "Akr1c17; RGD1559604"
        }, 
        {
            "type": "synonym", 
            "resource": "uniprotkb", 
            "name": "RGD1559604"
        }
    ], 
    "crossref": [
        {
            "url": "http://rgd.mcw.edu/tools/genes/genes_view.cgi?id=1559604", 
            "id": "1559604", 
            "database": "RGD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018170", 
            "id": "IPR018170", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193807", 
            "id": "R-RNO-193807", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193775", 
            "id": "R-RNO-193775", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+rno:498790", 
            "id": "rno:498790", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd06660", 
            "id": "cd06660", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR023210", 
            "id": "IPR023210", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-975634", 
            "id": "R-RNO-975634", 
            "database": "Reactome"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036812", 
            "id": "IPR036812", 
            "database": "InterPro"
        }, 
        {
            "url": "http://www.orthodb.org/?query=1016440at2759", 
            "id": "1016440at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11732", 
            "id": "PTHR11732", 
            "database": "PANTHER"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/498790", 
            "id": "498790", 
            "database": "GeneID"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR020471", 
            "id": "IPR020471", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.reactome.org/PathwayBrowser/#R-RNO-193368", 
            "id": "R-RNO-193368", 
            "database": "Reactome"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00248", 
            "id": "PF00248", 
            "database": "Pfam"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSRNOG00000050243", 
            "id": "ENSRNOG00000050243", 
            "database": "Bgee"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/NDAHRYE/", 
            "id": "NDAHRYE", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129216.1", 
            "id": "NP_001129216.1", 
            "database": "RefSeq"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 36956.0, 
        "chemical_mass": 36956.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2VD16", 
            "name": "Akr1c12l1", 
            "locus": {
                "end_pos": 69599142, 
                "start_pos": 69588085, 
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                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSRNOG00000050243", 
                        "id": "ENSRNOG00000050243", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
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            "resource": "uniprotkb", 
            "name": "Aldo-keto reductase family 1, member C12-like 1"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "aldo-keto reductase family 1, member C12-like 1"
        }
    ]
}