{
    "uniprot_canonical_ac": "A2AVA0-1", 
    "sequence": {
        "header": "sp|A2AVA0-1|SVEP1_MOUSE Isoform 1 of Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1  OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1 CANONICAL=A2AVA0-1", 
        "length": 3567, 
        "sequence": "MWSRLAFCCWALALVSGWTNFQPVAPSLNFSFRLFPEASPGALGRLAVPPASSEEEAAGSKVERLGRAFRSRVRRLRELSGSLELVFLVDESSSVGQTNFLNELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPAITYRGGGTYTKGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMARCSYLCEAGKDCCDRMASCKCGTHTGQFECICEKGYYGKGLQHECTACPSGTYKPEASPGGISTCIPCPDVSHTSPPGSTSPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQNTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRVRTCPHLRQPKHGHISCSTAEMSYNTLCLVTCNEGYRLEGSTRLTCQGNAQWDGPEPRCVERHCATFQKPKGVIISPPSCGKQPARPGMTCQLSCRQGYILSGVREVRCATSGKWSAKVQTAVCKDVEAPQISCPNDIEAKTGEQQDSANVTWQVPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAITYTATDSSGNQASCTFYIKVIDVEPPVIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAELVITSSHTQGDMFPHGETVVWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQDSAGVNCSLSCKEGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIKRFANHGFKSFEMLYKTTRCDDMDLFKKFSAAFETTLGNMVPSFCNDADDIDCRLEDLTKKYCIEYNYNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPTDVGKARSSRIKRTVPLSDPKIQLIFNITASVPLPEERNDTLELENQQRLIKTLETITNRLKSTLNKEPMYSFQLASETVVADSNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLECKLCPPRTHTEYLHSRSVSECKAQCKQGTYSSSGLETCESCPLGTYQPEFGSRSCLLCPETTTTVKRGAVDISACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFSAAEESIVPLVAPGHSQNKYEVSSQVFHECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDECSSLPCLNGGICRDQVGGFTCECSLGYSGQICEENINECISSPCLNKGTCTDGLASYRCTCVKGYMGVHCETDVNECQSSPCLNNAVCKDQVGGFSCKCPPGFLGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGTHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGHRCETEQPSGFNLDFEVSGIYGYVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEDDKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKLLASSCPEELSRGNVLAWPDFLSGITGKVKVDSSSMFCSDCPSLEGSVPHLRPASGNRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWTQPLPHCERIRCGLPPALENGFYSAEDFHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGISPSCLDVDECAVGSDCSEHASCLNTNGSYVCSCNPPYTGDGKNCAEPVKCKAPENPENGHSSGEIYTVGTAVTFSCDEGHELVGVSTITCLETGEWDRLRPSCEAISCGVPPVPENGGVDGSAFTYGSKVVYRCDKGYTLSGDEESACLASGSWSHSSPVCELVKCSQPEDINNGKYILSGLTYLSIASYSCENGYSLQGPSLLECTASGSWDRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAYTCKEGYTLAGPDTIVCQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLICNAQGNWVPPAGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECLRGGEWSPSPLSVQCIPVRCGEPPSIANGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQWSKPTPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAAGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLLENQLVLKELASEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSFPICKMVLCPSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNATTLCGENGQWLGGKPMCKPIECPEPKEILNGQFSSVSFQYGQTITYFCDRGFRLEGPKSLTCLETGDWDMDPPSCDAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVLGHAMQTCEESGWSSSSPTCVPIDCGLPPHIDFGDCTKVRDGQGHFDQEDDMMEVPYLAHPQHLEATAKALENTKESPASHASHFLYGTMVSYSCEPGYELLGIPVLICQEDGTWNGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHILEGSHLRLCLQNKQWSGTVPRCEAISCSKPNPLWNGSIKGDDYSYLGVLYYECDSGYILNGSKKRTCQENRDWDGHEPMCIPVDCGSPPVPTNGRVKGEEYTFQKEITYSCREGFILEGARSRICLTNGSWSGATPSCMPVRCPAPPQVPNGVADGLDYGFKKEVAFHCLEGYVLQGAPRLTCQSNGTWDAEVPVCKPATCGPPADLPQGFPNGFSFYHGGHIQYQCFTGYKLHGNPSRRCLPNGSWSGSSPSCLPCRCSTPIIQQGTINATDLGCGKTVQIECFKGFKLLGLSEITCDANGQWSDVPLCEHAQCGPLPTIPNAIVLEGSLSEDNVVTYSCRPGYTMQGSSDLICTEKAIWSQPYPTCEPLSCGPPPTVANAVATGEAHTYESKVKLRCLEGYVMDSDTDTFTCQQDGHWVPERITCSPKKCPVPSNMTRIRFHGDDFQVNRQVSVSCAEGFTHEGVNWSTCQPDGTWEPPFSDESCIPVVCGHPESPAHGSVVGNKHSFGSTIVYQCDPGYKLEGNRERICQENRQWSGEVAVCRENRCETPAEFPNGKAVLENTTSGPSLLFSCHRGYTLEGSPEAHCTANGTWNHLTPLCKPNPCPVPFVIPENAVLSEKEFYVDQNVSIKCREGFLLKGNGVITCSPDETWTHTNARCEKISCGPPSHVENAIARGVYYQYGDMITYSCYSGYMLEGSLRSVCLENGTWTPSPVCRAVCRFPCQNGGVCQRPNACSCPDGWMGRLCEEPICILPCLNGGRCVAPYQCDCPTGWTGSRCHTATCQSPCLNGGKCIRPNRCHCLSAWTGHDCSRKRRAGL"
    }, 
    "uniprot_id": "SVEP1_MOUSE", 
    "enzyme_annotation": [], 
    "glycation": [], 
    "keywords": [
        "glycoprotein", 
        "glycoprotein_predicted"
    ], 
    "species": [
        {
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                    "id": "A2AVA0", 
                    "database": "UniProtKB"
                }
            ], 
            "name": "Mus musculus", 
            "taxid": 10090
        }
    ], 
    "publication": [
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/26238476", 
                    "type": "PUBMED", 
                    "id": "26238476"
                }
            ], 
            "title": "Spatiotemporal regulation of GLI target genes in the mammalian limb bud.", 
            "journal": "Developmental biology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Lewandowski JP, Du F, Zhang S, Powell MB, Falkenstein KN, Ji H, Vokes SA", 
            "date": "2015"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27892606", 
                    "type": "PUBMED", 
                    "id": "27892606"
                }
            ], 
            "title": "SVEP1 plays a crucial role in epidermal differentiation.", 
            "journal": "Experimental dermatology", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Samuelov L, Li Q, Bochner R, Najor NA, Albrecht L, Malchin N, Goldsmith T, Grafi-Cohen M, Vodo D, Fainberg G, Meilik B, Goldberg I, Warshauer E, Rogers T, Edie S, Ishida-Yamamoto A, Burzenski L, Erez N, Murray SA, Irvine AD, Shultz L, Green KJ, Uitto J, Sprecher E, Sarig O", 
            "date": "2017"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/16206243", 
                    "type": "PUBMED", 
                    "id": "16206243"
                }
            ], 
            "title": "Molecular and cellular characterization of SEL-OB/SVEP1 in osteogenic cells in vivo and in vitro.", 
            "journal": "J. Cell. Physiol.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                    "id": "A2AVA0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Benayahu D., Shur I., Fried A., Hameiri M., Socher R.", 
            "date": "2006"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/11062057", 
                    "type": "PUBMED", 
                    "id": "11062057"
                }
            ], 
            "title": "Polydom: a secreted protein with pentraxin, complement control protein, epidermal growth factor and von Willebrand factor A domains.", 
            "journal": "Biochem. J.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                    "id": "A2AVA0", 
                    "database": "UniProtKB"
                }
            ], 
            "authors": "Callebaut I., Cacheux V., Romeo P.-H., Coulombel L., Gilges D., Vigon I., Vinit M.-A.", 
            "date": "2000"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/22654117", 
                    "type": "PUBMED", 
                    "id": "22654117"
                }
            ], 
            "title": "Polydom/SVEP1 is a ligand for integrin alpha9beta1.", 
            "journal": "The Journal of biological chemistry", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Sato-Nishiuchi R, Nakano I, Ozawa A, Sato Y, Takeichi M, Kiyozumi D, Yamazaki K, Yasunaga T, Futaki S, Sekiguchi K", 
            "date": "2012"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/15522233", 
                    "type": "PUBMED", 
                    "id": "15522233"
                }
            ], 
            "title": "Identification of potential nuclear reprogramming and differentiation factors by a novel selection method for cloning chromatin-binding proteins.", 
            "journal": "Biochemical and biophysical research communications", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Wang L, Zheng A, Yi L, Xu C, Ding M, Deng H", 
            "date": "2004"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28179432", 
                    "type": "PUBMED", 
                    "id": "28179432"
                }
            ], 
            "title": "An Evolutionarily Conserved Role for Polydom/Svep1 During Lymphatic Vessel Formation.", 
            "journal": "Circulation research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Karpanen T, Padberg Y, van de Pavert SA, Dierkes C, Morooka N, Peterson-Maduro J, van de Hoek G, Adrian M, Mochizuki N, Sekiguchi K, Kiefer F, Schulte D, Schulte-Merker S", 
            "date": "2017"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/28179430", 
                    "type": "PUBMED", 
                    "id": "28179430"
                }
            ], 
            "title": "Polydom Is an Extracellular Matrix Protein Involved in Lymphatic Vessel Remodeling.", 
            "journal": "Circulation research", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Morooka N, Futaki S, Sato-Nishiuchi R, Nishino M, Totani Y, Shimono C, Nakano I, Nakajima H, Mochizuki N, Sekiguchi K", 
            "date": "2017"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/21963386", 
                    "type": "PUBMED", 
                    "id": "21963386"
                }
            ], 
            "title": "SVEP1 promoter regulation by methylation of CpG sites.", 
            "journal": "Gene", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Glait-Santar C, Benayahu D", 
            "date": "2011"
        }, 
        {
            "reference": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/pubmed/27626380", 
                    "type": "PUBMED", 
                    "id": "27626380"
                }
            ], 
            "title": "High-throughput discovery of novel developmental phenotypes.", 
            "journal": "Nature", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ], 
            "authors": "Dickinson ME, Flenniken AM, Ji X, Teboul L, Wong MD, White JK, Meehan TF, Weninger WJ, Westerberg H, Adissu H, Baker CN, Bower L, Brown JM, Caddle LB, Chiani F, Clary D, Cleak J, Daly MJ, Denegre JM, Doe B, Dolan ME, Edie SM, Fuchs H, Gailus-Durner V, Galli A, Gambadoro A, Gallegos J, Guo S, Horner NR, Hsu CW, Johnson SJ, Kalaga S, Keith LC, Lanoue L, Lawson TN, Lek M, Mark M, Marschall S, Mason J, McElwee ML, Newbigging S, Nutter LM, Peterson KA, Ramirez-Solis R, Rowland DJ, Ryder E, Samocha KE, Seavitt JR, Selloum M, Szoke-Kovacs Z, Tamura M, Trainor AG, Tudose I, Wakana S, Warren J, Wendling O, West DB, Wong L, Yoshiki A, MacArthur DG, Tocchini-Valentini GP, Gao X, Flicek P, Bradley A, Skarnes WC, Justice MJ, Parkinson HE, Moore M, Wells S, Braun RE, Svenson KL, de Angelis MH, Herault Y, Mohun T, Mallon AM, Henkelman RM, Brown SD, Adams DJ, Lloyd KC, McKerlie C, Beaudet AL, Bucan M, Murray SA", 
            "date": "2016"
        }
    ], 
    "uniprot_ac": "A2AVA0", 
    "site_annotation": [
        {
            "end_pos": 2991, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2989
        }, 
        {
            "end_pos": 3184, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3182
        }, 
        {
            "end_pos": 2933, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2931
        }, 
        {
            "end_pos": 2476, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2474
        }, 
        {
            "end_pos": 3457, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3455
        }, 
        {
            "end_pos": 587, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 585
        }, 
        {
            "end_pos": 2120, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2118
        }, 
        {
            "end_pos": 2807, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2805
        }, 
        {
            "end_pos": 189, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 187
        }, 
        {
            "end_pos": 2011, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2009
        }, 
        {
            "end_pos": 1979, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1977
        }, 
        {
            "end_pos": 750, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 748
        }, 
        {
            "end_pos": 2875, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2873
        }, 
        {
            "end_pos": 1734, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1732
        }, 
        {
            "end_pos": 932, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 930
        }, 
        {
            "end_pos": 3312, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3310
        }, 
        {
            "end_pos": 3215, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3213
        }, 
        {
            "end_pos": 3377, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3375
        }, 
        {
            "end_pos": 2782, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2780
        }, 
        {
            "end_pos": 2705, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2703
        }, 
        {
            "end_pos": 1766, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 1764
        }, 
        {
            "end_pos": 715, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 713
        }, 
        {
            "end_pos": 920, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 918
        }, 
        {
            "end_pos": 2162, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2160
        }, 
        {
            "end_pos": 3017, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3015
        }, 
        {
            "end_pos": 2371, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 2369
        }, 
        {
            "end_pos": 3340, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 3338
        }, 
        {
            "end_pos": 31, 
            "annotation": "n_glycosylation_sequon", 
            "start_pos": 29
        }
    ], 
    "mutation": [], 
    "isoforms": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AVA0#A2AVA0-2", 
            "isoform_ac": "A2AVA0-2", 
            "locus": {
                "end_pos": 0, 
                "start_pos": 0, 
                "chromosome": "N/A", 
                "evidence": []
            }, 
            "sequence": {
                "header": "sp|A2AVA0-2|SVEP1_MOUSE Isoform 2 of Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1  OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1 CANONICAL=A2AVA0-1", 
                "length": 440, 
                "sequence": "MWSRLAFCCWALALVSGWTNFQPVAPSLNFSFRLFPEASPGALGRLAVPPASSEEEAAGSKVERLGRAFRSRVRRLRELSGSLELVFLVDESSSVGQTNFLNELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPAITYRGGGTYTKGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMARCSYLCEAGKDCCDRMASCKCGTHTGQFECICEKGYYGKGLQHECTACPSGTYKPEASPGGISTCIPCPDVSHTSPPGSTSPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQNTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRGMESG"
            }
        }, 
        {
            "url": "https://www.uniprot.org/uniprot/A2AVA0#A2AVA0-1", 
            "isoform_ac": "A2AVA0-1", 
            "locus": {
                "end_pos": 58043150, 
                "start_pos": 58206376, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUST00000042850", 
                        "id": "ENSMUST00000042850", 
                        "database": "Ensembl Transcript"
                    }, 
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSP00000045856", 
                        "id": "ENSMUSP00000045856", 
                        "database": "Ensembl Peptide"
                    }
                ]
            }, 
            "sequence": {
                "header": "sp|A2AVA0-1|SVEP1_MOUSE Isoform 1 of Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1  OS=Mus musculus OX=10090 GN=Svep1 PE=1 SV=1 CANONICAL=A2AVA0-1", 
                "length": 3567, 
                "sequence": "MWSRLAFCCWALALVSGWTNFQPVAPSLNFSFRLFPEASPGALGRLAVPPASSEEEAAGSKVERLGRAFRSRVRRLRELSGSLELVFLVDESSSVGQTNFLNELKFVRKLLSDFPVVSTATRVAIVTFSSKNNVVARVDYISTSRAHQHKCALLSREIPAITYRGGGTYTKGAFQQAAQILRHSRENSTKVIFLITDGYSNGGDPRPIAASLRDFGVEIFTFGIWQGNIRELNDMASTPKEEHCYLLHSFEEFEALARRALHEDLPSGSFIQEDMARCSYLCEAGKDCCDRMASCKCGTHTGQFECICEKGYYGKGLQHECTACPSGTYKPEASPGGISTCIPCPDVSHTSPPGSTSPEDCVCREGYQRSGQTCEVVHCPALKPPENGFFIQNTCKNHFNAACGVRCRPGFDLVGSSIHLCQPNGLWSGTESFCRVRTCPHLRQPKHGHISCSTAEMSYNTLCLVTCNEGYRLEGSTRLTCQGNAQWDGPEPRCVERHCATFQKPKGVIISPPSCGKQPARPGMTCQLSCRQGYILSGVREVRCATSGKWSAKVQTAVCKDVEAPQISCPNDIEAKTGEQQDSANVTWQVPTAKDNSGEKVSVHVHPAFTPPYLFPIGDVAITYTATDSSGNQASCTFYIKVIDVEPPVIDWCRSPPPIQVVEKEHPASWDEPQFSDNSGAELVITSSHTQGDMFPHGETVVWYTATDPSGNNRTCDIHIVIKGSPCEVPFTPVNGDFICAQDSAGVNCSLSCKEGYDFTEGSTEKYYCAFEDGIWRPPYSTEWPDCAIKRFANHGFKSFEMLYKTTRCDDMDLFKKFSAAFETTLGNMVPSFCNDADDIDCRLEDLTKKYCIEYNYNYENGFAIGPGGWGAGNRLDYSYDHFLDVVQETPTDVGKARSSRIKRTVPLSDPKIQLIFNITASVPLPEERNDTLELENQQRLIKTLETITNRLKSTLNKEPMYSFQLASETVVADSNSLETEKAFLFCRPGSVLRGRMCVNCPLGTSYSLEHSTCESCLMGSYQDEEGQLECKLCPPRTHTEYLHSRSVSECKAQCKQGTYSSSGLETCESCPLGTYQPEFGSRSCLLCPETTTTVKRGAVDISACGVPCPVGEFSRSGLTPCYPCPRDYYQPNAGKSFCLACPFYGTTTITGATSITDCSSFSSTFSAAEESIVPLVAPGHSQNKYEVSSQVFHECFLNPCHNSGTCQQLGRGYVCLCPPGYTGLKCETDIDECSSLPCLNGGICRDQVGGFTCECSLGYSGQICEENINECISSPCLNKGTCTDGLASYRCTCVKGYMGVHCETDVNECQSSPCLNNAVCKDQVGGFSCKCPPGFLGTRCEKNVDECLSQPCQNGATCKDGANSFRCQCPAGFTGTHCELNINECQSNPCRNQATCVDELNSYSCKCQPGFSGHRCETEQPSGFNLDFEVSGIYGYVLLDGVLPTLHAITCAFWMKSSDVINYGTPISYALEDDKDNTFLLTDYNGWVLYVNGKEKITNCPSVNDGIWHHIAITWTSTGGAWRVYIDGELSDGGTGLSIGKAIPGGGALVLGQEQDKKGEGFNPAESFVGSISQLNLWDYVLSPQQVKLLASSCPEELSRGNVLAWPDFLSGITGKVKVDSSSMFCSDCPSLEGSVPHLRPASGNRKPGSKVSLFCDPGFQMVGNPVQYCLNQGQWTQPLPHCERIRCGLPPALENGFYSAEDFHAGSTVTYQCTSGYYLLGDSRMFCTDNGSWNGISPSCLDVDECAVGSDCSEHASCLNTNGSYVCSCNPPYTGDGKNCAEPVKCKAPENPENGHSSGEIYTVGTAVTFSCDEGHELVGVSTITCLETGEWDRLRPSCEAISCGVPPVPENGGVDGSAFTYGSKVVYRCDKGYTLSGDEESACLASGSWSHSSPVCELVKCSQPEDINNGKYILSGLTYLSIASYSCENGYSLQGPSLLECTASGSWDRAPPSCQLVSCGEPPIVKDAVITGSNFTFGNTVAYTCKEGYTLAGPDTIVCQANGKWNSSNHQCLAVSCDEPPNVDHASPETAHRLFGDTAFYYCADGYSLADNSQLICNAQGNWVPPAGQAVPRCIAHFCEKPPSVSYSILESVSKAKFAAGSVVSFKCMEGFVLNTSAKIECLRGGEWSPSPLSVQCIPVRCGEPPSIANGYPSGTNYSFGAVVAYSCHKGFYIKGEKKSTCEATGQWSKPTPTCHPVSCNEPPKVENGFLEHTTGRTFESEARFQCNPGYKAAGSPVFVCQANRHWHSDAPLSCTPLNCGKPPPIQNGFLKGESFEVGSKVQFVCNEGYELVGDNSWTCQKSGKWSKKPSPKCVPTKCAEPPLLENQLVLKELASEVGVMTISCKEGHALQGPSVLKCLPSGQWNGSFPICKMVLCPSPPLIPFGVPASSGALHFGSTVKYLCVDGFFLRGSPTILCQADSTWSSPLPECVPVECPQPEEILNGIIHVQGLAYLSTTLYTCKPGFELVGNATTLCGENGQWLGGKPMCKPIECPEPKEILNGQFSSVSFQYGQTITYFCDRGFRLEGPKSLTCLETGDWDMDPPSCDAIHCSDPQPIENGFVEGADYRYGAMIIYSCFPGFQVLGHAMQTCEESGWSSSSPTCVPIDCGLPPHIDFGDCTKVRDGQGHFDQEDDMMEVPYLAHPQHLEATAKALENTKESPASHASHFLYGTMVSYSCEPGYELLGIPVLICQEDGTWNGTAPSCISIECDLPVAPENGFLHFTQTTMGSAAQYSCKPGHILEGSHLRLCLQNKQWSGTVPRCEAISCSKPNPLWNGSIKGDDYSYLGVLYYECDSGYILNGSKKRTCQENRDWDGHEPMCIPVDCGSPPVPTNGRVKGEEYTFQKEITYSCREGFILEGARSRICLTNGSWSGATPSCMPVRCPAPPQVPNGVADGLDYGFKKEVAFHCLEGYVLQGAPRLTCQSNGTWDAEVPVCKPATCGPPADLPQGFPNGFSFYHGGHIQYQCFTGYKLHGNPSRRCLPNGSWSGSSPSCLPCRCSTPIIQQGTINATDLGCGKTVQIECFKGFKLLGLSEITCDANGQWSDVPLCEHAQCGPLPTIPNAIVLEGSLSEDNVVTYSCRPGYTMQGSSDLICTEKAIWSQPYPTCEPLSCGPPPTVANAVATGEAHTYESKVKLRCLEGYVMDSDTDTFTCQQDGHWVPERITCSPKKCPVPSNMTRIRFHGDDFQVNRQVSVSCAEGFTHEGVNWSTCQPDGTWEPPFSDESCIPVVCGHPESPAHGSVVGNKHSFGSTIVYQCDPGYKLEGNRERICQENRQWSGEVAVCRENRCETPAEFPNGKAVLENTTSGPSLLFSCHRGYTLEGSPEAHCTANGTWNHLTPLCKPNPCPVPFVIPENAVLSEKEFYVDQNVSIKCREGFLLKGNGVITCSPDETWTHTNARCEKISCGPPSHVENAIARGVYYQYGDMITYSCYSGYMLEGSLRSVCLENGTWTPSPVCRAVCRFPCQNGGVCQRPNACSCPDGWMGRLCEEPICILPCLNGGRCVAPYQCDCPTGWTGSRCHTATCQSPCLNGGKCIRPNRCHCLSAWTGHDCSRKRRAGL"
            }
        }
    ], 
    "pathway": [
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:64817", 
            "resource": "KEGG Pathway", 
            "id": "mmu:64817", 
            "name": ""
        }
    ], 
    "function": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AVA0#function", 
            "annotation": "May play a role in the cell attachment process.", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AVA0#function", 
                    "id": "A2AVA0", 
                    "database": "UniProtKB"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
            "annotation": "Polydom/Svep1 is an essential extracellular factors for lymphangiogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
            "annotation": "Polydom deposited around lymphatic vessels seems to ensure Foxc2 upregulation in lymphatic endothelial cells, possibly via the Ang-2 and Tie1/Tie2 receptor system, to regulate lymphangiogenesis.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
            "annotation": "Polydom is a hitherto unknown ligand for integrin alpha9beta1 that functions as a physiological ligand in vivo.", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ]
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
            "annotation": "Our results show that the putative promoter of SVEP1 is hypermethylated in DA3- compared with MBA-15 cells, thus regulating SVEP1 expression levels", 
            "evidence": [
                {
                    "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
                    "id": "NP_073725.2", 
                    "database": "RefSeq"
                }
            ]
        }
    ], 
    "orthologs": [], 
    "interactions": [], 
    "synthesized_glycans": [], 
    "refseq": {
        "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
        "ac": "NP_073725.2", 
        "name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor", 
        "summary": ""
    }, 
    "go_annotation": {
        "categories": [
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0003682", 
                        "pmid": "15522233", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "chromatin binding", 
                        "id": "GO:0003682"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "calcium ion binding", 
                        "id": "GO:0005509"
                    }
                ], 
                "total": 2, 
                "name": "Molecular Function"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005576", 
                        "pmid": "11062057", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular region", 
                        "id": "GO:0005576"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", 
                        "pmid": "24006456", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "extracellular space", 
                        "id": "GO:0005615"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005737", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cytoplasm", 
                        "id": "GO:0005737"
                    }, 
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0016020", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "membrane", 
                        "id": "GO:0016020"
                    }
                ], 
                "total": 4, 
                "name": "Cellular Component"
            }, 
            {
                "go_terms": [
                    {
                        "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0007155", 
                        "pmid": "", 
                        "evidence": [
                            {
                                "url": "https://www.uniprot.org/uniprot/A2AVA0", 
                                "id": "A2AVA0", 
                                "database": "UniProtKB"
                            }
                        ], 
                        "name": "cell adhesion", 
                        "id": "GO:0007155"
                    }
                ], 
                "total": 1, 
                "name": "Biological Process"
            }
        ]
    }, 
    "gene_names": [
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "1110021D17Rik; 4833413O10Rik; AA387071; D430029O09Rik; Polydom"
        }, 
        {
            "type": "recommended", 
            "resource": "uniprotkb", 
            "name": "Svep1"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "Svep1"
        }
    ], 
    "crossref": [
        {
            "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073725.2", 
            "id": "NP_073725.2", 
            "database": "RefSeq"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/gene/64817", 
            "id": "64817", 
            "database": "GeneID"
        }, 
        {
            "url": "https://omabrowser.org/oma/group/GLMPCYP/", 
            "id": "GLMPCYP", 
            "database": "OMA"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001759", 
            "id": "IPR001759", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.genome.jp/dbget-bin/get_linkdb?-t+pathway+mmu:64817", 
            "id": "mmu:64817", 
            "database": "KEGG Pathway"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07699", 
            "id": "PF07699", 
            "database": "Pfam"
        }, 
        {
            "url": "http://www.informatics.jax.org/marker/MGI:1928849", 
            "id": "1928849", 
            "database": "MGI"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000742", 
            "id": "IPR000742", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR002035", 
            "id": "IPR002035", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR011641", 
            "id": "IPR011641", 
            "database": "InterPro"
        }, 
        {
            "url": "http://research.bioinformatics.udel.edu/pro/entry/PR_A2AVA0", 
            "id": "PR_A2AVA0", 
            "database": "PRO"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR009030", 
            "id": "IPR009030", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR001881", 
            "id": "IPR001881", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF02494", 
            "id": "PF02494", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF07645", 
            "id": "PF07645", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00152", 
            "id": "cd00152", 
            "database": "CDD"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR003410", 
            "id": "IPR003410", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00008", 
            "id": "PF00008", 
            "database": "Pfam"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000152", 
            "id": "IPR000152", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR000436", 
            "id": "IPR000436", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR036465", 
            "id": "IPR036465", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013320", 
            "id": "IPR013320", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00033", 
            "id": "cd00033", 
            "database": "CDD"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00084", 
            "id": "PF00084", 
            "database": "Pfam"
        }, 
        {
            "url": "https://acgg.asia/gpdb2/GPDB0001733", 
            "id": "GPDB0001733", 
            "database": "GlycoProtDB"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR035976", 
            "id": "IPR035976", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR013032", 
            "id": "IPR013032", 
            "database": "InterPro"
        }, 
        {
            "url": "https://www.ebi.ac.uk/interpro/entry/IPR018097", 
            "id": "IPR018097", 
            "database": "InterPro"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00092", 
            "id": "PF00092", 
            "database": "Pfam"
        }, 
        {
            "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000028369", 
            "id": "ENSMUSG00000028369", 
            "database": "Bgee"
        }, 
        {
            "url": "http://www.orthodb.org/?query=46968at2759", 
            "id": "46968at2759", 
            "database": "OrthoDB"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF12661", 
            "id": "PF12661", 
            "database": "Pfam"
        }, 
        {
            "url": "http://pfam.xfam.org/family/PF00354", 
            "id": "PF00354", 
            "database": "Pfam"
        }
    ], 
    "expression_disease": [], 
    "glycosylation": [
        {
            "residue": "Asn", 
            "site_category": "predicted", 
            "evidence": [
                {
                    "url": "https://www.uniprot.org/uniprot/A2AVA0#ptm_processing", 
                    "id": "A2AVA0", 
                    "database": "UniProtKB"
                }
            ], 
            "relation": "attached", 
            "position": 187, 
            "glytoucan_ac": "", 
            "type": "N-linked"
        }
    ], 
    "disease": [], 
    "phosphorylation": [], 
    "mass": {
        "monoisotopic_mass": 387457.0, 
        "chemical_mass": 387457.0
    }, 
    "expression_tissue": [], 
    "gene": [
        {
            "url": "https://www.uniprot.org/uniprot/A2AVA0", 
            "name": "Svep1", 
            "locus": {
                "end_pos": 58042442, 
                "start_pos": 58206859, 
                "chromosome": "4", 
                "evidence": [
                    {
                        "url": "https://www.ensembl.org/id/ENSMUSG00000028369", 
                        "id": "ENSMUSG00000028369", 
                        "database": "Ensembl Gene"
                    }
                ]
            }
        }
    ], 
    "protein_names": [
        {
            "type": "synonym", 
            "resource": "uniprotkb", 
            "name": "Polydom"
        }, 
        {
            "type": "recommended", 
            "resource": "uniprotkb", 
            "name": "Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1; polydomain protein (Polydom)"
        }, 
        {
            "type": "synonym", 
            "resource": "refseq", 
            "name": "sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 precursor"
        }
    ]
}