{ "uniprot_canonical_ac": "A2ASQ1-1", "sequence": { "header": "sp|A2ASQ1-1|AGRIN_MOUSE Isoform 1 of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1950, "sequence": "MPPLPLEHRPRQQPGASVLVRYFMIPCNICLILLATSTLGFAVLLFLSNYKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESELTNEIPAPETLDSRALFSEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" }, "uniprot_id": "AGRIN_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [ "glycoprotein", "glycoprotein_predicted" ], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/12796478", "type": "PUBMED", "id": "12796478" } ], "title": "The COOH-terminal domain of agrin signals via a synaptic receptor in central nervous system neurons.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Smith M.A., Hilgenberg L.G., Hoover C.L.", "date": "2003" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10402191", "type": "PUBMED", "id": "10402191" } ], "title": "Alternatively spliced isoforms of nerve- and muscle-derived agrin: their roles at the neuromuscular junction.", "journal": "Neuron", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Sanes J.R., Burgess R.W., Lichtman J.W., Nguyen Q.T., Son Y.J.", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21885656", "type": "PUBMED", "id": "21885656" } ], "title": "Destabilization of the neuromuscular junction by proteolytic cleavage of agrin results in precocious sarcopenia.", "journal": "FASEB J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Bolliger M.F., Kunz B., Sonderegger P., Zurlinden A., Butikofer L.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/10581249", "type": "PUBMED", "id": "10581249" } ], "title": "Interaction of agrin with laminin requires a coiled-coil conformation of the agrin-binding site within the laminin gamma1 chain.", "journal": "EMBO J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Engel J., Lustig A., Denzer A.J., Ruegg M.A., Schumacher B., Kammerer R.A., Yurchenco P.D., Landwehr R., Schulthess T.", "date": "1999" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11161480", "type": "PUBMED", "id": "11161480" } ], "title": "An alternative amino-terminus expressed in the central nervous system converts agrin to a type II transmembrane protein.", "journal": "Mol. Cell. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Annies M., Bittcher G., Kroger S., Neumann F.R., Ruegg M.A., Schumacher B.", "date": "2001" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/16452087", "type": "PUBMED", "id": "16452087" } ], "title": "Comprehensive identification of phosphorylation sites in postsynaptic density preparations.", "journal": "Mol. Cell. Proteomics", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Schoepfer R., Burlingame A.L., Thalhammer A., Specht C.G., Trinidad J.C.", "date": "2006" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/17611272", "type": "PUBMED", "id": "17611272" } ], "title": "Synapse loss in cortex of agrin-deficient mice after genetic rescue of perinatal death.", "journal": "J. Neurosci.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Burkhardt C., Lin S., Ruegg M.A., Sanes J.R., Maj M., Bettler B., Seddik R., Arber S., Caroni P., Bezakova G., Jucker M., Ksiazek I.", "date": "2007" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/9188458", "type": "PUBMED", "id": "9188458" } ], "title": "Selective regulation of agrin mRNA induction and alternative splicing in PC12 cells by Ras-dependent actions of nerve growth factor.", "journal": "J. Biol. Chem.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Smith M.A., Fanger G.R., Bridle P., Maue R.A., O'Connor L.T.", "date": "1997" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/18230682", "type": "PUBMED", "id": "18230682" } ], "title": "Neurotrypsin cleaves agrin locally at the synapse.", "journal": "FASEB J.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Kozlov S.V., Kunz B., Sonderegger P., Cinelli P., Stephan A., Hettwer S., Kistler A.D., Mateos J.M., Rulicke T., Streit P.", "date": "2008" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19303856", "type": "PUBMED", "id": "19303856" } ], "title": "Coincident pre- and postsynaptic activation induces dendritic filopodia via neurotrypsin-dependent agrin cleavage.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Kunz B., Sonderegger P., Zurlinden A., Matsumoto-Miyai K., Gee C.E., Gerber U., Hettwer S., Ladner A.P., Luscher D., Rulicke T., Sokolowska E., Ster J., Wolfel J.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/11018052", "type": "PUBMED", "id": "11018052" } ], "title": "Agrin isoforms with distinct amino termini: differential expression, localization, and function.", "journal": "J. Cell Biol.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Sanes J.R., Burgess R.W., Skarnes W.C.", "date": "2000" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21037280", "type": "PUBMED", "id": "21037280" } ], "title": "Structural and biophysical characterisation of agrin laminin G3 domain constructs.", "journal": "Protein Eng. Des. Sel.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Tidow H., Nissen P., Mattle D.", "date": "2011" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/8653787", "type": "PUBMED", "id": "8653787" } ], "title": "Agrin acts via a MuSK receptor complex.", "journal": "Cell", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Shah S., Burden S.J., Bruno J., Radziejewski C., Ryan T.E., Valenzuela D.M., Yancopoulos G.D., DiStefano P.S., DeChiara T.M., Glass D.J., Stitt T.N., Gies D.R., Mattsson K., Bowen D.C.", "date": "1996" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/19221030", "type": "PUBMED", "id": "19221030" } ], "title": "Rescuing Z+ agrin splicing in Nova null mice restores synapse formation and unmasks a physiologic defect in motor neuron firing.", "journal": "Proc. Natl. Acad. Sci. U.S.A.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Darnell R.B., Burden S.J., Kim N., Ruggiu M., Herbst R., Fak J.J., Fischbach G., Jevsek M., Mann M.A.", "date": "2009" }, { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/21890498", "type": "PUBMED", "id": "21890498" } ], "title": "A valid mouse model of AGRIN-associated congenital myasthenic syndrome.", "journal": "Hum. Mol. Genet.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "authors": "Burgess R.W., Bogdanik L.P.", "date": "2011" } ], "uniprot_ac": "A2ASQ1", "site_annotation": [ { "end_pos": 829, "annotation": "n_glycosylation_sequon", "start_pos": 827 }, { "end_pos": 674, "annotation": "n_glycosylation_sequon", "start_pos": 672 }, { "end_pos": 950, "annotation": "n_glycosylation_sequon", "start_pos": 948 }, { "end_pos": 147, "annotation": "n_glycosylation_sequon", "start_pos": 145 } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#Z4YK85-1", "isoform_ac": "Z4YK85-1", "locus": { "end_pos": 156166499, "start_pos": 156185698, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105574", "id": "ENSMUST00000105574", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101199", "id": "ENSMUSP00000101199", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YK85-1|AGRIN_MOUSE Computationally mapped isoform of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1927, "sequence": "MPPLPLEHRPRQQPGASVLVRYFMIPCNICLILLATSTLGFAVLLFLSNYKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#Z4YJS5-1", "isoform_ac": "Z4YJS5-1", "locus": { "end_pos": 156166465, "start_pos": 156185698, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000071248", "id": "ENSMUST00000071248", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000071229", "id": "ENSMUSP00000071229", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|Z4YJS5-1|AGRIN_MOUSE Computationally mapped isoform of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1151, "sequence": "MPPLPLEHRPRQQPGASVLVRYFMIPCNICLILLATSTLGFAVLLFLSNYKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDPAPLSELPLELPPSLL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#A2ASQ1-3", "isoform_ac": "A2ASQ1-3", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2ASQ1-3|AGRIN_MOUSE Isoform 3 of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1867, "sequence": "MPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESSEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#A2ASQ1-2", "isoform_ac": "A2ASQ1-2", "locus": { "end_pos": 0, "start_pos": 0, "chromosome": "N/A", "evidence": [] }, "sequence": { "header": "sp|A2ASQ1-2|AGRIN_MOUSE Isoform 2 of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1928, "sequence": "MPPLPLEHRPRQQPGASVLVRYFMIPCNICLILLATSTLGFAVLLFLSNYKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESSEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#M0QWP1-1", "isoform_ac": "M0QWP1-1", "locus": { "end_pos": 156166499, "start_pos": 156197420, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000180572", "id": "ENSMUST00000180572", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000137931", "id": "ENSMUSP00000137931", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|M0QWP1-1|AGRIN_MOUSE Computationally mapped isoform of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 2034, "sequence": "MVRPRLSFPAPLLPLLLLLAAAAPAVPGASGTCPERALERREEEANVVLTGTVEEILNVDPVQHTYSCKVRVWRYLKGKDVVAQESLLDGGNKVVIGGFGDPLICDNQVSTGDTRIFFVNPAPPYLWPAHKNELMLNSSLMRITLRNLEEVEFCVEDKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" } }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#A2ASQ1-1", "isoform_ac": "A2ASQ1-1", "locus": { "end_pos": 156166499, "start_pos": 156185698, "chromosome": "4", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000105575", "id": "ENSMUST00000105575", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000101200", "id": "ENSMUSP00000101200", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "sp|A2ASQ1-1|AGRIN_MOUSE Isoform 1 of Agrin OS=Mus musculus OX=10090 GN=Agrn PE=1 SV=1 CANONICAL=A2ASQ1-1", "length": 1950, "sequence": "MPPLPLEHRPRQQPGASVLVRYFMIPCNICLILLATSTLGFAVLLFLSNYKPGIHFTAAPSMPPDVCRGMLCGFGAVCEPSVEDPGRASCVCKKNVCPAMVAPVCGSDASTYSNECELQRAQCNQQRRIRLLRQGPCGSRDPCANVTCSFGSTCVPSADGQTASCLCPTTCFGAPDGTVCGSDGVDYPSECQLLRHACANQEHIFKKFDGPCDPCQGSMSDLNHICRVNPRTRHPEMLLRPENCPAQHTPICGDDGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQCPETCQFNSVCLSRRGRPHCSCDRVTCDGAYRPVCAQDGHTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKNGKAVCECQRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESAQPVCGSDGHTYASECELHVHACTHQISLYVASAGHCQTCGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAACQQQVQIEEARAGPCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCVCDFSCQSVLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEMHCEFGASCVEEAGFAQCVCPTLTCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQSLGPCRESVAPGVSPTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLATAIFRESGSTNGSGDEELSGDEEASGGGSGGLEPPVGSVVVTHGPPIERASCYNSPLGCCSDGKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELFGETARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASSVTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSGKGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNARGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGESPSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKMALEMVFLARGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNLKEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESELTNEIPAPETLDSRALFSEKALQSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAHREHREGSLQVGNEAPVTGSSPLGATQLDTDGALWLGGLQKLPVGQALPKAYGTGFVGCLRDVVVGHRQLHLLEDAVTKPELRPCPTL" } } ], "pathway": [ { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2024096", "resource": "Reactome", "id": "R-MMU-2024096", "name": "HS-GAG degradation" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-3000178", "resource": "Reactome", "id": "R-MMU-3000178", "name": "ECM proteoglycans" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-975634", "resource": "Reactome", "id": "R-MMU-975634", "name": "Retinoid metabolism and transport" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-1971475", "resource": "Reactome", "id": "R-MMU-1971475", "name": "A tetrasaccharide linker sequence is required for GAG synthesis" }, { "url": "https://www.reactome.org/PathwayBrowser/#R-MMU-2022928", "resource": "Reactome", "id": "R-MMU-2022928", "name": "HS-GAG biosynthesis" } ], "function": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "annotation": "involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling (By similarity).", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "id": "A2ASQ1", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "annotation": "this released fragment is important for agrin signaling and to exert a maximal dendritic filopodia-inducing effect. All 'z' splice variants (z+) of this fragment also show an increase in the number of filopodia.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "id": "A2ASQ1", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "annotation": "Isoform 2 and isoform 3: these isoforms lacking the 'z' insert (z0) are muscle-specific, have no AChR clustering ability and may be involved in nervous system endothelial cell differentiation.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "id": "A2ASQ1", "database": "UniProtKB" } ] }, { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "annotation": "heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This transmembrane agrin (TM-agrin) isoform, the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases.", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1#function", "id": "A2ASQ1", "database": "UniProtKB" } ] } ], "orthologs": [], "interactions": [], "synthesized_glycans": [], "refseq": {}, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0030548", "pmid": "14622576", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "acetylcholine receptor regulator activity", "id": "GO:0030548" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043395", "pmid": "12773545", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "heparan sulfate proteoglycan binding", "id": "GO:0043395" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0044325", "pmid": "19376779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "ion channel binding", "id": "GO:0044325" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0035374", "pmid": "12773545", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "chondroitin sulfate binding", "id": "GO:0035374" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042030", "pmid": "19376779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "ATPase inhibitor activity", "id": "GO:0042030" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005509", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "calcium ion binding", "id": "GO:0005509" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002162", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "dystroglycan binding", "id": "GO:0002162" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0050431", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "transforming growth factor beta binding", "id": "GO:0050431" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0033691", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "sialic acid binding", "id": "GO:0033691" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0036122", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "BMP binding", "id": "GO:0036122" } ], "total": 10, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "9422725", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "12165471", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0009986", "pmid": "19376779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "cell surface", "id": "GO:0009986" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0045202", "pmid": "18230682", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "synapse", "id": "GO:0045202" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0043083", "pmid": "23056392", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "synaptic cleft", "id": "GO:0043083" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0042383", "pmid": "19376779", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "sarcolemma", "id": "GO:0042383" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "pmid": "7670489", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "basement membrane", "id": "GO:0005604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005604", "pmid": "18757743", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2ASQ1", "id": "A2ASQ1", "database": "UniProtKB" } ], "name": "basement membrane", "id": "GO:0005604" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0062023", 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