{ "uniprot_canonical_ac": "A2AS37-1", "sequence": { "header": "tr|A2AS37-1|A2AS37_MOUSE Isoform 1 of Expressed sequence AI182371 OS=Mus musculus OX=10090 GN=AI182371 PE=1 SV=2 CANONICAL=A2AS37-1", "length": 356, "sequence": "MVLIPSQAMGFWGTLLFLIFLEQSWGQEQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSFSNSYLEVVSKHFAKLEIVPIIYDNDSLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATRETVLTFIDPEGSQVDTIEGNNLTGIASFPDFEIPSNPKHGRWTVKAKYREDASKTGTTYFEVKEYDKTYRISIMPTIDLQPEVEKQEAHGMCLHQPTECLRQKINEQASTYKHPMIKKCCYDGARYNIHETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLSSHSNHQAEHGDPQWRSQGKD" }, "uniprot_id": "A2AS37_MOUSE", "enzyme_annotation": [], "glycation": [], "keywords": [], "species": [ { "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "Mus musculus", "taxid": 10090 } ], "publication": [ { "reference": [ { "url": "https://www.ncbi.nlm.nih.gov/pubmed/2473064", "type": "PUBMED", "id": "2473064" } ], "title": "Alpha-macroglobulins: structure, shape, and mechanism of proteinase complex formation.", "journal": "The Journal of biological chemistry", "evidence": [ { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849216.2", "id": "NP_849216.2", "database": "RefSeq" } ], "authors": "Sottrup-Jensen L", "date": "1989" } ], "uniprot_ac": "A2AS37", "site_annotation": [ { "end_pos": 188, "annotation": "n_glycosylation_sequon", "start_pos": 186 }, { "end_pos": 48, "annotation": "n_glycosylation_sequon", "start_pos": 46 }, { "end_pos": 329, "annotation": "n_glycosylation_sequon", "start_pos": 327 }, { "end_pos": 82, "annotation": "n_glycosylation_sequon", "start_pos": 80 }, { "end_pos": 133, "annotation": "n_glycosylation_sequon", "start_pos": 131 } ], "mutation": [], "isoforms": [ { "url": "https://www.uniprot.org/uniprot/A2AS37#A0A0J9YUP3-1", "isoform_ac": "A0A0J9YUP3-1", "locus": { "end_pos": 35095872, "start_pos": 35100683, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000226375", "id": "ENSMUST00000226375", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000154339", "id": "ENSMUSP00000154339", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A0J9YUP3-1|A2AS37_MOUSE Computationally mapped isoform of Expressed sequence AI182371 OS=Mus musculus OX=10090 GN=AI182371 PE=1 SV=2 CANONICAL=A2AS37-1", "length": 57, "sequence": "MQSSLKEVTDMVLIPSQAMGFWGTLLFLIFLEQSWGQEQTFRPNSYLKDKTHFQIRI" } }, { "url": "https://www.uniprot.org/uniprot/A2AS37#A0A2I3BRQ1-1", "isoform_ac": "A0A2I3BRQ1-1", "locus": { "end_pos": 35082484, "start_pos": 35100683, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000226631", "id": "ENSMUST00000226631", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000154570", "id": "ENSMUSP00000154570", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2I3BRQ1-1|A2AS37_MOUSE Computationally mapped isoform of Expressed sequence AI182371 OS=Mus musculus OX=10090 GN=AI182371 PE=1 SV=1 CANONICAL=A2AS37-1", "length": 352, "sequence": "MQSSLKEVTDMVLIPSQAMGFWGTLLFLIFLEQSWGQEQTRYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSFSNSYLEVVSKHFAKLEIVPIIYDNDSLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATRETVLTFIDPEGSQVDTIEGNNLTGIASFPDFEIPSNPKHGRWTVKAKYREDASKTGTTYFEVKEYDKTYRISIMPTIDLQPEVEKQEAHGMCLHQPTECLRQKINEQASTYKHPMIKKCCYDGARYNIHETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLSSHYRS" } }, { "url": "https://www.uniprot.org/uniprot/A2AS37#A2AS37-1", "isoform_ac": "A2AS37-1", "locus": { "end_pos": 35084670, "start_pos": 35100653, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000045776", "id": "ENSMUST00000045776", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000037754", "id": "ENSMUSP00000037754", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A2AS37-1|A2AS37_MOUSE Isoform 1 of Expressed sequence AI182371 OS=Mus musculus OX=10090 GN=AI182371 PE=1 SV=2 CANONICAL=A2AS37-1", "length": 356, "sequence": "MVLIPSQAMGFWGTLLFLIFLEQSWGQEQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSFSNSYLEVVSKHFAKLEIVPIIYDNDSLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATRETVLTFIDPEGSQVDTIEGNNLTGIASFPDFEIPSNPKHGRWTVKAKYREDASKTGTTYFEVKEYDKTYRISIMPTIDLQPEVEKQEAHGMCLHQPTECLRQKINEQASTYKHPMIKKCCYDGARYNIHETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLSSHSNHQAEHGDPQWRSQGKD" } }, { "url": "https://www.uniprot.org/uniprot/A2AS37#A0A2I3BQE1-1", "isoform_ac": "A0A2I3BQE1-1", "locus": { "end_pos": 35082484, "start_pos": 35100683, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUST00000226972", "id": "ENSMUST00000226972", "database": "Ensembl Transcript" }, { "url": "https://www.ensembl.org/id/ENSMUSP00000154033", "id": "ENSMUSP00000154033", "database": "Ensembl Peptide" } ] }, "sequence": { "header": "tr|A0A2I3BQE1-1|A2AS37_MOUSE Computationally mapped isoform of Expressed sequence AI182371 OS=Mus musculus OX=10090 GN=AI182371 PE=1 SV=1 CANONICAL=A2AS37-1", "length": 351, "sequence": "MQSSLKEVTDMVLIPSQAMGFWGTLLFLIFLEQSWGQEQTYIISTPIVFRVGAPENVTVQAHGHTEAFDTTVSVKSYPDENVRYSFSTVNLSPENKFQNTAILTIQAKQLSEGQNSFSNSYLEVVSKHFAKLEIVPIIYDNDSLFVQTDKSVYTPQQPVKVRVYSVNDDLEPATRETVLTFIDPEGSQVDTIEGNNLTGIASFPDFEIPSNPKHGRWTVKAKYREDASKTGTTYFEVKEYDKTYRISIMPTIDLQPEVEKQEAHGMCLHQPTECLRQKINEQASTYKHPMIKKCCYDGARYNIHETCVQRAARVKIGPICVKAFTLCCNMAHQILENSTFKHIHLSSHYRS" } } ], "pathway": [], "function": [], "orthologs": [], "interactions": [], "synthesized_glycans": [], "refseq": { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849216.2", "ac": "NP_849216.2", "name": "hemolytic complement-like isoform 1 precursor", "summary": "" }, "go_annotation": { "categories": [ { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0002020", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "protease binding", "id": "GO:0002020" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0004866", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "endopeptidase inhibitor activity", "id": "GO:0004866" } ], "total": 2, "name": "Molecular Function" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0005615", "pmid": "21873635", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "extracellular space", "id": "GO:0005615" } ], "total": 1, "name": "Cellular Component" }, { "go_terms": [ { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006954", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "inflammatory response", "id": "GO:0006954" }, { "url": "https://www.ebi.ac.uk/QuickGO/term/GO:0006956", "pmid": "", "evidence": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "id": "A2AS37", "database": "UniProtKB" } ], "name": "complement activation", "id": "GO:0006956" } ], "total": 2, "name": "Biological Process" } ] }, "gene_names": [ { "type": "recommended", "resource": "uniprotkb", "name": "AI182371" }, { "type": "synonym", "resource": "refseq", "name": "AI182371" }, { "type": "synonym", "resource": "refseq", "name": "AI046667" } ], "crossref": [ { "url": "http://pfam.xfam.org/family/PF01821", "id": "PF01821", "database": "Pfam" }, { "url": "https://www.ncbi.nlm.nih.gov/protein/NP_849216.2", "id": "NP_849216.2", "database": "RefSeq" }, { "url": "http://www.informatics.jax.org/marker/MGI:2138853", "id": "2138853", "database": "MGI" }, { "url": "https://www.ncbi.nlm.nih.gov/Structure/cdd/cddsrv.cgi?uid=cd00017", "id": "cd00017", "database": "CDD" }, { "url": "https://www.ncbi.nlm.nih.gov/gene/98870", "id": "98870", "database": "GeneID" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR018081", "id": "IPR018081", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF01835", "id": "PF01835", "database": "Pfam" }, { "url": "http://www.orthodb.org/?query=840831at2759", "id": "840831at2759", "database": "OrthoDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR037562", "id": "IPR037562", "database": "InterPro" }, { "url": "http://www.pantherdb.org/panther/family.do?clsAccession=PTHR11412:SF83", "id": "PTHR11412:SF83", "database": "PANTHER" }, { "url": "https://bgee.org/?page=gene&gene_id=ENSMUSG00000035875", "id": "ENSMUSG00000035875", "database": "Bgee" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR002890", "id": "IPR002890", "database": "InterPro" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR000020", "id": "IPR000020", "database": "InterPro" }, { "url": "https://acgg.asia/gpdb2/GPDB0001725", "id": "GPDB0001725", "database": "GlycoProtDB" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR041425", "id": "IPR041425", "database": "InterPro" }, { "url": "http://pfam.xfam.org/family/PF17790", "id": "PF17790", "database": "Pfam" }, { "url": "https://www.ebi.ac.uk/interpro/entry/IPR001840", "id": "IPR001840", "database": "InterPro" } ], "expression_disease": [], "glycosylation": [], "disease": [], "phosphorylation": [], "mass": { "monoisotopic_mass": 40432.0, "chemical_mass": 40432.0 }, "expression_tissue": [], "gene": [ { "url": "https://www.uniprot.org/uniprot/A2AS37", "name": "AI182371", "locus": { "end_pos": 35081861, "start_pos": 35101543, "chromosome": "2", "evidence": [ { "url": "https://www.ensembl.org/id/ENSMUSG00000035875", "id": "ENSMUSG00000035875", "database": "Ensembl Gene" } ] } } ], "protein_names": [ { "type": "synonym", "resource": "refseq", "name": "hemolytic complement-like isoform 1 precursor" }, { "type": "synonym", "resource": "uniprotkb", "name": "Expressed sequence AI182371" } ] }